ago1 (SPCC736.11)


Gene Standard Nameago1 Characterisation Statuspublished
Systematic IDSPCC736.11 Feature Typeprotein coding
Synonymscsp9 Name Description
Productargonaute Product Size834aa, 94.44 kDa
Genomic Location Chromosome III, 334103-337070 (2968nt); CDS:334137-337012 (2876nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
endoribonuclease activity, producing 5'-phosphomonoesters23
Annotation ExtensionEvidenceWith/FromReference
protein binding859
Annotation ExtensionEvidenceWith/FromReference
RNA binding571
Annotation ExtensionEvidenceWith/FromReference
single-stranded RNA binding11
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
chromatin silencing at centromere61
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing by small RNA23
Annotation ExtensionEvidenceWith/FromReference
co-transcriptional gene silencing by RNA interference machinery3
Annotation ExtensionEvidenceWith/FromReference
conversion of ds siRNA to ss siRNA involved in RNA interference3
Annotation ExtensionEvidenceWith/FromReference
heterochromatin assembly involved in chromatin silencing by small RNA3
Annotation ExtensionEvidenceWith/FromReference
heterochromatin organization involved in chromatin silencing22
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid segregation184
Annotation ExtensionEvidenceWith/FromReference
negative regulation of transcription from RNA polymerase II promoter79
Annotation ExtensionEvidenceWith/FromReference
production of siRNA involved in chromatin silencing by small RNA3
Annotation ExtensionEvidenceWith/FromReference
regulation of histone H3-K9 methylation11
Annotation ExtensionEvidenceWith/FromReference
RNA phosphodiester bond hydrolysis, endonucleolytic26
Annotation ExtensionEvidenceWith/FromReference
NOT chromatin silencing at silent mating-type cassette
Annotation ExtensionEvidenceWith/FromReference
NOT chromatin silencing at telomere
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
ARC complex3
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
mating-type region heterochromatin26
Annotation ExtensionEvidenceWith/FromReference
nuclear chromosome, telomeric region50
Annotation ExtensionEvidenceWith/FromReference
nuclear pericentric heterochromatin39
Annotation ExtensionEvidenceWith/FromReference
nuclear subtelomeric heterochromatin18
Annotation ExtensionEvidenceWith/FromReference
RITS complex3
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on ammonia nitrogen sourceunnamed (unrecorded)4
normal growth on proline nitrogen sourceunnamed (unrecorded)2
sensitive to 5-fluorouracilago1ΔNull271
sensitive to hydroxyureaago1ΔNull534
sensitive to thiabendazoleago1ΔNull219
viable vegetative cell populationago1ΔNull3809
unnamed (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
abnormal microtubule cytoskeleton morphology during mitotic interphaseago1ΔNull186
abolished protein localization to nuclear centromeric heterochromatin6
affecting dsh1ago1ΔNull
centromeric outer repeat transcript-derived siRNA absentago1ΔNull7
decreased centromeric outer repeat transcript levelago1ΔNull15
increased level of stress responsive gene mRNA during vegetative growthago1ΔNull9
increased RNA level during vegetative growth200
affecting SO:0000286ago1ΔNull
viable vegetative cell with normal cell morphologyago1ΔNull3094
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4
FYPO affected by mutation in dcr1 dicer
FYPO affected by mutation in dsh1 RNAi protein, Dsh1
FYPO affected by mutation in tri1 triman, ribonuclease involved in priRNA formation Tri1
GO localized by rdp1 RNA-directed RNA polymerase Rdp1
GO regulated by arb1 argonaute inhibitor protein 1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons334103..334265, 334637..337070
mRNA334103..337070
5' UTR334103..334136PMID:18641648
5' UTR334103..334136PMID:20118936
CDS334137..334265, 334637..337012
3' UTR337013..337070PMID:18641648
3' UTR337013..337070PMID:20118936
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02171 Pfam IPR003165 Piwi domain 501 796 1
PF08699 Pfam IPR014811 Domain of unknown function DUF1785 161 207 1
PF02170 Pfam IPR003100 PAZ domain 219 346 1
SM00950 SMART IPR003165 Piwi domain 499 799 1
SM00949 SMART IPR003100 PAZ domain 213 348 1
PS50822 Prosite Profiles IPR003165 Piwi domain 500 799 1
PS50821 Prosite Profiles IPR003100 PAZ domain 212 326 1
PTHR22891:SF0 HMMPANTHER 8 834 1
PTHR22891 HMMPANTHER 8 834 1
3.30.420.10 Gene3D IPR012337 Ribonuclease H-like domain 574 797 32
2.170.260.10 Gene3D 204 329 1
3.40.50.2300 Gene3D 385 558 7
SSF101690 SuperFamily IPR003100 PAZ domain 203 366 1
SSF53098 SuperFamily IPR012337 Ribonuclease H-like domain 488 797 34

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0005093PAZ domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0005093

Protein Properties

Ave. residue weight 113.24 Da
Charge 32.50
Isoelectric point 9.34
Molecular weight 94.44 kDa
Number of residues 834
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6060during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6305during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6843during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6825during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
13705during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
1140.54during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.88during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.48during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by human hAGO2 PMID:14699070
Misc
DescriptionQualifierReferenceCount
