set1 (SPCC306.04c)


Gene Standard Nameset1 Characterisation Statuspublished
Systematic IDSPCC306.04c Feature Typeprotein coding
Synonymskmt2 Name Description
Producthistone lysine methyltransferase Set1 Product Size920aa, 105.04 kDa
Genomic Location Chromosome III, 416039-412293 (3747nt); CDS:415527-412765 (2763nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003723RNA bindingIEAUniProtKB-KW:KW-0694GO_REF:0000037646
GO:0042800histone methyltransferase activity (H3-K4 specific)TASPMID:121936581
GO:0018024histone-lysine N-methyltransferase activityIDAPMID:121936588
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingISSUniProtKB:P38827GO_REF:0000001160
GO:0051568histone H3-K4 methylationTASPMID:1219365815
GO:0034968histone lysine methylationIDAPMID:1219365829
GO:0018022peptidyl-lysine methylationIDAPMID:1219365813
GO:0000723telomere maintenanceIMPPMID:1258975548
NOT GO:0006342chromatin silencingIMPPMID:12193658
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0048188Set1C/COMPASS complexIDAPMID:124884478
GO:0005737cytoplasmIDAPMID:168233724205
GO:0000790nuclear chromatinNASGO_REF:0000001283
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001974increased number of cells with 1C DNA contentFlow cytometry dataset1ΔNullPECO:0000170, PECO:0000137, PECO:0000005PMID:2317367238
FYPO:0000095sensitive to bleomycinCell growth assayset1ΔNullPECO:0000137, PECO:0000005PMID:2317367248
FYPO:0000088sensitive to hydroxyureaCell growth assayset1ΔNullPECO:0000137, PECO:0000005PMID:23173672514
FYPO:0000089sensitive to methyl methanesulfonateCell growth assayset1ΔNullPECO:0000137, PECO:0000005PMID:23173672219
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidenceset1ΔNullPMID:20537132176
Cell growth assayset1ΔNullPECO:0000137, PECO:0000005PMID:23173672
FYPO:0002060viable vegetative cell populationMicroscopyset1ΔNullPMID:204732893759
Microscopyset1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Microscopynot recorded (unrecorded)PMID:12589755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002330abnormal histone H3-K4 methylationChromatin immunoprecipitation experimentset1ΔNullPECO:0000137PMID:238517198
FYPO:0003625abnormal microtubule cytoskeleton morphology during mitotic interphase186
penetrance FYPO_EXT:0000002experimental phenotypic evidenceset1ΔNullPECO:0000005, PECO:0000103, PECO:0000137DOI:10.1016/j.devcel.2014.09.005
FYPO:0000059abnormal mitotic cell cycleMicroscopyset1ΔNullPECO:0000005, PECO:0000137PMID:23697806686
FYPO:0001430abnormal mitotic cell cycle arrest with unreplicated DNAFlow cytometry dataset1ΔNullPECO:0000170, PECO:0000137, PECO:0000005PMID:2317367241
FYPO:0002368decreased histone H3-K4 trimethylationChromatin immunoprecipitation experimentset1ΔNullPECO:0000137PMID:238517192
FYPO:0003082normal genetic imprinting at mating-type locusGel electrophoresis evidenceset1ΔNullPMID:232606626
FYPO:0001492viable elongated vegetative cell221
expressivity FYPO_EXT:0000002
penetrance FYPO_EXT:0000003
experimental phenotypic evidenceset1ΔNullPECO:0000137, PECO:0000005, PECO:0000103DOI:10.1016/j.devcel.2014.09.005
expressivity FYPO_EXT:0000001
penetrance FYPO_EXT:0000001
Microscopyset1ΔNullPECO:0000137, PECO:0000005PMID:23697806
FYPO:0002197viable vegetative cell with abnormal cell shape467
penetrance FYPO_EXT:0000002experimental phenotypic evidenceset1ΔNullPECO:0000005, PECO:0000103, PECO:0000137DOI:10.1016/j.devcel.2014.09.005
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1416039412293

UTRs

Region Coordinates Reference
five_prime_UTR416039..415528PMID:21511999
three_prime_UTR412764..412293PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF11767 Pfam IPR024636 Histone lysine methyltransferase SET associated 279 343 1
PF11764 Pfam IPR024657 COMPASS complex Set1 subunit, N-SET domain 630 771 1
PF00856 Pfam IPR001214 SET domain 794 897 12
PF00076 Pfam IPR000504 RNA recognition motif domain 96 172 61
SM00508 SMART IPR003616 Post-SET domain 904 920 3
SM00360 SMART IPR000504 RNA recognition motif domain 95 175 68
SM00360 SMART IPR000504 RNA recognition motif domain 276 343 68
SM00317 SMART IPR001214 SET domain 781 904 11
PS50280 Prosite Profiles IPR001214 SET domain 781 898 13
