SPCC23B6.04c


Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPCC23B6.04c Feature Typeprotein coding
Synonyms Name Description
Productsec14 cytosolic factor family, glycerophospholipid-transfer protein (predicted) Product Size1008aa, 110.73 kDa
Genomic Location Chromosome III, 1280899-1277590 (3310nt); CDS:1280899-1277873 (3027nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phosphatidylinositol transporter activity5
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ergosterol biosynthetic process45
Annotation ExtensionEvidenceWith/FromReference
phospholipid transport13
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
plasma membrane251
Annotation ExtensionEvidenceWith/FromReference
prospore membrane30
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
sensitive to etoposideSPCC23B6.04c+ (wild type)16
viable vegetative cell populationSPCC23B6.04cΔ3819

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell, abnormal cell shape, normal cell sizeSPCC23B6.04cΔ215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1280899..1277590
mRNA1280899..1277590
CDS1280899..1277873
3' UTR1277872..1277590PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03765 Pfam IPR011074 CRAL/TRIO, N-terminal domain 599 658 4
PF00650 Pfam IPR001251 CRAL-TRIO lipid binding domain 678 823 5
SM01100 SMART IPR011074 CRAL/TRIO, N-terminal domain 634 659 4
SM00516 SMART IPR001251 CRAL-TRIO lipid binding domain 679 825 5
PS50191 Prosite Profiles IPR001251 CRAL-TRIO lipid binding domain 675 828 5
PTHR10174 HMMPANTHER 573 839 5
PTHR10174:SF127 HMMPANTHER 573 839 1
3.40.525.10 Gene3D IPR001251 CRAL-TRIO lipid binding domain 590 866 6
SSF46938 SuperFamily IPR011074 CRAL/TRIO, N-terminal domain 575 675 5
SSF52087 SuperFamily IPR001251 CRAL-TRIO lipid binding domain 674 854 6
Coil ncoils Predicted coiled-coil protein (DUF2205) 103 123 1048

