efr3 (SPCC794.08)


Gene Standard Nameefr3 Characterisation Statusbiological_role_inferred
Systematic IDSPCC794.08 Feature Typeprotein coding
Synonyms Name Description
ProductHEAT repeat protein, involved in protein localization to plasma membrane (predicted) Product Size798aa, 90.38 kDa
Genomic Location Chromosome III, 265315-268006 (2692nt); CDS:265445-267881 (2437nt)

Ensembl Gene Location
GO Biological Process

GO Slim Terms

membrane organization


GO Cellular Component
Term NameCount
mitochondrion761
Annotation ExtensionEvidenceWith/FromReference
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
protein complex1370
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased vegetative cell population growthefr3ΔNull571
loss of viability in stationary phaseefr3ΔNull49
sensitive to bleomycinefr3ΔNull75
sensitive to Calcofluor Whiteefr3ΔNull38
sensitive to thiabendazoleefr3ΔNull219
viable vegetative cell populationefr3ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
mislocalized septum during vegetative growthefr3ΔNull35
septation following abnormal mitotic chromosome segregationefr3ΔNull131
viable stubby vegetative cellefr3ΔNull72
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons265315..265644, 265685..268006
mRNA265315..268006
5' UTR265315..265444PMID:21511999
CDS265445..265644, 265685..267881
3' UTR267882..268006PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR12444 HMMPANTHER 5 419 1
SSF48371 SuperFamily IPR016024 Armadillo-type fold 242 522 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 68 129 130

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.26 Da
Charge 21.00
Isoelectric point 8.49
Molecular weight 90.38 kDa
Number of residues 798
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS210 1672
present during mitotic M phaseS697
present during mitotic M phaseS726
present during mitotic M phaseS729
present during mitotic M phaseS702
present during mitotic M phaseS705
level fluctuates during mitotic cell cycleS726
present during mitotic M phaseS734
level fluctuates during mitotic cell cycleS729
present during mitotic M phaseS700
present during mitotic M phaseS210
Annotation ExtensionEvidenceResidueReference
experimental evidence S210 PMID:24763107
present during mitotic M phase experimental evidence S210 PMID:21712547
present during mitotic M phase experimental evidence S697 PMID:21712547
present during mitotic M phase experimental evidence S700 PMID:21712547
present during mitotic M phase experimental evidence S702 PMID:21712547
present during mitotic M phase experimental evidence S705 PMID:21712547
present during mitotic M phase experimental evidence S726 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S726 PMID:24763107
present during mitotic M phase experimental evidence S729 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S729 PMID:24763107
present during mitotic M phase experimental evidence S734 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1458during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
1469during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2254.08during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1460during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
1708.21during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.88during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC794.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC794.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC794.08 BioGRID Interaction Datasets
Expression Viewer SPCC794.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC794.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC794.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC794.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC794.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC794.08 Transcriptome Viewer (Bähler Lab)
GEO SPCC794.08 GEO profiles
PInt SPCC794.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC794.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC794.08 Fission yeast phenotypic data & analysis
Cyclebase SPCC794.08.1 Cell Cycle Data
SPD / RIKEN28/28G05Orfeome Localization Data
UniProtKB/SwissProtO59817Protein efr3
ModBaseO59817Database of comparative protein structure models
STRINGO59817Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587756protein efr3
RefSeq mRNANM_001022749972h- protein efr3 (SPCC794.08), mRNA
European Nucleotide ArchiveCAA19135.1ENA Protein Mapping
UniParcUPI0000069FEBUniProt Archive

Literature for efr3

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015