sec59 (SPCC63.10c)

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Gene Standard Namesec59 Characterisation Statusbiological role inferred
Systematic IDSPCC63.10c Feature Typeprotein coding
Synonyms Name Description
Productdolichol kinase Sec59 (predicted) Product Size504aa, 57.43 kDa
Genomic Location Chromosome III, 856452-854405 (2048nt); CDS:856222-854651 (1572nt)

Ensembl Gene Location
  1. thg1
  2. atg1
  3. SPRRNA.55
  4. sec59
  5. prp28
  6. pup3
  7. SPCC63.13
  8. eis1
GO Molecular Function
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Term NameCount
dolichol kinase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

protein glycosylation carbohydrate derivative metabolic process


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Term NameCount
protein N-linked glycosylation30
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
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Term NameCount
endoplasmic reticulum602
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane203
Annotation ExtensionEvidenceWith/FromReference
integral component of endoplasmic reticulum membrane70
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

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Term NameGenotypesCount
inviable vegetative cell populationsec59Δ1468

Cell Phenotype

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Term NameGenotypesCount
increased cellular pigment accumulationsec59Δ31
inviable normal volume spheroid vegetative cellsec59Δ48
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons856452..855984, 855926..854405
Intron855983..855927
mRNA856452..854405
5' UTR856452..856223PMID:21511999
CDS856222..855984, 855926..854651
3' UTR854650..854405PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
TMhelix TMHMM 441 463 950
TMhelix TMHMM 374 396 950
TMhelix TMHMM 185 207 950
TMhelix TMHMM 406 428 950
TMhelix TMHMM 334 352 950
TMhelix TMHMM 56 78 950
TMhelix TMHMM 269 286 950
TMhelix TMHMM 82 104 950
TMhelix TMHMM 313 330 950
TMhelix TMHMM 158 180 950
TMhelix TMHMM 214 236 950
PTHR13205:SF15 HMMPANTHER 4 504 1
PTHR13205 HMMPANTHER IPR032974 Polyprenol kinase family 4 504 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.94 Da
Charge 10.00
Codon Adaptation Index 0.38
Isoelectric point 7.83
Molecular weight 57.43 kDa
Number of residues 504
Sequence
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Gene Expression
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Quantitative Gene Expression

View graphical display of gene expression data for sec59 (SPCC63.10c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.63during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.14during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
congenital disorders of glycosylation30
metabolic disorders143
fatty acid metabolism disorder4
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999435
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs
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Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC63.10c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withman1LEM domain protein Man1, Sad1 interacting factor Two-hybridPMID:26771498
External References
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Database Identifier Description
NBRP SPCC63.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC63.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC63.10c BioGRID Interaction Datasets
Expression Viewer SPCC63.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC63.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC63.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC63.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC63.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC63.10c Transcriptome Viewer (Bähler Lab)
GEO SPCC63.10c GEO profiles
PInt SPCC63.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC63.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC63.10c Fission yeast phenotypic data & analysis
Cyclebase SPCC63.10c.1 Cell Cycle Data
SPD / RIKEN25/25C01Orfeome Localization Data
UniProtKB/SwissProtQ9Y7T6Dolichol kinase sec59
ModBaseQ9Y7T6Database of comparative protein structure models
STRINGQ9Y7T6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587983dolichol kinase Sec59 (predicted)
RefSeq mRNANM_001022974972h- dolichol kinase Sec59 (predicted) (sec59), mRNA
European Nucleotide ArchiveCAB40014.3ENA Protein Mapping
UniParcUPI000228F3C9UniProt Archive

Literature for sec59
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Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017