eft202 (SPCP31B10.07)


Gene Standard Nameeft202 Characterisation Statuspublished
Systematic IDSPCP31B10.07 Feature Typeprotein coding
Synonyms Name Description
Producttranslation elongation factor 2 (EF-2) Eft2,B Product Size842aa, 93.23 kDa
Genomic Location Chromosome III, 537298-539922 (2625nt); CDS:537326-539854 (2529nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005525GTP bindingIEAUniProtKB-KW:KW-0342GO_REF:0000037113
GO:0003924GTPase activityIEAIPR000795GO_REF:000000261
GO:0003746translation elongation factor activityIEAUniProtKB-KW:KW-0251GO_REF:000003715
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0002182cytoplasmic translational elongationNASGO_REF:0000051193
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:168233724198
GO:0005829cytosolIDAPMID:168233722317
GO:0005840ribosomeISOSGD:S000005659GO_REF:0000024285
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyeft202ΔNullPMID:204732893755
Microscopyeft202ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyeft202ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1537298539922

UTRs

Region Start End Reference
three_prime_UTR539855539922PMID:21511999
five_prime_UTR537298537325PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF14492 Pfam IPR009022 Elongation factor G, III-V domain 487 548 5
PF00679 Pfam IPR000640 Translation elongation factor EFG, V domain 724 810 7
PF03764 Pfam IPR005517 Translation elongation factor EFG/EF2, domain IV 605 720 5
PF00009 Pfam IPR000795 Elongation factor, GTP-binding domain 18 344 18
PF03144 Pfam IPR004161 Translation elongation factor EFTu/EF1A, domain 2 394 469 16
SM00889 SMART IPR005517 Translation elongation factor EFG/EF2, domain IV 604 721 4
SM00838 SMART IPR000640 Translation elongation factor EFG, V domain 723 812 7
PS00301 Prosite Patterns IPR000795 Elongation factor, GTP-binding domain 58 73 10
PTHR23115 HMMPANTHER 1 841 17
PTHR23115:SF13 HMMPANTHER 1 841 3
G3DSA:3.90.1430.10 Gene3D 229 328 4
G3DSA:3.30.70.240 Gene3D IPR000640 728 828 7
G3DSA:3.40.50.300 Gene3D 2 228 279
G3DSA:3.30.230.10 Gene3D IPR014721 572 727 19
G3DSA:3.30.70.870 Gene3D 486 560 7
G3DSA:2.40.30.10 Gene3D 339 484 29
SSF54211 SuperFamily IPR020568 561 724 29
SSF54980 SuperFamily IPR009022 484 559 7
SSF54980 SuperFamily IPR009022 726 840 7
SSF50447 SuperFamily IPR009000 344 481 24
SSF52540 SuperFamily IPR027417 4 343 294
Low complexity (SEG) seg 485 495
Low complexity (SEG) seg 83 90
PR00315 PRINTS IPR000795 Elongation factor, GTP-binding domain 21 34 15
PR00315 PRINTS IPR000795 Elongation factor, GTP-binding domain 117 128 15
PR00315 PRINTS IPR000795 Elongation factor, GTP-binding domain 65 73 15
PR00315 PRINTS IPR000795 Elongation factor, GTP-binding domain 101 111 15
PR00315 PRINTS IPR000795 Elongation factor, GTP-binding domain 153 162 15
TIGR00231 tigrfam IPR005225 Small GTP-binding protein domain 20 164 35

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.73 Da
Charge -1.50
Isoelectric point 6.37
Molecular weight 93.23 kDa
Number of residues 842
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
51682.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
152630.81during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
63during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
7.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Two-hybridPMID:19682301
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
External References
Database Identifier Description
NBRP SPCP31B10.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCP31B10.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCP31B10.07 BioGRID Interaction Datasets
Expression Viewer SPCP31B10.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCP31B10.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCP31B10.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCP31B10.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCP31B10.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCP31B10.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCP31B10.07 Cell Cycle Data
GEO SPCP31B10.07 GEO profiles
PInt SPCP31B10.07 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN29/29C06Orfeome Localization Data
EntrezGene2539544translation elongation factor 2 (EF-2) Eft2,B
EntrezGene3361483translation elongation factor 2 (EF-2) Eft2,A
WikiGene2539544translation elongation factor 2 (EF-2) Eft2,B
WikiGene3361483translation elongation factor 2 (EF-2) Eft2,A
UniProtKB/SwissProtO14460Elongation factor 2
ModBaseO14460Database of comparative protein structure models
StringO14460Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587863translation elongation factor 2 (EF-2) Eft2,B
RefSeq mRNANM_001022856972h- translation elongation factor 2 (EF-2) Eft2,B (eft202), mRNA
European Nucleotide ArchiveBAA13813ENA Protein Mapping
European Nucleotide ArchiveBAA23590ENA Protein Mapping
European Nucleotide ArchiveBAA23591ENA Protein Mapping
European Nucleotide ArchiveCAB52147ENA Protein Mapping
European Nucleotide ArchiveCAB58373ENA Protein Mapping
UniParcUPI0000129C7EUniProt Archive

Literature for eft202

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014