swc5 (SPCC576.13)


Gene Standard Nameswc5 Characterisation Statuspublished
Systematic IDSPCC576.13 Feature Typeprotein coding
Synonyms Name Description
ProductSwr1 complex subunit Swc5 Product Size215aa, 24.56 kDa
Genomic Location Chromosome III, 2101753-2102400 (648nt); CDS:2101753-2102400 (648nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
chromatin remodeling157
Annotation ExtensionEvidenceWith/FromReference
histone exchange24
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Swr1 complex16
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to 5-fluorouracilswc5ΔNull271
sensitive to tacrolimusswc5ΔNull80
viable vegetative cell populationswc5ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyswc5ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2101753..2102400
mRNA2101753..2102400
CDS2101753..2102400
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07572 Pfam IPR011421 BCNT-C domain 141 213 1
PS51279 Prosite Profiles IPR011421 BCNT-C domain 139 215 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.22 Da
Charge -10.00
Isoelectric point 4.68
Molecular weight 24.56 kDa
Number of residues 215
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
16110during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
15813during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
17245during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
14514during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
15299during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
855.37during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.6during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
bucentaur or craniofacial development1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withago1argonaute Negative GeneticPMID:18818364
positive genetic interaction withalg9mannosyltransferase complex subunit Alg9 (predicted) Positive GeneticPMID:22681890
enhances phenotype ofalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withalp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:22681890
positive genetic interaction withalp31tubulin specific chaperone cofactor A, Alp31 Positive GeneticPMID:18818364
positive genetic interaction withamo1nuclear rim protein Amo1 Positive GeneticPMID:18818364
negative genetic interaction withapt1adenine phosphoribosyltransferase (APRT) (predicted) Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
positive genetic interaction witharp6actin-like protein Arp6 Positive GeneticPMID:18818364
positive genetic interaction witharp6actin-like protein Arp6 Positive GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
negative genetic interaction witharv1Arv1-like family protein Arv1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Positive GeneticPMID:18818364
positive genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Positive GeneticPMID:22681890
synthetic growth defect withash2Ash2-trithorax family protein Synthetic Growth DefectPMID:18931302
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
positive genetic interaction withatg17autophagy associated protein kinase activator Atg17 Positive GeneticPMID:22681890
positive genetic interaction withatp14F1-ATPase subunit H (predicted) Positive GeneticPMID:22681890
negative genetic interaction withbdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
negative genetic interaction withbst1GPI inositol deacylase Bst1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:18818364
negative genetic interaction withcis4cation diffusion family zinc transmembrane transporter Cis4 Negative GeneticPMID:22681890
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
negative genetic interaction withcpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
positive genetic interaction withddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:18818364
positive genetic interaction withddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:22681890
negative genetic interaction withelp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withemc1ER membrane protein complex subunit Emc1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
positive genetic interaction witherg28Erg28 protein (predicted) Positive GeneticPMID:22681890
negative genetic interaction withfep1iron-sensing transcription factor Fep1 Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
synthetic growth defect withfor3formin For3 Synthetic Growth DefectPMID:18931302
negative genetic interaction withfsv1SNARE Fsv1 Negative GeneticPMID:22681890
positive genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
positive genetic interaction withgmh4alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
positive genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withgyp1GTPase activating protein Gyp1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withhif2Set3 complex subunit Hif2 Negative GeneticPMID:18818364
positive genetic interaction withhob3BAR adaptor protein Hob3 Positive GeneticPMID:22681890
negative genetic interaction withhos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
positive genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:18818364
positive genetic interaction withlub1WD repeat protein Lub1 Positive GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmed20mediator complex subunit Med20 Negative GeneticPMID:18818364
negative genetic interaction withmed6mediator complex subunit Med6 Negative GeneticPMID:18818364
positive genetic interaction withmet16phosphoadenosine phosphosulfate reductase Positive GeneticPMID:22681890
negative genetic interaction withmms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
negative genetic interaction withmoe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
positive genetic interaction withmsc1multi-copy suppressor of Chk1 Positive GeneticPMID:18818364
positive genetic interaction withmsc1multi-copy suppressor of Chk1 Positive GeneticPMID:22681890
positive genetic interaction withmug154conserved fungal protein Positive GeneticPMID:18818364
positive genetic interaction withmug20Schizosaccharomyces specific protein Mug20 Positive GeneticPMID:22681890
positive genetic interaction withngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
negative genetic interaction withnot2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withnrl1NRDE-2 family protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withnta1protein N-terminal amidase Nta1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withomh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
positive genetic interaction withpds5mitotic cohesin-associated protein Pds5 Positive GeneticPMID:22681890
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:18818364
positive genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:18818364
negative genetic interaction withpmc1mediator complex subunit Pmc1 Negative GeneticPMID:18818364
positive genetic interaction withpmp1dual-specificity MAP kinase phosphatase Pmp1 Positive GeneticPMID:18818364
positive genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Positive GeneticPMID:18818364
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
negative genetic interaction withpof3F-box protein Pof3 Negative GeneticPMID:22681890
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
positive genetic interaction withpsh3ER chaperone SHR3 homologue Psh3 Positive GeneticPMID:22681890
phenotype enhanced bypst2Clr6 histone deacetylase complex subunit Pst2 Phenotypic EnhancementPMID:19547744
positive genetic interaction withptc3protein phosphatase 2c homolog 3 Positive GeneticPMID:18818364
