efr3 (SPCC794.08)


Gene Standard Nameefr3 Characterisation Statusbiological role inferred
Systematic IDSPCC794.08 Feature Typeprotein coding
Synonyms Name Description
ProductHEAT repeat protein, involved in protein localization to plasma membrane (predicted) Product Size798aa, 90.38 kDa
Genomic Location Chromosome III, 265315-268006 (2692nt); CDS:265445-267881 (2437nt)

Ensembl Gene Location
GO Biological Process

GO Slim Terms

membrane organization


GO Cellular Component
Term NameCount
mitochondrion752
Annotation ExtensionEvidenceWith/FromReference
plasma membrane253
Annotation ExtensionEvidenceWith/FromReference
protein complex1361
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased vegetative cell population growthefr3Δ729
loss of viability in stationary phaseefr3Δ61
sensitive to bleomycinefr3Δ92
sensitive to Calcofluor Whiteefr3Δ52
sensitive to thiabendazoleefr3Δ329
viable vegetative cell populationefr3Δ3850

Cell Phenotype

Term NameGenotypesCount
cutefr3Δ128
mislocalized septum during vegetative growthefr3Δ45
viable stubby vegetative cellefr3Δ75
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons265315..265644, 265685..268006
Intron265645..265684
mRNA265315..268006
5' UTR265315..265444PMID:21511999
CDS265445..265644, 265685..267881
3' UTR267882..268006PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR12444 HMMPANTHER 1 408 1
SSF48371 SuperFamily IPR016024 Armadillo-type fold 242 522 130
SSF48371 SuperFamily IPR016024 Armadillo-type fold 68 129 130

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.26 Da
Charge 21.00
Codon Adaptation Index 0.40
Isoelectric point 8.49
Molecular weight 90.38 kDa
Number of residues 798
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during mitotic M phaseS705
present during mitotic M phaseS702
present during mitotic M phaseS729
present during mitotic M phaseS726
present during mitotic M phaseS697
present during mitotic M phaseS700
present during mitotic M phaseS210
present during mitotic M phaseS734
S210, S697, S726, S729, S759, S761, S770, S786
level fluctuates during mitotic cell cycleS729
level fluctuates during mitotic cell cycleS726
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S705 PMID:21712547
present during mitotic M phase experimental evidence S702 PMID:21712547
present during mitotic M phase experimental evidence S729 PMID:21712547
present during mitotic M phase experimental evidence S726 PMID:21712547
present during mitotic M phase experimental evidence S697 PMID:21712547
present during mitotic M phase experimental evidence S700 PMID:21712547
present during mitotic M phase experimental evidence S210 PMID:21712547
present during mitotic M phase experimental evidence S734 PMID:21712547
IDA S697 PMID:25720772
IDA S759 PMID:25720772
experimental evidence S210 PMID:24763107
IDA S726 PMID:25720772
IDA S786 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S729 PMID:24763107
IDA S729 PMID:25720772
IDA S770 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S726 PMID:24763107
IDA S761 PMID:25720772
O-phospho-L-threonineT769 1085
Annotation ExtensionEvidenceResidueReference
IDA T769 PMID:25720772
ubiquitinylated lysineK10 512
Annotation ExtensionEvidenceResidueReference
IDA PMID:26412298
mass spectrometry evidence K10 PMID:26412298
O-phosphorylated residueS697,S700,S705, S697,S702,S705, S697,T699, S697,T699,S700, S697,Y704, S700,S701, S700,S705, S726,S729, S754,T755, S786,T788, T699,S700,S705, T752,T755, T752,T755,S761 2457
Annotation ExtensionEvidenceResidueReference
IDA S697,Y704 PMID:25720772
IDA S697,T699,S700 PMID:25720772
IDA T752,T755,S761 PMID:25720772
IDA S700,S705 PMID:25720772
IDA S697,T699 PMID:25720772
IDA S786,T788 PMID:25720772
IDA T699,S700,S705 PMID:25720772
IDA S700,S701 PMID:25720772
IDA T752,T755 PMID:25720772
IDA S754,T755 PMID:25720772
IDA S726,S729 PMID:25720772
IDA S697,S700,S705 PMID:25720772
IDA S697,S702,S705 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for efr3 (SPCC794.08)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1458during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1469during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1460during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
2254.08during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1708.21during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.88during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC794.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC794.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC794.08 BioGRID Interaction Datasets
Expression Viewer SPCC794.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC794.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC794.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC794.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC794.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC794.08 Transcriptome Viewer (Bähler Lab)
GEO SPCC794.08 GEO profiles
PInt SPCC794.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC794.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC794.08 Fission yeast phenotypic data & analysis
Cyclebase SPCC794.08.1 Cell Cycle Data
SPD / RIKEN28/28G05Orfeome Localization Data
UniProtKB/SwissProtO59817Protein efr3
ModBaseO59817Database of comparative protein structure models
STRINGO59817Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587756protein efr3
RefSeq mRNANM_001022749972h- protein efr3 (SPCC794.08), mRNA
European Nucleotide ArchiveCAA19135.1ENA Protein Mapping
UniParcUPI0000069FEBUniProt Archive

Literature for efr3

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016