ago1 (SPCC736.11)


Gene Standard Nameago1 Characterisation Statuspublished
Systematic IDSPCC736.11 Feature Typeprotein coding
Synonymscsp9 Name Description
Productargonaute Product Size834aa, 94.44 kDa
Genomic Location Chromosome III, 334103-337070 (2968nt); CDS:334137-337012 (2876nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003723RNA binding627
binds siRNAIDAPMID:24095277
GO:0005515protein bindingIPIchp1PMID:14704433887
IPItas3PMID:14704433
IPIoca2PMID:20404084
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030702chromatin silencing at centromereIMPPMID:1054544953
NOT GO:0030466chromatin silencing at silent mating-type cassetteIMPPMID:10545449
NOT GO:0006348chromatin silencing at telomereIMPPMID:10545449
GO:0031048chromatin silencing by small RNAIMPPMID:1273364020
GO:0033562co-transcriptional gene silencing by RNA interference machineryIMPPMID:224315123
GO:0033168conversion of ds siRNA to ss siRNA involved in RNA interferenceIMPPMID:173102503
GO:0000070mitotic sister chromatid segregationIGInda2PMID:10545449133
GO:0000122negative regulation of transcription from RNA polymerase II promoter74
regulates per1IMPPMID:20404084
GO:0090052regulation of chromatin silencing at centromere8
requiredIMPPMID:12193640
GO:0051570regulation of histone H3-K9 methylationIMPPMID:1219364016
GO:0006808regulation of nitrogen utilizationIMPPMID:204040844
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033167ARC complexIDAPMID:173102503
GO:0030958RITS complexIDAPMID:147044333
GO:0005721centromeric heterochromatinIDAPMID:1547595433
GO:0005829cytosolIDAPMID:168233722317
GO:0031934mating-type region heterochromatinIDAPMID:1547595425
GO:0005724nuclear telomeric heterochromatinIDAPMID:1547595413
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000249decreased cell population growth on ammonia nitrogen sourceno_namePMID:204040844
FYPO:0000243normal cell population growth on proline nitrogen sourceno_namePMID:204040842
FYPO:0000088sensitive to hydroxyureaCell Growth Assayago1ΔNullPECO:0000137, PECO:0000102PMID:23697806233
expressivity FYPO_EXT:0000003
FYPO:0002060viable vegetative cell populationMicroscopyago1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyago1ΔNullPMID:20473289
no_namePMID:12733640

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000273centromeric outer repeat transcripts absentno_namePMID:202111367
FYPO:0003094decreased centromeric outer repeat transcript levelTranscript expression level evidenceago1ΔNullPMID:240952778
FYPO:0000825increased RNA level during vegetative growthTranscript expression level evidenceago1ΔNullPMID:2115111481
affecting SO:0000286
FYPO:0002664increased level of stress responsive gene mRNA during vegetative growthTranscript expression level evidenceago1ΔNullPMID:224315124
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyago1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Target Of
RelationshipGeneProductReference
localized by rdp1 RNA-directed RNA polymerase Rdp1 PMID:14704433
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1334103334265
2334637337070

UTRs

Region Start End Reference
five_prime_UTR334103334136PMID:18641648
three_prime_UTR337013337070PMID:18641648
five_prime_UTR334103334136PMID:20118936
three_prime_UTR337013337070PMID:20118936
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02171 Pfam IPR003165 Stem cell self-renewal protein Piwi 501 796 1
PF02170 Pfam IPR003100 Argonaute/Dicer protein, PAZ domain 219 346 1
PF08699 Pfam IPR014811 Domain of unknown function DUF1785 161 207 1
SM00950 SMART IPR003165 Stem cell self-renewal protein Piwi 499 799 1
SM00949 SMART IPR003100 Argonaute/Dicer protein, PAZ domain 213 348 1
PS50822 Prosite Profiles IPR003165 Stem cell self-renewal protein Piwi 500 799 1
PS50821 Prosite Profiles IPR003100 Argonaute/Dicer protein, PAZ domain 212 326 1
PTHR22891 HMMPANTHER 8 834 1
G3DSA:3.40.50.2300 Gene3D 385 558 7
G3DSA:3.30.420.10 Gene3D 574 797 32
G3DSA:2.170.260.10 Gene3D 204 329 1
SSF53098 SuperFamily IPR012337 488 797 34
SSF101690 SuperFamily IPR003100 203 366 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0005093PAZ domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0005093

