emp24 (SPCC24B10.17)


Gene Standard Nameemp24 Characterisation Statusbiological role inferred
Systematic IDSPCC24B10.17 Feature Typeprotein coding
Synonyms Name Description
ProductCOPII-coated vesicle component Emp24 (predicted) Product Size199aa, 23.14 kDa
Genomic Location Chromosome III, 930468-931984 (1517nt); CDS:930591-931386 (796nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
ER to Golgi vesicle-mediated transport74
Annotation ExtensionEvidenceWith/FromReference
intracellular protein transport332
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
ER to Golgi transport vesicle26
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane963
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationemp24Δ3837

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyemp24Δ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons930468..930684, 930751..930947, 931078..931984
Intron930685..930750, 930948..931077
5' UTR930468..930590PMID:21511999
3' UTR931387..931984PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01105 Pfam IPR009038 GOLD domain 23 194 4
TMhelix TMHMM 4 26 953
TMhelix TMHMM 167 189 953
PS50866 Prosite Profiles IPR009038 GOLD domain 31 113 4
PTHR22811 HMMPANTHER IPR015720 TMP21-related 10 199 4
PTHR22811:SF31 HMMPANTHER 10 199 1
0041713 SuperFamily IPR009038 GOLD domain 29 119 3
SignalP-noTM signalp 1 21 207

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 116.27 Da
Charge 3.50
Codon Adaptation Index 0.49
Isoelectric point 7.57
Molecular weight 23.14 kDa
Number of residues 199
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for emp24 (SPCC24B10.17)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5814during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
4951during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
15244.68during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
5093during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
4782.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.24during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC24B10.17 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withvps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withago1argonaute Negative GeneticPMID:22681890
negative genetic interaction withsty1MAP kinase Sty1 Negative GeneticPMID:22681890
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
negative genetic interaction withdcr1dicer Negative GeneticPMID:22681890
positive genetic interaction withmsh2MutS protein homolog 2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC24B10.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC24B10.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC24B10.17 BioGRID Interaction Datasets
Expression Viewer SPCC24B10.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC24B10.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC24B10.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC24B10.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC24B10.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC24B10.17 Transcriptome Viewer (Bähler Lab)
GEO SPCC24B10.17 GEO profiles
PInt SPCC24B10.17 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC24B10.17 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC24B10.17 Fission yeast phenotypic data & analysis
Cyclebase SPCC24B10.17.1 Cell Cycle Data
SPD / RIKEN10/10A11Orfeome Localization Data
UniProtKB/SwissProtQ9P7I9Endosomal protein P24B
ModBaseQ9P7I9Database of comparative protein structure models
STRINGQ9P7I9Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588020COPII-coated vesicle component Emp24 (predicted)
RefSeq mRNANM_001023011972h- COPII-coated vesicle component Emp24 (predicted) (emp24), mRNA

Literature for emp24

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016