ght1 (SPCC548.07c)


Gene Standard Nameght1 Characterisation Statuspublished
Systematic IDSPCC548.07c Feature Typeprotein coding
Synonyms Name Description
Producthexose transporter Ght1 Product Size557aa, 61.64 kDa
Genomic Location Chromosome III, 235289-232288 (3002nt); CDS:234507-232834 (1674nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0055054fructose:proton symporter activityIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358573
GO:0005358high-affinity hydrogen:glucose symporter activityIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358573
inhibited by CCCPIMPPMID:9090050
inhibited by 1,3-dicyclohexylcarbodiimideIMPPMID:9090050
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0098655cation transmembrane transportIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:10735857128
GO:0032445fructose importIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358574
GO:0046323glucose importIMPPMID:90900506
IGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:10735857
GO:0035428hexose transmembrane transportIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358578
GO:0015992proton transportIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:1073585750
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005887integral component of plasma membraneICGO:0005358PMID:1073585750
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyght1ΔNullPMID:204732893759
Microscopyght1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyght1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1235289232288

UTRs

Region Coordinates Reference
five_prime_UTR235289..234508PMID:21511999
three_prime_UTR232833..232288PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 General substrate transporter 11 467 15
TMhelix TMHMM 433 452 959
TMhelix TMHMM 266 288 959
TMhelix TMHMM 332 354 959
TMhelix TMHMM 178 200 959
TMhelix TMHMM 404 426 959
TMhelix TMHMM 300 322 959
TMhelix TMHMM 54 76 959
TMhelix TMHMM 143 165 959
TMhelix TMHMM 367 389 959
TMhelix TMHMM 89 111 959
TMhelix TMHMM 7 29 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 9 456 55
PTHR24063 HMMPANTHER 6 494 11
PTHR24063:SF98 HMMPANTHER 6 494 8
1.20.1250.20 Gene3D 261 457 72
1.20.1250.20 Gene3D 48 204 72
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 7 465 76
SignalP-noTM signalp 1 21 212
PR00171 PRINTS IPR003663 Sugar/inositol transporter 114 133 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 392 404 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 17 27 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 369 390 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 276 286 10
TIGR00879 tigrfam IPR003663 Sugar/inositol transporter 5 463 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.66 Da
Charge 1.00
Isoelectric point 6.74
Molecular weight 61.64 kDa
Number of residues 557
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelpresent during GO:0071333Northern assay evidencePMID:9090050

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.8during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4600
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBPB10D8.02carylsulfatase (predicted) Negative GeneticPMID:22681890
SPBC1105.08EMP70 family Positive GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPCC548.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC548.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC548.07c BioGRID Interaction Datasets
Expression Viewer SPCC548.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC548.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC548.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC548.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC548.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC548.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC548.07c Cell Cycle Data
GEO SPCC548.07c GEO profiles
PInt SPCC548.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC548.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC548.07c Fission yeast phenotypic data & analysis
SPD / RIKEN35/35A08Orfeome Localization Data
UniProtKB/SwissProtQ9P3U6High-affinity glucose transporter ght1
ModBaseQ9P3U6Database of comparative protein structure models
STRINGQ9P3U6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587747hexose transporter Ght1
RefSeq mRNANM_001022741972h- hexose transporter Ght1 (ght1), mRNA
European Nucleotide Archive-ENA Protein Mapping
European Nucleotide ArchiveCAB94949.1ENA Protein Mapping
UniParcUPI000012B41EUniProt Archive

Literature for ght1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014