ctt1 (SPCC757.07c)


Gene Standard Namectt1 Characterisation Statuspublished
Systematic IDSPCC757.07c Feature Typeprotein coding
Synonymscta1 Name Description
Productcatalase Product Size512aa, 58.28 kDa
Genomic Location Chromosome III, 58865-56654 (2212nt); CDS:58465-56927 (1539nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
catalase activity1
Annotation ExtensionEvidenceWith/FromReference
heme binding11
Annotation ExtensionEvidenceWith/FromReference
metal ion binding747
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular response to oxidative stress52
Annotation ExtensionEvidenceWith/FromReference
hydrogen peroxide catabolic process7
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
mitochondrial matrix155
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
peroxisomal matrix3
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
normal anaerobic cell population growthctt1ΔNull8
normal growth on glucose carbon sourcectt1ΔNull200
normal vegetative cell population growthctt1ΔNull717
normal viability in stationary phasectt1+ (wild type)Overexpression21
resistance to hydrogen peroxidectt1+ (wild type)Overexpression73
sensitive to hydrogen peroxidectt1ΔNull137
viable vegetative cell populationctt1ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
abnormal hydrogen peroxide catabolismctt1ΔNull1
abnormal nucleosome positioningctt1.G4BS (ATGACGT-435CGGAAGACTCTCCTCCG)Not specified4
abolished catalase activityctt1ΔNull1
normal cellular reactive oxygen species level during vegetative growthctt1ΔNull6
viable vegetative cell, abnormal cell shape, normal cell sizectt1ΔNull215
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in atf1 transcription factor, Atf-CREB family Atf1 PMID:8824588
FYPO affected by mutation in dps1 decaprenyl diphosphate synthase subunit Dps1 PMID:14695938
FYPO affected by mutation in ecl1 extender of the chronological lifespan protein Ecl1 PMID:22212525
FYPO affected by mutation in ecl2 extender of the chronological lifespan protein Ecl2 PMID:22212525
FYPO affected by mutation in ecl3 extender of the chronological lifespan protein Ecl3 PMID:22212525
FYPO affected by mutation in elp3 elongator complex subunit Elp3 (predicted) PMID:23874237
FYPO affected by mutation in gcn5 SAGA complex histone acetyltransferase catalytic subunit Gcn5 PMID:23874237
FYPO affected by mutation in mcs4 response regulator Mcs4 PMID:9136929
FYPO affected by mutation in pap1 transcription factor Pap1/Caf3 PMID:10348908
FYPO affected by mutation in pap1 transcription factor Pap1/Caf3 PMID:18758731
FYPO affected by mutation in pap1 transcription factor Pap1/Caf3 PMID:9585505
FYPO affected by mutation in prr1 transcription factor Prr1 PMID:10348908
FYPO affected by mutation in sty1 MAP kinase Sty1 PMID:9136929
FYPO affected by mutation in sty1 MAP kinase Sty1 PMID:9585505
FYPO affected by mutation in trx1 cytosolic thioredoxin Trx1 PMID:18758731
FYPO affected by mutation in upf1 ATP-dependent RNA helicase Upf1 PMID:16914721
FYPO affected by mutation in win1 MAP kinase kinase kinase Win1 PMID:9450957
FYPO affected by mutation in wis1 MAP kinase kinase Wis1 PMID:9718372
FYPO affected by mutation in wis4 MAP kinase kinase kinase Wis4 PMID:9450957
GO regulated by pap1 transcription factor Pap1/Caf3 PMID:9585505
GO regulated by sty1 MAP kinase Sty1 PMID:9585505
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons58865..56654
mRNA58865..56654
5' UTR58865..58466PMID:21511999
CDS58465..56927
3' UTR56926..56654PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00199 Pfam IPR011614 Catalase core domain 13 392 1
PF06628 Pfam IPR010582 Catalase immune-responsive domain 423 485 1
SM01060 SMART IPR011614 Catalase core domain 13 397 1
PS51402 Prosite Profiles IPR018028 Catalase, mono-functional, haem-containing 9 491 1
PS00437 Prosite Patterns IPR002226 Catalase haem-binding site 340 348 1
PS00438 Prosite Patterns IPR024708 Catalase active site 49 65 1
PTHR11465 HMMPANTHER IPR018028 Catalase, mono-functional, haem-containing 10 506 1
2.40.180.10 Gene3D IPR011614 Catalase core domain 3 364 1
SSF56634 SuperFamily IPR020835 Catalase-like domain 8 497 1
PIRSF038928 PIRSF IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 1 491 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 89 107 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 129 147 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 327 353 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 295 322 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 26 49 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 110 127 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.83 Da
Charge 3.50
Isoelectric point 6.88
Molecular weight 58.28 kDa
Number of residues 512
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS512 1672
Annotation ExtensionEvidenceResidueReference
experimental evidence S512 PMID:24763107
phosphorylated residue 1926
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0070301Northern assay evidencePMID:24118096
present during GO:0072690Northern assay evidencePMID:10348908
present during GO:0072690Northern assay evidencePMID:23874237
unchanged during GO:0071493Northern assay evidencePMID:8537298
increased during GO:0070301Northern assay evidencePMID:23874237
unchanged during GO:0071276Northern assay evidencePMID:8537298
increased during GO:0070301Northern assay evidencePMID:10348908
increased during GO:0034599expression microarray evidencePMID:12529438
increased in presence of cadmium sulfate expression microarray evidencePMID:12529438
unchanged during GO:0071287Northern assay evidencePMID:8537298
unchanged during GO:0070417Northern assay evidencePMID:8537298
increased during GO:0071470expression microarray evidencePMID:12529438
increased during GO:0070301Northern assay evidencePMID:18758731
increased during GO:0036245Northern assay evidencePMID:8537298
increased during GO:0071494Northern assay evidencePMID:8537298
increased during GO:0071471Northern assay evidencePMID:8537298
increased during GO:0071475Northern assay evidencePMID:8537298
increased during GO:0034605expression microarray evidencePMID:12529438
increased during GO:0070301Northern assay evidencePMID:9450957
increased during GO:0072709Northern assay evidencePMID:8824588
increased during GO:0070301Northern assay evidencePMID:9585505
increased during GO:0070301Northern assay evidencePMID:8537298
increased in presence of methyl methanesulfonate expression microarray evidencePMID:12529438
absent during GO:0072690Northern assay evidencePMID:9585505

