cgs2 (SPCC285.09c)

Gene Standard Namecgs2 ChromosomeIII
Systematic IDSPCC285.09c Gene Start1812646
Synonymspde1 Gene End1810337
ProductcAMP-specific phosphodiesterase Cgs2 Gene Length2310
Feature Typeprotein coding CDS Start1812631
Name Description CDS End1811032
Characterisation Statuspublished CDS Length1600

Ensembl Gene Location
  1. SPCC285.05
  2. SPNCRNA.1232
  3. wtf17
  4. wtf18
  5. ret2
  6. cgs2
  7. SPCC285.10c
  8. dsc5
  9. lsm7
  10. nup60
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000085sensitive to camptothecincompetitive growth assay evidencecgs2delta (deletion)deletionPMID:20537132
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencecgs2delta (deletion)deletionPMID:20537132
FYPO:0001096normal RNA level during nitrogen starvationWestern blot assaycgs2-2 (unknown)unknownEndogenousPMID:9710608
assayed_using fnx1
FYPO:0001491viable vegetative cellMicroscopycgs2delta (deletion)deletionPMID:20473289
FYPO:0001664increased cellular cAMP level during cellular response to glucose stimulusSubstance quantification evidencecgs2delta (deletion)deletionNot specifiedPMID:1340462
has_expressivity FYPO_EXT:0000002
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:00041153',5'-cyclic-AMP phosphodiesterase activity
heterologous_systemIGIUniProtKB:P22434PMID:8392846
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006198cAMP catabolic processIMPPMID:11461899
ISMIPR000396GO_REF:0000001
GO:0006995cellular response to nitrogen starvationIMPPMID:15448137
GO:0007194negative regulation of adenylate cyclase activityTASPMID:16143612
GO:0019933cAMP-mediated signalingIMPPMID:1318497
GO:0030818negative regulation of cAMP biosynthetic processIMPPMID:1340462
GO:0031137regulation of conjugation with cellular fusionIMPPMID:1318497
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMPPMID:15448137
GO:0071333cellular response to glucose stimulusIMPPMID:1340462
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
118126461812542
218124801812472
318124251812013
418115601810337

References

Region Start End Reference
three_prime_UTR18110311810337PMID:20118936
three_prime_UTR18110311810337PMID:18641648
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF02112 IPR000396 Pfam Cyclic-AMP phosphodiesterase, class-II 25 341 1
PS00607 IPR024225 Prosite Patterns Cyclic-AMP phosphodiesterase class-II, conserved site 114 128 1
G3DSA:3.60.15.10 Gene3D 71 279 9
SSF56281 SuperFamily 103 280 9
PIRSF000962 IPR000396 PIRSF Cyclic-AMP phosphodiesterase, class-II 1 346 1
PR00388 IPR000396 PRINTS Cyclic-AMP phosphodiesterase, class-II 249 260 1
PR00388 IPR000396 PRINTS Cyclic-AMP phosphodiesterase, class-II 110 128 1
PR00388 IPR000396 PRINTS Cyclic-AMP phosphodiesterase, class-II 140 161 1
PR00388 IPR000396 PRINTS Cyclic-AMP phosphodiesterase, class-II 267 280 1
PR00388 IPR000396 PRINTS Cyclic-AMP phosphodiesterase, class-II 294 305 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.71 Da
Charge -2.00
Isoelectric point 6.29
Molecular weight 38.65 kDa
Number of residues 346
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2111.99PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide4490.79PMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide2PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.61PMID:23101633
Pathway
DescriptionQualifierReference
links stress-activated MAPK (Sty1) pathway to cAMP-dependent protein kinase (Pka1) pathway PMID:15448137
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in bacteria
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
par2protein phosphatase regulatory subunit Par2 Positive GeneticPMID:22681890
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Positive GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
cut20anaphase-promoting complex subunit Apc4 Dosage RescuePMID:10526233
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
cdc13G2/M B-type cyclin Cdc13 Negative GeneticPMID:22681890
git3G-protein coupled receptor Git3 Synthetic RescuePMID:16143612
sty1MAP kinase Sty1 Positive GeneticPMID:22681890
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
SPAC17A5.09cprotein phosphatase regulatory subunit Glc9 (predicted) Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Positive GeneticPMID:22681890
mob1Sid2-Mob1 kinase complex regulatory subunit Mob1 Negative GeneticPMID:22681890
rec14Ski complex subunit Rec14 Negative GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Positive GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
tps1alpha,alpha-trehalose-phosphate synthase Positive GeneticPMID:22681890
SPBC17A3.06phosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
SPBC1685.04sequence orphan Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
gpa2heterotrimeric G protein alpha-2 subunit Gpa2 Phenotypic EnhancementPMID:16143612
Synthetic Rescue
Phenotypic EnhancementPMID:1340462
msa1RNA-binding protein Msa1 Phenotypic SuppressionPMID:15166138
cut4anaphase-promoting complex subunit Apc1 Dosage RescuePMID:8918880
sak1transcriptional repressor Sak1 Phenotypic SuppressionPMID:7862141
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
cut9anaphase-promoting complex subunit Cut9 Dosage RescuePMID:15507118
cut23anaphase-promoting complex subunit Apc8 Dosage RescuePMID:15507118
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
cyr1adenylate cyclase Synthetic RescuePMID:16143612
mpr1histidine-containing response regulator phosphotransferase Mpr1 Positive GeneticPMID:22681890
ubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
SPBC839.03cneddylation protein Dcn1 (predicted) Negative GeneticPMID:22681890
swd3WD repeat protein Swd3 Negative GeneticPMID:22681890
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
SPBC582.10cATP-dependent DNA helicase Rhp16b (predicted) Positive GeneticPMID:22681890
hip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Co-localizationPMID:16819157
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External References
Database Identifier Description
NBRP SPCC285.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC285.09c Retrieval of eukaryotic orthologs
BioGrid SPCC285.09c BioGRID Interaction Datasets
Bähler Lab SPCC285.09c Cell Cycle Expression Profile
Bähler Lab SPCC285.09c Meiosis/Sporulation Expression Profies
Bähler Lab SPCC285.09c Pheromone response/mating expression profiles
Bähler Lab SPCC285.09c Environmental stress expression profiles
Bähler Lab SPCC285.09c Bähler Lab Transcriptome Viewer
Cyclebase SPCC285.09c Cell Cycle Data
PInt SPCC285.09c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC285.09c Entrez Gene
SPD / RIKEN25/25F07Orfeome Localization Data
IntEnz3.1.4.17
EntrezGene2539207cAMP-specific phosphodiesterase Cgs2
Uniprot_genenameCGS2
WikiGene2539207cAMP-specific phosphodiesterase Cgs2
UniProtKB/SwissProtP365993',5'-cyclic-nucleotide phosphodiesterase
ModBaseP36599Database of comparative protein structure models
Pfam Protein DomainsP36599Pfam Domain Arrangement
RefSeq PeptideNP_588337cAMP-specific phosphodiesterase Cgs2
RefSeq mRNANM_001023328972h- cAMP-specific phosphodiesterase Cgs2 (cgs2), mRNA
European Nucleotide ArchiveAAB20315ENA Protein Mapping
European Nucleotide ArchiveCAA20848ENA Protein Mapping
SPD / RIKEN25/25F07Orfeome Localization Data

Literature for cgs2
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013