ctp1 (SPCC338.08)

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Gene Standard Namectp1 Characterisation Statuspublished
Systematic IDSPCC338.08 Feature Typeprotein coding
Synonymsmug38, nip1, slr9 Name DescriptionMeiotically Upregulated Gene,
Synthetic Lethal with Rad2 mutant,
Nbs1-Interacting Protein 1
ProductCtIP-related endonuclease Product Size294aa, 33.10 kDa
Genomic Location Chromosome III, 1360260-1358737 (1524nt); CDS:1359819-1358891 (929nt)

Ensembl Gene Location
  1. cog4
  2. SPNCRNA.490
  3. pbi2
  4. pbi2-antisense-1
  5. rrg1
  6. cox5
  7. ctp1-antisense-1
  8. ctp1
  9. SPNCRNA.491
  10. SPCTRNATHR.10
  11. naa15
  12. SPCC338.06c
  13. mms2
GO Molecular Function
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Term NameCount
double-stranded DNA binding162
Annotation ExtensionEvidenceWith/FromReference
single-stranded DNA endodeoxyribonuclease activity8
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

DNA repair DNA recombination regulation of mitotic cell cycle phase transition meiotic nuclear division


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Term NameCount
DNA double-strand break processing6
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair involved in meiotic recombination5
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair via homologous recombination38
Annotation ExtensionEvidenceWith/FromReference
meiotic DNA double-strand break clipping1
Annotation ExtensionEvidenceWith/FromReference
meiotic DNA double-strand break processing2
Annotation ExtensionEvidenceWith/FromReference
meiotic DNA double-strand break resectioning1
Annotation ExtensionEvidenceWith/FromReference
mitotic DNA replication checkpoint22
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
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Term NameCount
site of double-strand break54
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

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Term NameGenotypesCount
decreased cell population growth on glucose carbon sourcectp1Δ393
decreased spore germination frequencyctp1-11 (Q120H, F232L)70
ctp1-17 (H274L)
decreased vegetative cell population growthctp1-SxxS (C226S, C229S)745
ctp1Δ
ctp1-GxxG (C226G, C229G)
inviable spore populationctp1-9 (C229F)21
ctp1-8 (H160Y, R214*)
ctp1-5 (frameshift at W288 truncating at position 292)
ctp1-1 (C226Y)
ctp1-6 (D250->stop)
ctp1Δ
ctp1-25 (G187->stop)
ctp1-10 (R201->stop)
ctp1-30 (I110N with frameshift at T197 truncating at position 208)
normal growth during cellular response to UV81
affecting ctp1ctp1-SQ/TQ (S35A, T175A)
affecting ctp1ctp1-SQ/TQ/SP1/SP2 (S35A, T175A, S114A, S165A)
affecting ctp1ctp1-SP1/SP2 (S114A, S165A)
normal growth on bleomycin9
affecting ctp1ctp1-SQ/TQ (S35A, T175A)
affecting ctp1ctp1-SP1/SP2 (S114A, S165A)
affecting ctp1ctp1-SQ/TQ/SP1/SP2 (S35A, T175A, S114A, S165A)
normal growth on methyl methanesulfonate60
affecting ctp1ctp1-SP1/SP2 (S114A, S165A)
affecting ctp1ctp1-SQ/TQ/SP1/SP2 (S35A, T175A, S114A, S165A)
affecting ctp1ctp1-SQ/TQ (S35A, T175A)
sensitive to 4-nitroquinoline N-oxidectp1Δ159
sensitive to amphotericin Bctp1Δ69
sensitive to bleomycinctp1Δ93
sensitive to camptothecinctp1-GxxG (C226G, C229G)259
ctp1-30 (I110N with frameshift at T197 truncating at position 208)
ctp1-8 (H160Y, R214*)
ctp1-17 (H274L)
ctp1-5 (frameshift at W288 truncating at position 292)
ctp1-SxxS (C226S, C229S)
ctp1-10 (R201->stop)
ctp1Δ
ctp1-6 (D250->stop)
ctp1-25 (G187->stop)
ctp1-1 (C226Y)
ctp1-9 (C229F)
sensitive to cisplatinctp1Δ111
sensitive to clotrimazolectp1Δ108
sensitive to cobaltctp1Δ115
sensitive to doxorubicinctp1Δ97
sensitive to hydroxyureactp1-25 (G187->stop)595
ctp1-6 (D250->stop)
ctp1-SxxS (C226S, C229S)
ctp1Δ
ctp1-GxxG (C226G, C229G)
sensitive to ionizing radiation during vegetative growthctp1-25 (G187->stop)76
ctp1-SxxS (C226S, C229S)
ctp1Δ
ctp1-GxxG (C226G, C229G)
ctp1-6 (D250->stop)
sensitive to methyl methanesulfonatectp1-6 (D250->stop)333
ctp1-5 (frameshift at W288 truncating at position 292)
ctp1-30 (I110N with frameshift at T197 truncating at position 208)
ctp1-10 (R201->stop)
ctp1Δ
ctp1-8 (H160Y, R214*)
ctp1-9 (C229F)
ctp1-1 (C226Y)
ctp1-25 (G187->stop)
sensitive to terbinafinectp1Δ103
sensitive to thiabendazolectp1Δ334
sensitive to UV during vegetative growthctp1-25 (G187->stop)161
ctp1Δ
ctp1-6 (D250->stop)
slow vegetative cell population growthctp1Δ369
viable vegetative cell populationctp1Δ3862