PS51572 Prosite Profiles IPR017111 Histone H3-K4 methyltransferase Set1, fungal 6 920 1
PS50102 Prosite Profiles IPR000504 RNA recognition motif domain 94 179 72
PS50868 Prosite Profiles IPR003616 Post-SET domain 904 920 3
PTHR22884 HMMPANTHER 399 920 3
PTHR22884:SF10 HMMPANTHER IPR015722 Histone-lysine N-methyltransferase 399 920 1
2.170.270.10 Gene3D 777 919 8
3.30.70.330 Gene3D IPR012677 Nucleotide-binding, alpha-beta plait 78 179 83
3.30.70.330 Gene3D IPR012677 Nucleotide-binding, alpha-beta plait 289 355 83
SSF54928 SuperFamily 289 351 78
SSF54928 SuperFamily 78 180 78
SSF82199 SuperFamily 777 917 13
PIRSF037104 PIRSF IPR017111 Histone H3-K4 methyltransferase Set1, fungal 1 920 1
Coil ncoils Rabaptin coiled-coil domain 191 212 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000302rrm RNA recognition motifTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000302
PBO:0001327SET domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001327

Protein Properties

Ave. residue weight 114.17 Da
Charge 25.50
Isoelectric point 9.26
Molecular weight 105.04 kDa
Number of residues 920
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS534PMID:247631071670
present during mitotic M phaseexperimental evidenceS593PMID:21712547
present during mitotic M phaseexperimental evidenceS531PMID:21712547
present during mitotic M phaseexperimental evidenceS534PMID:21712547
experimental evidenceS531PMID:24763107
MOD:00047O-phospho-L-threonineexperimental evidenceT533PMID:24763107692
MOD:00696phosphorylated residueNASPMID:195477441922
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
574during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
175.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.61during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
Set1 mediated H3 K4 methylation is preferentially enriched at euchromatic loci PMID:121936581
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPCC550.03cSki complex RNA helicase Ski2 (predicted) Negative GeneticPMID:18818364
rik1silencing protein Rik1 Negative GeneticPMID:18818364
ada1adenosine deaminase Ada1 Negative GeneticPMID:22681890
SPBC16C6.05mitochondrial translation initiation factor (predicted) Negative GeneticPMID:18818364
mca1transcription factor, zf-fungal binuclear cluster type Mca1 (predicted) Negative GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC1B3.08COP9 signalosome complex subunit 12 (predicted) Negative GeneticPMID:22681890
ubp4ubiquitin C-terminal hydrolase Ubp4 Negative GeneticPMID:18818364
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:22681890
SPBC25B2.08Schizosaccharomyces pombe specific protein Positive GeneticPMID:22681890
asl1cell wall protein Asl1, predicted O-glucosyl hydrolase Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:18818364
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
tol13'(2'),5'-bisphosphate nucleotidase/inositol-1,4- bisphosphate 1-phosphatase Negative GeneticPMID:22681890
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
vht1vitamin H transporter Vht1 Positive GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
SPCC4B3.03cmitochondrial morphology protein (predicted) Negative GeneticPMID:22681890
SPCC645.12cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC14C4.01cDUF1770 family protein Negative GeneticPMID:22681890
hhf2histone H4 h4.2 Negative GeneticPMID:22681890
pof10F-box protein Pof10 Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Positive GeneticPMID:18818364
csr102sec14 cytosolic factor family phosphatidylinositol transporter (predicted) Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
apm4AP-2 adaptor complex subunit Apm4 (predicted) Negative GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
rnh201ribonuclease H2 complex subunit Rnh201 (predicted) Positive GeneticPMID:22681890
rps340S ribosomal protein S3 (predicted) Negative GeneticPMID:22681890
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
SPAC227.06Rab GTPase binding (predicted) Positive GeneticPMID:22681890
SPBC336.13cmitochondrial inner membrane peptidase complex catalytic subunit 2 (predicted) Negative GeneticPMID:22681890
