SPCC23B6.04c


Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPCC23B6.04c Feature Typeprotein coding
Synonyms Name Description
Productsec14 cytosolic factor family, glycerophospholipid-transfer protein (predicted) Product Size1008aa, 110.73 kDa
Genomic Location Chromosome III, 1280899-1277590 (3310nt); CDS:1280899-1277873 (3027nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phosphatidylinositol transporter activity5
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ergosterol biosynthetic process45
Annotation ExtensionEvidenceWith/FromReference
phospholipid transport11
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
plasma membrane253
Annotation ExtensionEvidenceWith/FromReference
prospore membrane30
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
sensitive to etoposideSPCC23B6.04c+ (wild type)16
viable vegetative cell populationSPCC23B6.04cΔ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell, abnormal cell shape, normal cell sizeSPCC23B6.04cΔ215
Target Of
OntologyRelationshipGeneProduct
GO substrate of sst2 human AMSH/STAMBP protein homolog, ubiquitin specific-protease
GO substrate of ubp15 ubiquitin C-terminal hydrolase Ubp15
GO substrate of ubp4 ubiquitin C-terminal hydrolase Ubp4
GO substrate of ubp5 ubiquitin C-terminal hydrolase Ubp5
GO substrate of ubp9 ubiquitin C-terminal hydrolase Ubp9
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1280899..1277590
mRNA1280899..1277590
CDS1280899..1277873
3' UTR1277872..1277590PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00650 Pfam IPR001251 CRAL-TRIO lipid binding domain 678 823 5
PF03765 Pfam IPR011074 CRAL/TRIO, N-terminal domain 599 658 4
SM00516 SMART IPR001251 CRAL-TRIO lipid binding domain 679 825 5
SM01100 SMART IPR011074 CRAL/TRIO, N-terminal domain 634 659 4
PS50191 Prosite Profiles IPR001251 CRAL-TRIO lipid binding domain 675 828 5
PTHR10174:SF127 HMMPANTHER 573 839 1
PTHR10174 HMMPANTHER 573 839 5
3.40.525.10 Gene3D IPR001251 CRAL-TRIO lipid binding domain 590 866 6
SSF46938 SuperFamily IPR011074 CRAL/TRIO, N-terminal domain 575 675 5
SSF52087 SuperFamily IPR001251 CRAL-TRIO lipid binding domain 674 854 6
Coil ncoils Predicted coiled-coil protein (DUF2205) 103 123 1055