Cell Phenotype

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Term NameGenotypesCount
abnormal microtubule cytoskeleton morphology during mitotic interphasectp1Δ187
abnormal mitotic cell cyclectp1Δ903
abnormal mitotic DNA damage checkpointctp1Δ36
abnormal sporulation resulting in formation of ascus containing non-uniform sporesctp1Δ11
abolished meiotic DNA double-strand break clippingctp1Δ1
ctp1-1 (C226Y)
ctp1-17 (H274L)
ctp1-6 (D250->stop)
decreased double-strand break repair via homologous recombinationctp1-25 (G187->stop)13
ctp1Δ
ctp1-6 (D250->stop)
decreased intergenic meiotic recombinationctp1-25 (G187->stop)34
ctp1-9 (C229F)
ctp1-5 (frameshift at W288 truncating at position 292)
ctp1-30 (I110N with frameshift at T197 truncating at position 208)
ctp1-6 (D250->stop)
ctp1Δ
ctp1-8 (H160Y, R214*)
decreased intragenic meiotic recombinationctp1-17 (H274L)37
ctp1-1 (C226Y)
ctp1-9 (C229F)
decreased meiotic DNA double-strand break resectioningctp1Δ1
decreased protein localization to double-strand break site8
affects localization of ssb1ctp1Δ
decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation2
affecting chk1ctp1Δ
increased duration of meiotic recombination double-strand break repairctp1Δ2
increased duration of protein localization to double-strand break site1
affects localization of mre11ctp1Δ
increased number of double-strand break sites during meiotic cell cyclectp1Δ2
increased protein localization to chromatin at rDNA replication fork barrier2
affects localization of pku70ctp1Δ
increased protein phosphorylation during mitotic G2 phase3
affecting chk1ctp1Δ
normal double-strand break repair via nonhomologous end joiningctp1Δ11
normal meiotic DNA double-strand break resectioningctp1-1 (C226Y)1
ctp1-6 (D250->stop)
ctp1-10 (R201->stop)
ctp1-25 (G187->stop)
ctp1-17 (H274L)
normal mitotic DNA damage checkpoint during cellular response to ionizing radiationctp1Δ4
normal protein localization to double-strand break site12
affecting mre11ctp1Δ
normal protein phosphorylation during cellular response to bleomycin13
affecting ctp1ctp1-SQ/TQ/SP1/SP2 (S35A, T175A, S114A, S165A)
affecting ctp1ctp1-SQ/TQ (S35A, T175A)
affecting ctp1ctp1-SP1/SP2 (S114A, S165A)
normal protein phosphorylation during cellular response to ionizing radiation2
affecting chk1ctp1Δ
spores sensitive to ionizing radiationctp1Δ7
viable elongated vegetative cellctp1Δ329
viable vegetative cell with abnormal cell shapectp1Δ709