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Phenotypic SuppressionPMID:12589755
cch1calcium channel Cch1 Negative GeneticPMID:22681890
nup124nucleoporin Nup124 Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
wtf16wtf element Wtf16 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC2F7.09cmitochondrial GTPase related protein (prediected) Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:18818364
pac10prefoldin subunit 3 Pac10 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
png2ING family homolog Png2 Negative GeneticPMID:18818364
sap14U2 snRNP-associated protein SF3B14 Sap14 Negative GeneticPMID:22681890
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
mug147Schizosaccharomyces specific protein Mug147 Negative GeneticPMID:22681890
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
cit1citrate synthase Cit1 Positive GeneticPMID:22681890
sap145U2 snRNP-associated protein Sap145 Negative GeneticPMID:22681890
ptf2Mst2 histone acetytransferase acytyltransferase complex subunit Negative GeneticPMID:22681890
nrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
fin1serine/threonine protein kinase, NIMA related Fin1 Synthetic Growth DefectPMID:18931302
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cbf12CBF1/Su(H)/LAG-1 family transcription factor Cbf12 Positive GeneticPMID:22681890
ptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
sec28coatomer epsilon subunit (predicted) Negative GeneticPMID:18818364
reb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pof8F-box protein Pof8 Negative GeneticPMID:22681890
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Positive GeneticPMID:22681890
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Negative GeneticPMID:18818364
grx3monothiol glutaredoxin Grx3 Negative GeneticPMID:22681890
SPAC922.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
cbp1CENP-B homolog Phenotypic EnhancementPMID:22907751
Positive GeneticPMID:18818364
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1685.04Schizosaccharomyces specific protein Positive GeneticPMID:22681890
atp15F0-ATPase epsilon subunit (predicted) Positive GeneticPMID:22681890
ptr2PTR family peptide transporter Ptr2 Positive GeneticPMID:22681890
SPAP8A3.03ZIP zinc transporter 1 (predicted) Positive GeneticPMID:22681890
SPAC222.08cglutamine aminotransferase subunit (predicted) Positive GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:18931302
SPBC725.04oxalyl-CoA decarboxylase (predicted) Positive GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Positive GeneticPMID:22681890
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
alg12dolichyl pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase Alg12 (predicted) Negative GeneticPMID:22681890
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Positive GeneticPMID:22681890
rad3ATR checkpoint kinase Rad3 Phenotypic SuppressionPMID:12589755
ptc3protein phosphatase 2c homolog 3 Negative GeneticPMID:22681890
uch1ubiquitin C-terminal hydrolase Uch1 Positive GeneticPMID:22681890
adh8alcohol dehydrogenase (predicted) Positive GeneticPMID:22681890
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
alg5dolichyl-phosphate beta-glucosyltransferase Alg5 (predicted) Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
frp1ferric-chelate reductase Frp1 Positive GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cbs2protein kinase activator (predicted) Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Positive GeneticPMID:18818364
SPBC2F12.05csterol binding ankyrin repeat protein (predicted) Negative GeneticPMID:22681890
rad9checkpoint clamp complex protein Rad9 Synthetic RescuePMID:12589755
SPAC56E4.07N-acetyltransferase (predicted) Positive GeneticPMID:22681890
rem1meiosis-specific cyclin Rem1 Negative GeneticPMID:22681890
pmk1MAP kinase Pmk1 Positive GeneticPMID:22681890
SPAC1399.04curacil phosphoribosyltransferase (predicted) Negative GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Positive GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC29A10.16ccytochrome b5 (predicted) Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
SPAC4A8.06cesterase/lipase (predicted) Positive GeneticPMID:22681890
