rnc1 (SPCC757.09c)

Gene Standard Namernc1 Characterisation Statuspublished
Systematic IDSPCC757.09c Feature Typeprotein coding
Synonyms Name DescriptionRNA-binding protein that suppresses Calcineurin deletion
ProductRNA-binding protein that suppresses calcineurin deletion Rnc1 Product Size398aa, 43.38 kDa
Genomic Location Chromosome III, 66972-64099 (2874nt); CDS:66685-65489 (1197nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
mRNA 3'-UTR AU-rich region binding3
Annotation ExtensionEvidenceWith/FromReference
mRNA binding29
Annotation ExtensionEvidenceWith/FromReference
protein binding848
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms


Term NameCount
3'-UTR-mediated mRNA stabilization2
Annotation ExtensionEvidenceWith/FromReference
negative regulation of MAPK cascade7
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
normal growth on terbinafinernc1ΔNull37
resistance to caffeine26
expressivity FYPO_EXT:0000001rnc1ΔNull
resistance to hydrogen peroxide72
expressivity FYPO_EXT:0000001rnc1ΔNull
sensitive to camptothecinrnc1ΔNull214
expressivity FYPO_EXT:0000003rnc1ΔNull
sensitive to clotrimazole105
expressivity FYPO_EXT:0000003rnc1ΔNull
sensitive to micafunginrnc1ΔNull116
sensitive to sodium butyrate93
expressivity FYPO_EXT:0000001rnc1ΔNull
sensitive to tacrolimus81
expressivity FYPO_EXT:0000003rnc1ΔNull
sensitive to trichostatin A42
expressivity FYPO_EXT:0000003rnc1ΔNull
sensitive to valproic acid155
expressivity FYPO_EXT:0000001rnc1ΔNull
viable vegetative cell populationrnc1ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
abolished protein phosphorylation during cellular response to heat2
affecting pmk1rnc1+ (wild type)Overexpression
abolished protein phosphorylation during vegetative growth30
affecting rnc1T50A (T50A)Not specified
decreased protein level during vegetative growth80
affecting pmp1rnc1ΔNull
decreased RNA binding10
affecting pmp1 and rnc1G110D (G110D)Not specified
affecting pmp1 and rnc1G195D (G195D)Not specified
affecting pmp1 and rnc1G557D (G557D)Not specified
decreased RNA level during vegetative growth135
affecting pmp1rnc1ΔNull
increased protein phosphorylation during cellular response to heat2
affecting pmk1rnc1ΔNull
increased protein phosphorylation during vegetative growth31
affecting pmk1rnc1ΔNull
increased RNA catabolic process during vegetative growth4
affecting pmp1rnc1ΔNull
normal RNA level during vegetative growth91
affecting pek1rnc1ΔNull
viable vegetative cell, abnormal cell shape, normal cell size215
penetrance FYPO_EXT:0000001, expressivity FYPO_EXT:0000003rnc1ΔNull
Target Of
FYPO affected by mutation in pek1 MAP kinase kinase Pek1 PMID:12931193
FYPO affected by mutation in pmk1 MAP kinase Pmk1 PMID:12931193
FYPO affected by mutation in rnc1 RNA-binding protein that suppresses calcineurin deletion Rnc1 PMID:12931193
GO substrate of pmk1 MAP kinase Pmk1 PMID:12931193
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00013 Pfam IPR004088 K Homology domain, type 1 100 156 5
PF00013 Pfam IPR004088 K Homology domain, type 1 322 384 5
PF00013 Pfam IPR004088 K Homology domain, type 1 181 243 5
SM00322 SMART IPR004087 K Homology domain 92 162 5
SM00322 SMART IPR004087 K Homology domain 177 248 5
SM00322 SMART IPR004087 K Homology domain 319 390 5
PS50084 Prosite Profiles IPR004088 K Homology domain, type 1 93 157 4
PS50084 Prosite Profiles IPR004088 K Homology domain, type 1 320 385 4
PS50084 Prosite Profiles IPR004088 K Homology domain, type 1 178 243 4
PTHR10288:SF102 HMMPANTHER 92 396 1
PTHR10288 HMMPANTHER 92 396 2
3.30.1370.10 Gene3D IPR004088 K Homology domain, type 1 91 164 8
3.30.1370.10 Gene3D IPR004088 K Homology domain, type 1 176 246 8
3.30.1370.10 Gene3D IPR004088 K Homology domain, type 1 318 389 8
SSF54791 SuperFamily IPR004088 K Homology domain, type 1 317 389 9
SSF54791 SuperFamily IPR004088 K Homology domain, type 1 170 251 9
SSF54791 SuperFamily IPR004088 K Homology domain, type 1 90 163 9

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000766KH domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000766

Protein Properties

Ave. residue weight 108.99 Da
Charge 4.00
Isoelectric point 7.61
Molecular weight 43.38 kDa
Number of residues 398

