gyp3 (SPCC4G3.09c)


Gene Standard Namegyp3 Characterisation Statusbiological role inferred
Systematic IDSPCC4G3.09c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase activating protein Gyp3 (predicted) Product Size635aa, 72.79 kDa
Genomic Location Chromosome III, 455068-457759 (2692nt); CDS:455303-457210 (1908nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTPase activator activity43
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
actin filament organization53
Annotation ExtensionEvidenceWith/FromReference
exocytosis38
Annotation ExtensionEvidenceWith/FromReference
regulation of GTPase activity42
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4212
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane962
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
increased viability upon nitrogen starvationgyp3Δ54
viable vegetative cell populationgyp3Δ3844

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologygyp3Δ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons455068..457759
mRNA455068..457759
5' UTR455068..455302AU009261
CDS455303..457210
3' UTR457211..457759PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00566 Pfam IPR000195 Rab-GTPase-TBC domain 304 539 13
SM00164 SMART IPR000195 Rab-GTPase-TBC domain 297 543 13
PS50086 Prosite Profiles IPR000195 Rab-GTPase-TBC domain 300 520 13
PTHR22957:SF148 HMMPANTHER 32 62 1
PTHR22957:SF148 HMMPANTHER 379 626 1
PTHR22957 HMMPANTHER 32 62 11
PTHR22957 HMMPANTHER 379 626 11
PTHR22957 HMMPANTHER 220 360 11
PTHR22957:SF148 HMMPANTHER 220 360 1
2qq8A02 Gene3D 292 429 12
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 286 466 13
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 492 570 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.63 Da
Charge 2.00
Codon Adaptation Index 0.43
Isoelectric point 6.68
Molecular weight 72.79 kDa
Number of residues 635
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1677
present during mitotic M phaseS27
present during mitotic M phaseS191
present during mitotic M phaseS24
S24, S27, S190
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S27 PMID:21712547
present during mitotic M phase experimental evidence S191 PMID:21712547
present during mitotic M phase experimental evidence S24 PMID:21712547
experimental evidence S27 PMID:24763107
experimental evidence S24 PMID:24763107
experimental evidence S190 PMID:24763107
O-phospho-L-threonine 701
present during mitotic M phaseT193
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T193 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for gyp3 (SPCC4G3.09c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
988during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1228during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1074during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.86during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC4G3.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC4G3.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC4G3.09c BioGRID Interaction Datasets
Expression Viewer SPCC4G3.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC4G3.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC4G3.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC4G3.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC4G3.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC4G3.09c Transcriptome Viewer (Bähler Lab)
GEO SPCC4G3.09c GEO profiles
PInt SPCC4G3.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC4G3.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC4G3.09c Fission yeast phenotypic data & analysis
Cyclebase SPCC4G3.09c.1 Cell Cycle Data
SPD / RIKEN26/26F05Orfeome Localization Data
UniProtKB/SwissProtP87234GTPase-activating protein gyp3
ModBaseP87234Database of comparative protein structure models
STRINGP87234Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587829GTPase activating protein Gyp3 (predicted)
RefSeq mRNANM_001022822972h- GTPase activating protein Gyp3 (predicted) (gyp3), mRNA
European Nucleotide ArchiveCAB09776.1ENA Protein Mapping
UniParcUPI000006B716UniProt Archive

Literature for gyp3

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016