acs1 (SPCC191.02c)


Gene Standard Nameacs1 Characterisation Statusbiological_role_inferred
Systematic IDSPCC191.02c Feature Typeprotein coding
SynonymsSPCC417.14c Name Description
Productacetyl-CoA ligase (predicted) Product Size662aa, 73.04 kDa
Genomic Location Chromosome III, 1710511-1708234 (2278nt); CDS:1710222-1708234 (1989nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016208AMP bindingIEAIPR011904GO_REF:00000021
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0003987acetate-CoA ligase activityISOSGD:S000000050GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0019654acetate fermentationISOSGD:S000000050GO_REF:00000241
GO:0019427acetyl-CoA biosynthetic process from acetateIEAIPR011904GO_REF:00000021
GO:0006084acetyl-CoA metabolic processISOSGD:S000000050GO_REF:000002417
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:230917014198
GO:0005829cytosolIDAPMID:168233722317
ISOSGD:S000000050GO_REF:0000024
GO:0005739mitochondrionISOSGD:S000000050GO_REF:0000024756
GO:0005634nucleusIDAPMID:230917012730
IDAPMID:16823372
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyacs1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyacs1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyacs1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
117105111708234

UTRs

Region Start End Reference
five_prime_UTR17105111710223PMID:18641648
five_prime_UTR17105111710223PMID:20118936
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00501 Pfam IPR000873 AMP-dependent synthetase/ligase 93 533 9
PF13193 Pfam IPR025110 AMP-binding enzyme C-terminal domain 541 618 3
PS00455 Prosite Patterns IPR020845 AMP-binding, conserved site 270 281 7
PTHR24095:SF80 HMMPANTHER 33 653 1
PTHR24095 HMMPANTHER 33 653 5
G3DSA:3.30.300.30 Gene3D 528 649 4
G3DSA:2.30.38.10 Gene3D 442 522 7
G3DSA:3.40.50.980 Gene3D 88 274 9
G3DSA:3.40.50.980 Gene3D 275 431 9
SSF56801 SuperFamily 34 650 9
TIGR02188 tigrfam IPR011904 Acetate-CoA ligase 30 652 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.33 Da
Charge 3.50
Isoelectric point 6.79
Molecular weight 73.04 kDa
Number of residues 662
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
113103.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
17788.17during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
15during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
External References
Database Identifier Description
NBRP SPCC191.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC191.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC191.02c BioGRID Interaction Datasets
Expression Viewer SPCC191.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC191.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC191.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC191.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC191.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC191.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC191.02c Cell Cycle Data
GEO SPCC191.02c GEO profiles
PInt SPCC191.02c Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz6.2.1.1Integrated relational Enzyme database
Rhea6.2.1.1Annotated reactions database
WikiGene2539546acetyl-CoA ligase (predicted)
EntrezGene2539546acetyl-CoA ligase (predicted)
SPD / RIKEN27/27C09Orfeome Localization Data
UniProtKB/SwissProtP78773Probable acetyl-coenzyme A synthetase
ModBaseP78773Database of comparative protein structure models
StringP78773Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588291acetyl-CoA ligase (predicted)
RefSeq mRNANM_001023281972h- acetyl-CoA ligase (predicted) (SPCC191.02c), mRNA
European Nucleotide ArchiveBAA13783ENA Protein Mapping
European Nucleotide ArchiveCAA22660ENA Protein Mapping
UniParcUPI00001253BCUniProt Archive

Literature for acs1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014