emp24 (SPCC24B10.17)


Gene Standard Nameemp24 Characterisation Statusbiological_role_inferred
Systematic IDSPCC24B10.17 Feature Typeprotein coding
Synonyms Name Description
ProductCOPII-coated vesicle component Emp24 (predicted) Product Size199aa, 23.14 kDa
Genomic Location Chromosome III, 930468-931984 (1517nt); CDS:930591-931386 (796nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
ER to Golgi vesicle-mediated transport75
Annotation ExtensionEvidenceWith/FromReference
intracellular protein transport343
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
ER to Golgi transport vesicle26
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationemp24ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyemp24ΔNull3093
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons930468..930684, 930751..930947, 931078..931984
Introns930685..930750, 930948..931077
mRNA930468..931984
5' UTR930468..930590PMID:21511999
CDS930591..930684, 930751..930947, 931078..931386
3' UTR931387..931984PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01105 Pfam IPR009038 GOLD 23 194 4
TMhelix TMHMM 167 189 959
TMhelix TMHMM 4 26 959
PS50866 Prosite Profiles IPR009038 GOLD 31 113 4
PTHR22811:SF31 HMMPANTHER 10 199 1
PTHR22811 HMMPANTHER IPR015720 TMP21-related 10 199 4
0041713 SuperFamily IPR009038 GOLD 29 119 3
SignalP-noTM signalp 1 21 212

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 116.27 Da
Charge 3.50
Isoelectric point 7.57
Molecular weight 23.14 kDa
Number of residues 199
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5814during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4951during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
5093during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
15244.68during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
4782.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.24during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withago1argonaute Negative GeneticPMID:22681890
negative genetic interaction withdcr1dicer Negative GeneticPMID:22681890
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
positive genetic interaction withmsh2MutS protein homolog 2 Positive GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
negative genetic interaction withsty1MAP kinase Sty1 Negative GeneticPMID:22681890
negative genetic interaction withvps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC24B10.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC24B10.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC24B10.17 BioGRID Interaction Datasets
Expression Viewer SPCC24B10.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC24B10.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC24B10.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC24B10.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC24B10.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC24B10.17 Transcriptome Viewer (Bähler Lab)
GEO SPCC24B10.17 GEO profiles
PInt SPCC24B10.17 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC24B10.17 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC24B10.17 Fission yeast phenotypic data & analysis
Cyclebase SPCC24B10.17.1 Cell Cycle Data
SPD / RIKEN10/10A11Orfeome Localization Data
UniProtKB/SwissProtQ9P7I9Endosomal protein P24B
ModBaseQ9P7I9Database of comparative protein structure models
STRINGQ9P7I9Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588020COPII-coated vesicle component Emp24 (predicted)
RefSeq mRNANM_001023011972h- COPII-coated vesicle component Emp24 (predicted) (emp24), mRNA
European Nucleotide ArchiveCAB76226.1ENA Protein Mapping
UniParcUPI000006C6C7UniProt Archive

Literature for emp24

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015