gyp3 (SPCC4G3.09c)


Gene Standard Namegyp3 Characterisation Statusbiological_role_inferred
Systematic IDSPCC4G3.09c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase activating protein Gyp3 (predicted) Product Size635aa, 72.79 kDa
Genomic Location Chromosome III, 455068-457759 (2692nt); CDS:455303-457210 (1908nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005097Rab GTPase activator activityIEAIPR000195GO_REF:000000213
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0007015actin filament organizationISOSGD:S000005237GO_REF:000002454
GO:0006887exocytosisISOSGD:S000005237GO_REF:000002436
GO:0032313regulation of Rab GTPase activityIEAIPR000195GO_REF:000000220
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmISOSGD:S000005237GO_REF:00000244205
GO:0005829cytosolIDAPMID:168233722315
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopygyp3ΔNullPMID:204732893759
Microscopygyp3ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopygyp3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1455068457759

UTRs

Region Coordinates Reference
three_prime_UTR457211..457759PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00566 Pfam IPR000195 Rab-GTPase-TBC domain 304 539 13
SM00164 SMART IPR000195 Rab-GTPase-TBC domain 297 543 13
PS50086 Prosite Profiles IPR000195 Rab-GTPase-TBC domain 300 520 13
PTHR22957 HMMPANTHER 40 617 12
PTHR22957:SF55 HMMPANTHER 40 617 2
2qq8A02 Gene3D 292 429 12
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 492 570 13
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 286 466 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.63 Da
Charge 2.00
Isoelectric point 6.68
Molecular weight 72.79 kDa
Number of residues 635
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS24PMID:217125471670
present during mitotic M phase
present during mitotic M phaseexperimental evidenceS27PMID:21712547
experimental evidenceS190PMID:24763107
experimental evidenceS24PMID:24763107
experimental evidenceS27PMID:24763107
present during mitotic M phaseexperimental evidenceS191PMID:21712547
MOD:00047O-phospho-L-threonineexperimental evidenceT193PMID:21712547692
present during mitotic M phase
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
988during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
1228during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
1074during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.86during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC4G3.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC4G3.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC4G3.09c BioGRID Interaction Datasets
Expression Viewer SPCC4G3.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC4G3.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC4G3.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC4G3.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC4G3.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC4G3.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC4G3.09c Cell Cycle Data
GEO SPCC4G3.09c GEO profiles
PInt SPCC4G3.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC4G3.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC4G3.09c Fission yeast phenotypic data & analysis
SPD / RIKEN26/26F05Orfeome Localization Data
UniProtKB/SwissProtP87234GTPase-activating protein gyp3
ModBaseP87234Database of comparative protein structure models
STRINGP87234Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587829GTPase activating protein Gyp3 (predicted)
RefSeq mRNANM_001022822972h- GTPase activating protein Gyp3 (predicted) (gyp3), mRNA
European Nucleotide ArchiveCAB09776.1ENA Protein Mapping
UniParcUPI000006B716UniProt Archive

Literature for gyp3

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014