sdc1 (SPCC18.11c)


Gene Standard Namesdc1 Characterisation Statuspublished
Systematic IDSPCC18.11c Feature Typeprotein coding
Synonymsdpy30 Name Description
ProductDpy-30 domain protein Sdc1 Product Size109aa, 11.86 kDa
Genomic Location Chromosome III, 1976711-1975472 (1240nt); CDS:1976436-1976023 (414nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
chromatin remodeling156
Annotation ExtensionEvidenceWith/FromReference
histone H3-K4 methylation17
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
Lid2 complex5
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin309
Annotation ExtensionEvidenceWith/FromReference
nucleus2695
Annotation ExtensionEvidenceWith/FromReference
Set1C/COMPASS complex8
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
resistance to latrunculin Asdc1ΔNull5
sensitive to hydroxyureasdc1ΔNull534
viable vegetative cell populationsdc1ΔNull3795
unnamed (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologysdc1ΔNull3093
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1976711..1976348, 1976263..1975472
mRNA1976711..1975472
5' UTR1976711..1976437PMID:21511999
CDS1976436..1976348, 1976263..1976023
3' UTR1976022..1975472PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05186 Pfam IPR007858 Dpy-30 motif 6 46 1
PTHR23356:SF0 HMMPANTHER 3 72 1
PTHR23356 HMMPANTHER 3 72 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.77 Da
Charge -2.00
Isoelectric point 4.71
Molecular weight 11.86 kDa
Number of residues 109
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-threonineT65 698
present during mitotic M phaseT65
Annotation ExtensionEvidenceResidueReference
experimental evidence T65 PMID:24763107
present during mitotic M phase experimental evidence T65 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
27600during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
28551during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
28051during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
29886during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
17860.76during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
26741during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8765.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.3during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturesash2Ash2-trithorax family protein Affinity Capture-MSPMID:14617822
affinity captured byash2Ash2-trithorax family protein Affinity Capture-MSPMID:14617822
affinity capturesjmj3Lid2 complex subunit, histone demethylase H3-K36 specific Jmj3 Affinity Capture-MSPMID:14617822
affinity captureslid2Lid2 complex subunit, predicted histone demethylase Lid2 Affinity Capture-MSPMID:14617822
affinity captured bymtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
affinity capturessdc1Dpy-30 domain protein Sdc1 Affinity Capture-MSPMID:14617822
affinity captured byset1histone lysine methyltransferase Set1 Affinity Capture-MSPMID:14617822
affinity capturesset1histone lysine methyltransferase Set1 Affinity Capture-MSPMID:14617822
affinity capturesshg1Set1C complex subunit Shg1 Affinity Capture-MSPMID:14617822
affinity capturessnt2Lid2 complex subunit Snt2 Affinity Capture-MSPMID:14617822
affinity captured byspf1Set1C PHD Finger protein Spf1 Affinity Capture-MSPMID:14617822
affinity capturesspf1Set1C PHD Finger protein Spf1 Affinity Capture-MSPMID:14617822
affinity capturesswd1Set1C complex subunit Swd1 Affinity Capture-MSPMID:14617822
affinity capturesswd2Set1C complex subunit Swd2.1 Affinity Capture-MSPMID:14617822
affinity capturesswd3WD repeat protein Swd3 Affinity Capture-MSPMID:14617822
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withalg5dolichyl-phosphate beta-glucosyltransferase Alg5 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withalg6glucosyltransferase Alg6 Positive GeneticPMID:22681890
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witharp6actin-like protein Arp6 Negative GeneticPMID:18818364
negative genetic interaction witharp6actin-like protein Arp6 Negative GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
positive genetic interaction withash2Ash2-trithorax family protein Positive GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
negative genetic interaction withasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withatd1aldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withatp14F1-ATPase subunit H (predicted) Negative GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
negative genetic interaction withbdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
negative genetic interaction withbdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:22681890
negative genetic interaction withcay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcbp1CENP-B homolog Negative GeneticPMID:18818364
negative genetic interaction withccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:22681890
negative genetic interaction withcip1RNA-binding protein Cip1 Negative GeneticPMID:22681890
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
positive genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
negative genetic interaction withcwf11complexed with Cdc5 protein Cwf11 Negative GeneticPMID:22681890
negative genetic interaction withcwf16splicing factor Cwf16 Negative GeneticPMID:22681890
negative genetic interaction withcwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
negative genetic interaction withdef1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withdeg1tRNA-pseudouridine synthase Deg1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withdep1Sds3-like family protein Dep1 Negative GeneticPMID:22681890
negative genetic interaction withell1RNA polymerase II transcription elongation factor SpELL Negative GeneticPMID:22681890
positive genetic interaction withemc1ER membrane protein complex subunit Emc1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction witheri1double-strand siRNA ribonuclease Eri1 Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withgcd10tRNA (m1A) methyltransferase Gcd10 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withgim3prefoldin subunit 4, Gim3 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withgit5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
negative genetic interaction withhap2HMG box protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withhos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
negative genetic interaction withhos2histone deacetylase (class I) Hos2 Negative GeneticPMID:22681890
negative genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:18818364
negative genetic interaction withies2Ino80 complex subunit Ies2 Negative GeneticPMID:18818364
negative genetic interaction withies4Ino80 complex subunit Ies4 Negative GeneticPMID:22681890
negative genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withmed6mediator complex subunit Med6 Negative GeneticPMID:18818364
negative genetic interaction withmex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
negative genetic interaction withmga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmoe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withmrf1mitochondrial peptide chain release factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmsc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
