ctt1 (SPCC757.07c)


Gene Standard Namectt1 Characterisation Statuspublished
Systematic IDSPCC757.07c Feature Typeprotein coding
Synonymscta1 Name Description
Productcatalase Product Size512aa, 58.28 kDa
Genomic Location Chromosome III, 58865-56654 (2212nt); CDS:58465-56927 (1539nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004096catalase activityISOSGD:S000002664GO_REF:00000241
IMPPMID:10380645
GO:0020037heme bindingIEAIPR002226GO_REF:000000212
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037748
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0042744hydrogen peroxide catabolic processIMPPMID:245214635
IMPPMID:10380645
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0005759mitochondrial matrixISOSGD:S000002664GO_REF:0000024152
GO:0005634nucleusIDAPMID:168233722740
GO:0005782peroxisomal matrixISOSGD:S000002664GO_REF:00000243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001753normal anaerobic cell population growthCell growth assayctt1ΔNullPECO:0000102, PECO:0000137PMID:245214637
FYPO:0001164normal growth on glucose carbon sourceCell growth assayctt1ΔNullPECO:0000102, PECO:0000137PMID:24521463156
FYPO:0001357normal vegetative cell population growthCell growth assayctt1ΔNullPECO:0000103, PECO:0000126, PECO:0000005PMID:10380645562
FYPO:0001103resistance to hydrogen peroxideCell growth assayctt1+ (wild type)OverexpressionPECO:0000126, PECO:0000102PMID:2452146360
Cell growth assayctt1+ (wild type)OverexpressionPECO:0000103, PECO:0000005PMID:10380645
FYPO:0000087sensitive to hydrogen peroxideCell growth assayctt1ΔNullPECO:0000102, PECO:0000137PMID:24521463122
Cell growth assayctt1ΔNullPECO:0000025, PECO:0000137, PECO:0000005PMID:10380645
Cell growth assayctt1ΔNullPECO:0000005, PECO:0000137PMID:10380645
FYPO:0002060viable vegetative cell populationMicroscopyctt1ΔNullPMID:204732893730
Microscopyctt1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0003229abnormal hydrogen peroxide catabolismSubstance quantification evidencectt1ΔNullPMID:245214631
FYPO:0001105abolished catalase activityEnzyme assay datactt1ΔNullPMID:103806451
FYPO:0003118normal cellular reactive oxygen species level during vegetative growthSubstance quantification evidencectt1ΔNullPMID:245214633
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell size215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopyctt1ΔNullPECO:0000137, PECO:0000005PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in dps1 decaprenyl diphosphate synthase subunit Dps1 PMID:14695938
FYPO affected by mutation in elp3 elongator complex subunit Elp3 (predicted) PMID:23874237
FYPO affected by mutation in gcn5 SAGA complex histone acetyltransferase catalytic subunit Gcn5 PMID:23874237
FYPO affected by mutation in pap1 transcription factor Pap1/Caf3 PMID:18758731
FYPO affected by mutation in pap1 transcription factor Pap1/Caf3 PMID:9585505
FYPO affected by mutation in pap1 transcription factor Pap1/Caf3 PMID:10348908
FYPO affected by mutation in prr1 transcription factor Prr1 PMID:10348908
FYPO affected by mutation in sty1 MAP kinase Sty1 PMID:9585505
FYPO affected by mutation in trx1 cytosolic thioredoxin Trx1 PMID:18758731
FYPO affected by mutation in wis1 MAP kinase kinase Wis1 PMID:9718372
GO regulated by pap1 transcription factor Pap1/Caf3 PMID:9585505
GO regulated by sty1 MAP kinase Sty1 PMID:9585505
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
15886556654

