pcy1 (SPCC1827.02c)

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Gene Standard Namepcy1 Characterisation Statusbiological role inferred
Systematic IDSPCC1827.02c Feature Typeprotein coding
Synonymspct1 Name Description
Productcholinephosphate cytidylyltransferase Pcy1 (predicted) Product Size362aa, 41.75 kDa
Genomic Location Chromosome III, 2378199-2376299 (1901nt); CDS:2378127-2377039 (1089nt)

Ensembl Gene Location
  1. mug9
  2. SPCC70.10
  3. pof7
  4. utp25
  5. pcy1
  6. SPCC1827.03c
  7. SPNCRNA.1293
  8. SPNCRNA.523
  9. vms1
  10. SPCC1827.05c
GO Molecular Function
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Term NameCount
choline-phosphate cytidylyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

lipid metabolic process


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Term NameCount
CDP-choline pathway3
Annotation ExtensionEvidenceWith/FromReference
phosphatidylcholine biosynthetic process9
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
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Term NameCount
nucleus2690
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

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Term NameGenotypesCount
sensitive to cadmiumpcy1Δ321
viable vegetative cell populationpcy1Δ3862

Cell Phenotype

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Term NameGenotypesCount
viable vegetative cell with normal cell morphologypcy1Δ3103
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2378199..2376299
mRNA2378199..2376299
5' UTR2378199..2378128PMID:21511999
CDS2378127..2377039
3' UTR2377038..2376299PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01467 Pfam IPR004821 Cytidyltransferase-like domain 105 233 4
PTHR10739 HMMPANTHER 7 289 2
PTHR10739:SF13 HMMPANTHER 7 289 1
3.40.50.620 Gene3D IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 101 225 39
SSF52374 SuperFamily 103 234 24
TIGR00125 TIGRFAM IPR004821 Cytidyltransferase-like domain 103 170 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.33 Da
Charge -7.00
Codon Adaptation Index 0.47
Isoelectric point 5.62
Molecular weight 41.75 kDa
Number of residues 362
Modifications

Protein Modifications

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Term NameResidueCount
O-phospho-L-serine 2293
present during mitotic M phaseS67
present during mitotic M phaseS60
present during mitotic M phaseS58
present during mitotic M phaseS62
present during mitotic M phaseS71
present during mitotic M phaseS69
S22, S71, S226, S315, S318, S319, S337, S338, S339, S353, S354, S355, S356
level fluctuates during mitotic cell cycleS62
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S67 PMID:21712547
present during mitotic M phase experimental evidence S60 PMID:21712547
present during mitotic M phase experimental evidence S58 PMID:21712547
present during mitotic M phase experimental evidence S62 PMID:21712547
present during mitotic M phase experimental evidence S71 PMID:21712547
present during mitotic M phase experimental evidence S69 PMID:21712547
IDA S319 PMID:25720772
IDA S338 PMID:25720772
IDA S315 PMID:25720772
IDA S318 PMID:25720772
IDA S226 PMID:25720772
IDA S353 PMID:25720772
IDA S355 PMID:25720772
IDA S22 PMID:25720772
IDA S337 PMID:25720772
IDA S339 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S62 PMID:24763107
IDA S356 PMID:25720772
IDA S71 PMID:25720772
IDA S354 PMID:25720772
O-phospho-L-threonineT323, T358 1087
Annotation ExtensionEvidenceResidueReference
IDA T358 PMID:25720772
IDA T323 PMID:25720772
O4'-phospho-L-tyrosineY341 281
Annotation ExtensionEvidenceResidueReference
IDA Y341 PMID:25720772
phosphorylated residue 2515
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS62,S71, S67,S69,S71, S67,S71, S69,S71, S314,S318, S314,S319, S315,S318, S315,S319, S337,S338, S338,S339, S338,Y341, S353,S354, S353,S354,S355, S353,S354,T358, S353,S355, S353,S356, S354,S355,S356, S354,S356, S354,T358, S355,S356, S355,T358 2461
Annotation ExtensionEvidenceResidueReference
IDA S67,S69,S71 PMID:25720772
IDA S355,S356 PMID:25720772
IDA S353,S354 PMID:25720772
IDA S337,S338 PMID:25720772
IDA S355,T358 PMID:25720772
IDA S353,S354,T358 PMID:25720772
IDA S314,S319 PMID:25720772
IDA S315,S319 PMID:25720772
IDA S69,S71 PMID:25720772
IDA S354,T358 PMID:25720772
IDA S67,S71 PMID:25720772
IDA S62,S71 PMID:25720772
IDA S353,S355 PMID:25720772
IDA S338,Y341 PMID:25720772
IDA S314,S318 PMID:25720772
IDA S315,S318 PMID:25720772
IDA S353,S356 PMID:25720772
IDA S353,S354,S355 PMID:25720772
IDA S354,S355,S356 PMID:25720772
IDA S338,S339 PMID:25720772
IDA S354,S356 PMID:25720772
Sequence
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Gene Expression
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Quantitative Gene Expression

View graphical display of gene expression data for pcy1 (SPCC1827.02c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
18629during GO:0000080PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
23359during GO:0000084PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
17313during GO:0000085PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
22110during GO:0000087PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
19069during GO:0072690PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
15373.57during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
651.38during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.6during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs
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Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC1827.02c into the Query Builder
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View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycrp79poly(A) binding protein Crp79 Affinity Capture-RNAPMID:20531409
External References
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Database Identifier Description
NBRP SPCC1827.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1827.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1827.02c BioGRID Interaction Datasets
Expression Viewer SPCC1827.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1827.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1827.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1827.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1827.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1827.02c Transcriptome Viewer (Bähler Lab)
GEO SPCC1827.02c GEO profiles
PInt SPCC1827.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1827.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1827.02c Fission yeast phenotypic data & analysis
Cyclebase SPCC1827.02c.1 Cell Cycle Data
SPD / RIKEN18/18G07Orfeome Localization Data
UniProtKB/SwissProtO74975Probable choline-phosphate cytidylyltransferase
ModBaseO74975Database of comparative protein structure models
STRINGO74975Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588548cholinephosphate cytidylyltransferase (predicted)
RefSeq mRNANM_001023535972h- cholinephosphate cytidylyltransferase (predicted) (SPCC1827.02c), mRNA
European Nucleotide ArchiveCAA19310.3ENA Protein Mapping
UniParcUPI00001757B9UniProt Archive

Literature for pcy1
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Release Version: PomBase:30_62 - 30 Jan 2017