negative genetic interaction withmsc1multi-copy suppressor of Chk1 Negative GeneticPMID:22681890
negative genetic interaction withmug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
negative genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withomh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
positive genetic interaction withpac10prefoldin subunit 3 Pac10 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
negative genetic interaction withpng2ING family homolog Png2 Negative GeneticPMID:18818364
negative genetic interaction withpng2ING family homolog Png2 Negative GeneticPMID:22681890
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
negative genetic interaction withppk26protein kinase like PAN complex subunit Ppk26 Negative GeneticPMID:22681890
positive genetic interaction withppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
negative genetic interaction withpub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:22681890
positive genetic interaction withrav1RAVE complex subunit Rav1 Positive GeneticPMID:22681890
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:22681890
negative genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:18818364
negative genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:22681890
positive genetic interaction withrps40240S ribosomal protein S4 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrrp2ATP-dependent DNA helicase, ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
negative genetic interaction withrtf2replication termination factor Rtf2 Negative GeneticPMID:22681890
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:22681890
negative genetic interaction withsaf5splicing factor Saf5 Negative GeneticPMID:22681890
negative genetic interaction withsat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withsat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsde2silencing defective protein Sde2 Negative GeneticPMID:22681890
negative genetic interaction withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
negative genetic interaction withser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withset1histone lysine methyltransferase Set1 Positive GeneticPMID:18818364
positive genetic interaction withset1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
negative genetic interaction withset3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
negative genetic interaction withset3histone lysine methyltransferase Set3 Negative GeneticPMID:22681890
positive genetic interaction withsgf29SAGA complex subunit Sgf29 Positive GeneticPMID:22681890
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
negative genetic interaction withsno1glutamine aminotransferase subunit Sno1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsnt2Lid2 complex subunit Snt2 Negative GeneticPMID:18818364
negative genetic interaction withsnt2Lid2 complex subunit Snt2 Negative GeneticPMID:22681890
negative genetic interaction withsnz1pyridoxine biosynthesis protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC1486.01manganese superoxide dismutase Negative GeneticPMID:22681890
positive genetic interaction withSPAC18B11.03cN-acetyltransferase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC18G6.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC56F8.12conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC694.04cconserved eukaryotic protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC6B12.07cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAPB8E5.04cNiemann-Pick disease type C2 protein hE1 homolog (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC1348.03S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
positive genetic interaction withSPBC16H5.12cconserved fungal protein Positive GeneticPMID:22681890
positive genetic interaction withSPBC21B10.07glycosyl hydrolase family 16 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC365.16conserved protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withspc2signal peptidase subunit Spc2 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withspf1Set1C PHD Finger protein Spf1 Positive GeneticPMID:22681890
negative genetic interaction withspo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
negative genetic interaction withsst6ESCRT I complex subunit Vps23 Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withswc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:18818364
negative genetic interaction withswc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
negative genetic interaction withswc3Swr1 complex subunit Swc3 Negative GeneticPMID:22681890
positive genetic interaction withswd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
negative genetic interaction withswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Negative GeneticPMID:18818364
negative genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Negative GeneticPMID:18818364
negative genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Negative GeneticPMID:22681890
negative genetic interaction withtls1splicing factor Tls1 Negative GeneticPMID:22681890
negative genetic interaction withtop1DNA topoisomerase I Negative GeneticPMID:18818364
negative genetic interaction withtrm10tRNA m(1)G methyltransferase Trm10 Negative GeneticPMID:22681890
negative genetic interaction withuri1unconventional prefoldin chaperone involved protein complex assembly Uri1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvht1vitamin H transmembrane transporter Vht1 Negative GeneticPMID:22681890
positive genetic interaction withvps38phophatidylinositol 3-kinase complex subunit Vps38 Positive GeneticPMID:22681890
negative genetic interaction withvps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
negative genetic interaction withyaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
negative genetic interaction withzds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPCC18.11c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC18.11c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC18.11c BioGRID Interaction Datasets
Expression Viewer SPCC18.11c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC18.11c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC18.11c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC18.11c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC18.11c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC18.11c Transcriptome Viewer (Bähler Lab)
GEO SPCC18.11c GEO profiles
PInt SPCC18.11c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC18.11c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC18.11c Fission yeast phenotypic data & analysis
Cyclebase SPCC18.11c.1 Cell Cycle Data
SPD / RIKEN03/03C06Orfeome Localization Data
UniProtKB/SwissProtO74861Set1 complex component sdc1
ModBaseO74861Database of comparative protein structure models
STRINGO74861Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588390Dpy-30 domain protein Sdc1
RefSeq mRNANM_001023381972h- Dpy-30 domain protein Sdc1 (sdc1), mRNA
European Nucleotide ArchiveCAA21425.1ENA Protein Mapping
UniParcUPI0000069D3CUniProt Archive

Literature for sdc1

Search: Europe PMC or PubMed

Release Version: PomBase:26_51 - 07 Apr 2015