str2 (SPCC61.01c)


Gene Standard Namestr2 Characterisation Statuspublished
Systematic IDSPCC61.01c Feature Typeprotein coding
SynonymsSPCC622.20c, SPNCRNA.106 Name DescriptionSiderophore TRansporter
Productsiderophore-iron transporter Str2 Product Size597aa, 66.12 kDa
Genomic Location Chromosome III, 1442233-1435212 (7022nt); CDS:1441994-1440089 (1906nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
iron assimilation by chelation and transport4
Annotation ExtensionEvidenceWith/FromReference
transmembrane transport338
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
fungal-type vacuole membrane88
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane966
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationstr2Δ1455

Cell Phenotype

Term NameGenotypesCount
inviable sporestr2Δ476
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in fep1 iron-sensing transcription factor Fep1
GO regulated by fep1 iron-sensing transcription factor Fep1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1442233..1441783, 1441670..1435212
Intron1441782..1441671
mRNA1442233..1435212
5' UTR1442233..1441995PMID:21511999
CDS1441994..1441783, 1441670..1440089
3' UTR1440088..1435212PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07690 Pfam IPR011701 Major facilitator superfamily 357 504 50
TMhelix TMHMM 97 119 950
TMhelix TMHMM 276 298 950
TMhelix TMHMM 560 578 950
TMhelix TMHMM 483 505 950
TMhelix TMHMM 134 151 950
TMhelix TMHMM 387 409 950
TMhelix TMHMM 158 180 950
TMhelix TMHMM 223 245 950
TMhelix TMHMM 448 470 950
TMhelix TMHMM 416 438 950
TMhelix TMHMM 313 332 950
TMhelix TMHMM 352 374 950
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 64 585 55
PTHR23501:SF87 HMMPANTHER 280 597 2
PTHR23501:SF87 HMMPANTHER 9 251 2
PTHR23501 HMMPANTHER 280 597 10
PTHR23501 HMMPANTHER 9 251 10
1.20.1250.20 Gene3D Major facilitator superfamily domain 72 242 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 560 579 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 348 513 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 333 507 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 55 270 76

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 110.76 Da
Charge 12.00
Codon Adaptation Index 0.40
Isoelectric point 8.99
Molecular weight 66.12 kDa
Number of residues 597
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during mitotic M phaseS43
S46, S596
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S43 PMID:21712547
IDA S46 PMID:25720772
IDA S596 PMID:25720772
O-phospho-L-threonineT42 1085
Annotation ExtensionEvidenceResidueReference
IDA T42 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS43,S46 2457
Annotation ExtensionEvidenceResidueReference
IDA S43,S46 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreased during GO:0071281Northern assay evidencePMID:12888492
present during GO:0072690Northern assay evidencePMID:12888492
increased during GO:0010106Northern assay evidencePMID:12888492

Quantitative Gene Expression

View graphical display of gene expression data for str2 (SPCC61.01c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1409during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1294.26during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1613.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.59during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
conserved in bacteria1005
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC61.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC61.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC61.01c BioGRID Interaction Datasets
Expression Viewer SPCC61.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC61.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC61.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC61.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC61.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC61.01c Transcriptome Viewer (Bähler Lab)
GEO SPCC61.01c GEO profiles
PInt SPCC61.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC61.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC61.01c Fission yeast phenotypic data & analysis
Cyclebase SPCC61.01c.1 Cell Cycle Data
SPD / RIKEN26/26F03Orfeome Localization Data
UniProtKB/SwissProtO94607Siderophore iron transporter 2
ModBaseO94607Database of comparative protein structure models
STRINGO94607Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588192siderophore-iron transporter Str2
RefSeq mRNANM_001023182972h- siderophore-iron transporter Str2 (str2), mRNA
European Nucleotide ArchiveCAA21876.1ENA Protein Mapping
UniParcUPI000006C856UniProt Archive

Literature for str2

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016