FYPO Multi-allele Phenotypes

Population Phenotype

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Term NameGenotypes
decreased spore germination frequencyctp1Δ, rec12Δ
decreased vegetative cell population growthctp1Δ, exo1Δ
exo1Δ, ctp1Δ, pku80Δ
inviable vegetative cell populationctp1Δ, cdc17-K42 (E298K)
ctp1-6 (D250->stop), cdc17-K42 (E298K)
ctp1Δ, nrm1Δ
ctp1-6 (D250->stop), rad2Δ
ctp1-25 (G187->stop), cdc17-K42 (E298K)
ctp1Δ, rad2Δ
ctp1-25 (G187->stop), rad2Δ
normal growth during cellular response to ionizing radiationctp1Δ, pku80Δ
ctp1-6 (D250->stop), pku80Δ
ctp1-25 (G187->stop), pku80Δ
normal growth during cellular response to UVctp1+, nbs1-s10 (G308A)
normal growth on bleomycinctp1+, nbs1-s10 (G308A)
normal growth on camptothecinctp1Δ, pku80Δ
ctp1-6 (D250->stop), pku80Δ
ctp1-25 (G187->stop), pku80Δ
normal growth on hydroxyureactp1+, nbs1-s10 (G308A)
normal growth on methyl methanesulfonatectp1-25 (G187->stop), pku80Δ
ctp1+, nbs1-s10 (G308A)
ctp1-6 (D250->stop), pku80Δ
normal vegetative cell population growthctp1Δ, pku80Δ
sensitive to bleomycinctp1Δ, nbs1Δ
ctp1+, nbs1Δ
sensitive to camptothecinexo1Δ, chk1Δ, ctp1-6 (D250->stop)
nbs1Δ, ctp1Δ
exo1Δ, chk1Δ, ctp1-25 (G187->stop)
ctp1Δ, pku80Δ
exo1Δ, ctp1-25 (G187->stop)
ctp1-25 (G187->stop), exo1Δ, pku80Δ
exo1Δ, ctp1-6 (D250->stop)
exo1Δ, ctp1Δ, pku80Δ
ctp1-6 (D250->stop), exo1Δ, pku80Δ
exo1Δ, ctp1Δ
ctp1Δ, chk1Δ, exo1Δ
ctp1Δ, exo1Δ
sensitive to hydroxyureactp1Δ, exo1Δ
exo1Δ, ctp1Δ, pku80Δ
ctp1Δ, chk1Δ, exo1Δ
exo1Δ, chk1Δ, ctp1-6 (D250->stop)
ctp1Δ, pku80Δ
exo1Δ, chk1Δ, ctp1-25 (G187->stop)
exo1Δ, ctp1-6 (D250->stop)
ctp1-25 (G187->stop), exo1Δ, pku80Δ
ctp1+, nbs1Δ
ctp1-6 (D250->stop), exo1Δ, pku80Δ
exo1Δ, ctp1-25 (G187->stop)
sensitive to ionizing radiation during vegetative growthexo1Δ, ctp1-6 (D250->stop)
exo1Δ, ctp1-25 (G187->stop)
ctp1-25 (G187->stop), pku80Δ
ctp1Δ, exo1Δ
exo1Δ, ctp1Δ
exo1Δ, chk1Δ, ctp1-6 (D250->stop)
exo1Δ, chk1Δ, ctp1-25 (G187->stop)
ctp1Δ, pku80Δ
nbs1Δ, ctp1Δ
ctp1Δ, rad51Δ
exo1Δ, ctp1Δ, pku80Δ
ctp1Δ, chk1Δ, exo1Δ
ctp1-25 (G187->stop), exo1Δ, pku80Δ
ctp1-6 (D250->stop), pku80Δ
ctp1-6 (D250->stop), exo1Δ, pku80Δ
sensitive to methyl methanesulfonateexo1Δ, ctp1Δ, pku80Δ
ctp1-25 (G187->stop), exo1Δ, pku80Δ
exo1Δ, ctp1-6 (D250->stop)
ctp1Δ, nbs1Δ
exo1Δ, chk1Δ, ctp1-6 (D250->stop)
exo1Δ, chk1Δ, ctp1-25 (G187->stop)
ctp1Δ, exo1Δ
exo1Δ, ctp1-25 (G187->stop)
ctp1Δ, chk1Δ, exo1Δ
ctp1Δ, pku80Δ
ctp1+, nbs1Δ
ctp1-6 (D250->stop), exo1Δ, pku80Δ
sensitive to UV during vegetative growthexo1Δ, chk1Δ, ctp1-6 (D250->stop)
exo1Δ, ctp1Δ, pku80Δ
ctp1Δ, nbs1Δ
ctp1-6 (D250->stop), exo1Δ, pku80Δ
ctp1-25 (G187->stop), exo1Δ, pku80Δ
ctp1-6 (D250->stop), pku80Δ
exo1Δ, ctp1-6 (D250->stop)
ctp1Δ, exo1Δ
exo1Δ, chk1Δ, ctp1-25 (G187->stop)
ctp1-25 (G187->stop), pku80Δ
ctp1Δ, pku80Δ
exo1Δ, ctp1-25 (G187->stop)
ctp1+, nbs1Δ
ctp1Δ, chk1Δ, exo1Δ

