sds21 (SPCC31H12.05c)


Gene Standard Namesds21 Characterisation Statuspublished
Systematic IDSPCC31H12.05c Feature Typeprotein coding
Synonyms Name Description
Productserine/threonine protein phosphatase PP1 subfamily, Sds21 Product Size322aa, 36.83 kDa
Genomic Location Chromosome III, 631529-628570 (2960nt); CDS:630443-628996 (1448nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037748
GO:0004721phosphoprotein phosphatase activityIEAUniProtKB-KW:KW-0904GO_REF:000003738
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0007049cell cycleIEAUniProtKB-KW:KW-0131GO_REF:0000037631
GO:2000784positive regulation of establishment of cell polarity regulating cell shapeEXPPMID:245544325
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005730nucleolusIDAPMID:16823372355
GO:0005634nucleusIDAPMID:168233722740
GO:0000164protein phosphatase type 1 complexISOSGD:S000000935PMID:25442984
IPItea4PMID:24554432
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001701sensitive to bortezomib256
expressivity FYPO_EXT:0000003Cell growth assaysds21ΔNullPECO:0000005, PECO:0000137PMID:21760946
FYPO:0002060viable vegetative cell populationMicroscopysds21ΔNullPECO:0000005, PECO:0000137PMID:236978063730
Microscopysds21ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001757decreased protein phosphatase activity4
expressivity FYPO_EXT:0000002Enzyme assay datasds21::LEU2 (disruption)Not specifiedPMID:2170029
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopysds21ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in sds22 protein phosphatase regulatory subunit Sds22 PMID:1846086
FYPO affected by mutation in tea4 tip elongation aberrant protein Tea4 PMID:24554432
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1631529630838
2630719630401
3630342630218
4629847629146
5629094628570

UTRs

Region Coordinates Reference
five_prime_UTR631529..630838,630719..630444PMID:18488015
intron630837..630720PMID:18488015
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Calcineurin-like phosphoesterase domain, apaH type 55 246 20
SM00156 SMART IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 26 296 10
PS00125 Prosite Patterns IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 117 122 10
PTHR11668 HMMPANTHER 2 313 11
PTHR11668:SF204 HMMPANTHER 2 313 1
3.60.21.10 Gene3D IPR029052 Metallo-dependent phosphatase-like 6 306 23
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 21 299 22
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 258 274 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 179 206 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 236 256 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 150 176 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 116 140 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 54 81 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 83 110 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.38 Da
Charge -2.50
Isoelectric point 5.75
Molecular weight 36.83 kDa
Number of residues 322
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS302PMID:217125471669
present during mitotic M phase
present during mitotic M phaseS304PMID:21712547
present during mitotic M phaseS305PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
15693.75during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
3180.38during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.6during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.73during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
dis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Synthetic LethalityPMID:2170029
Synthetic LethalityPMID:2544298
sds22protein phosphatase regulatory subunit Sds22 Dosage RescuePMID:1846086
cdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:1944266
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Dosage RescuePMID:8978689
wee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1944266
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
tea4tip elongation aberrant protein Tea4 Co-purificationPMID:24554432
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
rif1telomere length regulator protein Rif1 Affinity Capture-WesternPMID:24656819
External References
Database Identifier Description
NBRP SPCC31H12.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC31H12.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC31H12.05c BioGRID Interaction Datasets
Expression Viewer SPCC31H12.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC31H12.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC31H12.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC31H12.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC31H12.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC31H12.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC31H12.05c Cell Cycle Data
GEO SPCC31H12.05c GEO profiles
PInt SPCC31H12.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC31H12.05c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN23/23C11Orfeome Localization Data
IntEnz3.1.3.16Integrated relational Enzyme database
Rhea3.1.3.16Annotated reactions database
WikiGene2539179serine/threonine protein phosphatase Sds21
EntrezGene2539179serine/threonine protein phosphatase Sds21
UniProtKB/SwissProtP23880Serine/threonine-protein phosphatase PP1-2
ModBaseP23880Database of comparative protein structure models
STRINGP23880Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587898serine/threonine protein phosphatase Sds21
RefSeq mRNANM_001022890972h- serine/threonine protein phosphatase Sds21 (sds21), mRNA
European Nucleotide ArchiveAAA35341ENA Protein Mapping
European Nucleotide ArchiveAAA35341.1ENA Protein Mapping
European Nucleotide ArchiveCAA21222ENA Protein Mapping
European Nucleotide ArchiveCAA21222.1ENA Protein Mapping
UniParcUPI0000131FB0UniProt Archive

Literature for sds21

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014