gyp3 (SPCC4G3.09c)

Gene Standard Namegyp3 Characterisation Statusbiological_role_inferred
Systematic IDSPCC4G3.09c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase activating protein Gyp3 (predicted) Product Size635aa, 72.79 kDa
Genomic Location Chromosome III, 455068-457759 (2692nt); CDS:455303-457210 (1908nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTPase activator activity42
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
actin filament organization54
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
regulation of GTPase activity76
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
increased viability upon nitrogen starvationgyp3ΔNull54
viable vegetative cell populationgyp3ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologygyp3ΔNull3092
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR455068..455302AU009261
3' UTR457211..457759PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00566 Pfam IPR000195 Rab-GTPase-TBC domain 304 539 13
SM00164 SMART IPR000195 Rab-GTPase-TBC domain 297 543 13
PS50086 Prosite Profiles IPR000195 Rab-GTPase-TBC domain 300 520 13
PTHR22957:SF244 HMMPANTHER 5 594 1
PTHR22957 HMMPANTHER 5 594 11
2qq8A02 Gene3D 292 429 12
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 492 570 13
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 286 466 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.63 Da
Charge 2.00
Isoelectric point 6.68
Molecular weight 72.79 kDa
Number of residues 635

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS191
present during mitotic M phaseS27
S24, S27, S190
present during mitotic M phaseS24
Annotation ExtensionEvidenceResidueReference
experimental evidence S24 PMID:24763107
present during mitotic M phase experimental evidence S24 PMID:21712547
experimental evidence S27 PMID:24763107
present during mitotic M phase experimental evidence S27 PMID:21712547
experimental evidence S190 PMID:24763107
present during mitotic M phase experimental evidence S191 PMID:21712547
O-phospho-L-threonine 698
present during mitotic M phaseT193
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T193 PMID:21712547
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
988during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
1228during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
1074during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.4during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.86during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPCC4G3.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC4G3.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC4G3.09c BioGRID Interaction Datasets
Expression Viewer SPCC4G3.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC4G3.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC4G3.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC4G3.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC4G3.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC4G3.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC4G3.09c Cell Cycle Data
GEO SPCC4G3.09c GEO profiles
PInt SPCC4G3.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC4G3.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC4G3.09c Fission yeast phenotypic data & analysis
SPD / RIKEN26/26F05Orfeome Localization Data
UniProtKB/SwissProtP87234GTPase-activating protein gyp3
ModBaseP87234Database of comparative protein structure models
STRINGP87234Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587829GTPase activating protein Gyp3 (predicted)
RefSeq mRNANM_001022822972h- GTPase activating protein Gyp3 (predicted) (gyp3), mRNA
European Nucleotide ArchiveCAB09776.1ENA Protein Mapping
UniParcUPI000006B716UniProt Archive

Literature for gyp3

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015