wee1 (SPCC18B5.03)


Gene Standard Namewee1 Characterisation Statuspublished
Systematic IDSPCC18B5.03 Feature Typeprotein coding
Synonyms Name Description
ProductM phase inhibitor protein kinase Wee1 Product Size877aa, 96.26 kDa
Genomic Location Chromosome III, 721788-725835 (4048nt); CDS:722234-724867 (2634nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
metal ion binding747
Annotation ExtensionEvidenceWith/FromReference
protein binding854
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine kinase activity114
Annotation ExtensionEvidenceWith/FromReference
protein tyrosine kinase activity9
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cytokinesis after mitosis checkpoint3
Annotation ExtensionEvidenceWith/FromReference
mitotic DNA damage checkpoint31
Annotation ExtensionEvidenceWith/FromReference
negative regulation of G2/M transition of mitotic cell cycle41
Annotation ExtensionEvidenceWith/FromReference
negative regulation of protein kinase activity by regulation of protein phosphorylation1
Annotation ExtensionEvidenceWith/FromReference
peptidyl-serine autophosphorylation4
Annotation ExtensionEvidenceWith/FromReference
peptidyl-tyrosine autophosphorylation7
Annotation ExtensionEvidenceWith/FromReference
signal transduction involved in G2 cell size control checkpoint1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
medial cortical node10
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nucleoplasm246
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased bipolar indexwee1ΔNull27
decreased cell population growth during glucose limitationwee1ΔNull8
decreased cell population growth on glucose carbon sourcewee1ΔNull247
increased monopolar indexwee1ΔNull35
increased septation indexwee1-50Not specified43
inviable vegetative cell populationwee1+ (wild type)Overexpression1428
sensitive to hydroxyureawee1ΔNull525
sensitive to ionizing radiationwee1-50Not specified58
sensitive to methyl methanesulfonatewee1-50Not specified228
sensitive to miconazolewee1+ (wild type)Overexpression37
viable vegetative cell populationwee1-50Not specified3792
wee1ΔNull

Cell Phenotype

Term NameAlleleExpressionCount
abnormal cell cycle regulation during cellular response to gamma radiationwee1-50Not specified6
abnormal regulation of DNA replication initiationwee1-50Not specified13
abolished protein kinase activityK596L (K596L)Not specified18
cell cycle arrest phenotypewee1-50Not specified177
elongated vegetative cellwee1+ (wild type)Overexpression752
increased RNA level during nitrogen starvation20
affecting ste11wee1-50Not specified
increased RNA level during vegetative growth173
affecting ste11wee1-50Not specified
inviable elongated vegetative cellwee1+ (wild type)Overexpression408
inviable vegetative cellwee1-50Overexpression1270
mitotic G1/S transition delaywee1-50Not specified12
normal cell cycle regulation during cellular response to hydroxyureawee1-50Not specified12
normal nucleus:cytoplasm ratiowee1-50Endogenous6
normal protein localization to actomyosin contractile ring14
affecting nod1wee1-50Not specified
normal protein localization to medial cortex11
affecting nod1wee1-50Not specified
normal protein localization to nucleus42
affecting cdc25wee1+ (wild type)Overexpression
normal protein phosphorylation during vegetative growth41
affecting cdc2wee1-50Not specified
normal S-phase DNA damage checkpointwee1-50Not specified17
normal vegetative cell sizewee1-50Not specified430
viable elongated vegetative cellwee1-50Overexpression283
viable elongated vegetative cell, elongated upon mitotic entrywee1+ (wild type)Overexpression9
viable small vegetative cellwee-115Not specified43
wee1-1Not specified
wee1-50Not specified
wee1-6Not specified
wee1-8Not specified
wee1ΔNull
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in cdr1 NIM1 family serine/threonine protein kinase Cdr1/Nim1 PMID:9135149
FYPO affected by mutation in cds1 replication checkpoint kinase Cds1 PMID:19357077
FYPO affected by mutation in dnt1 nucleolar protein Dnt1 PMID:24006256
FYPO affected by mutation in rad3 ATR checkpoint kinase Rad3 PMID:17189249
FYPO affected by mutation in rpn12 19S proteasome regulatory subunit Rpn12 PMID:24006256
FYPO affected by mutation in skp1 SCF ubiquitin ligase complex subunit Skp1 PMID:24006256
