SPCC5E4.10c


Gene Standard NameUnassigned Characterisation Statusconserved_unknown
Systematic IDSPCC5E4.10c Feature Typeprotein coding
Synonyms Name Description
Producthuman leukocyte receptor 1 ortholog Product Size198aa, 23.91 kDa
Genomic Location Chromosome III, 652710-650897 (1814nt); CDS:652455-651622 (834nt)

Ensembl Gene Location
GO Cellular Component
Term NameCount
nucleolus343
Annotation ExtensionEvidenceWith/FromReference
nucleus2740
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPCC5E4.10cΔNullPMID:204732893759
MicroscopySPCC5E4.10cΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001MicroscopySPCC5E4.10cΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1652710652419
2652371652280
3652225652115
4652045651973
5651905650897

UTRs

Region Coordinates Reference
five_prime_UTR652710..652456PMID:21511999
three_prime_UTR651621..650897PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
Coil ncoils Rabaptin coiled-coil domain 21 56 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 120.78 Da
Charge 16.50
Isoelectric point 10.40
Molecular weight 23.91 kDa
Number of residues 198
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.76during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated432
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog602
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
prp17splicing factor Prp17 Affinity Capture-MSPMID:21386897
prp19ubiquitin-protein ligase E4 Affinity Capture-MSPMID:21386897
cwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
cut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
SPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:22681890
SPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC5E4.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC5E4.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC5E4.10c BioGRID Interaction Datasets
Expression Viewer SPCC5E4.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC5E4.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC5E4.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC5E4.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC5E4.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC5E4.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC5E4.10c Cell Cycle Data
GEO SPCC5E4.10c GEO profiles
PInt SPCC5E4.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC5E4.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC5E4.10c Fission yeast phenotypic data & analysis
SPD / RIKEN02/02F05Orfeome Localization Data
UniProtKB/SwissProtQ9P7Z6Uncharacterized protein C5E4.10c
ModBaseQ9P7Z6Database of comparative protein structure models
STRINGQ9P7Z6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587905hypothetical protein SPCC5E4.10c
RefSeq mRNANM_001022897972h- hypothetical protein (SPCC5E4.10c), mRNA
European Nucleotide ArchiveCAB71863.2ENA Protein Mapping
UniParcUPI000228F4B2UniProt Archive

Literature for SPCC5E4.10c

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014