alg11 (SPCC330.08)


Gene Standard Namealg11 Characterisation Statuspublished
Systematic IDSPCC330.08 Feature Typeprotein coding
Synonymsgmd3 Name Description
Productalpha-1,2-mannosyltransferase Alg11 Product Size471aa, 53.28 kDa
Genomic Location Chromosome III, 124222-127134 (2913nt); CDS:124563-125978 (1416nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004377GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activityIEA EC:2.4.1.131GO_REF:00000031
GO:0000026alpha-1,2-mannosyltransferase activity9
heterologous_systemIGISGD:S000004993PMID:11015724
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0097502mannosylationIGISGD:S000004993PMID:1101572424
GO:0006490oligosaccharide-lipid intermediate biosynthetic process5
heterologous_systemIMPPMID:11015724
GO:0006486protein glycosylationIEA UniPathway:UPA00378GO_REF:000004163
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0005789endoplasmic reticulum membrane206
heterologous_systemIGISGD:S000004993PMID:11015724
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371017
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyalg11ΔNullPMID:204732891315
Microscopyalg11ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000311inviable after spore germination with normal, unseptated germ tube morphologyMicroscopyalg11ΔNullPECO:0000005, PECO:0000137PMID:23697806237
FYPO:0002151inviable spore457
penetrance FYPO_EXT:0000001Microscopyalg11ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1124222127134

UTRs

Region Coordinates Reference
five_prime_UTR124222..124562PMID:21511999
three_prime_UTR125979..127134PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 272 440 8
PTHR12526:SF23 HMMPANTHER 9 470 1
PTHR12526 HMMPANTHER 9 470 9
3.40.50.2000 Gene3D 266 441 15
SSF53756 SuperFamily 59 465 15
SignalP-noTM signalp 1 18 212

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.12 Da
Charge 19.00
Isoelectric point 9.44
Molecular weight 53.28 kDa
Number of residues 471
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
6432.08during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
18354during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
18209during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
17715during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
16797during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
16889during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.8during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by S. cerevisiae ALG11 PMID:11015724
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
External References
Database Identifier Description
NBRP SPCC330.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC330.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC330.08 BioGRID Interaction Datasets
Expression Viewer SPCC330.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC330.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC330.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC330.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC330.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC330.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC330.08 Cell Cycle Data
GEO SPCC330.08 GEO profiles
PInt SPCC330.08 Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz2.4.1.-Integrated relational Enzyme database
Rhea2.4.1.-Annotated reactions database
WikiGene2539054alpha-1,2-mannosyltransferase Alg11
EntrezGene2539054alpha-1,2-mannosyltransferase Alg11
SPD / RIKEN44/44E07Orfeome Localization Data
UniProtKB/SwissProtO74878GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
ModBaseO74878Database of comparative protein structure models
STRINGO74878Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587708alpha-1,2-mannosyltransferase Alg11
RefSeq mRNANM_001022703972h- alpha-1,2-mannosyltransferase Alg11 (alg11), mRNA
European Nucleotide ArchiveCAA20913ENA Protein Mapping
European Nucleotide ArchiveCAA20913.1ENA Protein Mapping
UniParcUPI000006A4EBUniProt Archive

Literature for alg11

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014