FYPO affected by mutation in tel2 Tel2/Rad-5/Clk-2 family protein Tel2 PMID:17189249
GO localized by cdr2 serine/threonine protein kinase Cdr2 PMID:19474789
GO regulated by cdr1 NIM1 family serine/threonine protein kinase Cdr1/Nim1 PMID:3453113
GO substrate of cdr1 NIM1 family serine/threonine protein kinase Cdr1/Nim1 PMID:7681363
GO substrate of cdr2 serine/threonine protein kinase Cdr2 PMID:9843572
GO substrate of cds1 replication checkpoint kinase Cds1 PMID:19357077
GO substrate of pyp1 tyrosine phosphatase Pyp1 PMID:8256510
GO substrate of wee1 M phase inhibitor protein kinase Wee1 PMID:1825699
GO substrate of wee1 M phase inhibitor protein kinase Wee1 PMID:8256510
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons721788..725835
mRNA721788..725835
5' UTR721788..722233PMID:21511999
CDS722234..724867
3' UTR724868..725835PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 567 837 109
SM00220 SMART IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain 566 840 107
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 689 701 97
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 572 597 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 566 843 110
PTHR11042 HMMPANTHER 66 856 5
PTHR11042:SF73 HMMPANTHER 66 856 2
1.10.510.10 Gene3D 646 836 112
3.30.200.20 Gene3D 563 645 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 545 836 127

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.76 Da
Charge 28.00
Isoelectric point 10.00
Molecular weight 96.26 kDa
Number of residues 877
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
added by wee1
Annotation ExtensionEvidenceResidueReference
IDA PMID:1372994
added by wee1 IDA PMID:8256510
added by wee1 IDA PMID:1825699
O-phospho-L-threonine 698
Annotation ExtensionEvidenceResidueReference
IDA PMID:1372994
O4'-phospho-L-tyrosine 86
added by wee1
removed by pyp1
Annotation ExtensionEvidenceResidueReference
IDA PMID:1372994
removed by pyp1 IDA PMID:8256510
added by wee1 IDA PMID:8256510
added by wee1 IDA PMID:1825699
phosphorylated residue 1926
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0034599expression microarray evidencePMID:12529438

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
trichostatin A delays mitotic entry in cdc25-22 mutant PMID:197238881
trichostatin A partially suppresses wee1delta sensitivity to UV and hydroxyurea PMID:197238881
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modifiescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:7982971
modifiescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:1850698
modifiescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:1372994
modified bycdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Biochemical ActivityPMID:8515817
binds DNA-binding domain construct withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Two-hybridPMID:9928955
modified bycdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Biochemical ActivityPMID:8515818
binds DNA-binding domain construct withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Two-hybridPMID:23615447
modified bycdr2serine/threonine protein kinase Cdr2 Biochemical ActivityPMID:9843572
modified bycds1replication checkpoint kinase Cds1 Biochemical ActivityPMID:21099360
affinity capturescds1replication checkpoint kinase Cds1 Affinity Capture-WesternPMID:9572736
affinity captured bycds1replication checkpoint kinase Cds1 Affinity Capture-WesternPMID:9572736
modifiescds1replication checkpoint kinase Cds1 Biochemical ActivityPMID:11606526
modified bychk1Chk1 protein kinase Biochemical ActivityPMID:9034337
affinity captured byhsp90Hsp90 chaperone Affinity Capture-WesternPMID:7813446
affinity captureshsp90Hsp90 chaperone Affinity Capture-WesternPMID:11298745
modified bypyp1tyrosine phosphatase Pyp1 Biochemical ActivityPMID:8256510
modified bypyp2tyrosine phosphatase Pyp2 Biochemical ActivityPMID:8256510
affinity captured byskb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:23615447
binds DNA-binding domain construct withskb1type II protein arginine N-methyltransferase Skb1 Two-hybridPMID:23615447
co-purifies withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Co-purificationPMID:1372994
affinity captureswos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:11298745
