opt3 (SPCC1840.12)

Gene Standard Nameopt3 Characterisation Statuspublished
Systematic IDSPCC1840.12 Feature Typeprotein coding
SynonymsSPCC965.02 Name Description
ProductOPT oligopeptide transmembrane transporter family protein Opt3 Product Size791aa, 89.26 kDa
Genomic Location Chromosome III, 2281612-2284101 (2490nt); CDS:2281612-2284101 (2490nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
oligopeptide transmembrane transporter activity8
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
oligopeptide transmembrane transport12
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of plasma membrane48
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
normal growth on dipeptide nitrogen sourceopt3Δ3
normal growth on tetrapeptide nitrogen sourceopt3Δ2
viable vegetative cell populationopt3Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyopt3Δ3103
Target Of
FYPO affected by mutation in mei4 meiotic forkhead transcription factor Mei4
FYPO affected by mutation in mmi1 nucleus specific RNA binding exosome specificity factor Mmi1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2281612..2281912, 2282027..2284101
CDS2281612..2281912, 2282027..2284101
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03169 Pfam IPR004813 Oligopeptide transporter, OPT superfamily 100 751 3
TMhelix TMHMM 178 200 950
TMhelix TMHMM 341 363 950
TMhelix TMHMM 695 717 950
TMhelix TMHMM 102 124 950
TMhelix TMHMM 472 494 950
TMhelix TMHMM 273 295 950
TMhelix TMHMM 584 606 950
TMhelix TMHMM 499 521 950
TMhelix TMHMM 129 151 950
TMhelix TMHMM 419 441 950
TMhelix TMHMM 534 556 950
TMhelix TMHMM 310 329 950
TMhelix TMHMM 653 675 950
TMhelix TMHMM 730 752 950
TMhelix TMHMM 230 252 950
PTHR22601 HMMPANTHER 23 791 3
PTHR22601:SF16 HMMPANTHER 23 791 2
TIGR00728 TIGRFAM IPR004813 Oligopeptide transporter, OPT superfamily 87 751 3
TIGR00727 TIGRFAM IPR004648 Tetrapeptide transporter, OPT1/isp4 83 754 3

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 112.84 Da
Charge 24.00
Codon Adaptation Index 0.41
Isoelectric point 8.92
Molecular weight 89.26 kDa
Number of residues 791

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2293
present during mitotic M phaseS49
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S49 PMID:21712547
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for opt3 (SPCC1840.12)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.46during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
conserved in fungi4608
conserved in eukaryotes4516

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC1840.12 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC713.07cvacuolar polyphosphatase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withslx4structure-specific endonuclease subunit Slx4 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1840.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1840.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1840.12 BioGRID Interaction Datasets
Expression Viewer SPCC1840.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1840.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1840.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1840.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1840.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1840.12 Transcriptome Viewer (Bähler Lab)
GEO SPCC1840.12 GEO profiles
PInt SPCC1840.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1840.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1840.12 Fission yeast phenotypic data & analysis
Cyclebase SPCC1840.12.1 Cell Cycle Data
SPD / RIKEN29/29A02Orfeome Localization Data
UniProtKB/SwissProtQ7LL00Uncharacterized oligopeptide transporter C1840.12
ModBaseQ7LL00Database of comparative protein structure models
STRINGQ7LL00Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588512OPT oligopeptide transporter family protein (predicted)
RefSeq mRNANM_001023501972h- OPT oligopeptide transporter family protein (predicted) (SPCC1840.12), mRNA
European Nucleotide ArchiveCAA20135.2ENA Protein Mapping
UniParcUPI0000069681UniProt Archive

Literature for opt3

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017