deletion mutant expression profiling PMID:1563206177
RDRC and RITS complexes associate together, and with noncoding centromeric RNA in a Dcr1 (hence siRNA) and Clr4 dependent manner PMID:156079761
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog599
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturesarb1argonaute inhibitor protein 1 Affinity Capture-MSPMID:24095277
affinity capturesarb1argonaute inhibitor protein 1 Affinity Capture-MSPMID:22989756
affinity capturesarb2argonaute binding protein 2 Affinity Capture-MSPMID:24095277
affinity capturesarb2argonaute binding protein 2 Affinity Capture-MSPMID:22989756
affinity captured bychp1chromodomain protein Chp1 Affinity Capture-WesternPMID:14704433
affinity captureschp1chromodomain protein Chp1 Affinity Capture-MSPMID:24095277
affinity captured bychp1chromodomain protein Chp1 Affinity Capture-MSPMID:15607976
affinity captured bychp1chromodomain protein Chp1 Affinity Capture-WesternPMID:17531816
affinity captured byclr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:20211136
forms complex withcut7kinesin-like protein Cut7 Reconstituted ComplexPMID:19883398
co-fractionates withdcr1dicer Co-fractionationPMID:16734665
affinity captured bydeb1transcription factor Deb1/Rdp1 Affinity Capture-WesternPMID:16734665
affinity capturesdeb1transcription factor Deb1/Rdp1 Affinity Capture-WesternPMID:16734665
affinity captured bydsh1RNAi protein, Dsh1 Affinity Capture-WesternPMID:22895252
affinity captureshrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Affinity Capture-MSPMID:15607976
affinity capturesptr1HECT-type ubiquitin ligase E3 Ptr1 Affinity Capture-WesternPMID:22989756
affinity captured byptr1HECT-type ubiquitin ligase E3 Ptr1 Affinity Capture-WesternPMID:22989756
affinity capturesptr1HECT-type ubiquitin ligase E3 Ptr1 Affinity Capture-MSPMID:22989756
affinity captured byrad2414-3-3 protein Rad24 Affinity Capture-WesternPMID:17043360
affinity captured byrad2514-3-3 protein Rad25 Affinity Capture-WesternPMID:17043360
affinity captured byrik1silencing protein Rik1 Affinity Capture-WesternPMID:20705239
forms complex withstc1LIM-like protein linking chromatin modification to RNAi, Stc1 Reconstituted ComplexPMID:23613586
forms complex withstc1LIM-like protein linking chromatin modification to RNAi, Stc1 Reconstituted ComplexPMID:20211136
affinity captured bystc1LIM-like protein linking chromatin modification to RNAi, Stc1 Affinity Capture-WesternPMID:20211136
binds DNA-binding domain construct withtas3RITS complex subunit 3 Two-hybridPMID:14704433
affinity captured bytas3RITS complex subunit 3 Affinity Capture-MSPMID:14704433
affinity capturestas3RITS complex subunit 3 Affinity Capture-MSPMID:24095277
forms complex withtas3RITS complex subunit 3 Reconstituted ComplexPMID:17891150
affinity captured bytas3RITS complex subunit 3 Affinity Capture-WesternPMID:17531816
affinity capturestri1triman, ribonuclease involved in priRNA formation Tri1 Affinity Capture-MSPMID:24095277
forms complex withtri1triman, ribonuclease involved in priRNA formation Tri1 Reconstituted ComplexPMID:24095277
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withabo2ATPase with bromodomain protein (predicted) Negative GeneticPMID:18818364
positive genetic interaction withado1adenosine kinase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withalp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
positive genetic interaction withamt1ammonium transmembrane transporter Amt1 Positive GeneticPMID:22681890
positive genetic interaction withapl5AP-3 adaptor complex subunit Apl5 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withapq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:18818364
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:22681890
enhances phenotype ofatf1transcription factor, Atf-CREB family Atf1 Phenotypic EnhancementPMID:15218150
negative genetic interaction withatg1801WD repeat protein involved in autophagy Atg18a Negative GeneticPMID:22681890
negative genetic interaction withath1ataxin-2 homolog Negative GeneticPMID:22681890
negative genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withatp12mitochondrial F1-ATPase chaperone Atp12 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withaut12autophagy associated protein Aut12 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withbdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
negative genetic interaction withbdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:22681890
negative genetic interaction withbob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withbqt4bouquet formation protein Bqt4 Negative GeneticPMID:22681890
negative genetic interaction withbtf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:22681890
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:22681890
negative genetic interaction withbun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit Negative GeneticPMID:18818364
negative genetic interaction withcbp1CENP-B homolog Negative GeneticPMID:18818364
positive genetic interaction withccq1telomere maintenance protein Ccq1 Positive GeneticPMID:22681890
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcho1phosphatidyl-N-dimethylethanolamine N-methyltransferase Negative GeneticPMID:18818364
positive genetic interaction withchp1chromodomain protein Chp1 Positive GeneticPMID:18818364
rescued bycid14poly(A) polymerase Cid14 Phenotypic SuppressionPMID:21892171
positive genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:18818364
positive genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