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
synthetic lethal withams2cell cycle regulated GATA-type transcription factor Ams2 Synthetic LethalityPMID:18077559
rescuesatf1transcription factor, Atf-CREB family Atf1 Phenotypic SuppressionPMID:9135083
growth defect in presence of overexpressedatf1transcription factor, Atf-CREB family Atf1 Dosage Growth DefectPMID:24728197
rescuesbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
enhances phenotype ofbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic EnhancementPMID:10503548
inviable in presence of overexpressedcdc13G2/M B-type cyclin Cdc13 Dosage LethalityPMID:9398669
synthetically rescuescdc14SIN component Cdc14 Synthetic RescuePMID:8334307
rescued by overexpression ofcdc14SIN component Cdc14 Dosage RescuePMID:24006256
rescuescdc16two-component GAP Cdc16 Phenotypic SuppressionPMID:20805322
synthetic growth defect withcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic Growth DefectPMID:11029045
synthetically rescued bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic RescuePMID:24861625
overexpression rescuescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Dosage RescuePMID:1427071
enhances phenotype ofcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic EnhancementPMID:9013342
synthetic lethal withcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic LethalityPMID:2474475
phenotype enhanced bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic EnhancementPMID:3116001
synthetic lethal withcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic LethalityPMID:9188094
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:9473044
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:7501024
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:11085271
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:2245912
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:3796591
synthetic growth defect withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic Growth DefectPMID:23333317
phenotype enhanced bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic EnhancementPMID:9013342
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:9013342
enhances phenotype ofcdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic EnhancementPMID:10233158
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:9843572
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:3442828
enhances phenotype ofcdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic EnhancementPMID:11531413
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:7217015
synthetic growth defect withcdc28ATP-dependent RNA helicase Cdc28 Synthetic Growth DefectPMID:16049013
rescuescdc3profilin Phenotypic SuppressionPMID:20805322
synthetically rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic RescuePMID:16816416
synthetically rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic RescuePMID:2245912
rescuescdr2serine/threonine protein kinase Cdr2 Phenotypic SuppressionPMID:9843572
synthetically rescuescdr2serine/threonine protein kinase Cdr2 Synthetic RescuePMID:9843572
synthetically rescuescdr2serine/threonine protein kinase Cdr2 Synthetic RescuePMID:2245912
phenotype enhanced bychk1Chk1 protein kinase Phenotypic EnhancementPMID:10637286
synthetic lethal withchk1Chk1 protein kinase Synthetic LethalityPMID:8497322
synthetic lethal withchk1Chk1 protein kinase Synthetic LethalityPMID:11270571
synthetically rescueschk1Chk1 protein kinase Synthetic RescuePMID:16816416
rescued bycig2G1/S-specific B-type cyclin Cig2 Phenotypic SuppressionPMID:8455610
synthetically rescued bycig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:8455610
rescued bycig2G1/S-specific B-type cyclin Cig2 Phenotypic SuppressionPMID:8972180
enhances phenotype ofclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:11683392
rescuesclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:11683392
synthetic growth defect withcrb2DNA repair protein Rad9 homolog Crb2 Synthetic Growth DefectPMID:20679488
synthetic growth defect withdbr1RNA lariat debranching enzyme Dbr1 Synthetic Growth DefectPMID:16049013
rescued by overexpression ofdis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Dosage RescuePMID:1944266
rescued by overexpression ofdis33'-5' exoribonuclease subunit Dis3 Dosage RescuePMID:1944266
