SPCC23B6.04c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC23B6.04c Feature Typeprotein coding
Synonyms Name Description
Productsec14 cytosolic factor family (predicted) Product Size1008aa, 110.73 kDa
Genomic Location Chromosome III, 1280899-1277590 (3310nt); CDS:1280899-1277873 (3027nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phosphatidylinositol transporter activity5
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ergosterol biosynthetic process44
Annotation ExtensionEvidenceWith/FromReference
phospholipid transport13
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
prospore membrane28
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to etoposideunnamed (wild type)16
viable vegetative cell populationSPCC23B6.04cΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell, abnormal cell shape, normal cell sizeSPCC23B6.04cΔNull215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
112808991277590

UTRs

Region Coordinates Reference
three_prime_UTR1277872..1277590PMID:21511999
exon1280899..1277873
mRNA1280899..1277590
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03765 Pfam IPR011074 CRAL/TRIO, N-terminal domain 597 659 4
PF00650 Pfam IPR001251 CRAL-TRIO domain 678 823 5
SM00516 SMART IPR001251 CRAL-TRIO domain 679 825 5
SM01100 SMART IPR011074 CRAL/TRIO, N-terminal domain 634 659 4
PS50191 Prosite Profiles IPR001251 CRAL-TRIO domain 675 828 5
PTHR10174:SF113 HMMPANTHER 568 881 1
PTHR10174 HMMPANTHER 568 881 5
3.40.525.10 Gene3D IPR001251 CRAL-TRIO domain 590 866 6
SSF46938 SuperFamily IPR011074 CRAL/TRIO, N-terminal domain 575 675 5
SSF52087 SuperFamily IPR001251 CRAL-TRIO domain 674 854 6
Coil ncoils Rabaptin coiled-coil domain 103 124 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.85 Da
Charge 9.00
Isoelectric point 7.19
Molecular weight 110.73 kDa
Number of residues 1008
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
present during mitotic M phaseS406
present during mitotic M phaseS36
present during mitotic M phaseS246
present during mitotic M phaseS294
present during mitotic M phaseS470
level fluctuates during mitotic cell cycleS914
present during cellular response to thiabendazole, mitotic M phaseS914
S185, S485, S559, S909, S934
present during mitotic M phaseS497
level fluctuates during mitotic cell cycleS543
level fluctuates during mitotic cell cycleS183
level fluctuates during mitotic cell cycleS539
present during mitotic M phaseS306
level fluctuates during mitotic cell cycleS72
present during mitotic M phaseS401
present during mitotic M phaseS409
present during mitotic M phaseS72
present during mitotic M phaseS37
present during mitotic M phaseS400
level fluctuates during mitotic cell cycleS525
present during mitotic M phaseS443
present during mitotic M phaseS307
level fluctuates during mitotic cell cycleS306
present during mitotic M phaseS183
present during mitotic M phaseS498
present during mitotic M phase, cellular response to thiabendazoleS525
present during mitotic M phaseS383
present during mitotic M phaseS33
present during mitotic M phaseS909
present during cellular response to thiabendazole, mitotic M phaseS543
present during mitotic M phaseS386
present during cellular response to thiabendazole, mitotic M phaseS559
present during mitotic M phaseS502
present during mitotic M phaseS556
present during mitotic M phaseS380
present during mitotic M phaseS258
present during mitotic M phaseS448
present during mitotic M phaseS957
present during mitotic M phaseS934
present during mitotic M phaseS951
present during mitotic M phaseS539
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S33 PMID:21712547
present during mitotic M phase experimental evidence S36 PMID:21712547
present during mitotic M phase experimental evidence S37 PMID:21712547
present during mitotic M phase experimental evidence S72 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S72 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S183 PMID:24763107
present during mitotic M phase experimental evidence S183 PMID:21712547
experimental evidence S185 PMID:24763107
present during mitotic M phase experimental evidence S246 PMID:21712547
present during mitotic M phase experimental evidence S258 PMID:21712547
present during mitotic M phase experimental evidence S294 PMID:21712547
present during mitotic M phase experimental evidence S306 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S306 PMID:24763107
present during mitotic M phase experimental evidence S307 PMID:21712547
present during mitotic M phase experimental evidence S380 PMID:21712547
present during mitotic M phase experimental evidence S383 PMID:21712547
present during mitotic M phase experimental evidence S386 PMID:21712547
present during mitotic M phase experimental evidence S400 PMID:21712547
present during mitotic M phase experimental evidence S401 PMID:21712547
present during mitotic M phase experimental evidence S406 PMID:21712547
present during mitotic M phase experimental evidence S409 PMID:21712547
present during mitotic M phase experimental evidence S443 PMID:21712547
present during mitotic M phase experimental evidence S448 PMID:21712547
present during mitotic M phase experimental evidence S470 PMID:21712547
experimental evidence S485 PMID:24763107
present during mitotic M phase experimental evidence S497 PMID:21712547