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
47621during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
48371during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
49657during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
44065during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
45444during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
7296.16during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
28579.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
peroxisomal defects8
acatalasia1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
conserved in metazoa3430
conserved in vertebrates3405
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byhhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
affinity captured byhhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
rescuesecl1extender of the chronological lifespan protein Ecl1 Phenotypic SuppressionPMID:24696293
rescuesecl1extender of the chronological lifespan protein Ecl1 Phenotypic SuppressionPMID:22212525
rescuesecl2extender of the chronological lifespan protein Ecl2 Phenotypic SuppressionPMID:22212525
rescuesecl3extender of the chronological lifespan protein Ecl3 Phenotypic SuppressionPMID:22212525
rescued by overexpression ofgpx1glutathione peroxidase Gpx1 Dosage RescuePMID:10455235
overexpression rescuespap1transcription factor Pap1/Caf3 Dosage RescuePMID:24521463
synthetic growth defect withtpx1thioredoxin peroxidase Tpx1 Synthetic Growth DefectPMID:24521463
overexpression rescuestpx1thioredoxin peroxidase Tpx1 Dosage RescuePMID:24521463
enhances phenotype oftpx1thioredoxin peroxidase Tpx1 Phenotypic EnhancementPMID:24521463
synthetic lethal withtpx1thioredoxin peroxidase Tpx1 Synthetic LethalityPMID:24521463
synthetic lethal withtrr1thioredoxin reductase Trr1 Synthetic LethalityPMID:24521463
External References
Database Identifier Description
NBRP SPCC757.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC757.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC757.07c BioGRID Interaction Datasets
Expression Viewer SPCC757.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC757.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC757.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC757.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC757.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC757.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC757.07c Cell Cycle Data
GEO SPCC757.07c GEO profiles
PInt SPCC757.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC757.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC757.07c Fission yeast phenotypic data & analysis
SPD / RIKEN24/24H11Orfeome Localization Data
IntEnz1.11.1.6Integrated relational Enzyme database
Rhea1.11.1.6Annotated reactions database
UniProtKB/SwissProtP55306Catalase
ModBaseP55306Database of comparative protein structure models
STRINGP55306Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587682catalase
RefSeq mRNANM_001022677972h- catalase (ctt1), mRNA
European Nucleotide ArchiveD89126ENA EMBL mapping
European Nucleotide ArchiveBAA09526.1ENA Protein Mapping
European Nucleotide ArchiveCAA21232.1ENA Protein Mapping
MetaCycPWY-5506Methanol oxidation to formaldehyde IV
KEGG_Enzyme00380+1.11.1.6Tryptophan metabolism
KEGG_Enzyme00630+1.11.1.6Glyoxylate and dicarboxylate metabolism
UniParcUPI000012707FUniProt Archive

Literature for ctt1

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015