SPCC23B6.04c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC23B6.04c Feature Typeprotein coding
Synonyms Name Description
Productsec14 cytosolic factor family (predicted) Product Size1008aa, 110.73 kDa
Genomic Location Chromosome III, 1280899-1277590 (3310nt); CDS:1280899-1277873 (3027nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008526phosphatidylinositol transporter activityISOSGD:S000005175GO_REF:00000245
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006696ergosterol biosynthetic processISOSGD:S000005175GO_REF:000002439
GO:0015914phospholipid transportISOSGD:S000005175GO_REF:000002413
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005886plasma membraneIEAUniProtKB-KW:KW-1003GO_REF:0000037242
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPCC23B6.04cΔNullPECO:0000005, PECO:0000137PMID:236978063760
MicroscopySPCC23B6.04cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell size215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
MicroscopySPCC23B6.04cΔNullPECO:0000137, PECO:0000005PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
112808991277590

UTRs

Region Coordinates Reference
three_prime_UTR1277872..1277590PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00650 Pfam IPR001251 CRAL-TRIO domain 678 823 5
PF03765 Pfam IPR011074 CRAL/TRIO, N-terminal domain 597 659 4
SM01100 SMART IPR011074 CRAL/TRIO, N-terminal domain 634 659 4
SM00516 SMART IPR001251 CRAL-TRIO domain 679 825 5
PS50191 Prosite Profiles IPR001251 CRAL-TRIO domain 675 828 5
PTHR10174:SF113 HMMPANTHER 568 881 1
PTHR10174 HMMPANTHER 568 881 5
3.40.525.10 Gene3D IPR001251 CRAL-TRIO domain 590 866 5
SSF52087 SuperFamily IPR001251 CRAL-TRIO domain 674 854 6
SSF46938 SuperFamily IPR011074 CRAL/TRIO, N-terminal domain 575 675 5
Coil ncoils Rabaptin coiled-coil domain 103 124 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.85 Da
Charge 9.00
Isoelectric point 7.19
Molecular weight 110.73 kDa
Number of residues 1008
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS934PMID:217125471663
present during mitotic M phase
present during mitotic M phaseS246PMID:21712547
present during mitotic M phaseS559PMID:21712547
present during mitotic M phaseS307PMID:21712547
S559PMID:24763107
S185PMID:24763107
present during mitotic M phaseS525PMID:21712547
present during mitotic M phaseS401PMID:21712547
present during mitotic M phaseS33PMID:21712547
present during mitotic M phaseS470PMID:21712547
present during mitotic M phaseS406PMID:21712547
present during mitotic M phaseS294PMID:21712547
level fluctuates during mitotic cell cycleS539PMID:24763107
level fluctuates during mitotic cell cycleS543PMID:24763107
S909PMID:24763107
level fluctuates during mitotic cell cycleS914PMID:24763107
present during mitotic M phaseS258PMID:21712547
present during mitotic M phaseS914PMID:21712547
S934PMID:24763107
present during mitotic M phaseS556PMID:21712547
present during mitotic M phaseS497PMID:21712547
present during cellular response to thiabendazoleIDAS914PMID:18257517
present during mitotic M phaseS951PMID:21712547
present during mitotic M phaseS957PMID:21712547
present during cellular response to thiabendazoleIDAS543PMID:18257517
present during cellular response to thiabendazoleIDAS559PMID:18257517
present during cellular response to thiabendazoleIDAS525PMID:18257517
present during mitotic M phaseS539PMID:21712547
present during mitotic M phaseS443PMID:21712547
present during mitotic M phaseS386PMID:21712547
level fluctuates during mitotic cell cycleS183PMID:24763107
present during mitotic M phaseS543PMID:21712547
present during mitotic M phaseS400PMID:21712547
present during mitotic M phaseS37PMID:21712547
present during mitotic M phaseS380PMID:21712547
level fluctuates during mitotic cell cycleS306PMID:24763107
level fluctuates during mitotic cell cycleS72PMID:24763107
S485PMID:24763107
level fluctuates during mitotic cell cycleS525PMID:24763107
present during mitotic M phaseS502PMID:21712547
present during mitotic M phaseS409PMID:21712547
present during mitotic M phaseS909PMID:21712547
present during mitotic M phaseS183PMID:21712547
present during mitotic M phaseS72PMID:21712547
present during mitotic M phaseS36PMID:21712547
present during mitotic M phaseS448PMID:21712547
present during mitotic M phaseS498PMID:21712547
present during mitotic M phaseS306PMID:21712547
present during mitotic M phaseS383PMID:21712547
MOD:00047O-phospho-L-threonineT958PMID:21712547682
present during mitotic M phase
present during mitotic M phaseT499PMID:21712547
T44PMID:24763107
present during mitotic M phaseT476PMID:21712547
present during mitotic M phaseT262PMID:21712547
level fluctuates during mitotic cell cycleT449PMID:24763107
present during mitotic M phaseT445PMID:21712547
T472PMID:24763107
present during mitotic M phaseT44PMID:21712547
present during mitotic M phaseT387PMID:21712547
present during mitotic M phaseT540PMID:21712547
present during mitotic M phaseT472PMID:21712547
present during mitotic M phaseT449PMID:21712547
present during mitotic M phaseT35PMID:21712547
present during mitotic M phaseT503PMID:21712547
present during mitotic M phaseT302PMID:21712547
present during mitotic M phaseT416PMID:21712547
MOD:00696phosphorylated residueNASPMID:182575171915
NASPMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
7726during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
7950during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8095during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
6025.62during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
4334.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
7959during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8473during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8.7during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4569
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC23B6.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC23B6.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC23B6.04c BioGRID Interaction Datasets
Expression Viewer SPCC23B6.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC23B6.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC23B6.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC23B6.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC23B6.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC23B6.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC23B6.04c Cell Cycle Data
GEO SPCC23B6.04c GEO profiles
PInt SPCC23B6.04c Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN29/29H01Orfeome Localization Data
WikiGene2539120sec14 cytosolic factor family
EntrezGene2539120sec14 cytosolic factor family
UniProtKB/SwissProtQ9UU99CRAL-TRIO domain-containing protein C23B6.04c
ModBaseQ9UU99Database of comparative protein structure models
STRINGQ9UU99Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588127sec14 cytosolic factor family
RefSeq mRNANM_001023117972h- sec14 cytosolic factor family (SPCC23B6.04c), mRNA
European Nucleotide ArchiveBAA87299ENA Protein Mapping
European Nucleotide ArchiveBAA87299.1ENA Protein Mapping
European Nucleotide ArchiveCAB51563ENA Protein Mapping
European Nucleotide ArchiveCAB51563.1ENA Protein Mapping
UniParcUPI000006A46DUniProt Archive

Literature for SPCC23B6.04c

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014