Protein Properties

Ave. residue weight 113.24 Da
Charge 32.50
Isoelectric point 9.34
Molecular weight 94.44 kDa
Number of residues 834
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1140.54during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.48during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
0.88during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReferenceCount
functionally complemented by human hAGO2 PMID:146990701
Misc
DescriptionQualifierReferenceCount
deletion mutant expression profiling PMID:1563206179
RDRC and RITS complexes associate together, and with non coding centromeric RNA in a Dcr1 (hence siRNA) and Clr4 dependent manner PMID:156079766
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog579
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
med20mediator complex subunit Med20 Positive GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
sle1eisosome assembly protein Seg1 Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rik1silencing protein Rik1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
Synthetic Growth DefectPMID:20705239
Dosage Rescue
klp6kinesin-like protein Klp6 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
rpl430260S ribosomal protein L37a (predicted) Negative GeneticPMID:22681890
pcr1transcription factor Pcr1 Phenotypic EnhancementPMID:15218150
mms19Dos2 silencing complex subunit Mms19 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
msh6MutS protein homolog Negative GeneticPMID:18818364
SPBC16C6.05mitochondrial translation initiation factor (predicted) Positive GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
dbl6double strand break localizing protein Dbl6 Positive GeneticPMID:22681890
fta6Sim4 and Mal2 associated (4 and 2 associated) protein 6 Positive GeneticPMID:22681890
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC63.06human WDR89 family WD repeat protein Negative GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
pas4peroxisomal ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
mxr2peptide-methionine (R)-S-oxide reductase MsrB Positive GeneticPMID:22681890
dbp3ATP-dependent RNA helicase Dbp3 (predicted) Negative GeneticPMID:22681890
SPBC3B8.04cmembrane transporter (predicted) Positive GeneticPMID:22681890
csk1cyclin-dependent kinase activating kinase Csk1 Negative GeneticPMID:22681890
met11methylenetetrahydrofolate reductase Met11 Positive GeneticPMID:22681890
atg1801WD repeat protein involved in autophagy Atg18a Negative GeneticPMID:22681890
mag1DNA-3-methyladenine glycosylase Mag1 Positive GeneticPMID:18818364
pmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:22681890
nab2poly(A) binding protein Nab2 (predicted) Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
SPCC126.13chistone deacetylase complex subunit, SAP128 family (predicted) Positive GeneticPMID:18818364
slt1sequence orphan Slt1 Negative GeneticPMID:22681890
SPAPB21F2.02Dopey family protein (predicted) Negative GeneticPMID:22681890
pmc5mediator complex subunit Pmc5 Positive GeneticPMID:18818364
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
git3G-protein coupled receptor Git3 Positive GeneticPMID:22681890
sft1SNARE Sft1 (predicted) Positive GeneticPMID:22681890
tas3RITS complex subunit 3 Phenotypic EnhancementPMID:17531816
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
SPBP16F5.05cribosome biogenesis protein Nop8 (predicted) Negative GeneticPMID:22681890
SPAC19D5.02cperoxisomal membrane protein Pex22 (predicted) Negative GeneticPMID:18818364
atb2tubulin alpha 2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
zip1transcription factor Zip1 Positive GeneticPMID:22681890
pac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Synthetic LethalityPMID:22002604
leo1RNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
ado1adenosine kinase (predicted) Positive GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
dot2ESCRT II complex subunit Dot2 Positive GeneticPMID:18818364
rpl100260S ribosomal protein L10 Positive GeneticPMID:22681890
SPBC18H10.07WW domain-binding protein 4 (predicted) Negative GeneticPMID:22681890
SPAC3H8.02sec14 cytosolic factor family phosphatidylinositol transporter (predicted) Negative GeneticPMID:22681890
SPAC3H8.04chromosome segregation protein (predicted) Negative GeneticPMID:22681890
swi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
gpa2heterotrimeric G protein alpha-2 subunit Gpa2 Positive GeneticPMID:22681890
pom152nucleoporin Pom152 Negative GeneticPMID:22681890
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
git5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
mad2spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
csn3COP9/signalosome complex subunit Csn3 (predicted) Positive GeneticPMID:22681890
rps170140S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
SPCC1840.05cphosphoglucomutase (predicted) Positive GeneticPMID:22681890
SPAC139.01cnuclease, XP-G family (predicted) Positive GeneticPMID:22681890
ath1ataxin-2 homolog Negative GeneticPMID:22681890
