nse1 (SPCC550.05)

Gene Standard Namense1 ChromosomeIII
Systematic IDSPCC550.05 Gene Start1193982
Synonyms Gene End1196023
ProductSmc5-6 complex non-SMC subunit 1 Gene Length2042
Feature Typeprotein coding CDS Start1194197
Name Description CDS End1194943
Characterisation Statuspublished CDS Length747

Ensembl Gene Location
  1. cwf5
  2. SPCC550.03c
  3. SPNCRNA.1178
  4. gpi2
  5. nse1
  6. hsp10
  7. SPCC550.07
  8. SPCC550.08
  9. SPCC550.09
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002061inviable vegetative cell populationMicroscopynse1delta (deletion)deletionPMID:20473289
no_name (unrecorded)unrecordedPMID:12966087
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004842ubiquitin-protein ligase activityTASPMID:15331764
GO:0005515protein bindingIPIsmc5PMID:12966087
GO:0046872metal ion bindingIEAUniProtKB:KW-0479GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000724double-strand break repair via homologous recombinationIGIrad51PMID:12966087
GO:0006281DNA repairIMPPMID:12966087
GO:0006311meiotic gene conversionIMPPMID:15331764
GO:0007131reciprocal meiotic recombinationIMPPMID:15331764
acts_downstream_ofIGIrec12PMID:15331764
GO:0016567protein ubiquitinationTASPMID:15331764
GO:0048478replication fork protectionIGIbrc1PMID:15331764
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
ICGO:0030915GO_REF:0000001
GO:0005829cytosolIDAPMID:16823372
GO:0030915Smc5-Smc6 complexIDAPMID:12966087
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111939821194775
211948241196023

References

Region Start End Reference
intron11947761194823PMID:1296608
intron11947761194823PMID:1296608
three_prime_UTR11949441196023PMID:21511999
five_prime_UTR11939821194196PMID:21511999
three_prime_UTR11949441196023PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF07574 IPR011513 Pfam Non-structural maintenance of chromosomes element 1 11 169 1
PTHR20973 IPR011513 hmmpanther Non-structural maintenance of chromosomes element 1 1 232 1
PTHR20973:SF0 hmmpanther 1 232 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000173zf-C3HC4 type (RING finger)PMID:15331764Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000173
PBO:0000176ubiquitin-protein ligase E3PMID:15331764Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000176

Protein Properties

Ave. residue weight 116.60 Da
Charge -5.00
Isoelectric point 5.53
Molecular weight 27.05 kDa
Number of residues 232
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1900PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.2PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.84PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated PMID:12966087
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rec12endonuclease Rec12 Synthetic RescuePMID:15331764
brc1BRCT domain protein Brc1 Synthetic LethalityPMID:15331764
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC6G10.07nuclear cap-binding complex large subunit (predicted) Two-hybridPMID:15331764
nse3Smc5-6 complex non-SMC subunit Nse3 Two-hybridPMID:21364888
Affinity Capture-WesternPMID:15331764
Two-hybrid
Reconstituted ComplexPMID:15601840
nse4Smc5-6 complex non-SMC subunit Nse4 Affinity Capture-MSPMID:16478984
smc5Smc5-6 complex SMC subunit Smc5 Affinity Capture-MSPMID:15331764
Affinity Capture-MSPMID:12966087
Affinity Capture-Western
Reconstituted ComplexPMID:16478984
Affinity Capture-MS
pgk1phosphoglycerate kinase Pgk1 (predicted) Two-hybridPMID:15331764
nse6Smc5-6 complex non-SMC subunit Nse6 Affinity Capture-MSPMID:16478984
Affinity Capture-Western
rps00140S ribosomal protein S0A (p40) Two-hybridPMID:15331764
nse5Smc5-6 complex non-SMC subunit Nse5 Affinity Capture-MSPMID:16478984
Affinity Capture-Western
smc6Smc5-6 complex SMC subunit Smc6 Affinity Capture-WesternPMID:14701739
Affinity Capture-MSPMID:15601840
SPCC1827.05cnucleolar RNA-binding protein NIFK (predicted) Two-hybridPMID:15331764
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External References
Database Identifier Description
NBRP SPCC550.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC550.05 Retrieval of eukaryotic orthologs
BioGrid SPCC550.05 BioGRID Interaction Datasets
Bähler Lab SPCC550.05 Cell Cycle Expression Profile
Bähler Lab SPCC550.05 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC550.05 Pheromone response/mating expression profiles
Bähler Lab SPCC550.05 Environmental stress expression profiles
Bähler Lab SPCC550.05 Bähler Lab Transcriptome Viewer
Cyclebase SPCC550.05 Cell Cycle Data
PInt SPCC550.05 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC550.05 Entrez Gene
WikiGene2539550Smc5-6 complex non-SMC subunit 1
Uniprot_genenameNSE1
EntrezGene2539550Smc5-6 complex non-SMC subunit 1
SPD / RIKEN06/06H04Orfeome Localization Data
UniProtKB/SwissProtQ53EK2Non-structural maintenance of chromosomes element 1
ModBaseQ53EK2Database of comparative protein structure models
Pfam Protein DomainsQ53EK2Pfam Domain Arrangement
RefSeq PeptideNP_588098mitochondrial heat shock protein Hsp10
RefSeq mRNANM_001023089972h- mitochondrial heat shock protein Hsp10 (hsp10), mRNA
RefSeq_mRNA_predictedXM_001713113972h- Smc5-6 complex non-SMC subunit 1 (nse1), mRNA
RefSeq_peptide_predictedXP_001713165Smc5-6 complex non-SMC subunit 1
European Nucleotide ArchiveCAI84978ENA Protein Mapping
UniParcUPI000050A499UniProt Archive

Literature for nse1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013