rnc1 (SPCC757.09c)

Gene Standard Namernc1 ChromosomeIII
Systematic IDSPCC757.09c Gene Start66972
Synonyms Gene End64099
ProductRNA-binding protein that suppresses calcineurin deletion Rnc1 Gene Length2874
Feature Typeprotein coding CDS Start66685
Name Description CDS End65489
Characterisation Statuspublished CDS Length1197

Ensembl Gene Location
  1. ctt1
  2. cox14
  3. SPNCRNA.453
  4. rrp45
  5. rnc1
  6. vph2
  7. SPCC757.11c
  8. SPCTRNAHIS.03
  9. SPCC757.12
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000085sensitive to camptothecincompetitive growth assay evidencernc1delta (deletion)deletionPMID:20537132
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencernc1delta (deletion)deletionPMID:20537132
FYPO:0002060viable vegetative cell populationMicroscopyrnc1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003729mRNA bindingIPIpmp1PMID:12931193
GO:0005515protein bindingIPIpmk1PMID:12931193
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0043409negative regulation of MAPK cascadeIGIpmp1PMID:12931193
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
16697264099

References

Region Start End Reference
five_prime_UTR6697266686PMID:21511999
three_prime_UTR6548864099PMID:21511999
three_prime_UTR6548864099PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00013 IPR004088 Pfam K Homology domain, type 1 100 155 5
PF00013 IPR004088 Pfam K Homology domain, type 1 322 385 5
PF00013 IPR004088 Pfam K Homology domain, type 1 181 243 5
SM00322 IPR004087 SMART K Homology domain 177 248 8
SM00322 IPR004087 SMART K Homology domain 92 162 8
SM00322 IPR004087 SMART K Homology domain 319 390 8
PS50084 IPR004088 Prosite Profiles K Homology domain, type 1 93 157 4
PS50084 IPR004088 Prosite Profiles K Homology domain, type 1 178 243 4
PS50084 IPR004088 Prosite Profiles K Homology domain, type 1 320 385 4
G3DSA:3.30.1370.10 Gene3D 91 164 8
G3DSA:3.30.1370.10 Gene3D 176 246 8
G3DSA:3.30.1370.10 Gene3D 318 389 8
SSF54791 SuperFamily 90 163 9
SSF54791 SuperFamily 170 251 9
SSF54791 SuperFamily 317 389 9
PTHR10288:SF29 hmmpanther 83 397 1
PTHR10288 hmmpanther 83 397 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:12931193

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000766KH domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000766