mal3EB1 family Mal3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC227.05prefoldin subunit 4 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
lem2LEM domain protein Heh1/Lem2 Negative GeneticPMID:22681890
SPAC18G6.13sequence orphan Negative GeneticPMID:22681890
btf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Positive GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
SPAC513.07flavonol reductase/cinnamoyl-CoA reductase family Positive GeneticPMID:22681890
pds5cohesin-associated protein Pds5 Negative GeneticPMID:18818364
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
vps38phophatidylinositol 3-kinase complex subunit Vps38 Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
mlo3RNA binding protein Mlo3 Synthetic RescuePMID:21892171
Phenotypic Suppression
rrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic SuppressionPMID:23151475
Phenotypic Enhancement
Phenotypic EnhancementPMID:21892171
SPAC1F3.03Lgl family protein (predicted) Negative GeneticPMID:22681890
atp11F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
nup124nucleoporin Nup124 Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
bdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Positive GeneticPMID:22681890
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
ccq1telomere maintenance protein Ccq1 Positive GeneticPMID:22681890
rps280240S ribosomal protein S28, Rps2802 Negative GeneticPMID:22681890
rps250240S ribosomal protein S25 (predicted) Positive GeneticPMID:22681890
SPAC1687.19cqueuine tRNA-ribosyltransferase (predicted) Positive GeneticPMID:22681890
rps80140S ribosomal protein S8 (predicted) Negative GeneticPMID:22681890
ptf2Mst2 histone acetytransferase acytyltransferase complex subunit Positive GeneticPMID:22681890
SPCC24B10.18human Leydig cell tumor 10 kDa protein homolog Negative GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
SPBC31F10.02acyl-CoA hydrolase (predicted) Positive GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mst2histone acetyltransferase Mst2 Positive GeneticPMID:22681890
Synthetic RescuePMID:21289066
fhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1778.05chuman LAMTOR2 ortholog Negative GeneticPMID:22681890
clr5Clr5 protein Positive GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
sce3translation initiation factor (predicted) Positive GeneticPMID:22681890
tim13TIM22 inner membrane protein import complex subunit Tim13 (predicted) Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:22681890
amt1ammonium transporter Amt1 Positive GeneticPMID:22681890
aut12autophagy associated protein Aut12 (predicted) Positive GeneticPMID:18818364
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
SPBC839.03cneddylation protein Dcn1 (predicted) Positive GeneticPMID:22681890
cid14poly(A) polymerase Cid14 Phenotypic SuppressionPMID:21892171
SPAC824.04WD repeat protein (predicted) Negative GeneticPMID:18818364
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
gyp1GTPase activating protein Gyp1 (predicted) Negative GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hmo1HMG box protein Hmo1 Positive GeneticPMID:18818364
mhf2FANCM-MHF complex subunit Mhf2 Negative GeneticPMID:22681890
rox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:23604080
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
msn5karyopherin (predicted) Negative GeneticPMID:18818364
pmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
nto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
rpl280160S ribosomal protein L27/L28 Negative GeneticPMID:22681890
SPBC25H2.15SSU-rRNA maturation protein Tsr4 homolog 1 (predicted) Negative GeneticPMID:22681890
rps170240S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
chp1chromodomain protein Chp1 Positive GeneticPMID:18818364
sgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
alp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
rps100140S ribosomal protein S10 (predicted) Negative GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor Reb1 Negative GeneticPMID:18818364
mak3histidine kinase Mak3 Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
yox1MBF complex corepressor Yox1 Positive GeneticPMID:22681890
SPAC3A11.07NADH dehydrogenase (predicted) Positive GeneticPMID:22681890
SPAC3A11.13prefoldin subunit 6 (predicted) Negative GeneticPMID:18818364
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
ptr2PTR family peptide transporter Ptr2 Negative GeneticPMID:22681890
cbp1CENP-B homolog Negative GeneticPMID:18818364
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
shk2PAK-related kinase Shk2 Negative GeneticPMID:18818364
mug30ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:18818364
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
ubp3ubiquitin C-terminal hydrolase Ubp3 Phenotypic SuppressionPMID:21892171
SPBC9B6.03zf-FYVE type zinc finger protein Positive GeneticPMID:22681890
SPAC30D11.14cRNA-binding protein (predicted) Negative GeneticPMID:22681890
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
msd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
rps340S ribosomal protein S3 (predicted) Positive GeneticPMID:22681890
