swc5 (SPCC576.13)


Gene Standard Nameswc5 Characterisation Statuspublished
Systematic IDSPCC576.13 Feature Typeprotein coding
Synonyms Name Description
ProductSwr1 complex subunit Swc5 Product Size215aa, 24.56 kDa
Genomic Location Chromosome III, 2101753-2102400 (648nt); CDS:2101753-2102400 (648nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingIPIGO:0000812PMID:19040720157
GO:0043486histone exchangeIPIGO:0000812PMID:1904072021
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000812Swr1 complexIDAPMID:1904072016
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000086sensitive to tacrolimus81
expressivity FYPO_EXT:0000003Cell growth assayswc5ΔNullPECO:0000201, PECO:0000005, PECO:0000142PMID:21850271
FYPO:0002060viable vegetative cell populationMicroscopyswc5ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopyswc5ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopyswc5ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121017532102400
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07572 Pfam IPR011421 BCNT-C domain 141 213 1
PS51279 Prosite Profiles IPR011421 BCNT-C domain 139 215 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.22 Da
Charge -10.00
Isoelectric point 4.68
Molecular weight 24.56 kDa
Number of residues 215
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
14514during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
17245during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
16110during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
15813during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
15299during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
855.37during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.6during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
bucentaur or craniofacial development1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Positive GeneticPMID:18818364
yaf9YEATS family histone acetyltransferase subunit Yaf9 Positive GeneticPMID:18818364
slx1structure-specific endonuclease catalytic subunit Positive GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:18818364
rik1silencing protein Rik1 Negative GeneticPMID:18818364
ucp12ATP-dependent RNA helicase Ucp12 (predicted) Negative GeneticPMID:22681890
atg17autophagy associated protein kinase activator Atg17 Positive GeneticPMID:22681890
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:18818364
gmh5alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
alg9mannosyltransferase complex subunit Alg9 (predicted) Positive GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:18818364
gyp1GTPase activating protein Gyp1 (predicted) Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Phenotypic EnhancementPMID:19547744
ash2Ash2-trithorax family protein Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
rap1telomere binding protein Rap1 Negative GeneticPMID:18818364
tma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
pds5cohesin-associated protein Pds5 Positive GeneticPMID:22681890
SPAPB21F2.02Dopey family protein (predicted) Positive GeneticPMID:22681890
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
sft1SNARE Sft1 (predicted) Negative GeneticPMID:22681890
amo1nuclear rim protein Amo1 Positive GeneticPMID:18818364
elp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
tas3RITS complex subunit 3 Negative GeneticPMID:18818364
swc2Swr1 complex complex subunit Swc2 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
gmh4alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:22681890
emc1ER membrane protein complex subunit Emc1 (predicted) Negative GeneticPMID:22681890
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:18818364
SPBP8B7.18cphosphomethylpyrimidine kinase (predicted) Positive GeneticPMID:18818364
rpl170260S ribosomal protein L17 (predicted) Positive GeneticPMID:22681890
pof3F-box protein Pof3 Negative GeneticPMID:22681890
tpp1trehalose-6-phosphate phosphatase Tpp1 Positive GeneticPMID:22681890
fsv1SNARE Fsv1 Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rpl380160S ribosomal protein L38 (predicted) Positive GeneticPMID:22681890
rtf1replication termination factor Rtf1 Positive GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:18818364
ago1argonaute Negative GeneticPMID:18818364
vps3CORVET complex subunit, GTPase regulator Vps3 (predicted) Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
SPCC613.03conserved fungal protein Negative GeneticPMID:22681890
spf38U5 snRNP complex subunit Spf38 Positive GeneticPMID:18818364
SPAC30C2.04cofactor for methionyl-and glutamyl-tRNA synthetases (predicted) Positive GeneticPMID:22681890
hob3BAR adaptor protein Hob3 Positive GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
msc1multi-copy suppressor of Chk1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
fep1iron-sensing transcription factor Fep1 Negative GeneticPMID:22681890
rrp16rRNA processing protein Rrp16 (predicted) Positive GeneticPMID:22681890
SPAC3H5.08cWD repeat protein, human WDR44 family Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
SPAC1F3.03Lgl family protein (predicted) Negative GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:18818364
bdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:18818364
arv1Arv1-like family protein Arv1 (predicted) Negative GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Positive GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:18818364