Protein Properties

Ave. residue weight 108.99 Da
Charge 4.00
Isoelectric point 7.61
Molecular weight 43.38 kDa
Number of residues 398
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide26554.51PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide14160.29PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide6PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide28PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
snz1pyridoxine biosynthesis protein Negative GeneticPMID:22681890
SPAC3H8.02sec14 cytosolic factor family phosphatidylinositol transporter (predicted) Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
tpp1trehalose-6-phosphate phosphatase Tpp1 Negative GeneticPMID:22681890
tip1CLIP170 family protein Tip1 Positive GeneticPMID:22681890
git3G-protein coupled receptor Git3 Negative GeneticPMID:22681890
fbp1fructose-1,6-bisphosphatase Fbp1 Positive GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Dosage RescuePMID:12931193
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
pfa3palmitoyltransferase Pfa3 (predicted) Negative GeneticPMID:22681890
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
pmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:18818364
rpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
rga2Rho-type GTPase activating protein Rga2 (predicted) Negative GeneticPMID:22681890
SPCC1919.05Ski complex TPR repeat subunit Ski3 (predicted) Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
erd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
SPBC21D10.09cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
cbs2protein kinase activator (predicted) Negative GeneticPMID:18818364
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Positive GeneticPMID:21504829
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
gef1RhoGEF Gef1 Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
SPAC4H3.07cprotein phosphatase Fmp31 (predicted) Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Positive GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:18818364
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
SPAC227.17cconserved protein Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
naa38NatC N-acetyltransferase non catalytic Sm-like domain subunit Naa38 (predicted) Negative GeneticPMID:22681890
bun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:18818364
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
cgs2cAMP-specific phosphodiesterase Cgs2 Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
SPAC222.08cglutamine aminotransferase subunit (predicted) Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
rav2RAVE complex subunit Rav2 Negative GeneticPMID:22681890
rox3mediator complex subunit Med19/Rox3 Negative GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
png2ING family homolog Png2 Negative GeneticPMID:18818364
git5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
liz1pantothenate transporter Liz1 Negative GeneticPMID:22681890
swi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
msh6MutS protein homolog Negative GeneticPMID:18818364
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:18818364
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC13G7.12ccholine kinase (predicted) Positive GeneticPMID:22681890
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
SPCC584.11cSvf1 family protein Svf1 Negative GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
SPAC1B3.02ctranscription elongation factor, Elf1 family (predicted) Positive GeneticPMID:22681890
SPAC977.05cconserved fungal family Negative GeneticPMID:22681890
rec14Ski complex subunit Rec14 Negative GeneticPMID:22681890
SPBP35G2.14RNA-binding protein Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
alm1medial ring protein Alm1 Negative GeneticPMID:22681890
SPAC3G9.05GTPase activating protein (predicted) Negative GeneticPMID:22681890
plb1phospholipase B homolog Plb1 Negative GeneticPMID:22681890
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
SPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:22681890
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
dph5diphthine synthase Dph5 (predicted) Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
SPCC126.07chuman CTD-binding SR-like protein rA9 homolog (predicted) Positive GeneticPMID:18818364
ppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
gcd10tRNA (m1A) methyltransferase, translation initiation factor eIF-3 gamma subunit Gcd10 (predicted) Negative GeneticPMID:22681890
mak3histidine kinase Mak3 Negative GeneticPMID:22681890
sen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rec11meiotic cohesin complex subunit Rec11 Negative GeneticPMID:22681890
SPAC1D4.01human C9orf78 ortholog Negative GeneticPMID:22681890
ilv1acetolactate synthase catalytic subunit Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
SPBC13E7.08cRNA polymerase II associated Paf1 complex (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mak10NatC N-acetyltransferase complex subunit Mak10 (predicted) Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
cwf19complexed with Cdc5 protein Cwf19 Negative GeneticPMID:22681890
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
met14adenylyl-sulfate kinase (predicted) Positive GeneticPMID:22681890
bst1GPI inositol deacylase Bst1 (predicted) Negative GeneticPMID:22681890
wtf15wtf element Wtf15 Negative GeneticPMID:22681890
mlh1MutL family protein Mlh1 (predicted) Negative GeneticPMID:18818364
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:22681890
SPAC17H9.04cRNA-binding protein Negative GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC29A10.16ccytochrome b5 (predicted) Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
nrc1bromodomain protein (predicted) Negative GeneticPMID:18818364
sec28coatomer epsilon subunit (predicted) Negative GeneticPMID:18818364
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Positive GeneticPMID:22681890
ppb1calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1 Dosage RescuePMID:12931193
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
SPAC26H5.09cgfo/idh/mocA family oxidoreductase (predicted) Negative GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
pmk1MAP kinase Pmk1 Biochemical ActivityPMID:12931193
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
pmp1dual-specificity MAP kinase phosphatase Pmp1 Affinity Capture-WesternPMID:12931193
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External References
Database Identifier Description
NBRP SPCC757.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC757.09c Retrieval of eukaryotic orthologs
BioGrid SPCC757.09c BioGRID Interaction Datasets
Bähler Lab SPCC757.09c Cell Cycle Expression Profile
Bähler Lab SPCC757.09c Meiosis/Sporulation Expression Profies
Bähler Lab SPCC757.09c Pheromone response/mating expression profiles
Bähler Lab SPCC757.09c Environmental stress expression profiles
Bähler Lab SPCC757.09c Bähler Lab Transcriptome Viewer
Cyclebase SPCC757.09c Cell Cycle Data
PInt SPCC757.09c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC757.09c Entrez Gene
EntrezGene2539434RNA-binding protein
Uniprot_genenameRNC1
WikiGene2539434RNA-binding protein
UniProtKB/SwissProtO74919RNA-binding protein rnc1
ModBaseO74919Database of comparative protein structure models
Pfam Protein DomainsO74919Pfam Domain Arrangement
RefSeq PeptideNP_587684RNA-binding protein
RefSeq mRNANM_001022679972h- RNA-binding protein (rnc1), mRNA
European Nucleotide ArchiveCAA21234ENA Protein Mapping
SPD / RIKEN19/19B07Orfeome Localization Data
UniParcUPI000006A460UniProt Archive

Literature for rnc1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013