alp16 (SPCC4G3.19)

Gene Standard Namealp16 ChromosomeIII
Systematic IDSPCC4G3.19 Gene Start435465
Synonyms Gene End432264
Productgamma tubulin complex subunit Alp16 Gene Length3202
Feature Typeprotein coding CDS Start434674
Name Description CDS End432395
Characterisation Statuspublished CDS Length2280

Ensembl Gene Location
  1. wtf8
  2. SPCC306.11
  3. alp16
  4. SPNCRNA.1138
  5. rix1
  6. SPCC4G3.17
  7. SPCC4G3.16
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000233long cytoplasmic microtubulesalp16delta (deletion)deletionPMID:12134075
FYPO:0000269sensitive to microtubule depolymerizing drugsalp16delta (deletion)deletionPMID:12134075
FYPO:0002060viable vegetative cell populationMicroscopyalp16delta (deletion)deletionPMID:20473289
GO Biological Process

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0000226microtubule cytoskeleton organization
requiredIMPPMID:12134075
GO:0051415interphase microtubule nucleation by interphase microtubule organizing center
same_pathwayIGImod21PMID:17021256
GO Cellular Component

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0000923equatorial microtubule organizing centerIDAPMID:12134075
GO:0000930gamma-tubulin complexIDAPMID:12134075
GO:0005816spindle pole bodyICGO:0000930PMID:12134075
GO:0005874microtubuleIEAUniProtKB:KW-0493GO_REF:0000037
GO:0044732mitotic spindle pole bodyIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1435465432264

References

Region Start End Reference
three_prime_UTR432394432264PMID:21511999
three_prime_UTR432394432264PMID:21511999
five_prime_UTR435465434675PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF04130 IPR007259 Pfam Spc97/Spc98 192 665 4

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.94 Da
Charge -8.50
Isoelectric point 5.20
Molecular weight 87.24 kDa
Number of residues 759
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.38PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.1PMID:23101633
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
SPAC3H8.02sec14 cytosolic factor family phosphatidylinositol transporter (predicted) Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
sre2membrane-tethered transcription factor (predicted) Negative GeneticPMID:21504829
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
tpp1trehalose-6-phosphate phosphatase Tpp1 Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:22681890
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hmt2sulfide-quinone oxidoreductase Negative GeneticPMID:22681890
git3G-protein coupled receptor Git3 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
exg3glucan 1,3-beta-glucosidase Exg3 Negative GeneticPMID:22681890
alp6gamma tubulin complex Spc98/GCP3 subunit Alp6 Synthetic LethalityPMID:12134075
Dosage Rescue
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
atp15F0-ATPase epsilon subunit (predicted) Negative GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:22681890
SPAC1610.02cmitochondrial ribosomal protein subunit L1 (predicted) Positive GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
lsg1Lsk1 complex gamma subunit (predicted) Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
snr13-hydroxyisobutyryl-CoA hydrolase snr1 Positive GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
nrc1bromodomain protein (predicted) Negative GeneticPMID:18818364
get1GET complex subunit Get1 (predicted) Negative GeneticPMID:18818364
alp4gamma tubulin complex Spc97/GCP2 subunit Alp4 Synthetic LethalityPMID:12134075
Dosage Rescue
arp6actin-like protein Arp6 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ntp1alpha,alpha-trehalase Ntp1 Negative GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
mad2spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
SPAC3A11.13prefoldin subunit 6 (predicted) Negative GeneticPMID:18818364
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
ctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
alp6gamma tubulin complex Spc98/GCP3 subunit Alp6 Affinity Capture-MSPMID:15004232
mod21gamma tubulin complex subunit Mod21 Affinity Capture-WesternPMID:17021256
gtb1gamma-tubulin Gtb1 Affinity Capture-WesternPMID:12134075
mto1MT organizer Mto1 Co-localizationPMID:15004232
alp4gamma tubulin complex Spc97/GCP2 subunit Alp4 Affinity Capture-MSPMID:15004232
Co-localization
Affinity Capture-WesternPMID:21444751
Affinity Capture-WesternPMID:17021256
gfh1gamma tubulin complex subunit Gfh1 Affinity Capture-WesternPMID:17021256
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External References
Database Identifier Description
NBRP SPCC4G3.19 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC4G3.19 Retrieval of eukaryotic orthologs
BioGrid SPCC4G3.19 BioGRID Interaction Datasets
Bähler Lab SPCC4G3.19 Cell Cycle Expression Profile
Bähler Lab SPCC4G3.19 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC4G3.19 Pheromone response/mating expression profiles
Bähler Lab SPCC4G3.19 Environmental stress expression profiles
Bähler Lab SPCC4G3.19 Bähler Lab Transcriptome Viewer
Cyclebase SPCC4G3.19 Cell Cycle Data
PInt SPCC4G3.19 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC4G3.19 Entrez Gene
SPD / RIKEN28/28B12Orfeome Localization Data
WikiGene2539309gamma tubulin complex subunit Alp16
Uniprot_genenameALP16
EntrezGene2539309gamma tubulin complex subunit Alp16
UniProtKB/SwissProtP87244Spindle pole body component alp16
ModBaseP87244Database of comparative protein structure models
Pfam Protein DomainsP87244Pfam Domain Arrangement
RefSeq PeptideNP_587819gamma tubulin complex subunit Alp16
RefSeq mRNANM_001022812972h- gamma tubulin complex subunit Alp16 (alp16), mRNA
European Nucleotide ArchiveBAB79248ENA Protein Mapping
European Nucleotide ArchiveCAB09763ENA Protein Mapping
UniParcUPI0000125798UniProt Archive

Literature for alp16
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013