Cell Phenotype

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Term NameGenotypes
abolished meiotic DNA double-strand break formationctp1Δ, rec12Δ
circularized chromosome during mitotic G2 phasectp1Δ, xlf1.AA (T180A, S192A), taz1Δ
decreased double-strand break repair via homologous recombinationchk1Δ, ctp1-25 (G187->stop)
chk1Δ, ctp1-6 (D250->stop)
increased double-strand break repair via nonhomologous end joiningctp1Δ, xlf1.AA (T180A, S192A)
increased duration of meiotic recombination double-strand break repairctp1Δ, mre11Δ
normal telomere lengthctp1Δ, rad3Δ
Target Of
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OntologyRelationshipGeneProduct
FYPO affected by mutation in mre11 Mre11 nuclease
FYPO affected by mutation in nrm1 MBF complex corepressor Nrm1
FYPO affected by mutation in rad3 ATR checkpoint kinase Rad3
FYPO affected by mutation in tel1 ATM checkpoint kinase
FYPO localization affected by mutation in mre11 Mre11 nuclease
GO regulated by cdc10 MBF transcription factor complex subunit Cdc10
GO regulated by nrm1 MBF complex corepressor Nrm1
GO regulated by res2 MBF transcription factor complex subunit Res2
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1360260..1359127, 1359082..1358737
Intron1359126..1359083
mRNA1360260..1358737
5' UTR1360260..1359820PMID:21511999
CDS1359819..1359127, 1359082..1358891
3' UTR1358890..1358737SPC01163
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR15107 HMMPANTHER IPR033316 DNA endonuclease RBBP8-like 54 294 1
Coil ncoils Predicted coiled-coil protein (DUF2205) 16 43 1049

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.59 Da
Charge -6.50
Codon Adaptation Index 0.39
Isoelectric point 5.17
Molecular weight 33.10 kDa
Number of residues 294
Modifications

Protein Modifications

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Term NameResidueCount
phosphorylated residue 2515
added during cellular response to bleomycin
Annotation ExtensionEvidenceResidueReference
added during cellular response to bleomycin IDA PMID:18378696
IDA PMID:19547744
O-phosphorylated residueS151,S155, S154,S155 2461
Annotation ExtensionEvidenceResidueReference
IDA S151,S155 PMID:25720772
IDA S154,S155 PMID:25720772
Sequence
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Gene Expression
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Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelabsent during GO:0000080Western blot evidencePMID:17936710
present during GO:0000084Western blot evidencePMID:17936710
present during GO:0090549Western blot evidencePMID:17936710
increased in presence of bleomycin Western blot evidencePMID:18378696
present during GO:0000085Western blot evidencePMID:17936710
RNA levelincreased during GO:0000084quantitative PCRPMID:17936710
increased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

View graphical display of gene expression data for ctp1 (SPCC338.08)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:18378696435
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs
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Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC338.08 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withctp1CtIP-related endonuclease Two-hybridPMID:17936710
affinity capturesnbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:20421724
(peptide) binds to proteinnbs1Mre11 complex subunit Nbs1 Protein-peptidePMID:19804756
affinity captured bynbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:19804755
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC338.08 into the Query Builder
View these interactions in esyN