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
SPAC9G1.10cinositol polyphosphate phosphatase (predicted) Negative GeneticPMID:18818364
gpd1glycerol-3-phosphate dehydrogenase Gpd1 Negative GeneticPMID:22681890
SPBC713.03mitochondrial D-lactate dehydrogenase, cytochrome (predicted) Positive GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
SPCC1840.09NAD dependent epimerase/dehydratase family protein Positive GeneticPMID:22681890
SPAC227.17cconserved protein Positive GeneticPMID:22681890
SPBC1347.09hexaprenyldihydroxybenzoate methyltransferase, Coq3 variant (predicted) Positive GeneticPMID:22681890
SPAPB2B4.04cvacuolar calcium transporting P-type ATPase P2 type, Pmc1 Positive GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Synthetic RescuePMID:12589755
ubp3ubiquitin C-terminal hydrolase Ubp3 Negative GeneticPMID:18818364
SPCC1827.03cacetyl-CoA ligase (predicted) Positive GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
cip2RNA-binding protein Cip2 Negative GeneticPMID:22681890
SPBC20F10.07GRAM domain protein Positive GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
SPAC22H10.02conserved fungal protein Negative GeneticPMID:22681890
SPAC1296.01cphosphoacetylglucosamine mutase (predicted) Negative GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
rav2RAVE complex subunit Rav2 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
rtf2replication termination factor Rtf2 Negative GeneticPMID:22681890
sec72Sec7 domain protein, ARF GEF Sec72 Positive GeneticPMID:22681890
mss1mitochondrial GTPase (predicted) Positive GeneticPMID:22681890
cwf5RNA-binding protein Cwf5 Negative GeneticPMID:22681890
atp11F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pof12F-box protein Pof12 Negative GeneticPMID:22681890
vrp1verprolin Positive GeneticPMID:18818364
omh1alpha-1,2-mannosyltransferase Omh1 Negative GeneticPMID:22681890
SPAC6G9.15cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
saf5splicing factor Negative GeneticPMID:22681890
SPAC1486.03cRNA-binding splicing factor (predicted) Negative GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
mst2histone acetyltransferase Mst2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
tsc2tuberin Positive GeneticPMID:22681890
prp43ATP-dependent RNA helicase Prp43 Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Positive GeneticPMID:22681890
snf30SWI/SNF complex subunit Snf30 Positive GeneticPMID:18818364
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:18818364
SPCC18.17cproteasome assembly chaperone (predicted) Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC12B10.01cHECT-type ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
slm9hira protein Slm9 Synthetic Growth DefectPMID:18931302
SPAC977.13cPositive GeneticPMID:22681890
pit1serine/threonine protein kinase, meiotic Pit1 Negative GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:18818364
rpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:22681890
lsg1Lsk1 complex gamma subunit (predicted) Negative GeneticPMID:22681890
erg28Erg28 protein (predicted) Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cdc6DNA polymerase delta catalytic subunit Cdc6 Synthetic RescuePMID:12589755
SPAC3A11.13prefoldin subunit 6 (predicted) Positive GeneticPMID:18818364
rud3Golgi matrix protein Rud3 (predicted) Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
shk2PAK-related kinase Shk2 Positive GeneticPMID:18818364
SPAC12B10.13proteasome-dependent catabolite inactivation protein, ubiquitin ligase complex subunit (predicted) Negative GeneticPMID:22681890
swd3WD repeat protein Swd3 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
erd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
ssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:22681890
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mug170arrestin family Schizosaccharomyces specific protein Mug170 Negative GeneticPMID:22681890
ppk38Ark1/Prk1 family protein kinase Ppk38 Positive GeneticPMID:22681890
alm1medial ring protein Alm1 Positive GeneticPMID:22681890
SPAC13G6.15ccalcipressin (predicted) Negative GeneticPMID:22681890
