efr3 (SPCC794.08)


Gene Standard Nameefr3 Characterisation Statusbiological role inferred
Systematic IDSPCC794.08 Feature Typeprotein coding
Synonyms Name Description
ProductHEAT repeat protein, involved in protein localization to plasma membrane (predicted) Product Size798aa, 90.38 kDa
Genomic Location Chromosome III, 265315-268006 (2692nt); CDS:265445-267881 (2437nt)

Ensembl Gene Location
GO Biological Process

GO Slim Terms

membrane organization


GO Cellular Component
Term NameCount
mitochondrion752
Annotation ExtensionEvidenceWith/FromReference
plasma membrane255
Annotation ExtensionEvidenceWith/FromReference
protein complex1349
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased vegetative cell population growthefr3Δ652
loss of viability in stationary phaseefr3Δ61
sensitive to bleomycinefr3Δ78
sensitive to Calcofluor Whiteefr3Δ43
sensitive to thiabendazoleefr3Δ264
viable vegetative cell populationefr3Δ3837

Cell Phenotype

Term NameGenotypesCount
cutefr3Δ125
mislocalized septum during vegetative growthefr3Δ44
viable stubby vegetative cellefr3Δ75
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons265315..265644, 265685..268006
Intron265645..265684
5' UTR265315..265444PMID:21511999
3' UTR267882..268006PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR12444 HMMPANTHER 1 408 1
SSF48371 SuperFamily IPR016024 Armadillo-type fold 68 129 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 242 522 130

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.26 Da
Charge 21.00
Codon Adaptation Index 0.40
Isoelectric point 8.49
Molecular weight 90.38 kDa
Number of residues 798
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during mitotic M phaseS705
present during mitotic M phaseS729
present during mitotic M phaseS726
present during mitotic M phaseS697
present during mitotic M phaseS210
present during mitotic M phaseS700
present during mitotic M phaseS702
present during mitotic M phaseS734
level fluctuates during mitotic cell cycleS729
level fluctuates during mitotic cell cycleS726
S210
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S705 PMID:21712547
present during mitotic M phase experimental evidence S729 PMID:21712547
present during mitotic M phase experimental evidence S726 PMID:21712547
present during mitotic M phase experimental evidence S697 PMID:21712547
present during mitotic M phase experimental evidence S210 PMID:21712547
present during mitotic M phase experimental evidence S700 PMID:21712547
present during mitotic M phase experimental evidence S702 PMID:21712547
present during mitotic M phase experimental evidence S734 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S729 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S726 PMID:24763107
experimental evidence S210 PMID:24763107
ubiquitinylated lysineK10 512
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence K10 PMID:26412298
IDA PMID:26412298
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for efr3 (SPCC794.08)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1458during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1469during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1460during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
2254.08during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1708.21during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.88during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC794.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC794.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC794.08 BioGRID Interaction Datasets
Expression Viewer SPCC794.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC794.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC794.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC794.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC794.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC794.08 Transcriptome Viewer (Bähler Lab)
GEO SPCC794.08 GEO profiles
PInt SPCC794.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC794.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC794.08 Fission yeast phenotypic data & analysis
Cyclebase SPCC794.08.1 Cell Cycle Data
SPD / RIKEN28/28G05Orfeome Localization Data
UniProtKB/SwissProtO59817Protein efr3
ModBaseO59817Database of comparative protein structure models
STRINGO59817Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587756protein efr3
RefSeq mRNANM_001022749972h- protein efr3 (SPCC794.08), mRNA

Literature for efr3

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016