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:18818364
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withrap1telomere binding protein Rap1 Negative GeneticPMID:18818364
positive genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Positive GeneticPMID:22681890
positive genetic interaction withres2MBF transcription factor complex subunit Res2 Positive GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
positive genetic interaction withrpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withrpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrpl170260S ribosomal protein L17 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrpl190260S ribosomal protein L19 Positive GeneticPMID:22681890
positive genetic interaction withrpl230160S ribosomal protein L23 Positive GeneticPMID:22681890
positive genetic interaction withrpl270160S ribosomal protein L27 Positive GeneticPMID:22681890
positive genetic interaction withrpl380160S ribosomal protein L38 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrpl70260S ribosomal protein L7 Positive GeneticPMID:22681890
positive genetic interaction withrpp20360S acidic ribosomal protein A2 Positive GeneticPMID:22681890
positive genetic interaction withrps10140S ribosomal protein S3a Positive GeneticPMID:22681890
positive genetic interaction withrps2340S ribosomal protein S23 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrpt419S proteasome regulatory subunit Rpt4 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrrp16rRNA processing protein Rrp16 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
negative genetic interaction withrsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
positive genetic interaction withrtf1replication termination factor Rtf1 Positive GeneticPMID:22681890
positive genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Positive GeneticPMID:22681890
negative genetic interaction withsaf5splicing factor Saf5 Negative GeneticPMID:22681890
positive genetic interaction withscs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
positive genetic interaction withscs7sphingosine hydroxylase Scs7 Positive GeneticPMID:22681890
negative genetic interaction withsde2silencing defective protein Sde2 Negative GeneticPMID:22681890
positive genetic interaction withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Positive GeneticPMID:22681890
negative genetic interaction withset3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
negative genetic interaction withsft1SNARE Sft1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withslx1structure-specific endonuclease catalytic subunit Slx1 Positive GeneticPMID:18818364
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:18818364
negative genetic interaction withsnt2Lid2 complex subunit Snt2 Negative GeneticPMID:18818364
positive genetic interaction withSPAC17H9.08mitochondrial coenzyme A transmembrane transporter (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC17H9.13cglutamate 5-kinase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC30C2.04cofactor for methionyl-and glutamyl-tRNA synthetases (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC3H5.08cWD repeat protein, human WDR44 family Positive GeneticPMID:22681890
positive genetic interaction withSPAC926.06cleucine-rich repeat protein, unknown role Positive GeneticPMID:22681890
positive genetic interaction withSPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAPB21F2.02Dopey family protein (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
negative genetic interaction withSPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
positive genetic interaction withSPBC29A10.16ccytochrome b5 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC365.16conserved protein Positive GeneticPMID:22681890
negative genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPBC83.17transcriptional coactivator, multiprotein bridging factor Mbf1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBP8B7.18cphosphomethylpyrimidine kinase (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:18818364
negative genetic interaction withSPCC584.01csulfite reductase NADPH flavoprotein subunit (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC613.03conserved fungal protein Negative GeneticPMID:22681890
positive genetic interaction withspf38U5 snRNP complex subunit Spf38 Positive GeneticPMID:18818364
negative genetic interaction withspo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
positive genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:18818364
negative genetic interaction withsro7Lgl family protein Sro7 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withswc2Swr1 complex complex subunit Swc2 Positive GeneticPMID:18818364
positive genetic interaction withswc2Swr1 complex complex subunit Swc2 Positive GeneticPMID:22681890
negative genetic interaction withswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Negative GeneticPMID:18818364
positive genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Positive GeneticPMID:18818364
positive genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Positive GeneticPMID:22681890
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:18818364
negative genetic interaction withtcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
negative genetic interaction withtls1splicing factor Tls1 Negative GeneticPMID:22681890
positive genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withtpp1trehalose-6-phosphate phosphatase Tpp1 Positive GeneticPMID:22681890
positive genetic interaction withubc6ubiquitin conjugating enzyme E2 Ubc6 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withubp6ubiquitin C-terminal hydrolase Ubp6 Positive GeneticPMID:18818364
positive genetic interaction withubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:18818364
negative genetic interaction withucp12ATP-dependent RNA helicase Ucp12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withvps1dynamin family protein Vps1 Negative GeneticPMID:22681890
negative genetic interaction withvps3CORVET complex subunit, GTPase regulator Vps3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withvps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
positive genetic interaction withyaf9YEATS family histone acetyltransferase subunit Yaf9 Positive GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPCC576.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC576.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC576.13 BioGRID Interaction Datasets
Expression Viewer SPCC576.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC576.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC576.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC576.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC576.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC576.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC576.13 Cell Cycle Data
GEO SPCC576.13 GEO profiles
PInt SPCC576.13 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC576.13 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC576.13 Fission yeast phenotypic data & analysis
SPD / RIKEN07/07E02Orfeome Localization Data
UniProtKB/SwissProtO74897SWR1-complex protein 5
ModBaseO74897Database of comparative protein structure models
STRINGO74897Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588440Swr1 complex subunit Swc5
RefSeq mRNANM_001023431972h- Swr1 complex subunit Swc5 (swc5), mRNA
European Nucleotide ArchiveCAA21192.1ENA Protein Mapping
UniParcUPI000006C553UniProt Archive

Literature for swc5

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015