UTRs

Region Coordinates Reference
five_prime_UTR58865..58466PMID:21511999
three_prime_UTR56926..56654PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06628 Pfam IPR010582 Catalase immune-responsive domain 423 485 1
PF00199 Pfam IPR011614 Catalase core domain 13 392 1
SM01060 SMART IPR011614 Catalase core domain 13 397 1
PS51402 Prosite Profiles IPR018028 Catalase, mono-functional, haem-containing 9 491 1
PS00437 Prosite Patterns IPR002226 Catalase haem-binding site 340 348 1
PS00438 Prosite Patterns IPR024708 Catalase active site 49 65 1
PTHR11465 HMMPANTHER IPR018028 Catalase, mono-functional, haem-containing 10 506 1
2.40.180.10 Gene3D IPR011614 Catalase core domain 3 364 1
SSF56634 SuperFamily IPR020835 Catalase-like domain 8 497 1
PIRSF038928 PIRSF IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 1 492 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 110 127 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 327 353 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 89 107 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 26 49 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 129 147 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 295 322 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.83 Da
Charge 3.50
Isoelectric point 6.88
Molecular weight 58.28 kDa
Number of residues 512
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS512PMID:247631071669
MOD:00696phosphorylated residueNASPMID:195477441921
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0034605expression microarray evidencePMID:12529438
increased during GO:0071470expression microarray evidencePMID:12529438
increased during GO:0034599expression microarray evidencePMID:12529438
increased in presence of cadmium sulfate expression microarray evidencePMID:12529438
unchanged during GO:0070417Northern assay evidencePMID:8537298
increased during GO:0070301Northern assay evidencePMID:18758731
increased during GO:0036245Northern assay evidencePMID:8537298
increased during GO:0071494Northern assay evidencePMID:8537298
increased during GO:0071471Northern assay evidencePMID:8537298
increased during GO:0071475Northern assay evidencePMID:8537298
increased during GO:0070301Northern assay evidencePMID:8537298
increased during GO:0070301Northern assay evidencePMID:9585505
absent during GO:0072690Northern assay evidencePMID:9585505
increased in presence of methyl methanesulfonate expression microarray evidencePMID:12529438
present during GO:0072690Northern assay evidencePMID:10348908
increased during GO:0070301Northern assay evidencePMID:10348908
present during GO:0072690Northern assay evidencePMID:23874237
increased during GO:0070301Northern assay evidencePMID:24118096
unchanged during GO:0071493Northern assay evidencePMID:8537298
increased during GO:0070301Northern assay evidencePMID:23874237
unchanged during GO:0071287Northern assay evidencePMID:8537298
unchanged during GO:0071276Northern assay evidencePMID:8537298

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
47621during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
48371during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
49657during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
44065during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
7296.16during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
45444during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
28579.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
peroxisomal defects8
acatalasia1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3393
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ecl2extender of the chronological lifespan protein Ecl2 Phenotypic SuppressionPMID:22212525
ecl1extender of the chronological lifespan protein Ecl1 Phenotypic SuppressionPMID:24696293
Phenotypic SuppressionPMID:22212525
ecl3extender of the chronological lifespan protein Ecl3 Phenotypic SuppressionPMID:22212525
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC757.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC757.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC757.07c BioGRID Interaction Datasets
Expression Viewer SPCC757.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC757.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC757.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC757.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC757.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC757.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC757.07c Cell Cycle Data
GEO SPCC757.07c GEO profiles
PInt SPCC757.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC757.07c Peptides identified in tandem mass spectrometry proteomics experiments
IntEnz1.11.1.6Integrated relational Enzyme database
Rhea1.11.1.6Annotated reactions database
SPD / RIKEN24/24H11Orfeome Localization Data
WikiGene2539418catalase
EntrezGene2539418catalase
UniProtKB/SwissProtP55306Catalase
ModBaseP55306Database of comparative protein structure models
STRINGP55306Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587682catalase
RefSeq mRNANM_001022677972h- catalase (ctt1), mRNA
European Nucleotide ArchiveD89126ENA EMBL mapping
European Nucleotide ArchiveBAA09526ENA Protein Mapping
European Nucleotide ArchiveBAA09526.1ENA Protein Mapping
European Nucleotide ArchiveBAA13788ENA Protein Mapping
European Nucleotide ArchiveCAA21232ENA Protein Mapping
European Nucleotide ArchiveCAA21232.1ENA Protein Mapping
ReactomeREACT_219607
ReactomeREACT_223903
UniParcUPI000012707FUniProt Archive

Literature for ctt1

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014