str2 (SPCC61.01c)

Gene Standard Namestr2 Characterisation Statuspublished
Systematic IDSPCC61.01c Feature Typeprotein coding
SynonymsSPCC622.20c Name Description
Productsiderophore-iron transporter Str2 Product Size597aa, 66.12 kDa
Genomic Location Chromosome III, 1442233-1435212 (7022nt); CDS:1441994-1440089 (1906nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
siderophore uptake transmembrane transporter activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
iron assimilation by chelation and transport5
Annotation ExtensionEvidenceWith/FromReference
iron ion transmembrane transport12
Annotation ExtensionEvidenceWith/FromReference
siderophore transmembrane transport3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
fungal-type vacuole membrane91
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopystr2ΔNullPECO:0000005, PECO:0000137PMID:236978061338

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable spore465
penetrance FYPO_EXT:0000001Microscopystr2ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
GO regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07690 Pfam IPR011701 Major facilitator superfamily 357 504 50
TMhelix TMHMM 158 180 959
TMhelix TMHMM 387 409 959
TMhelix TMHMM 352 374 959
TMhelix TMHMM 276 298 959
TMhelix TMHMM 448 470 959
TMhelix TMHMM 223 245 959
TMhelix TMHMM 313 332 959
TMhelix TMHMM 560 578 959
TMhelix TMHMM 97 119 959
TMhelix TMHMM 416 438 959
TMhelix TMHMM 483 505 959
TMhelix TMHMM 134 151 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 64 585 55
PTHR24003:SF396 HMMPANTHER 17 593 1
PTHR24003 HMMPANTHER 17 593 17
1.20.1250.20 Gene3D 560 579 72
1.20.1250.20 Gene3D 348 513 72
1.20.1250.20 Gene3D 72 242 72
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 333 507 76
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 55 270 76

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 110.76 Da
Charge 12.00
Isoelectric point 8.99
Molecular weight 66.12 kDa
Number of residues 597

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS43PMID:217125471670
present during mitotic M phase
MOD:00696phosphorylated residueNASPMID:195477441922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1294.26during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1409during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
1613.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.59during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPCC61.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC61.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC61.01c BioGRID Interaction Datasets
Expression Viewer SPCC61.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC61.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC61.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC61.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC61.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC61.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC61.01c Cell Cycle Data
GEO SPCC61.01c GEO profiles
PInt SPCC61.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC61.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC61.01c Fission yeast phenotypic data & analysis
SPD / RIKEN26/26F03Orfeome Localization Data
UniProtKB/SwissProtO94607Siderophore iron transporter 2
ModBaseO94607Database of comparative protein structure models
STRINGO94607Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_58819060S ribosomal protein L6
RefSeq PeptideNP_588192siderophore-iron transporter Str2
RefSeq mRNANM_001023180972h- 60S ribosomal protein L6 (rpl6), mRNA
RefSeq mRNANM_001023182972h- siderophore-iron transporter Str2 (str2), mRNA
European Nucleotide ArchiveCAA21876.1ENA Protein Mapping
UniParcUPI000006C856UniProt Archive

Literature for str2

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014