emp24COPII-coated vesicle component Emp24 (predicted) Negative GeneticPMID:22681890
rpl230160S ribosomal protein L23 Negative GeneticPMID:22681890
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
ura1carbamoyl-phosphate synthase (glutamine hydrolyzing), aspartate carbamoyltransferase Ura1 Negative GeneticPMID:22681890
chl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC16E8.12cING family homolog Png3 (predicted) Positive GeneticPMID:22681890
SPAC10F6.08cHMG box protein Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
bub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pmk1MAP kinase Pmk1 Positive GeneticPMID:18818364
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
apl5AP-3 adaptor complex subunit Apl5 (predicted) Positive GeneticPMID:22681890
gpd3glyceraldehyde 3-phosphate dehydrogenase Gpd3 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
atf1transcription factor, Atf-CREB family Atf1 Phenotypic EnhancementPMID:15218150
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
mug129sequence orphan Negative GeneticPMID:22681890
SPCPB16A4.05curease accessory protein UREG (predicted) Negative GeneticPMID:22681890
atp12F1-ATPase chaperone Atp12 (predicted) Negative GeneticPMID:22681890
rps190240S ribosomal protein S19 (predicted) Negative GeneticPMID:22681890
rps40240S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
abo2ATPase with bromodomain protein (predicted) Negative GeneticPMID:18818364
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
SPBC1348.01S. pombe specific DUF999 protein family 5 Negative GeneticPMID:22681890
mit1SHREC complex subunit Mit1 Positive GeneticPMID:18818364
tos4FHA domain protein Tos4 (predicted) Positive GeneticPMID:18818364
zrg17cation diffusion family zinc membrane transporter Zrg17 Negative GeneticPMID:22681890
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:18818364
dcr1dicer Phenotypic SuppressionPMID:22989756
Dosage RescuePMID:14699070
SPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
bqt4bouquet formation protein Bqt4 Negative GeneticPMID:22681890
tfs1transcription elongation factor TFIIS Phenotypic SuppressionPMID:21892171
Synthetic Rescue
Positive GeneticPMID:22681890
hht3histone H3 h3.3 Positive GeneticPMID:22681890
rps40140S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
mex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
tri1triman, ribonuclease involved in priRNA formation Tri1 Affinity Capture-MSPMID:24095277
Reconstituted Complex
deb1transcription factor Deb1/Rdp1 Affinity Capture-WesternPMID:16734665
arb1argonaute inhibitor protein 1 Affinity Capture-MSPMID:24095277
Affinity Capture-MSPMID:22989756
rik1silencing protein Rik1 Affinity Capture-WesternPMID:20705239
arb2argonaute binding protein 2 Affinity Capture-MSPMID:24095277
Affinity Capture-MSPMID:22989756
stc1LIM-like protein linking chromatin modification to RNAi, Stc1 Reconstituted ComplexPMID:23613586
Reconstituted ComplexPMID:20211136
Affinity Capture-Western
tas3RITS complex subunit 3 Two-hybridPMID:14704433
Affinity Capture-MS
Affinity Capture-MSPMID:24095277
Reconstituted ComplexPMID:17891150
Affinity Capture-WesternPMID:17531816
dcr1dicer Co-fractionationPMID:16734665
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Affinity Capture-MSPMID:15607976
clr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:20211136
rad2514-3-3 protein Rad25 Affinity Capture-WesternPMID:17043360
rad2414-3-3 protein Rad24 Affinity Capture-WesternPMID:17043360
dsh1RNAi protein, Dsh1 Affinity Capture-WesternPMID:22895252
chp1chromodomain protein Chp1 Affinity Capture-WesternPMID:14704433
Affinity Capture-MSPMID:24095277
Affinity Capture-MSPMID:15607976
Affinity Capture-WesternPMID:17531816
cut7kinesin-like protein Cut7 Reconstituted ComplexPMID:19883398
ptr1HECT-type ubiquitin ligase E3 Ptr1 Affinity Capture-WesternPMID:22989756
Affinity Capture-MS
External References
Database Identifier Description
NBRP SPCC736.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC736.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC736.11 BioGRID Interaction Datasets
Expression Viewer SPCC736.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC736.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC736.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC736.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC736.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC736.11 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC736.11 Cell Cycle Data
GEO SPCC736.11 GEO profiles
PInt SPCC736.11 Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2539403argonaute
WikiGene2539403argonaute
SPD / RIKEN29/29F08Orfeome Localization Data
UniProtKB/SwissProtO74957Protein argonaute
ModBaseO74957Database of comparative protein structure models
StringO74957Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587782argonaute
RefSeq mRNANM_001022775972h- argonaute (ago1), mRNA
European Nucleotide ArchiveCAA19275ENA Protein Mapping
UniParcUPI000012D2A7UniProt Archive

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Release Version: PomBase:21_41 - 24 Feb 2014