spn6 (SPCC188.12)


Gene Standard Namespn6 Characterisation Statuspublished
Systematic IDSPCC188.12 Feature Typeprotein coding
SynonymsSPCC584.09 Name Description
Productmeiotic (sorulation) septin Spn6 Product Size380aa, 44.01 kDa
Genomic Location Chromosome III, 1504862-1506851 (1990nt); CDS:1504941-1506145 (1205nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTP binding88
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2298
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationspn6Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyspn6Δ3103
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1504862..1504999, 1505062..1506851
Intron1505000..1505061
mRNA1504862..1506851
5' UTR1504862..1504940PMID:21511999
CDS1504941..1504999, 1505062..1506145
3' UTR1506146..1506851PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00735 Pfam IPR030379 Septin-type guanine nucleotide-binding (G) domain 27 300 7
PS51719 Prosite Profiles IPR030379 Septin-type guanine nucleotide-binding (G) domain 27 297 7
PTHR18884 HMMPANTHER IPR016491 Septin 31 368 7
PTHR18884:SF30 HMMPANTHER 31 368 1
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 30 213 288
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 244 363 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 13 268 294
Coil ncoils Predicted coiled-coil protein (DUF2205) 310 330 1049
Coil ncoils Predicted coiled-coil protein (DUF2205) 346 373 1049
PIRSF006698 PIRSF IPR016491 Septin 2 380 7

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.82 Da
Charge 2.50
Codon Adaptation Index 0.39
Isoelectric point 6.91
Molecular weight 44.01 kDa
Number of residues 380
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0034293experimental evidencePMID:PMPB:0

Quantitative Gene Expression

View graphical display of gene expression data for spn6 (SPCC188.12)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.12during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.56during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
faster evolving duplicate23
conserved in fungi only552
conserved in fungi4608
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC188.12 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byspn5meiotic septin Spn5 Affinity Capture-WesternPMID:20123972
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC188.12 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
phenotype enhanced bymeu14sporulation specific PIL domain protein Meu14 Phenotypic EnhancementPMID:20123972
negative genetic interaction witheso1mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPCC188.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC188.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC188.12 BioGRID Interaction Datasets
Expression Viewer SPCC188.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC188.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC188.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC188.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC188.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC188.12 Transcriptome Viewer (Bähler Lab)
GEO SPCC188.12 GEO profiles
PInt SPCC188.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC188.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC188.12 Fission yeast phenotypic data & analysis
Cyclebase SPCC188.12.1 Cell Cycle Data
SPD / RIKEN22/22B01Orfeome Localization Data
UniProtKB/SwissProtQ09883Septin homolog spn6
ModBaseQ09883Database of comparative protein structure models
STRINGQ09883Network display of known and predicted interactions and functional associations
RefSeq mRNAXM_001713116972h- septin Spn6 (predicted) (spn6), mRNA
RefSeq PeptideXP_001713168septin Spn6 (predicted)
European Nucleotide ArchiveCAB37422.1ENA Protein Mapping
UniParcUPI0000135E57UniProt Archive

Literature for spn6

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017