rescuesfin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
rescuesfkh2forkhead transcription factor Fkh2 Phenotypic SuppressionPMID:22451489
synthetically rescueshhp1serine/threonine protein kinase Hhp1 Synthetic RescuePMID:24861625
rescueshob1BAR adaptor protein Hob1 Phenotypic SuppressionPMID:12569356
synthetic growth defect withhus1checkpoint clamp complex protein Hus1 Synthetic Growth DefectPMID:1427071
synthetic growth defect withhus5SUMO conjugating enzyme E2 Hus5 Synthetic Growth DefectPMID:1427071
synthetic growth defect withhus5SUMO conjugating enzyme E2 Hus5 Synthetic Growth DefectPMID:7768995
rescuesini1RING finger-like protein Ini1 Phenotypic SuppressionPMID:14762117
phenotype enhanced byklp5kinesin-like protein Klp5 Phenotypic EnhancementPMID:11739790
phenotype enhanced byklp6kinesin-like protein Klp6 Phenotypic EnhancementPMID:11739790
enhances phenotype ofliz1pantothenate transmembrane transporter Liz1 Phenotypic EnhancementPMID:9950674
synthetic growth defect withmcl1DNA polymerase alpha accessory factor Mcl1 Synthetic Growth DefectPMID:12455694
synthetically rescued bymcs4response regulator Mcs4 Synthetic RescuePMID:9383051
enhances phenotype ofmed8mediator complex subunit Med8 Phenotypic EnhancementPMID:10392445
synthetic lethal withmik1mitotic inhibitor kinase Mik1 Synthetic LethalityPMID:11809834
synthetic growth defect withmik1mitotic inhibitor kinase Mik1 Synthetic Growth DefectPMID:11029045
phenotype enhanced bymik1mitotic inhibitor kinase Mik1 Phenotypic EnhancementPMID:10947840
synthetic lethal withmik1mitotic inhibitor kinase Mik1 Synthetic LethalityPMID:1706223
rescued by overexpression ofmik1mitotic inhibitor kinase Mik1 Dosage RescuePMID:1706223
synthetic lethal withmik1mitotic inhibitor kinase Mik1 Synthetic LethalityPMID:9398669
phenotype enhanced bymis3rRNA processing protein Mis3 Phenotypic EnhancementPMID:10947840
synthetic lethal withmor2morphogenesis protein Mor2 Synthetic LethalityPMID:12234926
enhances phenotype oforc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
rescuespab1protein phosphatase regulatory subunit Pab1 Phenotypic SuppressionPMID:20876564
synthetic lethal withpal1membrane associated protein Pal1 Synthetic LethalityPMID:15975911
synthetic growth defect withpcp1pericentrin Pcp1 Synthetic Growth DefectPMID:21233285
enhances phenotype ofpcp1pericentrin Pcp1 Phenotypic EnhancementPMID:19942852
synthetic growth defect withpin1peptidyl-prolyl cis-trans isomerase Pin1 Synthetic Growth DefectPMID:11707530
rescuespof3F-box protein Pof3 Phenotypic SuppressionPMID:11809834
synthetic lethal withppa2serine/threonine protein phosphatase Ppa2 Synthetic LethalityPMID:8389306
synthetic growth defect withprp12U2 snRNP-associated protein Sap130 Synthetic Growth DefectPMID:16049013
synthetic lethal withpub1HECT-type ubiquitin-protein ligase E3 Pub1 Synthetic LethalityPMID:8635463
rescuespyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
synthetically rescued bypyp1tyrosine phosphatase Pyp1 Synthetic RescuePMID:1464319
rescuespyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
synthetic growth defect withrad1checkpoint clamp complex protein Rad1 Synthetic Growth DefectPMID:1427071
synthetic lethal withrad1checkpoint clamp complex protein Rad1 Synthetic LethalityPMID:8590806
synthetic growth defect withrad17RFC related checkpoint protein Rad17 Synthetic Growth DefectPMID:1427071
synthetic growth defect withrad3ATR checkpoint kinase Rad3 Synthetic Growth DefectPMID:1427071
synthetic lethal withrad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:9398669
enhances phenotype ofrad31SUMO activating enzyme E1-type Rad31 Phenotypic EnhancementPMID:9092625
rescuesran1serine/threonine protein kinase Ran1 Phenotypic SuppressionPMID:10521402
synthetic lethal withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Synthetic LethalityPMID:21118960
enhances phenotype ofreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Phenotypic EnhancementPMID:21118960
synthetically rescued byres2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
synthetic growth defect withrqh1RecQ type DNA helicase Rqh1 Synthetic Growth DefectPMID:1427071
phenotype enhanced byrum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:9013342
