acs1 (SPCC191.02c)


Gene Standard Nameacs1 Characterisation Statusbiological_role_inferred
Systematic IDSPCC191.02c Feature Typeprotein coding
SynonymsSPCC417.14c Name Description
Productacetyl-CoA ligase (predicted) Product Size662aa, 73.04 kDa
Genomic Location Chromosome III, 1710511-1708234 (2278nt); CDS:1710222-1708234 (1989nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
acetate-CoA ligase activity1
Annotation ExtensionEvidenceWith/FromReference
AMP binding2
Annotation ExtensionEvidenceWith/FromReference
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
acetate fermentation1
Annotation ExtensionEvidenceWith/FromReference
acetyl-CoA biosynthetic process from acetate1
Annotation ExtensionEvidenceWith/FromReference
acetyl-CoA metabolic process18
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4205
Annotation ExtensionEvidenceWith/FromReference
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
mitochondrion758
Annotation ExtensionEvidenceWith/FromReference
nucleus2740
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyacs1ΔNullPECO:0000005, PECO:0000137PMID:236978063759
Microscopyacs1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyacs1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
117105111708234

UTRs

Region Coordinates Reference
five_prime_UTR1710511..1710223PMID:20118936
five_prime_UTR1710511..1710223PMID:18641648
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF13193 Pfam IPR025110 AMP-binding enzyme C-terminal domain 541 618 3
PF00501 Pfam IPR000873 AMP-dependent synthetase/ligase 93 533 9
PS00455 Prosite Patterns IPR020845 AMP-binding, conserved site 270 281 7
PTHR24095 HMMPANTHER 33 653 5
PTHR24095:SF80 HMMPANTHER 33 653 1
3.30.300.30 Gene3D 528 649 4
3.40.50.980 Gene3D 88 274 9
3.40.50.980 Gene3D 275 431 9
2.30.38.10 Gene3D 442 522 7
SSF56801 SuperFamily 34 650 9
TIGR02188 tigrfam IPR011904 Acetate-CoA ligase 30 652 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.33 Da
Charge 3.50
Isoelectric point 6.79
Molecular weight 73.04 kDa
Number of residues 662
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
199238during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
193861during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
198629during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
189512during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
113103.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
197680during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
17788.17during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
15during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC191.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC191.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC191.02c BioGRID Interaction Datasets
Expression Viewer SPCC191.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC191.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC191.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC191.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC191.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC191.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC191.02c Cell Cycle Data
GEO SPCC191.02c GEO profiles
PInt SPCC191.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC191.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC191.02c Fission yeast phenotypic data & analysis
SPD / RIKEN27/27C09Orfeome Localization Data
IntEnz6.2.1.1Integrated relational Enzyme database
Rhea6.2.1.1Annotated reactions database
UniProtKB/SwissProtP78773Probable acetyl-coenzyme A synthetase
ModBaseP78773Database of comparative protein structure models
STRINGP78773Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588291acetyl-CoA ligase (predicted)
RefSeq mRNANM_001023281972h- acetyl-CoA ligase (predicted) (SPCC191.02c), mRNA
European Nucleotide ArchiveD89121ENA EMBL mapping
European Nucleotide ArchiveCAA22660.1ENA Protein Mapping
UniParcUPI00001253BCUniProt Archive

Literature for acs1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014