positive genetic interaction withclr5Clr5 protein Positive GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcsk1cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1 Negative GeneticPMID:22681890
positive genetic interaction withcsn3COP9/signalosome complex subunit Csn3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withcsr102sec14 cytosolic factor family phosphatidylinositol transmembrane transporter (predicted) Negative GeneticPMID:22681890
rescuescwf10U5 snRNP GTPase subunit Cwf10 Phenotypic SuppressionPMID:24874881
overexpression rescuescwf14G10 protein Dosage RescuePMID:24874881
rescuescwf14G10 protein Phenotypic SuppressionPMID:24874881
positive genetic interaction withdbl6double strand break localizing protein Dbl6 Positive GeneticPMID:22681890
negative genetic interaction withdbp3ATP-dependent RNA helicase Dbp3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
rescuesdcr1dicer Phenotypic SuppressionPMID:22989756
overexpression rescuesdcr1dicer Dosage RescuePMID:14699070
negative genetic interaction withdef1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withdot2ESCRT II complex subunit Dot2 Positive GeneticPMID:18818364
positive genetic interaction withebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
negative genetic interaction withemp24COPII-coated vesicle component Emp24 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:22681890
rescued byepe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:23604080
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withfhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withfta6Mis6-Sim4 complex Fta6 Positive GeneticPMID:22681890
negative genetic interaction withgar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
negative genetic interaction withgim1prefoldin subunit 6, Gim1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withgim3prefoldin subunit 4, Gim3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withgim3prefoldin subunit 4, Gim3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withgit3G-protein coupled receptor Git3 Positive GeneticPMID:22681890
positive genetic interaction withgit5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
negative genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withgpa2heterotrimeric G protein alpha-2 subunit Gpa2 Positive GeneticPMID:22681890
negative genetic interaction withgpd3glyceraldehyde 3-phosphate dehydrogenase Gpd3 Negative GeneticPMID:22681890
negative genetic interaction withgyp1GTPase activating protein Gyp1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withhht3histone H3 h3.3 Positive GeneticPMID:22681890
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
positive genetic interaction withhmo1HMG box protein Hmo1 Positive GeneticPMID:18818364
negative genetic interaction withhos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
negative genetic interaction withhrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withklp6kinesin-like protein Klp6 Positive GeneticPMID:18818364
positive genetic interaction withklp6kinesin-like protein Klp6 Positive GeneticPMID:22681890
negative genetic interaction withlaf1Clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
negative genetic interaction withlaf1Clr6 L associated factor 1 Laf1 Negative GeneticPMID:22681890
negative genetic interaction withlem2LEM domain protein Heh1/Lem2 Negative GeneticPMID:22681890
positive genetic interaction withleo1RNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:18818364
positive genetic interaction withleo1RNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:22681890
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
positive genetic interaction withmag1DNA-3-methyladenine glycosylase Mag1 Positive GeneticPMID:18818364
negative genetic interaction withmak3histidine kinase Mak3 Negative GeneticPMID:22681890
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:22681890
positive genetic interaction withmed20mediator complex subunit Med20 Positive GeneticPMID:18818364
positive genetic interaction withmed6mediator complex subunit Med6 Positive GeneticPMID:18818364
positive genetic interaction withmet11methylenetetrahydrofolate reductase Met11 Positive GeneticPMID:22681890
negative genetic interaction withmex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
negative genetic interaction withmgr2TIM23 translocase complex subunit Mgr2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmhf2CENP-X homolog, FANCM-MHF complex subunit Mhf2 Negative GeneticPMID:22681890
rescued bymip1WD repeat protein, Raptor homolog Mip1 Phenotypic SuppressionPMID:24766403
positive genetic interaction withmit1SHREC complex ATP-dependent DNA helicase subunit Mit1 Positive GeneticPMID:18818364
rescued bymlo3RNA binding protein Mlo3 Phenotypic SuppressionPMID:21892171
synthetically rescued bymlo3RNA binding protein Mlo3 Synthetic RescuePMID:21892171
negative genetic interaction withmms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withmms19Dos2 silencing complex subunit Mms19 Positive GeneticPMID:18818364
positive genetic interaction withmms19Dos2 silencing complex subunit Mms19 Positive GeneticPMID:22681890
positive genetic interaction withmoe1translation initiation factor eIF3d Moe1 Positive GeneticPMID:22681890
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmsd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:18818364
negative genetic interaction withmsn5karyopherin (predicted) Negative GeneticPMID:18818364
positive genetic interaction withmst2histone acetyltransferase Mst2 Positive GeneticPMID:22681890
