acs1 (SPCC191.02c)


Gene Standard Nameacs1 Characterisation Statusbiological role inferred
Systematic IDSPCC191.02c Feature Typeprotein coding
SynonymsSPCC417.14c Name Description
Productacetyl-CoA ligase (predicted) Product Size662aa, 73.04 kDa
Genomic Location Chromosome III, 1710511-1708234 (2278nt); CDS:1710222-1708234 (1989nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
acetate-CoA ligase activity1
Annotation ExtensionEvidenceWith/FromReference
AMP binding2
Annotation ExtensionEvidenceWith/FromReference
ATP binding557
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
acetyl-CoA biosynthetic process from acetate1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4213
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
mitochondrion752
Annotation ExtensionEvidenceWith/FromReference
nucleus2700
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationacs1Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyacs1Δ3102
Target Of
OntologyRelationshipGeneProduct
GO substrate of sst2 human AMSH/STAMBP protein homolog, ubiquitin specific-protease
GO substrate of ubp15 ubiquitin C-terminal hydrolase Ubp15
GO substrate of ubp4 ubiquitin C-terminal hydrolase Ubp4
GO substrate of ubp5 ubiquitin C-terminal hydrolase Ubp5
GO substrate of ubp9 ubiquitin C-terminal hydrolase Ubp9
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1710511..1708234
mRNA1710511..1708234
5' UTR1710511..1710223PMID:18641648
5' UTR1710511..1710223PMID:20118936
CDS1710222..1708234
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF13193 Pfam IPR025110 AMP-binding enzyme C-terminal domain 541 618 3
PF00501 Pfam IPR000873 AMP-dependent synthetase/ligase 93 532 9
PF16177 Pfam IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain 35 90 1
PS00455 Prosite Patterns IPR020845 AMP-binding, conserved site 270 281 7
PTHR24095 HMMPANTHER 29 654 5
PTHR24095:SF210 HMMPANTHER 29 654 1
2.30.38.10 Gene3D AMP-dependent synthetase/ligase 442 522 7
3.30.300.30 Gene3D AMP-binding enzyme C-terminal domain 528 649 4
3.40.50.980 Gene3D AMP-dependent synthetase/ligase 88 274 9
3.40.50.980 Gene3D AMP-dependent synthetase/ligase 275 431 9
SSF56801 SuperFamily 34 650 9
TIGR02188 TIGRFAM IPR011904 Acetate-CoA ligase 30 652 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.33 Da
Charge 3.50
Codon Adaptation Index 0.61
Isoelectric point 6.79
Molecular weight 73.04 kDa
Number of residues 662
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS595, S602, S609 2289
Annotation ExtensionEvidenceResidueReference
IDA S602 PMID:25720772
IDA S595 PMID:25720772
IDA S609 PMID:25720772
O-phospho-L-threonineT596 1085
Annotation ExtensionEvidenceResidueReference
IDA T596 PMID:25720772
ubiquitinylated lysineK605 512
Annotation ExtensionEvidenceResidueReference
IDA PMID:26412298
mass spectrometry evidence K605 PMID:26412298
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for acs1 (SPCC191.02c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
199238during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
193861during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
198629during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
189512during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
197680during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
113103.9during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
17788.17during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
15during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in bacteria1005
conserved in metazoa3427
conserved in vertebrates3402
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC191.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC191.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC191.02c BioGRID Interaction Datasets
Expression Viewer SPCC191.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC191.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC191.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC191.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC191.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC191.02c Transcriptome Viewer (Bähler Lab)
GEO SPCC191.02c GEO profiles
PInt SPCC191.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC191.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC191.02c Fission yeast phenotypic data & analysis
Cyclebase SPCC191.02c.1 Cell Cycle Data
IntEnz6.2.1.1Integrated relational Enzyme database
Rhea6.2.1.1Annotated reactions database
SPD / RIKEN27/27C09Orfeome Localization Data
UniProtKB/SwissProtP78773Probable acetyl-coenzyme A synthetase
ModBaseP78773Database of comparative protein structure models
STRINGP78773Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588291acetyl-CoA ligase (predicted)
RefSeq mRNANM_001023281972h- acetyl-CoA ligase (predicted) (SPCC191.02c), mRNA
European Nucleotide ArchiveD89121ENA EMBL mapping
European Nucleotide ArchiveCAA22660.1ENA Protein Mapping
MetaCycPWY-6672Cis-genanyl-coa degradation
MetaCycPWY-7118Chitin degradation to ethanol
KEGG00010+6.2.1.1Glycolysis / Gluconeogenesis
KEGG00620+6.2.1.1Pyruvate metabolism
KEGG00640+6.2.1.1Propanoate metabolism
KEGG00680+6.2.1.1Methane metabolism
KEGG00720+6.2.1.1Carbon fixation pathways in prokaryotes
UniParcUPI00001253BCUniProt Archive

Literature for acs1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016