skb5 (SPCC24B10.13)

Gene Standard Nameskb5 ChromosomeIII
Systematic IDSPCC24B10.13 Gene Start923069
Synonyms Gene End923491
ProductShk1 kinase binding protein 5 Gene Length423
Feature Typeprotein coding CDS Start923069
Name Description CDS End923491
Characterisation Statuspublished CDS Length423

Ensembl Gene Location
  1. ada2
  2. SPNCRNA.1161
  3. rps1702
  4. yta4
  5. mft1
  6. cgi121
  7. skb5
  8. snR94
  9. xlf1
  10. SPCTRNAARG.09
  11. SPRRNA.26
  12. SPNCRNA.475
  13. SPNCRNA.526
  14. SPCC24B10.15
  15. SPCC24B10.16c
  16. emp24
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopyskb5delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0019901protein kinase bindingIPIshk1PMID:10593886
IDAPMID:10593886
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005783endoplasmic reticulumIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1923069923491
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00018 IPR001452 Pfam Src homology-3 domain 86 132 21
SM00326 IPR001452 SMART Src homology-3 domain 83 140 21
PS50002 IPR001452 Prosite Profiles Src homology-3 domain 85 140 21
G3DSA:2.30.30.40 Gene3D 85 137 21
SSF50044 IPR001452 SuperFamily 69 138 21
PR00452 IPR001452 PRINTS Src homology-3 domain 127 139 12
PR00452 IPR001452 PRINTS Src homology-3 domain 97 112 12
PR00452 IPR001452 PRINTS Src homology-3 domain 83 93 12
PTHR26391 hmmpanther 31 140 1
PTHR26391:SF102 hmmpanther 31 140 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residue

Protein Properties

Ave. residue weight 113.26 Da
Charge -30.50
Isoelectric point 3.63
Molecular weight 15.86 kDa
Number of residues 140
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencePECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide4.6PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.6PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPCC736.07cunconventional prefoldin involved in translation initiation (predicted) Negative GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
cwf28splicing factor Cwf28 Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
pyp1tyrosine phosphatase Pyp1 Synthetic Growth DefectPMID:18931302
rpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
pmp1dual-specificity MAP kinase phosphatase Pmp1 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
pub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:22681890
SPAC17A5.09cprotein phosphatase regulatory subunit Glc9 (predicted) Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
shk1PAK-related kinase Shk1 Synthetic RescuePMID:10593886
Dosage Rescue
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
san1sir antagonist Positive GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
clr1cryptic loci regulator Clr1 Negative GeneticPMID:22681890
skb1type II protein arginine N-methyltransferase Skb1 Dosage RescuePMID:10593886
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
ubp4ubiquitin C-terminal hydrolase Ubp4 Positive GeneticPMID:22681890
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
mkh1MEK kinase (MEKK) Mkh1 Affinity Capture-LuminescencePMID:22570491
shk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:10593886
Two-hybrid
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External References
Database Identifier Description
NBRP SPCC24B10.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC24B10.13 Retrieval of eukaryotic orthologs
BioGrid SPCC24B10.13 BioGRID Interaction Datasets
Bähler Lab SPCC24B10.13 Cell Cycle Expression Profile
Bähler Lab SPCC24B10.13 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC24B10.13 Pheromone response/mating expression profiles
Bähler Lab SPCC24B10.13 Environmental stress expression profiles
Bähler Lab SPCC24B10.13 Bähler Lab Transcriptome Viewer
Cyclebase SPCC24B10.13 Cell Cycle Data
PInt SPCC24B10.13 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC24B10.13 Entrez Gene
WikiGene2539237Shk1 kinase binding protein 5
Uniprot_genenameSKB5
EntrezGene2539237Shk1 kinase binding protein 5
UniProtKB/SwissProtQ9US59Shk1 kinase-binding protein 5
ModBaseQ9US59Database of comparative protein structure models
Pfam Protein DomainsQ9US59Pfam Domain Arrangement
RefSeq PeptideNP_588016Shk1 kinase binding protein 5
RefSeq mRNANM_001023007972h- Shk1 kinase binding protein 5 (skb5), mRNA
European Nucleotide ArchiveAAF19175ENA Protein Mapping
European Nucleotide ArchiveCAB76222ENA Protein Mapping
SPD / RIKEN03/03D12Orfeome Localization Data
UniParcUPI000006A970UniProt Archive

Literature for skb5
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013