ekc1 (SPCC663.01c)

Gene Standard Nameekc1 ChromosomeIII
Systematic IDSPCC663.01c Gene Start1629437
Synonymseck1, SPCC777.16c Gene End1625987
Productprotein phosphatase regulatory subunit Ekc1 (predicted) Gene Length3451
Feature Typeprotein coding CDS Start1629120
Name DescriptionExtragenic suppressor of KinetoChore CDS End1626547
Characterisation Statuspublished CDS Length2574

Ensembl Gene Location
  1. vps35
  2. prp4
  3. SPNCRNA.1212
  4. SPCC777.15
  5. ekc1
  6. wtf14
  7. wtf15
  8. pmd1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopyekc1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIppe1PMID:12773390
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0033047regulation of mitotic sister chromatid segregationIGImis12PMID:12773390
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005721centromeric heterochromatinIDAPMID:12773390
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
116294371626619
216265611625987

References

Region Start End Reference
three_prime_UTR16265461625987PMID:21511999
five_prime_UTR16294371629121PMID:21511999
three_prime_UTR16265461625987PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF04499 IPR007587 Pfam SIT4 phosphatase-associated protein family 141 653 1
PTHR12634 IPR007587 hmmpanther SIT4 phosphatase-associated protein family 2 827 1
PTHR12634:SF8 hmmpanther 2 827 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744
PMID:18257517

Protein Properties

Ave. residue weight 113.33 Da
Charge -87.00
Isoelectric point 4.07
Molecular weight 94.97 kDa
Number of residues 838
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide13751.89PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide6325.13PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide4.7PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide11PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
shf1small histone ubiquitination factor Shf1 Positive GeneticPMID:22681890
rpl270160S ribosomal protein L27 Negative GeneticPMID:22681890
mis12kinetochore protein Mis12 Synthetic RescuePMID:12773390
Synthetic Growth Defect
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Positive GeneticPMID:22681890
ath1ataxin-2 homolog Negative GeneticPMID:22681890
SPAC644.07mitochondrial Rieske ISP assembly ATPase (predicted) Positive GeneticPMID:22681890
SPAC1A6.01chuman thyroid receptor interacting protein homolog, transcription coactivator (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ppe1serine/threonine protein phosphatase Ppe1 Affinity Capture-MSPMID:19371376
Affinity Capture-WesternPMID:12773390
Co-fractionation
mis12kinetochore protein Mis12 Co-fractionationPMID:12773390
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Affinity Capture-MSPMID:19371376
elp6elongator complex subunit Elp6 (predicted) Affinity Capture-MSPMID:19371376
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Affinity Capture-MSPMID:19371376
Two-hybrid
Affinity Capture-Western
elp1elongator subunit Elp1 (predicted) Affinity Capture-MSPMID:19371376
cnp1centromere-specific histone H3 CENP-A Co-fractionationPMID:12773390
elp5elongator complex subunit Elp5 (predicted) Affinity Capture-MSPMID:19371376
elp4elongator complex subunit Elp4 (predicted) Affinity Capture-MSPMID:19371376
elp2elongator complex subunit Elp2 (predicted) Affinity Capture-MSPMID:19371376
tip41TIP41-like type 2a phosphatase regulator Tip41 Affinity Capture-MSPMID:19371376
kap109karyopherin Kap109 Affinity Capture-MSPMID:19371376
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External References
Database Identifier Description
NBRP SPCC663.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC663.01c Retrieval of eukaryotic orthologs
BioGrid SPCC663.01c BioGRID Interaction Datasets
Bähler Lab SPCC663.01c Cell Cycle Expression Profile
Bähler Lab SPCC663.01c Meiosis/Sporulation Expression Profies
Bähler Lab SPCC663.01c Pheromone response/mating expression profiles
Bähler Lab SPCC663.01c Environmental stress expression profiles
Bähler Lab SPCC663.01c Bähler Lab Transcriptome Viewer
Cyclebase SPCC663.01c Cell Cycle Data
PInt SPCC663.01c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC663.01c Entrez Gene
WikiGene2539511protein phosphatase regulatory subunit Ekc1 (predicted)
Uniprot_genenameEKC1
EntrezGene2539511protein phosphatase regulatory subunit Ekc1 (predicted)
UniProtKB/SwissProtO74511Extragenic suppressor of kinetochore protein 1
ModBaseO74511Database of comparative protein structure models
Pfam Protein DomainsO74511Pfam Domain Arrangement
RefSeq PeptideNP_588263protein phosphatase regulatory subunit Ekc1 (predicted)
RefSeq mRNANM_001023253972h- protein phosphatase regulatory subunit Ekc1 (predicted) (ekc1), mRNA
European Nucleotide ArchiveCAA20720ENA Protein Mapping
SPD / RIKEN38/38D12Orfeome Localization Data
UniParcUPI000006C811UniProt Archive

Literature for ekc1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013