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Gene Product Evidence Reference
synthetic lethal withrad2FEN-1 endonuclease Rad2 Synthetic LethalityPMID:27325741
synthetic lethal withcdc17ATP-dependent DNA replication ligase Cdc17 Synthetic LethalityPMID:27325741
synthetic lethal withnrm1MBF complex corepressor Nrm1 Synthetic LethalityPMID:25533348
phenotype enhanced bychk1Chk1 protein kinase Phenotypic EnhancementPMID:27325741
phenotype enhanced bynbs1Mre11 complex subunit Nbs1 Phenotypic EnhancementPMID:21098122
phenotype enhanced bycrb2DNA repair protein Rad9 homolog Crb2 Phenotypic EnhancementPMID:21098122
phenotype enhanced bytel1ATM checkpoint kinase Phenotypic EnhancementPMID:21098122
phenotype enhanced byhus1checkpoint clamp complex protein Hus1 Phenotypic EnhancementPMID:21098122
phenotype enhanced bypku80Ku domain protein Pku80 Phenotypic EnhancementPMID:21931565
rescued by overexpression ofrec12meiotic recombination endonuclease Rec12 Dosage RescuePMID:17936710
rescued bypku80Ku domain protein Pku80 Phenotypic SuppressionPMID:17936710
enhances phenotype ofxlf1XRCC4-like nonhomologous end joining factor, Cernunnon Xlf1/Nej1 Phenotypic EnhancementPMID:25533340
synthetically rescued bypku80Ku domain protein Pku80 Synthetic RescuePMID:27325741
synthetically rescued bypku70Ku domain protein Pku70 Synthetic RescuePMID:21931565
synthetically rescued byrad3ATR checkpoint kinase Rad3 Synthetic RescuePMID:21098122
overexpression rescuesnbs1Mre11 complex subunit Nbs1 Dosage RescuePMID:18378696
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
negative genetic interaction withsap18histone deacetylase complex subunit Sap18 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein Cph2 Negative GeneticPMID:22681890
negative genetic interaction withsty1MAP kinase Sty1 Negative GeneticPMID:22681890
negative genetic interaction withnrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
negative genetic interaction withspt2non-specific DNA binding protein Spt2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcsn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:22681890
negative genetic interaction withres2MBF transcription factor complex subunit Res2 Negative GeneticPMID:22681890
negative genetic interaction withfzr3meiotic fizzy-related APC coactivator Fzr3 Negative GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction witharp8Ino80 complex actin-like protein Arp8 Negative GeneticPMID:22681890
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC126.01cconserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withpus1tRNA pseudouridine synthase Lsp1 Negative GeneticPMID:22681890
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
negative genetic interaction withrad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:22681890
negative genetic interaction withgcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withclr1SHREC complex subunit Clr1 Negative GeneticPMID:22681890
negative genetic interaction withset5histone lysine methyltransferase Set5 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withduo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
negative genetic interaction withdam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
negative genetic interaction withdad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
negative genetic interaction withcwf26complexed with Cdc5 protein Cwf26 Negative GeneticPMID:22681890
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
negative genetic interaction withexo1exonuclease I Exo1 Negative GeneticPMID:22681890
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
negative genetic interaction withcsn2COP9/signalosome complex subunit Csn2 Negative GeneticPMID:22681890
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
rescuestrt1telomerase reverse transcriptase 1 protein Trt1 Phenotypic SuppressionPMID:23335786
rescuesrad3ATR checkpoint kinase Rad3 Phenotypic SuppressionPMID:21098122
rescuestaz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:23335786
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Positive GeneticPMID:22681890
positive genetic interaction withatb2tubulin alpha 2 Positive GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
synthetic growth defect withdcd1deoxycytidylate deaminase (predicted) Synthetic Growth DefectPMID:22927644
synthetic growth defect withhta2histone H2A beta Synthetic Growth DefectPMID:21098122
synthetic growth defect withhus1checkpoint clamp complex protein Hus1 Synthetic Growth DefectPMID:21098122
synthetic growth defect withcrb2DNA repair protein Rad9 homolog Crb2 Synthetic Growth DefectPMID:21098122
synthetic growth defect withnbs1Mre11 complex subunit Nbs1 Synthetic Growth DefectPMID:21098122
synthetically rescuesrad3ATR checkpoint kinase Rad3 Synthetic RescuePMID:21098122
External References
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Database Identifier Description
NBRP SPCC338.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC338.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC338.08 BioGRID Interaction Datasets
Expression Viewer SPCC338.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC338.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC338.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC338.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC338.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC338.08 Transcriptome Viewer (Bähler Lab)
GEO SPCC338.08 GEO profiles
PInt SPCC338.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC338.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC338.08 Fission yeast phenotypic data & analysis
Cyclebase SPCC338.08.1 Cell Cycle Data
SPD / RIKEN11/11D10Orfeome Localization Data
UniProtKB/SwissProtO74986DNA endonuclease ctp1
ModBaseO74986Database of comparative protein structure models
STRINGO74986Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588159CtIP-related endonuclease
RefSeq mRNANM_001023148972h- CtIP-related endonuclease (ctp1), mRNA
European Nucleotide ArchiveAB363065ENA EMBL mapping
European Nucleotide ArchiveEU168806ENA EMBL mapping
ePDB3HUFThe European PDB
PDB3HUFPDB
PDBsum3HUFPDBsum
ePDB4X01The European PDB
PDB4X01PDB
PDBsum4X01PDBsum
European Nucleotide ArchiveCAA19339.2ENA Protein Mapping
UniParcUPI00015FED0CUniProt Archive

Literature for ctp1
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Release Version: PomBase:30_62 - 30 Jan 2017