mog1 (SPCC1840.01c)

Gene Standard Namemog1 Characterisation Statuspublished
Systematic IDSPCC1840.01c Feature Typeprotein coding
SynonymsSPCC790.04c Name Description
ProductRan GTPase binding protein Mog1 Product Size190aa, 20.88 kDa
Genomic Location Chromosome III, 2248273-2247361 (913nt); CDS:2248164-2247592 (573nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
Ran GTPase binding15
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
poly(A)+ mRNA export from nucleus16
Annotation ExtensionEvidenceWith/FromReference
protein import into nucleus22
Annotation ExtensionEvidenceWith/FromReference
small GTPase mediated signal transduction106
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at high temperaturemog1-3 (W79R)142
mog1-2 (S180P)
mog1-4 (L9H)
mog1-5 (F5L)
mog1-6 (F5S)
inviable vegetative cell population1443

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cyclemog1Δ852
decreased poly(A)+ mRNA export from nucleusmog1-5 (F5L)6
mog1-4 (L9H)
mog1-6 (F5S)
mog1-2 (S180P)
mog1-3 (W79R)
inviable after spore germination with elongated germ tubemog1Δ164
inviable after spore germination, single or double cell divisionmog1Δ105
normal RNA level during vegetative growth102
affecting rec8mog1-1
affecting mei4mog1-1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR2248273..2248165PMID:21511999
3' UTR2247591..2247361PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04603 Pfam IPR007681 Ran-interacting Mog1 protein 2 145 1
PTHR15837 HMMPANTHER 2 190 1
PTHR15837:SF0 HMMPANTHER 2 190 1
3.40.1000.10 Gene3D IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich 2 190 1
SSF55724 SuperFamily IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich 2 190 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.92 Da
Charge -7.50
Codon Adpatation Index 0.43
Isoelectric point 4.44
Molecular weight 20.88 kDa
Number of residues 190

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS83
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S83 PMID:21712547
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
50446during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
44556during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
43867during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
45399during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
46393during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
5123.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3421
conserved in vertebrates3396
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturescid13poly(A) polymerase Cid13 Affinity Capture-WesternPMID:17651922
affinity capturesnxt2nuclear transport factor Nxt2 Affinity Capture-WesternPMID:17651922
affinity capturesspi1Ran GTPase Spi1 Affinity Capture-WesternPMID:17651922
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
synthetically rescued bycid13poly(A) polymerase Cid13 Synthetic RescuePMID:17651922
synthetically rescued bycrp79poly(A) binding protein Crp79 Synthetic RescuePMID:17651922
synthetically rescued bydef1RNAPII degradation factor Def1 (predicted) Synthetic RescuePMID:17651922
synthetically rescued bynxt2nuclear transport factor Nxt2 Synthetic RescuePMID:17651922
synthetically rescued byspi1Ran GTPase Spi1 Synthetic RescuePMID:17651922
rescued by overexpression ofspi1Ran GTPase Spi1 Dosage RescuePMID:11290708
synthetically rescued byssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Synthetic RescuePMID:17651922
External References
Database Identifier Description
NBRP SPCC1840.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1840.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1840.01c BioGRID Interaction Datasets
Expression Viewer SPCC1840.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1840.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1840.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1840.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1840.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1840.01c Transcriptome Viewer (Bähler Lab)
GEO SPCC1840.01c GEO profiles
PInt SPCC1840.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1840.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1840.01c Fission yeast phenotypic data & analysis
Cyclebase SPCC1840.01c.1 Cell Cycle Data
SPD / RIKEN06/06B04Orfeome Localization Data
UniProtKB/SwissProtO75002Nuclear import protein mog1
ModBaseO75002Database of comparative protein structure models
STRINGO75002Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588500Ran GTPase binding protein Mog1
RefSeq mRNANM_001023490972h- Ran GTPase binding protein Mog1 (mog1), mRNA
European Nucleotide ArchiveCU329672ENA EMBL mapping
European Nucleotide ArchiveCAA21294ENA Protein Mapping
European Nucleotide ArchiveCAA21294.1ENA Protein Mapping
UniParcUPI0000069F90UniProt Archive

Literature for mog1

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015