mug73 (SPCC31H12.02c)


Gene Standard Namemug73 Characterisation Statusbiological role inferred
Systematic IDSPCC31H12.02c Feature Typeprotein coding
Synonyms Name DescriptionMeiotically Upregulated Gene
Productplasma membrane transmembrane transport regulator (predicted) Product Size306aa, 34.66 kDa
Genomic Location Chromosome III, 624527-623516 (1012nt); CDS:624527-623607 (921nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
regulation of ion transmembrane transport6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of membrane966
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationmug73Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologymug73Δ3102
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons624527..623516
mRNA624527..623516
CDS624527..623607
3' UTR623606..623516PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01036 Pfam IPR001425 Archaeal/bacterial/fungal rhodopsins 29 246 1
SM01021 SMART IPR001425 Archaeal/bacterial/fungal rhodopsins 24 256 1
TMhelix TMHMM 188 210 950
TMhelix TMHMM 60 79 950
TMhelix TMHMM 125 147 950
TMhelix TMHMM 99 121 950
TMhelix TMHMM 154 173 950
TMhelix TMHMM 28 50 950
TMhelix TMHMM 223 245 950
PTHR28286 HMMPANTHER 17 305 1
PTHR28286:SF1 HMMPANTHER 17 305 1
1.20.1070.10 Gene3D Archaeal/bacterial/fungal rhodopsins 22 254 1
SSF81321 SuperFamily 21 253 1
PR00251 PRINTS IPR001425 Archaeal/bacterial/fungal rhodopsins 152 173 1
PR00251 PRINTS IPR001425 Archaeal/bacterial/fungal rhodopsins 56 76 1
PR00251 PRINTS IPR001425 Archaeal/bacterial/fungal rhodopsins 193 211 1
PR00251 PRINTS IPR001425 Archaeal/bacterial/fungal rhodopsins 100 121 1

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001809signal_anchor10
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 113.28 Da
Charge 2.50
Codon Adaptation Index 0.39
Isoelectric point 7.33
Molecular weight 34.66 kDa
Number of residues 306
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-threonineT302 1085
Annotation ExtensionEvidenceResidueReference
IDA T302 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

View graphical display of gene expression data for mug73 (SPCC31H12.02c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.47during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi only616
conserved in fungi4607
conserved in eukaryotes4517
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC31H12.02c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withrpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:22681890
negative genetic interaction withtma22translation machinery associated protein ortholog Tma22 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withnup132nucleoporin Nup132 Negative GeneticPMID:22681890
positive genetic interaction withtps1alpha,alpha-trehalose-phosphate synthase [UDP-forming] Positive GeneticPMID:22681890
positive genetic interaction withSPAC1952.10cconserved fungal protein Positive GeneticPMID:22681890
positive genetic interaction withSPBC1348.10cphospholipase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC6F6.11cpyridoxine-pyridoxal-pyridoxamine kinase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withhip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
positive genetic interaction withmak3histidine kinase Mak3 Positive GeneticPMID:22681890
positive genetic interaction withSPAC27F1.06cFKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpho1acid phosphatase Pho1 Positive GeneticPMID:22681890
positive genetic interaction withppk9serine/threonine protein kinase Ppk9 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtea4tip elongation aberrant protein Tea4 Positive GeneticPMID:22681890
positive genetic interaction withSPAC4C5.01pseudouridine-5'-phosphatase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpap1transcription factor Pap1/Caf3 Positive GeneticPMID:22681890
positive genetic interaction withSPBC1271.03cNLI interacting factor family phosphatase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC17A3.06phosphoprotein phosphatase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
positive genetic interaction withnpp1nucleotide pyrophosphatase Npp1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withusp102U1 snRNP-associated protein Usp102 Positive GeneticPMID:22681890
positive genetic interaction withlsb5cortical component Lsb5 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC1778.03cNADH pyrophosphatase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withshk2PAK-related kinase Shk2 Positive GeneticPMID:22681890
positive genetic interaction withhht2histone H3 h3.2 Positive GeneticPMID:22681890
positive genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Positive GeneticPMID:22681890
positive genetic interaction withpub3HECT-type ubiquitin-protein ligase E3 Pub3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrnh201ribonuclease H2 complex subunit Rnh201 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsfp1transcription factor Sfp1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withres1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
positive genetic interaction withace2transcription factor Ace2 Positive GeneticPMID:22681890
positive genetic interaction withmkh1MEK kinase (MEKK) Mkh1 Positive GeneticPMID:22681890
positive genetic interaction withgmh2alpha-1,2-galactosyltransferase Gmh2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withswd3WD repeat protein Swd3 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC31H12.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC31H12.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC31H12.02c BioGRID Interaction Datasets
Expression Viewer SPCC31H12.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC31H12.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC31H12.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC31H12.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC31H12.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC31H12.02c Transcriptome Viewer (Bähler Lab)
GEO SPCC31H12.02c GEO profiles
PInt SPCC31H12.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC31H12.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC31H12.02c Fission yeast phenotypic data & analysis
Cyclebase SPCC31H12.02c.1 Cell Cycle Data
SPD / RIKEN12/12H01Orfeome Localization Data
UniProtKB/SwissProtO74870Meiotically up-regulated gene 73 protein
ModBaseO74870Database of comparative protein structure models
STRINGO74870Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587895membrane transporter (predicted)
RefSeq mRNANM_001022887972h- membrane transporter (predicted) (mug73), mRNA
European Nucleotide ArchiveCAA21219.1ENA Protein Mapping
UniParcUPI00000695BBUniProt Archive

Literature for mug73

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016