tti1 (SPCC622.13c)

Gene Standard Nametti1 Characterisation Statuspublished
Systematic IDSPCC622.13c Feature Typeprotein coding
Synonyms Name Description
ProductTel Two Interacting protein 1 Product Size1098aa, 124.76 kDa
Genomic Location Chromosome III, 1425868-1421146 (4723nt); CDS:1425846-1422550 (3297nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
chromatin remodeling159
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
ASTRA complex7
Annotation ExtensionEvidenceWith/FromReference
TORC2 complex8
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationtti1Δ1468

Cell Phenotype

Term NameGenotypesCount
inviable small vegetative celltti1Δ28
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR1425868..1425847PMID:21511999
3' UTR1422549..1421146PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR18460 HMMPANTHER 1 1006 1
SSF48371 SuperFamily IPR016024 Armadillo-type fold 394 647 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 89 162 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 804 924 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 292 366 130
PIRSF005250 PIRSF IPR016441 TEL2-interacting protein 1 1 1048 1

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.63 Da
Charge -9.50
Codon Adaptation Index 0.38
Isoelectric point 5.84
Molecular weight 124.76 kDa
Number of residues 1098

Protein Modifications

Term NameResidueCount
O-phosphorylated residueS19,Y21,S22 2461
Annotation ExtensionEvidenceResidueReference
IDA S19,Y21,S22 PMID:25720772
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for tti1 (SPCC622.13c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1502during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
1594during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
1469during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
1781during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
577.99during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
1328during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.3during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC622.13c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bytel2Tel2/Rad-5/Clk-2 family protein Tel2 Affinity Capture-MSPMID:20801936
affinity captured bytor2serine/threonine protein kinase Tor2 Affinity Capture-MSPMID:18076573
affinity captured bytra1SAGA complex phosphatidylinositol pseudokinase Tra1 Affinity Capture-MSPMID:21642955
affinity captured bytor1serine/threonine protein kinase Tor1 Affinity Capture-MSPMID:18076573
External References
Database Identifier Description
NBRP SPCC622.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC622.13c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC622.13c BioGRID Interaction Datasets
Expression Viewer SPCC622.13c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC622.13c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC622.13c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC622.13c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC622.13c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC622.13c Transcriptome Viewer (Bähler Lab)
GEO SPCC622.13c GEO profiles
PInt SPCC622.13c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC622.13c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC622.13c Fission yeast phenotypic data & analysis
Cyclebase SPCC622.13c.1 Cell Cycle Data
SPD / RIKEN48/48B09Orfeome Localization Data
UniProtKB/SwissProtO94600TEL2-interacting protein 1
ModBaseO94600Database of comparative protein structure models
STRINGO94600Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588185Tel Two Interacting protein 1
RefSeq mRNANM_001023175972h- Tel Two Interacting protein 1 (tti1), mRNA
European Nucleotide ArchiveCAA21869.1ENA Protein Mapping
UniParcUPI000006C7CBUniProt Archive

Literature for tti1

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017