sds21 (SPCC31H12.05c)


Gene Standard Namesds21 Characterisation Statuspublished
Systematic IDSPCC31H12.05c Feature Typeprotein coding
Synonyms Name Description
Productserine/threonine protein phosphatase Sds21 Product Size322aa, 36.83 kDa
Genomic Location Chromosome III, 631529-628570 (2960nt); CDS:630443-628996 (1448nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO:0004721phosphoprotein phosphatase activityIEAUniProtKB-KW:KW-0904GO_REF:000003737
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000226microtubule cytoskeleton organizationIGIcdc13PMID:3428262110
GO:0006364rRNA processingISOSGD:S000000935GO_REF:0000024182
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005730nucleolusIDAPMID:16823372345
GO:0005634nucleusIDAPMID:168233722730
GO:0000164protein phosphatase type 1 complexISOSGD:S000000935, MGI:104872, UniProtKB:P62139, MGI:104871PMID:25442984
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001701sensitive to bortezomibCell growth assaysds21ΔNullPECO:0000005, PECO:0000137PMID:21760946256
expressivity FYPO_EXT:0000003
FYPO:0002060viable vegetative cell populationMicroscopysds21ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopysds21ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001757decreased protein phosphatase activityEnzyme assay datasds21::LEU2 (disruption)Not specifiedPMID:21700293
expressivity FYPO_EXT:0000002
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopysds21ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1631529630838
2630719630401
3630342630218
4629847629146
5629094628570

UTRs

Region Start End Reference
five_prime_UTR631529630838PMID:18488015
intron630837630720PMID:18488015
five_prime_UTR630719630444PMID:18488015
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Phosphoesterase domain 55 246 20
SM00156 SMART IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 26 296 10
PS00125 Prosite Patterns IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 117 122 10
PTHR11668 HMMPANTHER 1 306 11
PTHR11668:SF74 HMMPANTHER 1 306 1
G3DSA:3.60.21.10 Gene3D 6 306 22
SSF56300 SuperFamily 21 299 22
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 54 81 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 179 206 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 150 176 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 83 110 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 116 140 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 236 256 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 258 274 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.38 Da
Charge -2.50
Isoelectric point 5.75
Molecular weight 36.83 kDa
Number of residues 322
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3180.38during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
15693.75during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.73during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
dis2serine/threonine protein phosphatase PP1 Synthetic LethalityPMID:2170029
Synthetic LethalityPMID:2544298
sds22protein phosphatase regulatory subunit Sds22 Dosage RescuePMID:1846086
cdc25M phase inducer phosphatase Cdc25 Dosage RescuePMID:1944266
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Dosage RescuePMID:8978689
wee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1944266
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC31H12.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC31H12.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC31H12.05c BioGRID Interaction Datasets
Expression Viewer SPCC31H12.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC31H12.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC31H12.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC31H12.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC31H12.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC31H12.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC31H12.05c Cell Cycle Data
GEO SPCC31H12.05c GEO profiles
PInt SPCC31H12.05c Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN23/23C11Orfeome Localization Data
IntEnz3.1.3.16Integrated relational Enzyme database
Rhea3.1.3.16Annotated reactions database
WikiGene2539179serine/threonine protein phosphatase Sds21
EntrezGene2539179serine/threonine protein phosphatase Sds21
UniProtKB/SwissProtP23880Serine/threonine-protein phosphatase PP1-2
ModBaseP23880Database of comparative protein structure models
StringP23880Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587898serine/threonine protein phosphatase Sds21
RefSeq mRNANM_001022890972h- serine/threonine protein phosphatase Sds21 (sds21), mRNA
European Nucleotide ArchiveAAA35341ENA Protein Mapping
European Nucleotide ArchiveCAA21222ENA Protein Mapping
UniParcUPI0000131FB0UniProt Archive

Literature for sds21

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014