synthetically rescued bymst2histone acetyltransferase Mst2 Synthetic RescuePMID:21289066
negative genetic interaction withmug129Schizosaccharomyces specific protein Mug129 Negative GeneticPMID:22681890
negative genetic interaction withmug30HECT-type ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withmxr2peptide-methionine (R)-S-oxide reductase MsrB Positive GeneticPMID:22681890
negative genetic interaction withnab2poly(A) binding protein Nab2 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withnde2mitochondrial NADH dehydrogenase (ubiquinone) Nde2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withnem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withnht1Ino80 complex HMG box subunit Nht1 Negative GeneticPMID:22681890
positive genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withnup124nucleoporin Nup124 Positive GeneticPMID:22681890
negative genetic interaction withpac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
positive genetic interaction withpas4peroxisomal ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
enhances phenotype ofpcr1transcription factor Pcr1 Phenotypic EnhancementPMID:15218150
negative genetic interaction withpds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
negative genetic interaction withpex22peroxisomal membrane protein Pex22 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:18818364
positive genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:22681890
positive genetic interaction withpmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:22681890
positive genetic interaction withpmk1MAP kinase Pmk1 Positive GeneticPMID:18818364
positive genetic interaction withpng3ING family homolog Png3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
negative genetic interaction withpom152nucleoporin Pom152 Negative GeneticPMID:22681890
negative genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withptf2Mst2 histone acetytransferase acytyltransferase complex subunit Positive GeneticPMID:22681890
negative genetic interaction withptr2PTR family peptide transmembrane transporter Ptr2 Negative GeneticPMID:22681890
positive genetic interaction withpuf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
positive genetic interaction withqtr1queuine tRNA-ribosyltransferase Qtrt1 Positive GeneticPMID:22681890
synthetic lethal withrad51RecA family recombinase Rad51/Rhp51 Synthetic LethalityPMID:22002604
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
positive genetic interaction withrik1silencing protein Rik1 Positive GeneticPMID:18818364
positive genetic interaction withrik1silencing protein Rik1 Positive GeneticPMID:22681890
overexpression rescuesrik1silencing protein Rik1 Dosage RescuePMID:20705239
synthetic growth defect withrik1silencing protein Rik1 Synthetic Growth DefectPMID:20705239
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:18818364
positive genetic interaction withrox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:22681890
positive genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:18818364
positive genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:22681890
positive genetic interaction withrpl100260S ribosomal protein L10 Positive GeneticPMID:22681890
negative genetic interaction withrpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpl230160S ribosomal protein L23 Negative GeneticPMID:22681890
negative genetic interaction withrpl280160S ribosomal protein L27/L28 Negative GeneticPMID:22681890
negative genetic interaction withrpl430260S ribosomal protein L37a (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps100140S ribosomal protein S10 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps170140S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps170240S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps190240S ribosomal protein S19 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrps250240S ribosomal protein S25 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrps280240S ribosomal protein S28, Rps2802 Negative GeneticPMID:22681890
positive genetic interaction withrps340S ribosomal protein S3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrps40140S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps40240S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps80140S ribosomal protein S8 (predicted) Negative GeneticPMID:22681890
enhances phenotype ofrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic EnhancementPMID:23151475
rescuesrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic SuppressionPMID:23151475
phenotype enhanced byrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic EnhancementPMID:21892171
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:22681890
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:18818364
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:22681890
negative genetic interaction withsat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withsce3translation initiation factor (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
positive genetic interaction withsft1SNARE Sft1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsgf29SAGA complex subunit Sgf29 Positive GeneticPMID:22681890
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
negative genetic interaction withshk2PAK-related kinase Shk2 Negative GeneticPMID:18818364
negative genetic interaction withsle1eisosome assembly protein Seg1 Negative GeneticPMID:22681890
negative genetic interaction withslt1Schizosaccharomyces specific protein Slt1 Negative GeneticPMID:22681890