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:18818364
saf5splicing factor Negative GeneticPMID:22681890
arp6actin-like protein Arp6 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
rpl190260S ribosomal protein L19 Positive GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:18931302
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
SPBC83.17transcriptional coactivator, multiprotein bridging factor Mbf1 (predicted) Positive GeneticPMID:22681890
rpl270160S ribosomal protein L27 Positive GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
rtt109RTT109 family histone lysine acetyltransferase Positive GeneticPMID:22681890
SPAC926.06cleucine-rich repeat protein, unknown Positive GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
vps1dynamin family protein Vps1 Negative GeneticPMID:22681890
SPAC824.04WD repeat protein (predicted) Negative GeneticPMID:18818364
bst1GPI inositol deacylase Bst1 (predicted) Negative GeneticPMID:22681890
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
rpl70260S ribosomal protein L7 Positive GeneticPMID:22681890
SPAC1D4.01human C9orf78 ortholog Negative GeneticPMID:22681890
rps10140S ribosomal protein S3a Positive GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
cis4cation diffusion family zinc membrane transporter Cis4 Negative GeneticPMID:22681890
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
mug20sequence orphan Positive GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
rpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
erg28Erg28 protein (predicted) Positive GeneticPMID:22681890
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
SPBC365.16conserved protein Positive GeneticPMID:22681890
SPBC29A10.16ccytochrome b5 (predicted) Positive GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
reb1RNA polymerase I transcription termination factor Reb1 Positive GeneticPMID:22681890
nta1protein N-terminal amidase Nta1 (predicted) Positive GeneticPMID:22681890
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Positive GeneticPMID:22681890
alp31tubulin specific chaperone cofactor A, Alp31 Positive GeneticPMID:18818364
nrl1NRDE-2 family protein (predicted) Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Negative GeneticPMID:18818364
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
rps2340S ribosomal protein S23 (predicted) Positive GeneticPMID:22681890
ubp6ubiquitin C-terminal hydrolase Ubp6 Positive GeneticPMID:18818364
pmp1dual-specificity MAP kinase phosphatase Pmp1 Positive GeneticPMID:18818364
set3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Positive GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:18818364
rpl230160S ribosomal protein L23 Positive GeneticPMID:22681890
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
alp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
swr1SNF2 family helicase Swr1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
ptc3protein phosphatase 2c homolog 3 Positive GeneticPMID:18818364
rpp20360S acidic ribosomal protein A2 Positive GeneticPMID:22681890
mug154conserved fungal protein Positive GeneticPMID:18818364
atp14F1-ATPase subunit H (predicted) Positive GeneticPMID:22681890
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:18818364
met16phosphoadenosine phosphosulfate reductase Positive GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
SPCC584.01csulfite reductase NADPH flavoprotein subunit (predicted) Negative GeneticPMID:22681890
rpt419S proteasome regulatory subunit Rpt4 (predicted) Positive GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
res2MBF transcription factor complex subunit Res2 Positive GeneticPMID:18818364
apt1adenine phosphoribosyltransferase (APRT) (predicted) Negative GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Positive GeneticPMID:22681890
tos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:18818364
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:18818364
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC576.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC576.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC576.13 BioGRID Interaction Datasets
Expression Viewer SPCC576.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC576.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC576.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC576.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC576.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC576.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC576.13 Cell Cycle Data
GEO SPCC576.13 GEO profiles
PInt SPCC576.13 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN07/07E02Orfeome Localization Data
WikiGene2539444Swr1 complex subunit Swc5
EntrezGene2539444Swr1 complex subunit Swc5
UniProtKB/SwissProtO74897SWR1-complex protein 5
ModBaseO74897Database of comparative protein structure models
STRINGO74897Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588440Swr1 complex subunit Swc5
RefSeq mRNANM_001023431972h- Swr1 complex subunit Swc5 (swc5), mRNA
European Nucleotide ArchiveCAA21192ENA Protein Mapping
European Nucleotide ArchiveCAA21192.1ENA Protein Mapping
UniParcUPI000006C553UniProt Archive

Literature for swc5

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014