efr3 (SPCC794.08)


Gene Standard Nameefr3 Characterisation Statusbiological_role_inferred
Systematic IDSPCC794.08 Feature Typeprotein coding
Synonyms Name Description
ProductHEAT repeat protein, involved in protein localization to plasma membrane (predicted) Product Size798aa, 90.38 kDa
Genomic Location Chromosome III, 265315-268006 (2692nt); CDS:265445-267881 (2437nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0090002establishment of protein localization to plasma membraneISOSGD:S000004825GO_REF:000002420
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005739mitochondrionISOSGD:S000004825GO_REF:0000024758
GO:0005886plasma membraneISOSGD:S000004825GO_REF:0000024242
GO:0043234protein complexNASGO_REF:00000511358
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000245loss of viability in stationary phaseMicroscopyefr3ΔNullPECO:0000005, PECO:0000137PMID:2369780623
FYPO:0002060viable vegetative cell populationMicroscopyefr3ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopyefr3ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002106viable stubby vegetative cell50
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopyefr3ΔNullPECO:0000137, PECO:0000005PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1265315265644
2265685268006

UTRs

Region Coordinates Reference
five_prime_UTR265315..265444PMID:21511999
three_prime_UTR267882..268006PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR12444 HMMPANTHER 5 419 1
SSF48371 SuperFamily IPR016024 Armadillo-type fold 242 522 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 68 129 130

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.26 Da
Charge 21.00
Isoelectric point 8.49
Molecular weight 90.38 kDa
Number of residues 798
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS729PMID:217125471663
present during mitotic M phase
present during mitotic M phaseS700PMID:21712547
present during mitotic M phaseS734PMID:21712547
S210PMID:24763107
level fluctuates during mitotic cell cycleS726PMID:24763107
level fluctuates during mitotic cell cycleS729PMID:24763107
present during mitotic M phaseS726PMID:21712547
present during mitotic M phaseS702PMID:21712547
present during mitotic M phaseS697PMID:21712547
present during mitotic M phaseS210PMID:21712547
present during mitotic M phaseS705PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1460during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2254.08during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1708.21during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
1469during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
1458during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.88during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
4during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC794.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC794.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC794.08 BioGRID Interaction Datasets
Expression Viewer SPCC794.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC794.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC794.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC794.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC794.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC794.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC794.08 Cell Cycle Data
GEO SPCC794.08 GEO profiles
PInt SPCC794.08 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2538740protein efr3
EntrezGene2538740protein efr3
SPD / RIKEN28/28G05Orfeome Localization Data
UniProtKB/SwissProtO59817Protein efr3
ModBaseO59817Database of comparative protein structure models
STRINGO59817Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587756protein efr3
RefSeq mRNANM_001022749972h- protein efr3 (SPCC794.08), mRNA
European Nucleotide ArchiveCAA19135ENA Protein Mapping
European Nucleotide ArchiveCAA19135.1ENA Protein Mapping
UniParcUPI0000069FEBUniProt Archive

Literature for efr3

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014