opt3 (SPCC1840.12)


Gene Standard Nameopt3 Characterisation Statuspublished
Systematic IDSPCC1840.12 Feature Typeprotein coding
SynonymsSPCC965.02 Name Description
ProductOPT oligopeptide transporter family protein Opt3 Product Size791aa, 89.26 kDa
Genomic Location Chromosome III, 2281612-2284101 (2490nt); CDS:2281612-2284101 (2490nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0022857transmembrane transporter activityNASGO_REF:0000051292
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015833peptide transportIEAUniProtKB-KW:KW-0571GO_REF:000003713
GO:0055085transmembrane transportIEAIPR004648GO_REF:0000002322
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722319
GO:0005887integral component of plasma membraneISOSGD:S000003748GO_REF:000002450
GO:0005634nucleusIDAPMID:168233722737
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001578normal growth on dipeptide nitrogen sourceCell growth assayopt3ΔNullPMID:222269463
FYPO:0001579normal growth on tetrapeptide nitrogen sourceCell growth assayopt3ΔNullPMID:222269462
FYPO:0002060viable vegetative cell populationMicroscopyopt3ΔNullPECO:0000005, PECO:0000137PMID:236978063751
Microscopyopt3ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyopt3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
122816122281912
222820272284101
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03169 Pfam IPR004813 Oligopeptide transporter, OPT superfamily 100 751 3
TMhelix TMHMM 419 441 959
TMhelix TMHMM 310 329 959
TMhelix TMHMM 472 494 959
TMhelix TMHMM 102 124 959
TMhelix TMHMM 230 252 959
TMhelix TMHMM 273 295 959
TMhelix TMHMM 584 606 959
TMhelix TMHMM 695 717 959
TMhelix TMHMM 653 675 959
TMhelix TMHMM 499 521 959
TMhelix TMHMM 178 200 959
TMhelix TMHMM 534 556 959
TMhelix TMHMM 129 151 959
TMhelix TMHMM 730 752 959
TMhelix TMHMM 341 363 959
PTHR22601 HMMPANTHER 24 791 3
TIGR00727 tigrfam IPR004648 Tetrapeptide transporter, OPT1/isp4 83 754 3
TIGR00728 tigrfam IPR004813 Oligopeptide transporter, OPT superfamily 87 751 3

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 112.84 Da
Charge 24.00
Isoelectric point 8.92
Molecular weight 89.26 kDa
Number of residues 791
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS49PMID:217125471670
present during mitotic M phase
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.46during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4599
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
SPBC713.07cvacuolar polyphosphatase (predicted) Positive GeneticPMID:22681890
slx4structure-specific endonuclease subunit Slx4 Positive GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1840.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1840.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1840.12 BioGRID Interaction Datasets
Expression Viewer SPCC1840.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1840.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1840.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1840.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1840.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1840.12 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1840.12 Cell Cycle Data
GEO SPCC1840.12 GEO profiles
PInt SPCC1840.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1840.12 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN29/29A02Orfeome Localization Data
UniProtKB/SwissProtQ7LL00Uncharacterized oligopeptide transporter C1840.12
ModBaseQ7LL00Database of comparative protein structure models
STRINGQ7LL00Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588512OPT oligopeptide transporter family protein (predicted)
RefSeq mRNANM_001023501972h- OPT oligopeptide transporter family protein (predicted) (SPCC1840.12), mRNA
European Nucleotide ArchiveCAA20135.2ENA Protein Mapping
UniParcUPI0000069681UniProt Archive

Literature for opt3

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014