ght8 (SPCC548.06c)


Gene Standard Nameght8 Characterisation Statuspublished
Systematic IDSPCC548.06c Feature Typeprotein coding
Synonyms Name Description
Producthexose transmembrane transporter Ght8 (predicted) Product Size547aa, 60.18 kDa
Genomic Location Chromosome III, 230546-226336 (4211nt); CDS:228400-226757 (1644nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
hexose transmembrane transporter activity6
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
hexose transmembrane transport8
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of plasma membrane49
Annotation ExtensionEvidenceWith/FromReference
plasma membrane255
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
normal cell population growth during glucose starvationght8Δ8
normal growth on glucose carbon sourceght8Δ282
viable vegetative cell populationght8Δ3840

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyght8Δ3100

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased cell population growth on glucose carbon sourceght8Δ, ght5Δ, ght2Δ, ght1Δ
ght1Δ, ght8Δ, ght5Δ
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons230546..226336
mRNA230546..226336
5' UTR230546..228401PMID:21511999
CDS228400..226757
3' UTR226756..226336SPC05276
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 Major facilitator, sugar transporter-like 11 467 16
TMhelix TMHMM 7 29 953
TMhelix TMHMM 403 425 953
TMhelix TMHMM 429 451 953
TMhelix TMHMM 180 199 953
TMhelix TMHMM 89 111 953
TMhelix TMHMM 304 326 953
TMhelix TMHMM 145 167 953
TMhelix TMHMM 368 390 953
TMhelix TMHMM 118 135 953
TMhelix TMHMM 331 353 953
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 9 456 55
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 318 335 15
PTHR23500:SF131 HMMPANTHER 5 523 8
PTHR23500 HMMPANTHER 5 523 10
1.20.1250.20 Gene3D Major facilitator superfamily domain 263 457 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 48 204 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 8 464 76
SignalP-noTM signalp 1 21 207
PR00171 PRINTS IPR003663 Sugar/inositol transporter 114 133 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 276 286 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 369 390 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 17 27 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 392 404 10
TIGR00879 TIGRFAM IPR003663 Sugar/inositol transporter 6 463 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.01 Da
Charge -2.50
Codon Adaptation Index 0.70
Isoelectric point 5.94
Molecular weight 60.18 kDa
Number of residues 547
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during mitotic M phaseS537
S537
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S537 PMID:21712547
experimental evidence S537 PMID:24763107
phosphorylated residue 1931
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
ubiquitinylated lysineK494 512
Annotation ExtensionEvidenceResidueReference
IDA PMID:26412298
mass spectrometry evidence K494 PMID:26412298
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelpresent during GO:0072690Western blot evidencePMID:25411338
decreased during GO:0042149Western blot evidencePMID:25411338
RNA leveldecreased during GO:0042149quantitative PCRPMID:25411338

Quantitative Gene Expression

View graphical display of gene expression data for ght8 (SPCC548.06c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
11694during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
11514during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
11563during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
12459during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
10868during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
27740.37during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
6575.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
24during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
5.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Genome Organisation
DescriptionQualifierReferenceCount
tandem duplication30
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4606
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC548.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC548.06c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC548.06c BioGRID Interaction Datasets
Expression Viewer SPCC548.06c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC548.06c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC548.06c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC548.06c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC548.06c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC548.06c Transcriptome Viewer (Bähler Lab)
GEO SPCC548.06c GEO profiles
PInt SPCC548.06c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC548.06c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC548.06c Fission yeast phenotypic data & analysis
Cyclebase SPCC548.06c.1 Cell Cycle Data
SPD / RIKEN34/34E10Orfeome Localization Data
UniProtKB/SwissProtQ9P3U7Probable high-affinity hexose transporter ght8, mitochondrial
ModBaseQ9P3U7Database of comparative protein structure models
STRINGQ9P3U7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587746hexose transporter Ght8 (predicted)
RefSeq mRNANM_001022740972h- hexose transporter Ght8 (predicted) (ght8), mRNA

Literature for ght8

Search: Europe PMC or PubMed

Release Version: PomBase:30_59 - 12 Apr 2016