tti1 (SPCC622.13c)


Gene Standard Nametti1 Characterisation Statuspublished
Systematic IDSPCC622.13c Feature Typeprotein coding
Synonyms Name Description
ProductTel Two Interacting protein 1 Product Size1098aa, 124.76 kDa
Genomic Location Chromosome III, 1425868-1421146 (4723nt); CDS:1425846-1422550 (3297nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005515protein bindingIPItel2PMID:18076573887
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingIPIGO:0070209PMID:19040720156
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0070209ASTRA complexIDAPMID:190407207
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopytti1ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopytti1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000951inviable small vegetative cellMicroscopytti1ΔNullPECO:0000005, PECO:0000137PMID:2369780621
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
114258681421146

UTRs

Region Start End Reference
five_prime_UTR14258681425847PMID:21511999
three_prime_UTR14225491421146PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR18460:SF3 HMMPANTHER 1 1006 1
PTHR18460 HMMPANTHER 1 1006 1
SSF48371 SuperFamily IPR016024 394 647 130
SSF48371 SuperFamily IPR016024 804 924 130
SSF48371 SuperFamily IPR016024 292 366 130
SSF48371 SuperFamily IPR016024 89 162 130
Low complexity (SEG) seg 108 118
Low complexity (SEG) seg 783 798
PIRSF005250 PIRSF IPR016441 Uncharacterised conserved protein UCP005250 1 1034 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.63 Da
Charge -9.50
Isoelectric point 5.84
Molecular weight 124.76 kDa
Number of residues 1098
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
577.99during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.3during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
tor2phosphatidylinositol kinase Tor2 Affinity Capture-MSPMID:18076573
tor1phosphatidylinositol kinase Tor1 Affinity Capture-MSPMID:18076573
tel2Tel2/Rad-5/Clk-2 family protein Tel2 Affinity Capture-MSPMID:18076573
Affinity Capture-MSPMID:20801936
tra1SAGA complex phosphatidylinositol pseudokinase Tra1 Affinity Capture-MSPMID:21642955
External References
Database Identifier Description
NBRP SPCC622.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC622.13c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC622.13c BioGRID Interaction Datasets
Expression Viewer SPCC622.13c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC622.13c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC622.13c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC622.13c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC622.13c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC622.13c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC622.13c Cell Cycle Data
GEO SPCC622.13c GEO profiles
PInt SPCC622.13c Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2539480Tel Two Interacting protein 1
WikiGene2539480Tel Two Interacting protein 1
SPD / RIKEN48/48B09Orfeome Localization Data
UniProtKB/SwissProtO94600TEL2-interacting protein 1
ModBaseO94600Database of comparative protein structure models
StringO94600Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588185Tel Two Interacting protein 1
RefSeq mRNANM_001023175972h- Tel Two Interacting protein 1 (tti1), mRNA
European Nucleotide ArchiveCAA21869ENA Protein Mapping
UniParcUPI000006C7CBUniProt Archive

Literature for tti1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014