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
pfa3palmitoyltransferase Pfa3 (predicted) Negative GeneticPMID:22681890
ura5orotate phosphoribosyltransferase Ura5 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPAC31A2.12arrestin/PY protein 1 (predicted) Negative GeneticPMID:22681890
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:18818364
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:18818364
trx2mitochondrial thioredoxin Trx2 Positive GeneticPMID:22681890
dni2tetraspan protein Dni2 (predicted) Negative GeneticPMID:22681890
gos1SNARE Gos1 (predicted) Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
SPBC17D11.08WD repeat protein, DDB1 and CUL4-associated factor 7 (predicted) Positive GeneticPMID:22681890
SPBC651.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
rfp2SUMO-targeted ubiquitin-protein ligase subunit Rfp2 Positive GeneticPMID:22681890
rad2514-3-3 protein Rad25 Positive GeneticPMID:18818364
atg9autophagy associated protein Atg9 Positive GeneticPMID:22681890
rap1telomere binding protein Rap1 Negative GeneticPMID:18818364
SPBC30D10.03cIMP 5'-nucleotidase (predicted) Positive GeneticPMID:22681890
rad17RFC related checkpoint protein Rad17 Synthetic RescuePMID:12589755
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
SPBC15C4.04camino acid permease (predicted) Negative GeneticPMID:22681890
SPAC23C4.09cDNA-binding TFAR19-related protein (predicted) Negative GeneticPMID:22681890
whi2phosphatase activator Whi2 Negative GeneticPMID:18818364
SPCC1795.10cSed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
pof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
trm12tRNA methyltransferase Trm12 (predicted) Positive GeneticPMID:22681890
ppk31serine/threonine protein kinase Ppk31 (predicted) Negative GeneticPMID:18818364
mso1endocytic docking protein Mso1 Positive GeneticPMID:22681890
cha4transcription factor Cha4 (predicted) Positive GeneticPMID:22681890
fep1iron-sensing transcription factor Fep1 Negative GeneticPMID:22681890
ofd12-oxoglutarate and Fe(II) dioxygenase domain containing protein 1 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
imp1importin alpha Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
cwf15complexed with Cdc5 protein Cwf15 Negative GeneticPMID:22681890
vms1Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ER associated ubiquitin-dependent protein catabolic process Vms1 (predicted) Positive GeneticPMID:22681890
nht10Ino80 complex HMG box subunit Nhp10 (predicted) Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
rpn130219S proteasome regulatory subunit Rpn13b Positive GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
SPBCPT2R1.01cS. pombe specific DUF999 protein family 9 Negative GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
stt41-phosphatidylinositol 4-kinase Stt4 (predicted) Positive GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:18818364
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ayr11-acyldihydroxyacetone phosphate reductase (predicted) Positive GeneticPMID:22681890
puf3RNA-binding protein Puf3 (predicted) Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC1259.08conserved fungal protein, DUF2457 family Positive GeneticPMID:22681890
SPAC824.04WD repeat protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
vps13achorein homolog (predicted) Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
crb2DNA repair protein Rad9 homolog, Rhp9 Synthetic RescuePMID:12589755
msn5karyopherin (predicted) Negative GeneticPMID:18818364
SPAP27G11.11cdubious Negative GeneticPMID:22681890
get1GET complex subunit Get1 (predicted) Negative GeneticPMID:18818364
SPBC365.16conserved protein Positive GeneticPMID:22681890
trs130TRAPP complex subunit Trs130 (predicted) Negative GeneticPMID:22681890
SPBC577.11DUF3074 family protein Negative GeneticPMID:22681890
dsc5UBX domain containing protein required for Sre1 cleavage Negative GeneticPMID:22681890
knd1Cullin-associated NEDD8-dissociated protein Knd1 (predicted) Positive GeneticPMID:22681890
sap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
SPAC15A10.07Schizosaccharomyces specific protein Positive GeneticPMID:22681890