rescued by overexpression ofrum1CDK inhibitor Rum1 Dosage RescuePMID:9571240
rescued by overexpression ofsds21serine/threonine protein phosphatase PP1 subfamily, Sds21 Dosage RescuePMID:1944266
enhances phenotype ofsep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
enhances phenotype ofsep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:10392445
inviable in presence of overexpressedshk1PAK-related kinase Shk1 Dosage LethalityPMID:9843966
inviable in presence of overexpressedskb1type II protein arginine N-methyltransferase Skb1 Dosage LethalityPMID:9843966
rescuesskb1type II protein arginine N-methyltransferase Skb1 Phenotypic SuppressionPMID:23615447
synthetic growth defect withslm9hira protein Slm9 Synthetic Growth DefectPMID:9843572
rescuesslm9hira protein Slm9 Phenotypic SuppressionPMID:10835386
synthetically rescuesslp1mitotic spindle checkpoint component/ APC activator Slp1 Synthetic RescuePMID:11058086
synthetically rescuesslp1mitotic spindle checkpoint component/ APC activator Slp1 Synthetic RescuePMID:9001228
rescuesslp1mitotic spindle checkpoint component/ APC activator Slp1 Phenotypic SuppressionPMID:9001228
rescuesSPAC144.17c6-phosphofructo-2-kinase (predicted) Phenotypic SuppressionPMID:17900713
rescued bySPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
rescuesspo5meiotic RNA-binding protein 1 Phenotypic SuppressionPMID:24506453
enhances phenotype ofspt8SAGA complex subunit Spt8 Phenotypic EnhancementPMID:10392445
enhances phenotype ofsrk1MAPK-activated protein kinase Srk1 Phenotypic EnhancementPMID:15629716
synthetic lethal withsrw1fizzy-related CDK inhibitor Srw1 Synthetic LethalityPMID:9571240
rescued by overexpression ofsrw1fizzy-related CDK inhibitor Srw1 Dosage RescuePMID:9398669
synthetic lethal withsrw1fizzy-related CDK inhibitor Srw1 Synthetic LethalityPMID:9398669
rescuesssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Phenotypic SuppressionPMID:10233158
synthetically rescuessty1MAP kinase Sty1 Synthetic RescuePMID:7501024
rescued by overexpression ofswr1SNF2 family ATP-dependent DNA helicase Swr1 Dosage RescuePMID:9571240
synthetic lethal withtor1phosphatidylinositol kinase Tor1 Synthetic LethalityPMID:19546237
rescued bytor1phosphatidylinositol kinase Tor1 Phenotypic SuppressionPMID:19546237
phenotype enhanced bywin1MAP kinase kinase kinase Win1 Phenotypic EnhancementPMID:3442828
rescued bywin1MAP kinase kinase kinase Win1 Phenotypic SuppressionPMID:3442828
rescued by overexpression ofwis1MAP kinase kinase Wis1 Dosage RescuePMID:1756736
rescueswis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescued byyox1MBF complex corepressor Yox1 Phenotypic SuppressionPMID:21132016
enhances phenotype ofzfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Phenotypic EnhancementPMID:10462526
External References
Database Identifier Description
NBRP SPCC18B5.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC18B5.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC18B5.03 BioGRID Interaction Datasets
Expression Viewer SPCC18B5.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC18B5.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC18B5.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC18B5.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC18B5.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC18B5.03 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC18B5.03 Cell Cycle Data
GEO SPCC18B5.03 GEO profiles
PInt SPCC18B5.03 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC18B5.03 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC18B5.03 Fission yeast phenotypic data & analysis
SPD / RIKEN47/47A06Orfeome Localization Data
UniProtKB/SwissProtP07527Mitosis inhibitor protein kinase wee1
ModBaseP07527Database of comparative protein structure models
STRINGP07527Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587933M phase inhibitor protein kinase Wee1
RefSeq mRNANM_001022924972h- M phase inhibitor protein kinase Wee1 (wee1), mRNA
European Nucleotide ArchiveAAA35354.1ENA Protein Mapping
European Nucleotide ArchiveBAA87204.1ENA Protein Mapping
European Nucleotide ArchiveCAB52150.1ENA Protein Mapping
UniParcUPI0000138EF6UniProt Archive

Literature for wee1

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Release Version: PomBase:25_50 - 10 Mar 2015