sdc1 (SPCC18.11c)


Gene Standard Namesdc1 Characterisation Statuspublished
Systematic IDSPCC18.11c Feature Typeprotein coding
Synonymsdpy30 Name Description
ProductDpy-30 domain protein Sdc1 Product Size109aa, 11.86 kDa
Genomic Location Chromosome III, 1976711-1975472 (1240nt); CDS:1976436-1976023 (414nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingICGO:0048188GO_REF:0000001157
GO:0016571histone methylationIMPPMID:1248844716
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0048189Lid2 complexIDAPMID:124884475
GO:0048188Set1C/COMPASS complexIDAPMID:124884478
GO:0005829cytosolIDAPMID:168233722316
GO:0000790nuclear chromatinICGO:0048188GO_REF:0000001279
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopynot recorded (unrecorded)PMID:124884473730
Microscopysdc1ΔNullPMID:20473289
Microscopysdc1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopysdc1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
119767111976348
219762631975472

UTRs

Region Coordinates Reference
five_prime_UTR1976711..1976437PMID:21511999
three_prime_UTR1976022..1975472PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05186 Pfam IPR007858 Dpy-30 motif 6 46 1
PTHR23356:SF0 HMMPANTHER 3 72 1
PTHR23356 HMMPANTHER 3 72 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.77 Da
Charge -2.00
Isoelectric point 4.71
Molecular weight 11.86 kDa
Number of residues 109
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00047O-phospho-L-threonineT65PMID:24763107689
present during mitotic M phaseT65PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
27600during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
28551during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
28051during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
29886during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
17860.76during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
26741during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8765.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4.3during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC1486.01manganese superoxide dismutase (predicted) Negative GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
SPAC6B12.07cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Positive GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:22681890
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
vht1vitamin H transporter Vht1 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
SPAC56F8.12conserved fungal protein Negative GeneticPMID:22681890
spc2signal peptidase subunit Spc2 (predicted) Negative GeneticPMID:22681890
vps38phophatidylinositol 3-kinase complex subunit Vps38 Positive GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:22681890
dep1Sds3-like family protein Dep1 Negative GeneticPMID:22681890
emc1ER membrane protein complex subunit Emc1 (predicted) Positive GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
asp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
SPAC18B11.03cN-acetyltransferase (predicted) Positive GeneticPMID:22681890
gcd10tRNA (m1A) methyltransferase Gcd10 (predicted) Negative GeneticPMID:22681890
SPAC694.04cconserved eukaryotic protein Negative GeneticPMID:22681890
cwf16splicing factor Cwf16 Negative GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
rav1RAVE complex subunit Rav1 Positive GeneticPMID:22681890
atd1aldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
mal3EB1 family Mal3 Negative GeneticPMID:18818364
SPAC227.05prefoldin subunit 4 (predicted) Positive GeneticPMID:18818364
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
SPAC18G6.13sequence orphan Negative GeneticPMID:22681890
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
cip1RNA-binding protein Cip1 Negative GeneticPMID:22681890
rtf2replication termination factor Rtf2 Negative GeneticPMID:22681890
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
ies2Ino80 complex subunit Ies2 Negative GeneticPMID:18818364
spo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
bdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Positive GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:18818364
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
saf5splicing factor Negative GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
SPAC25B8.05tRNA-pseudouridine synthase (predicted) Negative GeneticPMID:18818364
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Positive GeneticPMID:18818364
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
trm10tRNA m(1)G methyltransferase Trm10 Negative GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
snz1pyridoxine biosynthesis protein Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
png2ING family homolog Png2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC824.04WD repeat protein (predicted) Negative GeneticPMID:18818364
