opt3 (SPCC1840.12)

Gene Standard Nameopt3 Characterisation Statuspublished
Systematic IDSPCC1840.12 Feature Typeprotein coding
SynonymsSPCC965.02 Name Description
ProductOPT oligopeptide transmembrane transporter family protein Opt3 Product Size791aa, 89.26 kDa
Genomic Location Chromosome III, 2281612-2284101 (2490nt); CDS:2281612-2284101 (2490nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
transmembrane transporter activity286
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
peptide transport15
Annotation ExtensionEvidenceWith/FromReference
transmembrane transport361
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
integral component of plasma membrane52
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
normal growth on dipeptide nitrogen sourceopt3Δ3
normal growth on tetrapeptide nitrogen sourceopt3Δ2
viable vegetative cell populationopt3Δ3815

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyopt3Δ3095
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2281612..2281912, 2282027..2284101
CDS2281612..2281912, 2282027..2284101
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03169 Pfam IPR004813 Oligopeptide transporter, OPT superfamily 100 751 3
TMhelix TMHMM 653 675 959
TMhelix TMHMM 472 494 959
TMhelix TMHMM 230 252 959
TMhelix TMHMM 419 441 959
TMhelix TMHMM 273 295 959
TMhelix TMHMM 730 752 959
TMhelix TMHMM 310 329 959
TMhelix TMHMM 341 363 959
TMhelix TMHMM 534 556 959
TMhelix TMHMM 178 200 959
TMhelix TMHMM 499 521 959
TMhelix TMHMM 695 717 959
TMhelix TMHMM 584 606 959
TMhelix TMHMM 102 124 959
TMhelix TMHMM 129 151 959
PTHR22601:SF5 HMMPANTHER 16 782 2
PTHR22601 HMMPANTHER 16 782 3
TIGR00727 tigrfam IPR004648 Tetrapeptide transporter, OPT1/isp4 83 754 3
TIGR00728 tigrfam IPR004813 Oligopeptide transporter, OPT superfamily 87 751 3

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 112.84 Da
Charge 24.00
Codon Adpatation Index 0.41
Isoelectric point 8.92
Molecular weight 89.26 kDa
Number of residues 791

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS49
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S49 PMID:21712547
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.46during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
conserved in fungi4604
conserved in eukaryotes4514

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withslx4structure-specific endonuclease subunit Slx4 Positive GeneticPMID:22681890
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC713.07cvacuolar polyphosphatase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1840.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1840.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1840.12 BioGRID Interaction Datasets
Expression Viewer SPCC1840.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1840.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1840.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1840.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1840.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1840.12 Transcriptome Viewer (Bähler Lab)
GEO SPCC1840.12 GEO profiles
PInt SPCC1840.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1840.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1840.12 Fission yeast phenotypic data & analysis
Cyclebase SPCC1840.12.1 Cell Cycle Data
SPD / RIKEN29/29A02Orfeome Localization Data
UniProtKB/SwissProtQ7LL00Uncharacterized oligopeptide transporter C1840.12
ModBaseQ7LL00Database of comparative protein structure models
STRINGQ7LL00Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588512OPT oligopeptide transporter family protein (predicted)
RefSeq mRNANM_001023501972h- OPT oligopeptide transporter family protein (predicted) (SPCC1840.12), mRNA
European Nucleotide ArchiveCU329672ENA EMBL mapping
European Nucleotide ArchiveCAA20135ENA Protein Mapping
European Nucleotide ArchiveCAA20135.2ENA Protein Mapping
UniParcUPI0000069681UniProt Archive

Literature for opt3

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015