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
present during mitotic M phaseS18
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S18 PMID:21712547
O-phospho-L-threonine 693
added by pmk1T50
Annotation ExtensionEvidenceResidueReference
added by pmk1 IDA T50 PMID:12931193
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
NAS PMID:12931193
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
50319during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
52078during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
47201during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
44239during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
49074during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
26554.51during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
14160.29during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
28during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Two-hybridPMID:23695164
pmp1dual-specificity MAP kinase phosphatase Pmp1 Affinity Capture-WesternPMID:12931193
SPAC19A8.07cU3 snoRNP-associated protein Imp4 (predicted) Two-hybridPMID:23695164
pmk1MAP kinase Pmk1 Biochemical ActivityPMID:12931193
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
liz1pantothenate transmembrane transporter Liz1 Negative GeneticPMID:22681890
msh6MutS protein homolog Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
SPAC1B3.02ctranscription elongation factor, Elf1 family (predicted) Positive GeneticPMID:22681890
met14adenylyl-sulfate kinase (predicted) Positive GeneticPMID:22681890
SPAC4H3.07cprotein phosphatase Fmp31 (predicted) Negative GeneticPMID:22681890
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC29A10.16ccytochrome b5 (predicted) Positive GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
med6mediator complex subunit Med6 Negative GeneticPMID:18818364
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
git3G-protein coupled receptor Git3 Negative GeneticPMID:22681890
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Positive GeneticPMID:22681890
dph5diphthine synthase Dph5 (predicted) Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:18818364
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Positive GeneticPMID:21504829
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
leo1RNA polymerase II associated Paf1 complex (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
SPAC227.17cconserved protein Negative GeneticPMID:22681890
tpp1trehalose-6-phosphate phosphatase Tpp1 Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
cbs2protein kinase activator (predicted) Negative GeneticPMID:18818364
mlh1MutL family protein Mlh1 (predicted) Negative GeneticPMID:18818364
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
csr102sec14 cytosolic factor family phosphatidylinositol transmembrane transporter (predicted) Negative GeneticPMID:22681890
gcd10tRNA (m1A) methyltransferase Gcd10 (predicted) Negative GeneticPMID:22681890
SPAC13G7.12ccholine kinase (predicted) Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
git5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
cwf19complexed with Cdc5 protein Cwf19 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
SPAC26H5.09cgfo/idh/mocA family oxidoreductase (predicted) Negative GeneticPMID:22681890
SPCC1919.05Ski complex TPR repeat subunit Ski3 (predicted) Negative GeneticPMID:18818364
rec14Ski complex subunit Rec14 Negative GeneticPMID:22681890
pbr1ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
rav2RAVE complex subunit Rav2 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:18818364
SPCC584.11cSvf1 family protein Svf1 Negative GeneticPMID:22681890
cgs2cAMP-specific phosphodiesterase Cgs2 Negative GeneticPMID:22681890
rkr1RQC complex ubiquitin-protein ligase E3 Rkr1 (predicted) Negative GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
bdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
mak10NatC N-acetyltransferase complex subunit Mak10 (predicted) Negative GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rga2Rho-type GTPase activating protein Rga2 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:18818364
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
SPAC17H9.04cRNA-binding protein Negative GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
wtf15wtf element Wtf15 Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
snz1pyridoxine biosynthesis protein Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
gef1Cdc42 RhoGEF Gef1 Negative GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
png2ING family homolog Png2 Negative GeneticPMID:18818364
pek1MAP kinase kinase Pek1 Dosage RescuePMID:12931193
bst1GPI inositol deacylase Bst1 (predicted) Negative GeneticPMID:22681890
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
tls1splicing factor Tls1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
rox3mediator complex subunit Med19/Rox3 Negative GeneticPMID:22681890
sen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:22681890
SPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:22681890
pmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:18818364
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
sec28coatomer epsilon subunit (predicted) Negative GeneticPMID:18818364
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
mak3histidine kinase Mak3 Negative GeneticPMID:22681890
naa38NatC N-acetyltransferase non-catalytic Sm-like domain subunit Naa38 (predicted) Negative GeneticPMID:22681890
tip1CLIP170 family protein Tip1 Positive GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
plb1phospholipase B homolog Plb1 Negative GeneticPMID:22681890
ppb1calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1 Dosage RescuePMID:12931193
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:22681890
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
rec11meiotic cohesin complex subunit Rec11 Negative GeneticPMID:22681890
sno1glutamine aminotransferase subunit Sno1 (predicted) Negative GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
erd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
ilv1acetolactate synthase catalytic subunit Negative GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
alm1medial ring protein Alm1 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
SPAC977.05cconserved fungal family Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
fbp1fructose-1,6-bisphosphatase Fbp1 Positive GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Positive GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
pfa3palmitoyltransferase Pfa3 (predicted) Negative GeneticPMID:22681890
SPBP35G2.14RNA-binding protein Negative GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
spa2GTPase activating protein Spa2 (predicted) Negative GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
bun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC757.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC757.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC757.09c BioGRID Interaction Datasets
Expression Viewer SPCC757.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC757.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC757.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC757.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC757.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC757.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC757.09c Cell Cycle Data
GEO SPCC757.09c GEO profiles
PInt SPCC757.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC757.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC757.09c Fission yeast phenotypic data & analysis
SPD / RIKEN19/19B07Orfeome Localization Data
UniProtKB/SwissProtO74919RNA-binding protein rnc1
ModBaseO74919Database of comparative protein structure models
STRINGO74919Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587684RNA-binding protein
RefSeq mRNANM_001022679972h- RNA-binding protein (rnc1), mRNA
European Nucleotide ArchiveCAA21234.1ENA Protein Mapping
UniParcUPI000006A460UniProt Archive

Literature for rnc1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015