mog1 (SPCC1840.01c)


Gene Standard Namemog1 Characterisation Statuspublished
Systematic IDSPCC1840.01c Feature Typeprotein coding
SynonymsSPCC790.04c Name Description
ProductRan GTPase binding protein Mog1 Product Size190aa, 20.88 kDa
Genomic Location Chromosome III, 2248273-2247361 (913nt); CDS:2248164-2247592 (573nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008536Ran GTPase bindingISOSGD:S000003835GO_REF:000002415
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0007049cell cycleIEAUniProtKB-KW:KW-0131GO_REF:0000037959
GO:0016973poly(A)+ mRNA export from nucleusIMPPMID:1129070816
GO:0006606protein import into nucleusISOSGD:S000003835GO_REF:000002417
GO:0007264small GTPase mediated signal transductionIGIspi1PMID:11290708139
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722315
GO:0005634nucleusIDAPMID:168233722740
predominantlyIDAPMID:11290708
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopynot recorded (unrecorded)PMID:112907081338
Microscopymog1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Microscopymog1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopymog1ΔNullPECO:0000005, PECO:0000137PMID:23697806686
FYPO:0000314inviable after spore germination with elongated germ tubeMicroscopymog1ΔNullPECO:0000005, PECO:0000137PMID:23697806163
FYPO:0001042inviable after spore germination, single or double cell divisionMicroscopymog1ΔNullPECO:0000005, PECO:0000137PMID:2369780697
FYPO:0001317normal RNA level during vegetative growth80
affecting rec8Transcript expression level evidencemog1-1Not specifiedPMID:23658229
affecting mei4Transcript expression level evidencemog1-1Not specifiedPMID:23658229
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
122482732247361

UTRs

Region Coordinates Reference
five_prime_UTR2248273..2248165PMID:21511999
three_prime_UTR2247591..2247361PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04603 Pfam IPR007681 Ran-interacting Mog1 protein 1 146 1
PTHR15837 HMMPANTHER 2 190 1
PTHR15837:SF0 HMMPANTHER 2 190 1
3.40.1000.10 Gene3D IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich 2 190 1
SSF55724 SuperFamily IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich 2 190 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.92 Da
Charge -7.50
Isoelectric point 4.44
Molecular weight 20.88 kDa
Number of residues 190
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS83PMID:217125471670
present during mitotic M phase
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
50446during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
44556during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
43867during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
45399during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
46393during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
5123.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
cid13poly(A) polymerase Cid13 Synthetic RescuePMID:17651922
def1RNAPII degradation factor Def1 (predicted) Synthetic RescuePMID:17651922
spi1Ran GTPase Spi1 Synthetic RescuePMID:17651922
Dosage RescuePMID:11290708
ssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Synthetic RescuePMID:17651922
crp79poly(A) binding protein Crp79 Synthetic RescuePMID:17651922
nxt2nuclear transport factor Nxt2 Synthetic RescuePMID:17651922
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
spi1Ran GTPase Spi1 Affinity Capture-WesternPMID:17651922
nxt2nuclear transport factor Nxt2 Affinity Capture-WesternPMID:17651922
cid13poly(A) polymerase Cid13 Affinity Capture-WesternPMID:17651922
External References
Database Identifier Description
NBRP SPCC1840.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1840.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1840.01c BioGRID Interaction Datasets
Expression Viewer SPCC1840.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1840.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1840.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1840.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1840.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1840.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1840.01c Cell Cycle Data
GEO SPCC1840.01c GEO profiles
PInt SPCC1840.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1840.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1840.01c Fission yeast phenotypic data & analysis
SPD / RIKEN06/06B04Orfeome Localization Data
UniProtKB/SwissProtO75002Nuclear import protein mog1
ModBaseO75002Database of comparative protein structure models
STRINGO75002Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588500Ran GTPase binding protein Mog1
RefSeq mRNANM_001023490972h- Ran GTPase binding protein Mog1 (mog1), mRNA
European Nucleotide ArchiveCAA21294.1ENA Protein Mapping
UniParcUPI0000069F90UniProt Archive

Literature for mog1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014