emp24 (SPCC24B10.17)


Gene Standard Nameemp24 Characterisation Statusbiological_role_inferred
Systematic IDSPCC24B10.17 Feature Typeprotein coding
Synonyms Name Description
ProductCOPII-coated vesicle component Emp24 (predicted) Product Size199aa, 23.14 kDa
Genomic Location Chromosome III, 930468-931984 (1517nt); CDS:930591-931386 (796nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
ER to Golgi vesicle-mediated transport77
Annotation ExtensionEvidenceWith/FromReference
intracellular protein transport338
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum594
Annotation ExtensionEvidenceWith/FromReference
ER to Golgi transport vesicle25
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus355
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyemp24ΔNullPMID:204732893759
Microscopyemp24ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyemp24ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1930468930684
2930751930947
3931078931984

UTRs

Region Coordinates Reference
five_prime_UTR930468..930590PMID:21511999
three_prime_UTR931387..931984PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01105 Pfam IPR009038 GOLD 23 194 4
TMhelix TMHMM 167 189 959
TMhelix TMHMM 4 26 959
PS50866 Prosite Profiles IPR009038 GOLD 31 113 4
PTHR22811 HMMPANTHER TMP21-related 1 199 4
PTHR22811:SF11 HMMPANTHER 1 199 1
0041713 SuperFamily IPR009038 GOLD 29 119 3
SignalP-noTM signalp 1 21 212

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 116.27 Da
Charge 3.50
Isoelectric point 7.57
Molecular weight 23.14 kDa
Number of residues 199
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5814during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
4951during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
5093during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
15244.68during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
4782.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.24during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
msh2MutS protein homolog 2 Positive GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
ago1argonaute Negative GeneticPMID:22681890
dcr1dicer Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC24B10.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC24B10.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC24B10.17 BioGRID Interaction Datasets
Expression Viewer SPCC24B10.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC24B10.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC24B10.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC24B10.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC24B10.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC24B10.17 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC24B10.17 Cell Cycle Data
GEO SPCC24B10.17 GEO profiles
PInt SPCC24B10.17 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC24B10.17 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC24B10.17 Fission yeast phenotypic data & analysis
SPD / RIKEN10/10A11Orfeome Localization Data
UniProtKB/SwissProtQ9P7I9Endosomal protein P24B
ModBaseQ9P7I9Database of comparative protein structure models
STRINGQ9P7I9Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588020COPII-coated vesicle component Emp24 (predicted)
RefSeq mRNANM_001023011972h- COPII-coated vesicle component Emp24 (predicted) (emp24), mRNA
European Nucleotide ArchiveCAB76226.1ENA Protein Mapping
UniParcUPI000006C6C7UniProt Archive

Literature for emp24

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014