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAPB8E5.04cNiemann-Pick disease type C2 protein hE1 homolog (predicted) Positive GeneticPMID:22681890
SPAC1D4.01human C9orf78 ortholog Negative GeneticPMID:22681890
sgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
cwf11complexed with Cdc5 protein Cwf11 Negative GeneticPMID:22681890
chp1chromodomain protein Chp1 Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
SPBC365.16conserved protein Negative GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Positive GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor Reb1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ppk26protein kinase like PAN complex subunit Ppk26 Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
pub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:22681890
swc3Swr1 complex subunit Swc3 Negative GeneticPMID:22681890
ell1RNA polymerase II transcription elongation factor SpELL Negative GeneticPMID:22681890
SPAC2F7.17mitochondrial peptide chain release factor (predicted) Negative GeneticPMID:22681890
SPCC736.07cunconventional prefoldin involved in translation initiation (predicted) Negative GeneticPMID:22681890
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cbp1CENP-B homolog Negative GeneticPMID:18818364
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
SPBC21B10.07glycosyl hydrolase family 16 (predicted) Positive GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
SPBC16H5.12cconserved fungal protein Positive GeneticPMID:22681890
SPAC222.08cglutamine aminotransferase subunit (predicted) Negative GeneticPMID:22681890
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
sst6ESCRT I complex subunit Vps23 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
atp14F1-ATPase subunit H (predicted) Negative GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
eri1double-strand siRNA ribonuclease Eri1 Negative GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rps40240S ribosomal protein S4 (predicted) Positive GeneticPMID:22681890
top1DNA topoisomerase I Negative GeneticPMID:18818364
SPBC1348.03S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
alg5dolichyl-phosphate beta-glucosyltransferase Alg5 (predicted) Positive GeneticPMID:22681890
rrp2ATP-dependent DNA helicase (predicted) Negative GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ies4Ino80 complex subunit Ies4 Negative GeneticPMID:22681890
alg6glucosyltransferase Alg6 Positive GeneticPMID:22681890
mex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
lid2Lid2 complex subunit, predicted histone demethylase Lid2 Affinity Capture-MSPMID:14617822
jmj3Lid2 complex subunit, histone demethylase H3-K36 specific Jmj3 Affinity Capture-MSPMID:14617822
shg1Set1C complex subunit Shg1 Affinity Capture-MSPMID:14617822
set1histone lysine methyltransferase Set1 Affinity Capture-MSPMID:14617822
snt2Lid2 complex subunit Snt2 Affinity Capture-MSPMID:14617822
swd3WD repeat protein Swd3 Affinity Capture-MSPMID:14617822
sdc1Dpy-30 domain protein Sdc1 Affinity Capture-MSPMID:14617822
swd2Set1C complex subunit Swd2.1 Affinity Capture-MSPMID:14617822
ash2Ash2-trithorax family protein Affinity Capture-MSPMID:14617822
swd1Set1C complex subunit Swd1 Affinity Capture-MSPMID:14617822
spf1Set1C PHD Finger protein Spf1 Affinity Capture-MSPMID:14617822
External References
Database Identifier Description
NBRP SPCC18.11c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC18.11c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC18.11c BioGRID Interaction Datasets
Expression Viewer SPCC18.11c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC18.11c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC18.11c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC18.11c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC18.11c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC18.11c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC18.11c Cell Cycle Data
GEO SPCC18.11c GEO profiles
PInt SPCC18.11c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC18.11c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN03/03C06Orfeome Localization Data
WikiGene2539145Dpy-30 domain protein Sdc1
EntrezGene2539145Dpy-30 domain protein Sdc1
UniProtKB/SwissProtO74861Set1 complex component sdc1
ModBaseO74861Database of comparative protein structure models
STRINGO74861Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588390Dpy-30 domain protein Sdc1
RefSeq mRNANM_001023381972h- Dpy-30 domain protein Sdc1 (sdc1), mRNA
European Nucleotide ArchiveCAA21425ENA Protein Mapping
European Nucleotide ArchiveCAA21425.1ENA Protein Mapping
UniParcUPI0000069D3CUniProt Archive

Literature for sdc1

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014