SPAC15A10.06CPA1 sodium ion/proton antiporter (predicted) Positive GeneticPMID:22681890
tip1CLIP170 family protein Tip1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:18818364
spn1septin Spn1 Negative GeneticPMID:18818364
lsd1histone demethylase SWIRM1 Synthetic RescuePMID:17434129
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
xap5xap-5-like protein Synthetic RescuePMID:24957674
ppk6serine/threonine protein kinase Ppk6 (predicted) Positive GeneticPMID:22681890
SPAC4A8.10lipase (predicted) Negative GeneticPMID:22681890
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
SPBC106.12cTHO complex subunit (predicted) Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:18818364
sum1translation initiation factor eIF3i Positive GeneticPMID:22681890
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
mto1MT organizer Mto1 Negative GeneticPMID:22681890
rsv2transcription factor Rsv2 Negative GeneticPMID:18818364
sdc1Dpy-30 domain protein Sdc1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
res2MBF transcription factor complex subunit Res2 Negative GeneticPMID:18818364
rpl210260S ribosomal protein L21 (predicted) Positive GeneticPMID:22681890
cxr1mRNA processing factor Negative GeneticPMID:22681890
rps240140S ribosomal protein S24 (predicted) Positive GeneticPMID:22681890
pof2F-box protein Pof2 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC2C4.06ctRNA (cytosine-5-)-methyltransferase (predicted) Positive GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
SPAC3H1.08cmitochondrial calcium uniporter regulator (predicted) Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
fta6Sim4 and Mal2 associated (4 and 2 associated) protein 6 Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Positive GeneticPMID:22681890
rad1checkpoint clamp complex protein Rad1 Synthetic RescuePMID:12589755
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
tma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:22681890
med6mediator complex subunit Med6 Negative GeneticPMID:18818364
git3G-protein coupled receptor Git3 Positive GeneticPMID:22681890
SPAC4G8.03cRNA-binding protein (predicted) Positive GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
gmh4alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
din1Dhp1p-interacting protein Din1 Negative GeneticPMID:18818364
prz1calcineurin responsive transcription factor Prz1 Positive GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC18H10.05WD repeat protein, human WDR44 family Negative GeneticPMID:18818364
SPBC18H10.07WW domain-binding protein 4 (predicted) Negative GeneticPMID:22681890
pom152nucleoporin Pom152 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
SPAC30C2.04cofactor for methionyl-and glutamyl-tRNA synthetases (predicted) Positive GeneticPMID:22681890
SPAC30C2.07Schizosaccharomyces specific protein Positive GeneticPMID:22681890
mal3EB1 family Mal3 Negative GeneticPMID:18818364
SPBC1773.16ctranscription factor, zf-fungal binuclear cluster type(predicted) Positive GeneticPMID:18818364
lem2LEM domain protein Heh1/Lem2 Negative GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
gmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
tma20RNA-binding protein Tma20 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
SPCC584.11cSvf1 family protein Svf1 Positive GeneticPMID:22681890
sck2serine/threonine protein kinase Sck2 Positive GeneticPMID:24463365
Positive GeneticPMID:22681890
pof14F-box protein Pof14 Negative GeneticPMID:22681890
dap1cytochrome P450 regulator Dap1 Negative GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
vps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:22681890
SPBC1683.04glycosyl hydrolase family 3 (predicted) Positive GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
pmr1P-type ATPase, calcium transporting Pmr1 Negative GeneticPMID:22681890
hst2Sir2 family histone deacetylase Hst2 Positive GeneticPMID:22681890
acp2F-actin capping protein beta subunit Acp2 Positive GeneticPMID:22681890
SPCC188.10cPositive GeneticPMID:22681890
tel1ATM checkpoint kinase Phenotypic SuppressionPMID:12589755
rpl70260S ribosomal protein L7 Positive GeneticPMID:22681890
