str2 (SPCC61.01c)


Gene Standard Namestr2 Characterisation Statuspublished
Systematic IDSPCC61.01c Feature Typeprotein coding
SynonymsSPCC622.20c Name Description
Productsiderophore-iron transporter Str2 Product Size597aa, 66.12 kDa
Genomic Location Chromosome III, 1442233-1435212 (7022nt); CDS:1441994-1440089 (1906nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015344siderophore uptake transmembrane transporter activityTASPMID:128884921
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0034755iron ion transmembrane transportTASPMID:1288849212
GO:0044718siderophore transmembrane transportTASPMID:128884923
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000329fungal-type vacuole membraneIDAPMID:1682337291
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopystr2ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopystr2ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable sporeMicroscopystr2ΔNullPECO:0000005, PECO:0000137PMID:23697806447
penetrance FYPO_EXT:0000001
Target Of
RelationshipGeneProductReference
regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
114422331441783
214416701435212

UTRs

Region Start End Reference
five_prime_UTR14422331441995PMID:21511999
three_prime_UTR14400881435212PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07690 Pfam IPR011701 Major facilitator superfamily 357 504 50
TMhelix TMHMM 134 151 959
TMhelix TMHMM 483 505 959
TMhelix TMHMM 416 438 959
TMhelix TMHMM 97 119 959
TMhelix TMHMM 560 578 959
TMhelix TMHMM 313 332 959
TMhelix TMHMM 223 245 959
TMhelix TMHMM 448 470 959
TMhelix TMHMM 276 298 959
TMhelix TMHMM 352 374 959
TMhelix TMHMM 387 409 959
TMhelix TMHMM 158 180 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 64 585 55
PTHR24003 HMMPANTHER 17 593 17
PTHR24003:SF396 HMMPANTHER 17 593 1
G3DSA:1.20.1250.20 Gene3D 560 579 69
G3DSA:1.20.1250.20 Gene3D 348 513 69
G3DSA:1.20.1250.20 Gene3D 72 242 69
SSF103473 SuperFamily IPR016196 55 270 76
SSF103473 SuperFamily IPR016196 333 507 76
Low complexity (SEG) seg 429 439
Low complexity (SEG) seg 312 326

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 110.76 Da
Charge 12.00
Isoelectric point 8.99
Molecular weight 66.12 kDa
Number of residues 597
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1294.26during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1613.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.59during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC61.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC61.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC61.01c BioGRID Interaction Datasets
Expression Viewer SPCC61.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC61.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC61.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC61.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC61.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC61.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC61.01c Cell Cycle Data
GEO SPCC61.01c GEO profiles
PInt SPCC61.01c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539559siderophore-iron transporter Str2
EntrezGene2539559siderophore-iron transporter Str2
SPD / RIKEN26/26F03Orfeome Localization Data
UniProtKB/SwissProtO94607Siderophore iron transporter 2
ModBaseO94607Database of comparative protein structure models
StringO94607Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_58819060S ribosomal protein L6
RefSeq PeptideNP_588192siderophore-iron transporter Str2
RefSeq mRNANM_001023180972h- 60S ribosomal protein L6 (rpl6), mRNA
RefSeq mRNANM_001023182972h- siderophore-iron transporter Str2 (str2), mRNA
European Nucleotide ArchiveCAA21876ENA Protein Mapping
UniParcUPI000006C856UniProt Archive

Literature for str2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014