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.85 Da
Charge 9.00
Codon Adaptation Index 0.43
Isoelectric point 7.19
Molecular weight 110.73 kDa
Number of residues 1008
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during mitotic M phaseS37
present during mitotic M phaseS72
present during mitotic M phaseS498
present during cellular response to thiabendazole, mitotic M phaseS525
present during cellular response to thiabendazole, mitotic M phaseS914
present during mitotic M phaseS909
present during mitotic M phaseS183
present during mitotic M phaseS556
present during mitotic M phaseS383
present during mitotic M phaseS401
present during cellular response to thiabendazole, mitotic M phaseS543
present during mitotic M phaseS406
present during mitotic M phaseS448
present during mitotic M phaseS443
present during mitotic M phaseS386
present during mitotic M phaseS294
present during mitotic M phaseS539
present during mitotic M phaseS400
present during mitotic M phaseS258
present during cellular response to thiabendazole, mitotic M phaseS559
present during mitotic M phaseS951
present during mitotic M phaseS33
present during mitotic M phaseS934
present during mitotic M phaseS502
present during mitotic M phaseS380
present during mitotic M phaseS497
present during mitotic M phaseS957
present during mitotic M phaseS306
present during mitotic M phaseS470
present during mitotic M phaseS246
present during mitotic M phaseS36
present during mitotic M phaseS307
present during mitotic M phaseS409
S183, S185, S289, S294, S306, S307, S359, S362, S383, S439, S441, S470, S475, S485, S525, S543, S559, S888, S889, S890, S909, S914, S934, S951
level fluctuates during mitotic cell cycleS183
level fluctuates during mitotic cell cycleS525
level fluctuates during mitotic cell cycleS306
level fluctuates during mitotic cell cycleS539
level fluctuates during mitotic cell cycleS914
level fluctuates during mitotic cell cycleS72
level fluctuates during mitotic cell cycleS543
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S37 PMID:21712547
present during mitotic M phase experimental evidence S72 PMID:21712547
present during mitotic M phase experimental evidence S498 PMID:21712547
present during mitotic M phase experimental evidence S525 PMID:21712547
present during mitotic M phase experimental evidence S914 PMID:21712547
present during mitotic M phase experimental evidence S909 PMID:21712547
present during mitotic M phase experimental evidence S183 PMID:21712547
present during mitotic M phase experimental evidence S556 PMID:21712547
present during mitotic M phase experimental evidence S383 PMID:21712547
present during mitotic M phase experimental evidence S401 PMID:21712547
present during cellular response to thiabendazole IDA S543 PMID:18257517
present during mitotic M phase experimental evidence S406 PMID:21712547
present during mitotic M phase experimental evidence S448 PMID:21712547
present during mitotic M phase experimental evidence S443 PMID:21712547
present during mitotic M phase experimental evidence S386 PMID:21712547
present during mitotic M phase experimental evidence S294 PMID:21712547
present during mitotic M phase experimental evidence S539 PMID:21712547
present during mitotic M phase experimental evidence S400 PMID:21712547
present during mitotic M phase experimental evidence S258 PMID:21712547
present during mitotic M phase experimental evidence S559 PMID:21712547
present during mitotic M phase experimental evidence S951 PMID:21712547
present during mitotic M phase experimental evidence S33 PMID:21712547
present during cellular response to thiabendazole IDA S525 PMID:18257517
present during mitotic M phase experimental evidence S934 PMID:21712547
present during mitotic M phase experimental evidence S502 PMID:21712547
present during mitotic M phase experimental evidence S380 PMID:21712547
present during cellular response to thiabendazole IDA S914 PMID:18257517
present during mitotic M phase experimental evidence S497 PMID:21712547
present during mitotic M phase experimental evidence S543 PMID:21712547
present during mitotic M phase experimental evidence S957 PMID:21712547
present during mitotic M phase experimental evidence S306 PMID:21712547
present during cellular response to thiabendazole IDA S559 PMID:18257517
present during mitotic M phase experimental evidence S470 PMID:21712547
present during mitotic M phase experimental evidence S246 PMID:21712547
present during mitotic M phase experimental evidence S36 PMID:21712547
present during mitotic M phase experimental evidence S307 PMID:21712547
present during mitotic M phase experimental evidence S409 PMID:21712547
experimental evidence S559 PMID:24763107
IDA S559 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S183 PMID:24763107
IDA S306 PMID:25720772
IDA S359 PMID:25720772
experimental evidence S934 PMID:24763107
IDA S183 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S525 PMID:24763107
experimental evidence S909 PMID:24763107
IDA S383 PMID:25720772
IDA S889 PMID:25720772
IDA S951 PMID:25720772
IDA S914 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S306 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S539 PMID:24763107
IDA S543 PMID:25720772
IDA S289 PMID:25720772
IDA S909 PMID:25720772
IDA S934 PMID:25720772
IDA S888 PMID:25720772
IDA S475 PMID:25720772
IDA S439 PMID:25720772
IDA S185 PMID:25720772
IDA S470 PMID:25720772
experimental evidence S485 PMID:24763107
IDA S525 PMID:25720772
IDA S890 PMID:25720772
IDA S362 PMID:25720772
IDA S307 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S914 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S72 PMID:24763107
IDA S441 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S543 PMID:24763107
experimental evidence S185 PMID:24763107
IDA S294 PMID:25720772
O-phospho-L-threonine 1085
present during mitotic M phaseT499
present during mitotic M phaseT540
present during mitotic M phaseT503
present during mitotic M phaseT302
present during mitotic M phaseT476
present during mitotic M phaseT44
present during mitotic M phaseT472
present during mitotic M phaseT958
present during mitotic M phaseT449
present during mitotic M phaseT35
present during mitotic M phaseT416
present during mitotic M phaseT387
present during mitotic M phaseT445
present during mitotic M phaseT262
T44, T288, T302, T365, T472, T476, T892, T907
level fluctuates during mitotic cell cycleT449
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T499 PMID:21712547
present during mitotic M phase experimental evidence T540 PMID:21712547
present during mitotic M phase experimental evidence T503 PMID:21712547
present during mitotic M phase experimental evidence T302 PMID:21712547
present during mitotic M phase experimental evidence T476 PMID:21712547
present during mitotic M phase experimental evidence T44 PMID:21712547
present during mitotic M phase experimental evidence T472 PMID:21712547
present during mitotic M phase experimental evidence T958 PMID:21712547
present during mitotic M phase experimental evidence T449 PMID:21712547
present during mitotic M phase experimental evidence T35 PMID:21712547
present during mitotic M phase experimental evidence T416 PMID:21712547
present during mitotic M phase experimental evidence T387 PMID:21712547
present during mitotic M phase experimental evidence T445 PMID:21712547
present during mitotic M phase experimental evidence T262 PMID:21712547
IDA T302 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence T449 PMID:24763107
IDA T288 PMID:25720772
IDA T476 PMID:25720772
IDA T472 PMID:25720772
experimental evidence T472 PMID:24763107
IDA T365 PMID:25720772
IDA T907 PMID:25720772
experimental evidence T44 PMID:24763107
IDA T892 PMID:25720772
O4'-phospho-L-tyrosineY363 281
Annotation ExtensionEvidenceResidueReference
IDA Y363 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS36,S37, S61,T62, S63,S64, S63,T65, S289,S294, S359,S361, S359,S361,S362, S359,S361,T365, S359,S361,Y363, S359,S362, S359,S362,T365, S359,T365, S359,Y363,T365, S361,S362, S361,S362,T365, S361,T365, S362,T365, S362,Y363, S362,Y363,T365, S383,S386, S439,S448, S439,T445,T449, S439,T449, S441,S443,T449, S441,S448, S441,T445,S448, S441,T445,T449, S441,T449, S497,S498, S497,S502, S498,S502, S536,S539, S536,T537, S539,S543, S539,S543,S551, S539,T540, S543,S551, S556,S559, S888,S889, S888,S890, S888,T892, S888,T894, S888,T896, S888,T899, S889,S890, S890,T892, S890,T894, S890,T896, S890,T899, S909,S914, S974,S979, S976,S979, S976,T981, T62,S63, T288,S294, T445,S448, T445,T449, T472,S475, T472,S485, T472,T476, T472,T476,S485, T499,S502, T499,T503, T537,S539, T540,S543, T892,T894, T907,S914, Y363,T365 2457
Annotation ExtensionEvidenceResidueReference
IDA S359,T365 PMID:25720772
IDA T472,S475 PMID:25720772
IDA S439,S448 PMID:25720772
IDA S359,S361 PMID:25720772
IDA S890,T892 PMID:25720772
IDA S539,S543,S551 PMID:25720772
IDA S362,Y363 PMID:25720772
IDA S359,S362,T365 PMID:25720772
IDA S383,S386 PMID:25720772
IDA S361,T365 PMID:25720772
IDA S63,T65 PMID:25720772
IDA S909,S914 PMID:25720772
IDA S888,T892 PMID:25720772
IDA S888,T894 PMID:25720772
IDA T540,S543 PMID:25720772
IDA S289,S294 PMID:25720772
IDA S890,T896 PMID:25720772
IDA S976,T981 PMID:25720772
IDA S36,S37 PMID:25720772
IDA T472,T476,S485 PMID:25720772
IDA S536,S539 PMID:25720772
IDA T62,S63 PMID:25720772
IDA Y363,T365 PMID:25720772
IDA S890,T899 PMID:25720772
IDA S539,T540 PMID:25720772
IDA S888,S890 PMID:25720772
IDA T445,T449 PMID:25720772
IDA S536,T537 PMID:25720772
IDA S888,S889 PMID:25720772
IDA S888,T899 PMID:25720772
IDA T499,S502 PMID:25720772
IDA S497,S502 PMID:25720772
IDA S359,S362 PMID:25720772
IDA T472,S485 PMID:25720772
IDA S889,S890 PMID:25720772
IDA S359,S361,Y363 PMID:25720772
IDA S359,Y363,T365 PMID:25720772
IDA S441,T445,T449 PMID:25720772
IDA S441,T449 PMID:25720772
IDA S439,T449 PMID:25720772
IDA S888,T896 PMID:25720772
IDA S976,S979 PMID:25720772
IDA S61,T62 PMID:25720772
IDA S441,S448 PMID:25720772
IDA S556,S559 PMID:25720772
IDA S361,S362,T365 PMID:25720772
IDA S974,S979 PMID:25720772
IDA S359,S361,T365 PMID:25720772
IDA S359,S361,S362 PMID:25720772
IDA S441,T445,S448 PMID:25720772
IDA S362,T365 PMID:25720772
IDA S890,T894 PMID:25720772
IDA T907,S914 PMID:25720772
IDA S539,S543 PMID:25720772
IDA S63,S64 PMID:25720772
IDA S439,T445,T449 PMID:25720772
IDA S441,S443,T449 PMID:25720772
IDA S497,S498 PMID:25720772
IDA S543,S551 PMID:25720772
IDA T472,T476 PMID:25720772
IDA T445,S448 PMID:25720772
IDA S498,S502 PMID:25720772
IDA T537,S539 PMID:25720772
IDA T499,T503 PMID:25720772
IDA T892,T894 PMID:25720772
IDA S361,S362 PMID:25720772
IDA T288,S294 PMID:25720772
IDA S362,Y363,T365 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for SPCC23B6.04c

