alg11 (SPCC330.08)

Gene Standard Namealg11 Characterisation Statuspublished
Systematic IDSPCC330.08 Feature Typeprotein coding
Synonymsgmd3 Name Description
Productalpha-1,2-mannosyltransferase Alg11 Product Size471aa, 53.28 kDa
Genomic Location Chromosome III, 124222-127134 (2913nt); CDS:124563-125978 (1416nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
oligosaccharide biosynthetic process7
Annotation ExtensionEvidenceWith/FromReference
protein glycosylation70
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum599
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane204
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane966
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
decreased vegetative cell population growthgmd3-729
inviable vegetative cell populationalg11Δ1455
normal growth on sorbitolgmd3-21
sensitive to hygromycin Bgmd3-16
sensitive to vanadategmd3-5

Cell Phenotype

Term NameGenotypesCount
decreased galactose level in glycoprotein glycangmd3-6
decreased mannose level in glycoprotein glycangmd3-1
inviable after spore germination with normal, unseptated germ tube morphologyalg11Δ237
inviable sporealg11Δ476
inviable vegetative cellalg11Δ1358
normal galactose:mannose ratio in glycoprotein glycangmd3-1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR124222..124562PMID:21511999
3' UTR125979..127134PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF15924 Pfam IPR031814 ALG11 mannosyltransferase, N-terminal 55 248 1
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 273 440 5
PTHR12526:SF315 HMMPANTHER 21 466 1
PTHR12526 HMMPANTHER 21 466 8 Gene3D Glycosyl transferase, family 35 266 441 15
SSF53756 SuperFamily 59 465 15
SignalP-noTM signalp 1 18 207

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.12 Da
Charge 19.00
Codon Adaptation Index 0.43
Isoelectric point 9.44
Molecular weight 53.28 kDa
Number of residues 471

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS80 2289
Annotation ExtensionEvidenceResidueReference
IDA S80 PMID:25720772
O-phosphorylated residueS145,Y157 2457
Annotation ExtensionEvidenceResidueReference
IDA S145,Y157 PMID:25720772
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for alg11 (SPCC330.08)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
18209during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
16889during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
17715during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
18354during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
6432.08during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
16797during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.8during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
functionally complemented by S. cerevisiae ALG11 PMID:11015724
Disease Association
congenital disorders of glycosylation30
metabolic disorders143
fatty acid metabolism disorder4
Taxonomic Conservation
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC330.08 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
External References
Database Identifier Description
NBRP SPCC330.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC330.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC330.08 BioGRID Interaction Datasets
Expression Viewer SPCC330.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC330.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC330.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC330.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC330.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC330.08 Transcriptome Viewer (Bähler Lab)
GEO SPCC330.08 GEO profiles
PInt SPCC330.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC330.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC330.08 Fission yeast phenotypic data & analysis
Cyclebase SPCC330.08.1 Cell Cycle Data
IntEnz2.4.1.-Integrated relational Enzyme database
Rhea2.4.1.-Annotated reactions database
SPD / RIKEN44/44E07Orfeome Localization Data
UniProtKB/SwissProtO74878GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
ModBaseO74878Database of comparative protein structure models
STRINGO74878Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587708alpha-1,2-mannosyltransferase Alg11
RefSeq mRNANM_001022703972h- alpha-1,2-mannosyltransferase Alg11 (alg11), mRNA
European Nucleotide ArchiveCAA20913.1ENA Protein Mapping
MetaCycPWY-3801Sucrose degradation II (sucrose synthase)
KEGG00500+ and sucrose metabolism
KEGG00510+ biosynthesis
KEGG00513+ types of N-glycan biosynthesis
UniParcUPI000006A4EBUniProt Archive

Literature for alg11

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016