mog1 (SPCC1840.01c)


Gene Standard Namemog1 Characterisation Statuspublished
Systematic IDSPCC1840.01c Feature Typeprotein coding
SynonymsSPCC790.04c Name Description
ProductRan GTPase binding protein Mog1 Product Size190aa, 20.88 kDa
Genomic Location Chromosome III, 2248273-2247361 (913nt); CDS:2248164-2247592 (573nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
Ran GTPase binding14
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
poly(A)+ mRNA export from nucleus16
Annotation ExtensionEvidenceWith/FromReference
protein import into nucleus22
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4212
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
nucleus2691
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
abolished cell population growth at high temperaturemog1-1 (S151C, S152T, V153A, L185R)37
decreased cell population growth at high temperaturemog1-4 (L9H)173
mog1-3 (W79R)
mog1-2 (S180P)
mog1-1 (S151C, S152T, V153A, L185R)
mog1-5 (F5L)
mog1-6 (F5S)
inviable cell populationmog1Δ1466
mog1::ura4
inviable vegetative cell populationmog1Δ1452
viable vegetative cell populationmog1+3844

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cyclemog1Δ882
abnormal mitotic cell cycle arrest with condensed chromosomes, septated cellmog1::ura42
abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell with 1C DNA content per nucleusmog1-1 (S151C, S152T, V153A, L185R)2
abnormal nuclear envelope morphology during vegetative growthmog1-1 (S151C, S152T, V153A, L185R)17
binucleate monoseptate cell with mitotic cell cycle arrest before cell separationmog1-1 (S151C, S152T, V153A, L185R)8
mog1::ura4
decreased poly(A)+ mRNA export from nucleusmog1-4 (L9H)17
mog1-6 (F5S)
mog1-3 (W79R)
mog1-2 (S180P)
mog1-1 (S151C, S152T, V153A, L185R)
mog1-5 (F5L)
inviable after spore germination with elongated germ tubemog1Δ164
inviable after spore germination, single or double cell divisionmog1Δ107
normal RNA level during vegetative growth126
affecting rec8mog1-1 (S151C, S152T, V153A, L185R)
affecting mei4mog1-1 (S151C, S152T, V153A, L185R)
poly(A)+ RNA-containing focus present in nucleusmog1-1 (S151C, S152T, V153A, L185R)3

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
viable vegetative cell populationspi1+, mog1Δ
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2248273..2247361
mRNA2248273..2247361
5' UTR2248273..2248165PMID:21511999
CDS2248164..2247592
3' UTR2247591..2247361PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04603 Pfam IPR007681 Ran-interacting Mog1 protein 2 145 1
PTHR15837 HMMPANTHER 2 190 1
3.40.1000.10 Gene3D IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich 2 190 1
SSF55724 SuperFamily IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich 2 190 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.92 Da
Charge -7.50
Codon Adaptation Index 0.43
Isoelectric point 4.44
Molecular weight 20.88 kDa
Number of residues 190
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1677
present during mitotic M phaseS83
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S83 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for mog1 (SPCC1840.01c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
50446during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
44556during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
43867during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
45399during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
46393during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
5123.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by S. cerevisiae MOG1 PMID:11290708 PMID:11686304
functionally complemented by Xenopus XMog1 PMID:11686304
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC1840.01c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withspo7sporulation protein Spo7 Two-hybridPMID:26771498
binds DNA-binding domain construct withcaf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Two-hybridPMID:26771498
binds DNA-binding domain construct withspi1Ran GTPase Spi1 Two-hybridPMID:26771498
affinity capturesspi1Ran GTPase Spi1 Affinity Capture-WesternPMID:17651922
affinity capturesnxt2nuclear transport factor Nxt2 Affinity Capture-WesternPMID:17651922
affinity capturescid13poly(A) polymerase Cid13 Affinity Capture-WesternPMID:17651922
binds activation domain construct withmog1Ran GTPase binding protein Mog1 Two-hybridPMID:26771498
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC1840.01c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetically rescued bycrp79poly(A) binding protein Crp79 Synthetic RescuePMID:17651922
synthetically rescued byspi1Ran GTPase Spi1 Synthetic RescuePMID:17651922
synthetically rescued bydef1RNAPII degradation factor Def1 (predicted) Synthetic RescuePMID:17651922
synthetically rescued bycid13poly(A) polymerase Cid13 Synthetic RescuePMID:17651922
synthetically rescued bynxt2nuclear transport factor Nxt2 Synthetic RescuePMID:17651922
synthetically rescued byssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Synthetic RescuePMID:17651922
rescued by overexpression ofspi1Ran GTPase Spi1 Dosage RescuePMID:11290708
External References
Database Identifier Description
NBRP SPCC1840.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1840.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1840.01c BioGRID Interaction Datasets
Expression Viewer SPCC1840.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1840.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1840.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1840.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1840.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1840.01c Transcriptome Viewer (Bähler Lab)
GEO SPCC1840.01c GEO profiles
PInt SPCC1840.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1840.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1840.01c Fission yeast phenotypic data & analysis
Cyclebase SPCC1840.01c.1 Cell Cycle Data
SPD / RIKEN06/06B04Orfeome Localization Data
UniProtKB/SwissProtO75002Nuclear import protein mog1
ModBaseO75002Database of comparative protein structure models
STRINGO75002Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588500Ran GTPase binding protein Mog1
RefSeq mRNANM_001023490972h- Ran GTPase binding protein Mog1 (mog1), mRNA
European Nucleotide ArchiveCAA21294.1ENA Protein Mapping
UniParcUPI0000069F90UniProt Archive

Literature for mog1

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016