str2 (SPCC61.01c)


Gene Standard Namestr2 Characterisation Statuspublished
Systematic IDSPCC61.01c Feature Typeprotein coding
SynonymsSPCC622.20c Name Description
Productsiderophore-iron transporter Str2 Product Size597aa, 66.12 kDa
Genomic Location Chromosome III, 1442233-1435212 (7022nt); CDS:1441994-1440089 (1906nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015344siderophore uptake transmembrane transporter activityTASPMID:128884921
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033214iron assimilation by chelation and transportTASPMID:169636265
GO:0034755iron ion transmembrane transportTASPMID:1288849211
GO:0044718siderophore transmembrane transportTASPMID:128884923
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000329fungal-type vacuole membraneIDAPMID:1682337291
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371017
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopystr2ΔNullPECO:0000005, PECO:0000137PMID:236978061331
Microscopystr2ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable spore459
penetrance FYPO_EXT:0000001Microscopystr2ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
GO regulated by fep1 iron-sensing transcription factor Fep1 GO_REF:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
114422331441783
214416701435212

UTRs

Region Coordinates Reference
five_prime_UTR1442233..1441995PMID:21511999
three_prime_UTR1440088..1435212PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07690 Pfam IPR011701 Major facilitator superfamily 357 504 50
TMhelix TMHMM 134 151 959
TMhelix TMHMM 483 505 959
TMhelix TMHMM 416 438 959
TMhelix TMHMM 97 119 959
TMhelix TMHMM 560 578 959
TMhelix TMHMM 313 332 959
TMhelix TMHMM 223 245 959
TMhelix TMHMM 448 470 959
TMhelix TMHMM 276 298 959
TMhelix TMHMM 352 374 959
TMhelix TMHMM 158 180 959
TMhelix TMHMM 387 409 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 64 585 55
PTHR24003 HMMPANTHER 1 572 17
PTHR24003:SF499 HMMPANTHER 1 572 1
1.20.1250.20 Gene3D 72 242 72
1.20.1250.20 Gene3D 348 513 72
1.20.1250.20 Gene3D 560 579 72
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 55 270 76
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 333 507 76

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 110.76 Da
Charge 12.00
Isoelectric point 8.99
Molecular weight 66.12 kDa
Number of residues 597
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS43PMID:217125471669
present during mitotic M phase
MOD:00696phosphorylated residueNASPMID:195477441921
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1294.26during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1409during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
1613.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.59during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC61.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC61.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC61.01c BioGRID Interaction Datasets
Expression Viewer SPCC61.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC61.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC61.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC61.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC61.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC61.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC61.01c Cell Cycle Data
GEO SPCC61.01c GEO profiles
PInt SPCC61.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC61.01c Peptides identified in tandem mass spectrometry proteomics experiments
WikiGene2539559siderophore-iron transporter Str2
EntrezGene2539559siderophore-iron transporter Str2
SPD / RIKEN26/26F03Orfeome Localization Data
UniProtKB/SwissProtO94607Siderophore iron transporter 2
ModBaseO94607Database of comparative protein structure models
STRINGO94607Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_58819060S ribosomal protein L6
RefSeq PeptideNP_588192siderophore-iron transporter Str2
RefSeq mRNANM_001023180972h- 60S ribosomal protein L6 (rpl6), mRNA
RefSeq mRNANM_001023182972h- siderophore-iron transporter Str2 (str2), mRNA
European Nucleotide ArchiveCAA21876ENA Protein Mapping
European Nucleotide ArchiveCAA21876.1ENA Protein Mapping
UniParcUPI000006C856UniProt Archive

Literature for str2

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014