SPAC9G1.07Schizosaccharomyces specific protein Negative GeneticPMID:22681890
gas5cell wall protein Gas5, 1,3-beta-glucanosyltransferase (predicted) Negative GeneticPMID:22681890
rps10140S ribosomal protein S3a Positive GeneticPMID:22681890
SPCC126.08clectin family glycoprotein receptor (predicted) Negative GeneticPMID:22681890
pdr1ABC transporter Pdr1 Positive GeneticPMID:22681890
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ymr1phosphatidylinositol-3-phosphatase, myotubularin family (predicted) Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
uds1septation protein Uds1 Positive GeneticPMID:22681890
nop12RNA-binding protein Nop12 (predicted) Positive GeneticPMID:22681890
spt5transcription elongation factor Spt5 Phenotypic EnhancementPMID:22876190
cyp7cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 (predicted) Negative GeneticPMID:18818364
set3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
saf4splicing associated factor Saf4 Positive GeneticPMID:22681890
mik1mitotic inhibitor kinase Mik1 Negative GeneticPMID:22681890
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
are2acyl-coA-sterol acyltransferase Are2 (predicted) Negative GeneticPMID:22681890
alg10dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase Alg10 (predicted) Negative GeneticPMID:22681890
slx9ribosome biogenesis protein Slx9 (predicted) Negative GeneticPMID:22681890
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Positive GeneticPMID:22681890
SPAC144.05ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
iqw1WD repeat protein, Iqw1 Positive GeneticPMID:22681890
SPBP4H10.14cSchizosaccharomyces specific protein Positive GeneticPMID:22681890
atp12F1-ATPase chaperone Atp12 (predicted) Positive GeneticPMID:22681890
SPAC694.02DEAD/DEAH box helicase Negative GeneticPMID:22681890
hob3BAR adaptor protein Hob3 Negative GeneticPMID:22681890
SPAC2H10.02c26S proteasome regulatory particle assembly protein (predicted) Positive GeneticPMID:22681890
fcf2rRNA processing protein Fcf2 (predicted) Negative GeneticPMID:22681890
cho2phosphatidylethanolamine N-methyltransferase Cho2 Positive GeneticPMID:22681890
SPCC417.11cglutamate-1-semialdehyde 2,1-aminomutase (predicted) Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
swd2Set1C complex subunit Swd2.1 Affinity Capture-MSPMID:14617822
set1histone lysine methyltransferase Set1 Affinity Capture-MSPMID:14617822
shg1Set1C complex subunit Shg1 Affinity Capture-MSPMID:14617822
swd3WD repeat protein Swd3 Affinity Capture-MSPMID:14617822
sdc1Dpy-30 domain protein Sdc1 Affinity Capture-MSPMID:14617822
hht3histone H3 h3.3 Biochemical ActivityPMID:12589755
ash2Ash2-trithorax family protein Affinity Capture-MSPMID:14617822
swd1Set1C complex subunit Swd1 Affinity Capture-MSPMID:14617822
spf1Set1C PHD Finger protein Spf1 Affinity Capture-MSPMID:14617822
External References
Database Identifier Description
NBRP SPCC306.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC306.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC306.04c BioGRID Interaction Datasets
Expression Viewer SPCC306.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC306.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC306.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC306.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC306.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC306.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC306.04c Cell Cycle Data
GEO SPCC306.04c GEO profiles
PInt SPCC306.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC306.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC306.04c Fission yeast phenotypic data & analysis
SPD / RIKEN39/39B01Orfeome Localization Data
UniProtKB/SwissProtQ9Y7R4Histone-lysine N-methyltransferase, H3 lysine-4 specific
ModBaseQ9Y7R4Database of comparative protein structure models
STRINGQ9Y7R4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587812histone lysine methyltransferase Set1
RefSeq mRNANM_001022805972h- histone lysine methyltransferase Set1 (set1), mRNA
European Nucleotide ArchiveCAB41652.1ENA Protein Mapping
UniParcUPI000006BCFAUniProt Archive

Literature for set1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014