positive genetic interaction withSPAC139.01cnuclease, XP-G family (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC18G6.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC30D11.14cRNA-binding protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC3H8.04possible chromosome segregation protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC513.07flavonol reductase/cinnamoyl-CoA reductase family Positive GeneticPMID:22681890
negative genetic interaction withSPAPB21F2.02Dopey family protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1348.01S. pombe specific DUF999 protein family 5 Negative GeneticPMID:22681890
positive genetic interaction withSPBC16C6.05mitochondrial translation initiation factor (predicted) Positive GeneticPMID:18818364
negative genetic interaction withSPBC1778.05chuman LAMTOR2 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC25H2.15SSU-rRNA maturation protein Tsr4 homolog 1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPBC31F10.02acyl-CoA hydrolase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC3B8.04csodium ion transmembrane transporter (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC839.03cneddylation protein Dcn1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC9B6.03zf-FYVE type zinc finger protein Positive GeneticPMID:22681890
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
positive genetic interaction withSPCC126.13chistone deacetylase complex subunit, SAP128 family (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPCC1840.05cphosphoglucomutase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPCC24B10.18human Leydig cell tumor 10 kDa protein homolog Negative GeneticPMID:22681890
negative genetic interaction withSPCC63.06human WDR89 family WD repeat protein Negative GeneticPMID:22681890
negative genetic interaction withSPCPB16A4.05curease accessory protein UREG (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsro7Lgl family protein Sro7 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withswc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
negative genetic interaction withswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Negative GeneticPMID:18818364
negative genetic interaction withswi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
positive genetic interaction withswi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:18818364
positive genetic interaction withswi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
enhances phenotype oftas3RITS complex subunit 3 Phenotypic EnhancementPMID:17531816
negative genetic interaction withtcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
synthetically rescued bytfs1transcription elongation factor TFIIS Synthetic RescuePMID:21892171
rescued bytfs1transcription elongation factor TFIIS Phenotypic SuppressionPMID:21892171
positive genetic interaction withtfs1transcription elongation factor TFIIS Positive GeneticPMID:22681890
negative genetic interaction withtim13TIM22 inner membrane protein import complex subunit Tim13 (predicted) Negative GeneticPMID:18818364
rescued bytls1splicing factor Tls1 Phenotypic SuppressionPMID:25245948
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withtos4FHA domain protein Tos4 (predicted) Positive GeneticPMID:18818364
rescued byubp3ubiquitin C-terminal hydrolase Ubp3 Phenotypic SuppressionPMID:21892171
negative genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withura1carbamoyl-phosphate synthase (glutamine hydrolyzing), aspartate carbamoyltransferase Ura1 Negative GeneticPMID:22681890
positive genetic interaction withvps38phophatidylinositol 3-kinase complex subunit Vps38 Positive GeneticPMID:22681890
negative genetic interaction withvps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
negative genetic interaction withwbp4WW domain-binding protein Wbp4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withyar1ribosome biogenesis protein Yar1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withyox1MBF complex corepressor Yox1 Positive GeneticPMID:22681890
positive genetic interaction withzip1transcription factor Zip1 Positive GeneticPMID:22681890
negative genetic interaction withzrg17cation diffusion family zinc transmembrane transporter Zrg17 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC736.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC736.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC736.11 BioGRID Interaction Datasets
Expression Viewer SPCC736.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC736.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC736.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC736.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC736.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC736.11 Transcriptome Viewer (Bähler Lab)
GEO SPCC736.11 GEO profiles
PInt SPCC736.11 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC736.11 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC736.11 Fission yeast phenotypic data & analysis
Cyclebase SPCC736.11.1 Cell Cycle Data
SPD / RIKEN29/29F08Orfeome Localization Data
UniProtKB/SwissProtO74957Protein argonaute
ModBaseO74957Database of comparative protein structure models
STRINGO74957Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587782argonaute
RefSeq mRNANM_001022775972h- argonaute (ago1), mRNA
European Nucleotide ArchiveCAA19275.1ENA Protein Mapping
UniParcUPI000012D2A7UniProt Archive

Literature for ago1

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015