ctt1 (SPCC757.07c)


Gene Standard Namectt1 Characterisation Statuspublished
Systematic IDSPCC757.07c Feature Typeprotein coding
Synonymscta1 Name Description
Productcatalase Product Size512aa, 58.28 kDa
Genomic Location Chromosome III, 58865-56654 (2212nt); CDS:58465-56927 (1539nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004096catalase activityISOSGD:S000002664GO_REF:00000241
IMPPMID:10380645
GO:0020037heme bindingIEAIPR002226GO_REF:000000212
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0042744hydrogen peroxide catabolic processIMPPMID:103806455
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0005759mitochondrial matrixISOSGD:S000002664GO_REF:0000024152
GO:0005634nucleusIDAPMID:168233722730
GO:0005782peroxisomal matrixISOSGD:S000002664GO_REF:00000243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001357normal vegetative cell population growthCell growth assayctt1ΔNullPECO:0000103, PECO:0000126, PECO:0000005PMID:10380645415
FYPO:0001103resistance to hydrogen peroxideCell growth assayctt1+ (wild type)OverexpressionPECO:0000103, PECO:0000005PMID:1038064559
FYPO:0000087sensitive to hydrogen peroxideCell growth assayctt1ΔNullPECO:0000005, PECO:0000137PMID:10380645112
Cell growth assayctt1ΔNullPECO:0000025, PECO:0000137, PECO:0000005PMID:10380645
FYPO:0002060viable vegetative cell populationMicroscopyctt1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyctt1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001105abolished catalase activityEnzyme assay datactt1ΔNullPMID:103806451
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell sizeMicroscopyctt1ΔNullPECO:0000137, PECO:0000005PMID:23697806215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Target Of
RelationshipGeneProductReference
regulated by pap1 transcription factor Pap1/Caf3 PMID:9585505
regulated by prr1 transcription factor Prr1 PMID:10348908
regulated by sty1 MAP kinase Sty1 PMID:9585505
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
15886556654

UTRs

Region Start End Reference
three_prime_UTR5692656654PMID:21511999
five_prime_UTR5886558466PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00199 Pfam IPR011614 Catalase core domain 13 392 1
PF06628 Pfam IPR010582 Catalase immune-responsive domain 423 485 1
SM01060 SMART IPR011614 Catalase core domain 13 397 1
PS51402 Prosite Profiles IPR018028 Catalase, mono-functional, haem-containing 9 491 1
PS00437 Prosite Patterns IPR002226 Catalase haem-binding site 340 348 1
PS00438 Prosite Patterns IPR024708 Catalase haem-binding site 49 65 1
PTHR11465:SF0 HMMPANTHER 10 507 1
PTHR11465 HMMPANTHER IPR018028 Catalase, mono-functional, haem-containing 10 507 1
G3DSA:2.40.180.10 Gene3D IPR011614 3 364 1
SSF56634 SuperFamily IPR020835 8 497 1
PIRSF038928 PIRSF IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 1 492 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 89 107 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 327 353 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 129 147 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 26 49 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 295 322 1
PR00067 PRINTS IPR018028 Catalase, mono-functional, haem-containing 110 127 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.83 Da
Charge 3.50
Isoelectric point 6.88
Molecular weight 58.28 kDa
Number of residues 512
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased,
in presence of cadmium sulfate
expression microarray evidencePMID:12529438
increasedexpression microarray evidencePMID:12529438
during GO:0034605
increasedexpression microarray evidencePMID:12529438
during GO:0034599
increasedexpression microarray evidencePMID:12529438
during GO:0071470
increased,
in presence of methyl methanesulfonate
expression microarray evidencePMID:12529438
increasedNorthern assay evidencePMID:8537298
during GO:0071494
unchangedNorthern assay evidencePMID:8537298
during GO:0071287
unchangedNorthern assay evidencePMID:8537298
during GO:0070417
unchangedNorthern assay evidencePMID:8537298
during GO:0071493
unchangedNorthern assay evidencePMID:8537298
during GO:0071276
increasedNorthern assay evidencePMID:8537298
during GO:0071471
increasedNorthern assay evidencePMID:18758731
during GO:0070301
increasedNorthern assay evidencePMID:8537298
during GO:0036245
increasedNorthern assay evidencePMID:9585505
during GO:0070301
absentNorthern assay evidencePMID:9585505
during GO:0072690
increasedNorthern assay evidencePMID:8537298
during GO:0071475
increasedNorthern assay evidencePMID:8537298
during GO:0070301

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
7296.16during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
28579.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
peroxisomal defects8
acatalasia1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ecl2extender of the chronological lifespan protein Ecl2 Phenotypic SuppressionPMID:22212525
ecl1extender of the chronological lifespan protein Ecl1 Phenotypic SuppressionPMID:22212525
ecl3extender of the chronological lifespan protein Ecl3 Phenotypic SuppressionPMID:22212525
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC757.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC757.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC757.07c BioGRID Interaction Datasets
Expression Viewer SPCC757.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC757.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC757.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC757.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC757.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC757.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC757.07c Cell Cycle Data
GEO SPCC757.07c GEO profiles
PInt SPCC757.07c Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz1.11.1.6Integrated relational Enzyme database
Rhea1.11.1.6Annotated reactions database
SPD / RIKEN24/24H11Orfeome Localization Data
WikiGene2539418catalase
EntrezGene2539418catalase
UniProtKB/SwissProtP55306Catalase
ModBaseP55306Database of comparative protein structure models
StringP55306Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587682catalase
RefSeq mRNANM_001022677972h- catalase (ctt1), mRNA
European Nucleotide ArchiveBAA09526ENA Protein Mapping
European Nucleotide ArchiveBAA13788ENA Protein Mapping
European Nucleotide ArchiveCAA21232ENA Protein Mapping
UniParcUPI000012707FUniProt Archive

Literature for ctt1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014