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.85 Da
Charge 9.00
Isoelectric point 7.19
Molecular weight 110.73 kDa
Number of residues 1008
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1674
present during mitotic M phaseS386
present during mitotic M phaseS246
present during mitotic M phaseS183
level fluctuates during mitotic cell cycleS525
present during mitotic M phaseS294
level fluctuates during mitotic cell cycleS543
present during mitotic M phaseS909
present during mitotic M phaseS33
present during mitotic M phaseS498
present during mitotic M phaseS934
level fluctuates during mitotic cell cycleS539
present during mitotic M phaseS36
level fluctuates during mitotic cell cycleS914
present during mitotic M phaseS400
present during mitotic M phaseS37
present during cellular response to thiabendazole, mitotic M phaseS525
present during mitotic M phaseS951
present during mitotic M phase, cellular response to thiabendazoleS543
present during mitotic M phaseS383
present during mitotic M phaseS443
S185, S485, S559, S909, S934
present during mitotic M phaseS406
present during mitotic M phase, cellular response to thiabendazoleS914
present during mitotic M phaseS957
present during mitotic M phaseS409
present during mitotic M phaseS258
present during mitotic M phaseS539
present during mitotic M phaseS556
level fluctuates during mitotic cell cycleS72
present during mitotic M phaseS401
level fluctuates during mitotic cell cycleS306
present during mitotic M phaseS502
level fluctuates during mitotic cell cycleS183
present during cellular response to thiabendazole, mitotic M phaseS559
present during mitotic M phaseS448
present during mitotic M phaseS470
present during mitotic M phaseS307
present during mitotic M phaseS497
present during mitotic M phaseS380
present during mitotic M phaseS306
present during mitotic M phaseS72
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S33 PMID:21712547
present during mitotic M phase experimental evidence S36 PMID:21712547
present during mitotic M phase experimental evidence S37 PMID:21712547
present during mitotic M phase experimental evidence S72 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S72 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S183 PMID:24763107
present during mitotic M phase experimental evidence S183 PMID:21712547
experimental evidence S185 PMID:24763107
present during mitotic M phase experimental evidence S246 PMID:21712547
present during mitotic M phase experimental evidence S258 PMID:21712547
present during mitotic M phase experimental evidence S294 PMID:21712547
present during mitotic M phase experimental evidence S306 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S306 PMID:24763107
present during mitotic M phase experimental evidence S307 PMID:21712547
present during mitotic M phase experimental evidence S380 PMID:21712547
present during mitotic M phase experimental evidence S383 PMID:21712547
present during mitotic M phase experimental evidence S386 PMID:21712547
present during mitotic M phase experimental evidence S400 PMID:21712547
present during mitotic M phase experimental evidence S401 PMID:21712547
present during mitotic M phase experimental evidence S406 PMID:21712547
present during mitotic M phase experimental evidence S409 PMID:21712547
present during mitotic M phase experimental evidence S443 PMID:21712547
present during mitotic M phase experimental evidence S448 PMID:21712547
present during mitotic M phase experimental evidence S470 PMID:21712547
experimental evidence S485 PMID:24763107
present during mitotic M phase experimental evidence S497 PMID:21712547
present during mitotic M phase experimental evidence S498 PMID:21712547
present during mitotic M phase experimental evidence S502 PMID:21712547
present during cellular response to thiabendazole IDA S525 PMID:18257517
present during mitotic M phase experimental evidence S525 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S525 PMID:24763107
present during mitotic M phase experimental evidence S539 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S539 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S543 PMID:24763107
present during mitotic M phase experimental evidence S543 PMID:21712547
present during cellular response to thiabendazole IDA S543 PMID:18257517
present during mitotic M phase experimental evidence S556 PMID:21712547
experimental evidence S559 PMID:24763107
present during mitotic M phase experimental evidence S559 PMID:21712547
present during cellular response to thiabendazole IDA S559 PMID:18257517
experimental evidence S909 PMID:24763107
present during mitotic M phase experimental evidence S909 PMID:21712547
present during mitotic M phase experimental evidence S914 PMID:21712547
present during cellular response to thiabendazole IDA S914 PMID:18257517
level fluctuates during mitotic cell cycle experimental evidence S914 PMID:24763107
experimental evidence S934 PMID:24763107
present during mitotic M phase experimental evidence S934 PMID:21712547
present during mitotic M phase experimental evidence S951 PMID:21712547
present during mitotic M phase experimental evidence S957 PMID:21712547
O-phospho-L-threonine 699
present during mitotic M phaseT476
present during mitotic M phaseT472
level fluctuates during mitotic cell cycleT449
present during mitotic M phaseT503
present during mitotic M phaseT262
present during mitotic M phaseT44
present during mitotic M phaseT416
present during mitotic M phaseT445
present during mitotic M phaseT540
present during mitotic M phaseT302
present during mitotic M phaseT499
present during mitotic M phaseT449
T44, T472
present during mitotic M phaseT958
present during mitotic M phaseT387
present during mitotic M phaseT35
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T35 PMID:21712547
experimental evidence T44 PMID:24763107
present during mitotic M phase experimental evidence T44 PMID:21712547
present during mitotic M phase experimental evidence T262 PMID:21712547
present during mitotic M phase experimental evidence T302 PMID:21712547
present during mitotic M phase experimental evidence T387 PMID:21712547
present during mitotic M phase experimental evidence T416 PMID:21712547
present during mitotic M phase experimental evidence T445 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence T449 PMID:24763107
present during mitotic M phase experimental evidence T449 PMID:21712547
experimental evidence T472 PMID:24763107
present during mitotic M phase experimental evidence T472 PMID:21712547
present during mitotic M phase experimental evidence T476 PMID:21712547
present during mitotic M phase experimental evidence T499 PMID:21712547
present during mitotic M phase experimental evidence T503 PMID:21712547
present during mitotic M phase experimental evidence T540 PMID:21712547
present during mitotic M phase experimental evidence T958 PMID:21712547
phosphorylated residue 1930
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7959during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7950during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7726during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8473during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8095during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
6025.62during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
4334.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
8.7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load gene that interact geneitically with SPCC23B6.04c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withmis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPCC23B6.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC23B6.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC23B6.04c BioGRID Interaction Datasets
Expression Viewer SPCC23B6.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC23B6.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC23B6.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC23B6.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC23B6.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC23B6.04c Transcriptome Viewer (Bähler Lab)
GEO SPCC23B6.04c GEO profiles
PInt SPCC23B6.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC23B6.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC23B6.04c Fission yeast phenotypic data & analysis
Cyclebase SPCC23B6.04c.1 Cell Cycle Data
SPD / RIKEN29/29H01Orfeome Localization Data
UniProtKB/SwissProtQ9UU99CRAL-TRIO domain-containing protein C23B6.04c
ModBaseQ9UU99Database of comparative protein structure models
STRINGQ9UU99Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588127sec14 cytosolic factor family (predicted)
RefSeq mRNANM_001023117972h- sec14 cytosolic factor family (predicted) (SPCC23B6.04c), mRNA
European Nucleotide ArchiveAB027995ENA EMBL mapping
European Nucleotide ArchiveCU329672ENA EMBL mapping
European Nucleotide ArchiveBAA87299ENA Protein Mapping
European Nucleotide ArchiveBAA87299.1ENA Protein Mapping
European Nucleotide ArchiveCAB51563ENA Protein Mapping
European Nucleotide ArchiveCAB51563.1ENA Protein Mapping
UniParcUPI000006A46DUniProt Archive

Literature for SPCC23B6.04c

Search: Europe PMC or PubMed

Release Version: PomBase:29_56 - 12 Nov 2015