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7959during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7950during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7726during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8473during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8095during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
6025.62during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
4334.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
8.7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC23B6.04c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withmis4cohesin loading factor (adherin) Mis4 Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPCC23B6.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC23B6.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC23B6.04c BioGRID Interaction Datasets
Expression Viewer SPCC23B6.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC23B6.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC23B6.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC23B6.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC23B6.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC23B6.04c Transcriptome Viewer (Bähler Lab)
GEO SPCC23B6.04c GEO profiles
PInt SPCC23B6.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC23B6.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC23B6.04c Fission yeast phenotypic data & analysis
Cyclebase SPCC23B6.04c.1 Cell Cycle Data
SPD / RIKEN29/29H01Orfeome Localization Data
UniProtKB/SwissProtQ9UU99CRAL-TRIO domain-containing protein C23B6.04c
ModBaseQ9UU99Database of comparative protein structure models
STRINGQ9UU99Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588127sec14 cytosolic factor family (predicted)
RefSeq mRNANM_001023117972h- sec14 cytosolic factor family (predicted) (SPCC23B6.04c), mRNA
European Nucleotide ArchiveBAA87299.1ENA Protein Mapping
European Nucleotide ArchiveCAB51563.1ENA Protein Mapping
UniParcUPI000006A46DUniProt Archive

Literature for SPCC23B6.04c

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016