SPCC306.06c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC306.06c Feature Typeprotein coding
Synonyms Name Description
ProductER membrane protein, BIG1 family (predicted) Product Size311aa, 34.64 kDa
Genomic Location Chromosome III, 419553-418005 (1549nt); CDS:419473-418476 (998nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
(1->6)-beta-D-glucan biosynthetic process6
Annotation ExtensionEvidenceWith/FromReference
fungal-type cell wall biogenesis70
Annotation ExtensionEvidenceWith/FromReference
fungal-type cell wall organization56
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum594
Annotation ExtensionEvidenceWith/FromReference
fungal-type vacuole membrane91
Annotation ExtensionEvidenceWith/FromReference
integral component of endoplasmic reticulum membrane67
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPCC306.06cΔNullPECO:0000005, PECO:0000137PMID:236978061338
MicroscopySPCC306.06cΔNullPMID:20473289
FYPO:0001098sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000002Cell growth assaySPCC306.06cΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0000097sensitive to caffeine105
expressivity FYPO_EXT:0000001Cell growth assaySPCC306.06cΔNullPECO:0000137PMID:19672306
FYPO:0000085sensitive to camptothecin211
expressivity FYPO_EXT:0000002Cell growth assaySPCC306.06cΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0000087sensitive to hydrogen peroxide131
expressivity FYPO_EXT:0000001Cell growth assaySPCC306.06cΔNullPECO:0000137PMID:19672306
FYPO:0000088sensitive to hydroxyurea514
expressivity FYPO_EXT:0000003Cell growth assaySPCC306.06cΔNullPECO:0000137, PECO:0000005PMID:19264558

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000054abnormal microtubule cytoskeleton organizationMicroscopynot recorded (overexpression)PMID:15797925266
FYPO:0002151inviable spore465
penetrance FYPO_EXT:0000001MicroscopySPCC306.06cΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1419553419382
2419319418005

UTRs

Region Coordinates Reference
five_prime_UTR419553..419474PMID:21511999
three_prime_UTR418475..418005PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05827 Pfam IPR024722 BIG/ATPase V1 complex, subunit S1 21 295 1
TMhelix TMHMM 271 293 959
SignalP-noTM signalp 1 17 212

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 111.37 Da
Charge -10.00
Isoelectric point 4.65
Molecular weight 34.64 kDa
Number of residues 311
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5109.15during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi only623
conserved in fungi4600
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC306.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC306.06c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC306.06c BioGRID Interaction Datasets
Expression Viewer SPCC306.06c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC306.06c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC306.06c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC306.06c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC306.06c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC306.06c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC306.06c Cell Cycle Data
GEO SPCC306.06c GEO profiles
PInt SPCC306.06c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC306.06c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC306.06c Fission yeast phenotypic data & analysis
SPD / RIKEN14/14F02Orfeome Localization Data
UniProtKB/SwissProtQ9Y7R6Protein big1
ModBaseQ9Y7R6Database of comparative protein structure models
STRINGQ9Y7R6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587814ER membrane protein, BIG1 family (predicted)
RefSeq mRNANM_001022807972h- ER membrane protein, BIG1 family (predicted) (SPCC306.06c), mRNA
European Nucleotide ArchiveCAB41654.1ENA Protein Mapping
UniParcUPI0000069B7FUniProt Archive

Literature for SPCC306.06c

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014