present during mitotic M phase experimental evidence S498 PMID:21712547
present during mitotic M phase experimental evidence S502 PMID:21712547
present during cellular response to thiabendazole IDA S525 PMID:18257517
present during mitotic M phase experimental evidence S525 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S525 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S539 PMID:24763107
present during mitotic M phase experimental evidence S539 PMID:21712547
present during mitotic M phase experimental evidence S543 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S543 PMID:24763107
present during cellular response to thiabendazole IDA S543 PMID:18257517
present during mitotic M phase experimental evidence S556 PMID:21712547
experimental evidence S559 PMID:24763107
present during mitotic M phase experimental evidence S559 PMID:21712547
present during cellular response to thiabendazole IDA S559 PMID:18257517
experimental evidence S909 PMID:24763107
present during mitotic M phase experimental evidence S909 PMID:21712547
present during cellular response to thiabendazole IDA S914 PMID:18257517
present during mitotic M phase experimental evidence S914 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S914 PMID:24763107
experimental evidence S934 PMID:24763107
present during mitotic M phase experimental evidence S934 PMID:21712547
present during mitotic M phase experimental evidence S951 PMID:21712547
present during mitotic M phase experimental evidence S957 PMID:21712547
O-phospho-L-threonine 694
present during mitotic M phaseT302
present during mitotic M phaseT262
present during mitotic M phaseT387
present during mitotic M phaseT958
present during mitotic M phaseT445
present during mitotic M phaseT472
present during mitotic M phaseT416
T44, T472
present during mitotic M phaseT44
present during mitotic M phaseT499
level fluctuates during mitotic cell cycleT449
present during mitotic M phaseT35
present during mitotic M phaseT476
present during mitotic M phaseT540
present during mitotic M phaseT503
present during mitotic M phaseT449
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T35 PMID:21712547
experimental evidence T44 PMID:24763107
present during mitotic M phase experimental evidence T44 PMID:21712547
present during mitotic M phase experimental evidence T262 PMID:21712547
present during mitotic M phase experimental evidence T302 PMID:21712547
present during mitotic M phase experimental evidence T387 PMID:21712547
present during mitotic M phase experimental evidence T416 PMID:21712547
present during mitotic M phase experimental evidence T445 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence T449 PMID:24763107
present during mitotic M phase experimental evidence T449 PMID:21712547
experimental evidence T472 PMID:24763107
present during mitotic M phase experimental evidence T472 PMID:21712547
present during mitotic M phase experimental evidence T476 PMID:21712547
present during mitotic M phase experimental evidence T499 PMID:21712547
present during mitotic M phase experimental evidence T503 PMID:21712547
present during mitotic M phase experimental evidence T540 PMID:21712547
present during mitotic M phase experimental evidence T958 PMID:21712547
phosphorylated residue 1923
Annotation ExtensionEvidenceResidueReference
NAS PMID:18257517
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7959during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
7950during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
7726during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8473during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6025.62during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
8095during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4334.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
8.7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byhhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withmis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPCC23B6.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC23B6.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC23B6.04c BioGRID Interaction Datasets
Expression Viewer SPCC23B6.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC23B6.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC23B6.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC23B6.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC23B6.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC23B6.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC23B6.04c Cell Cycle Data
GEO SPCC23B6.04c GEO profiles
PInt SPCC23B6.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC23B6.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC23B6.04c Fission yeast phenotypic data & analysis
SPD / RIKEN29/29H01Orfeome Localization Data
UniProtKB/SwissProtQ9UU99CRAL-TRIO domain-containing protein C23B6.04c
ModBaseQ9UU99Database of comparative protein structure models
STRINGQ9UU99Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588127sec14 cytosolic factor family (predicted)
RefSeq mRNANM_001023117972h- sec14 cytosolic factor family (predicted) (SPCC23B6.04c), mRNA
European Nucleotide ArchiveBAA87299.1ENA Protein Mapping
European Nucleotide ArchiveCAB51563.1ENA Protein Mapping
UniParcUPI000006A46DUniProt Archive

Literature for SPCC23B6.04c

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015