SPCC965.10


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC965.10 Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor (predicted) Product Size525aa, 59.80 kDa
Genomic Location Chromosome III, 2302442-2305222 (2781nt); CDS:2302549-2304126 (1578nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingNASGO_REF:000005191
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityNASGO_REF:000005191
GO:0008270zinc ion bindingIEAIPR001138GO_REF:0000002249
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006357regulation of transcription from RNA polymerase II promoterNASGO_REF:0000051291
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722315
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPCC965.10ΔNullPMID:204732893759
MicroscopySPCC965.10ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001MicroscopySPCC965.10ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
123024422305222

UTRs

Region Coordinates Reference
five_prime_UTR2302442..2302548PMID:21511999
three_prime_UTR2304127..2305222PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF11951 Pfam IPR021858 Protein of unknown function DUF3468 155 522 1
PF00172 Pfam IPR001138 Zn(2)-C6 fungal-type DNA-binding domain 20 50 29
SM00066 SMART IPR001138 Zn(2)-C6 fungal-type DNA-binding domain 15 59 31
PS00463 Prosite Patterns IPR001138 Zn(2)-C6 fungal-type DNA-binding domain 20 48 29
PS50048 Prosite Profiles IPR001138 Zn(2)-C6 fungal-type DNA-binding domain 20 50 32
4.10.240.10 Gene3D IPR001138 Zn(2)-C6 fungal-type DNA-binding domain 13 52 31
SSF57701 SuperFamily IPR001138 Zn(2)-C6 fungal-type DNA-binding domain 11 57 32

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000138zf-fungal Zn(2)-Cys(6) binuclear cluster domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000138

Protein Properties

Ave. residue weight 113.91 Da
Charge 0.50
Isoelectric point 6.63
Molecular weight 59.80 kDa
Number of residues 525
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi only623
conserved in fungi4600
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Positive GeneticPMID:21504829
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
pir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
External References
Database Identifier Description
NBRP SPCC965.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC965.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC965.10 BioGRID Interaction Datasets
Expression Viewer SPCC965.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC965.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC965.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC965.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC965.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC965.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC965.10 Cell Cycle Data
GEO SPCC965.10 GEO profiles
PInt SPCC965.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC965.10 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC965.10 Fission yeast phenotypic data & analysis
SPD / RIKEN25/25D08Orfeome Localization Data
UniProtKB/SwissProtO59830Uncharacterized transcriptional regulatory protein C965.10
ModBaseO59830Database of comparative protein structure models
STRINGO59830Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588520transcription factor (predicted)
RefSeq mRNANM_001023509972h- transcription factor (predicted) (SPCC965.10), mRNA
European Nucleotide ArchiveCAA19070.1ENA Protein Mapping
UniParcUPI000006BA3EUniProt Archive

Literature for SPCC965.10

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014