Gene Standard NameUnassigned Characterisation Statusconserved unknown
Systematic IDSPCC5E4.10c Feature Typeprotein coding
Synonyms Name Description
Producthuman leukocyte receptor 1 ortholog Product Size198aa, 23.91 kDa
Genomic Location Chromosome III, 652710-650897 (1814nt); CDS:652455-651622 (834nt)

Ensembl Gene Location
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationSPCC5E4.10cΔ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologySPCC5E4.10cΔ3103
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons652710..652419, 652371..652280, 652225..652115, 652045..651973, 651905..650897
Intron652418..652372, 652279..652226, 652114..652046, 651972..651906
5' UTR652710..652456PMID:21511999
CDS652455..652419, 652371..652280, 652225..652115, 652045..651973, 651905..651622
3' UTR651621..650897PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
Coil ncoils Predicted coiled-coil protein (DUF2205) 21 55 1049

View domain organization at Pfam

Protein Properties

Ave. residue weight 120.78 Da
Charge 16.50
Codon Adaptation Index 0.35
Isoelectric point 10.40
Molecular weight 23.91 kDa
Number of residues 198
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for SPCC5E4.10c

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.4during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.76during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
gene structure updated435
Taxonomic Conservation
no apparent S. cerevisiae ortholog600
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC5E4.10c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byprp17splicing factor Prp17 Affinity Capture-MSPMID:21386897
affinity captured bycwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
affinity captured byprp19ubiquitin-protein ligase E4 involved in splicing Prp19 Affinity Capture-MSPMID:21386897
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC5E4.10c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withvps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
negative genetic interaction withSPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withcut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
negative genetic interaction withSPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC5E4.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC5E4.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC5E4.10c BioGRID Interaction Datasets
Expression Viewer SPCC5E4.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC5E4.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC5E4.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC5E4.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC5E4.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC5E4.10c Transcriptome Viewer (Bähler Lab)
GEO SPCC5E4.10c GEO profiles
PInt SPCC5E4.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC5E4.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC5E4.10c Fission yeast phenotypic data & analysis
Cyclebase SPCC5E4.10c.1 Cell Cycle Data
SPD / RIKEN02/02F05Orfeome Localization Data
UniProtKB/SwissProtQ9P7Z6Uncharacterized protein C5E4.10c
ModBaseQ9P7Z6Database of comparative protein structure models
STRINGQ9P7Z6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587905hypothetical protein SPCC5E4.10c
RefSeq mRNANM_001022897972h- hypothetical protein (SPCC5E4.10c), mRNA
European Nucleotide ArchiveCAB71863.2ENA Protein Mapping
UniParcUPI000228F4B2UniProt Archive

Literature for SPCC5E4.10c

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017