ter1 (SPNCRNA.214)

Gene Standard Nameter1 Characterisation Status
Systematic IDSPNCRNA.214 Feature TypencRNA
SynonymsSPNCRNA.884, SPNG585 Name Description
Producttelomerase RNA Product Size1413nt
Genomic Location Chromosome I, 3086022-3084610, 1413nt

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding900
Annotation ExtensionEvidenceWith/FromReference
template for synthesis of G-rich strand of telomere DNA activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

telomere organization

Term NameCount
positive regulation of telomerase activity1
Annotation ExtensionEvidenceWith/FromReference
positive regulation of telomere capping1
Annotation ExtensionEvidenceWith/FromReference
telomere maintenance via telomerase13
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
telomerase catalytic core complex2
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth on glucose carbon sourceter1::his3393

Cell Phenotype

Term NameGenotypesCount
abnormal telomerase template activityter1-STEloop (UUUU1071AAAA)1
abnormal telomeric repeat sequenceter1-5 (U236C)1
ter1-1 (T228G)
ter1-4 (G235U)
ter1-STEloop (UUUU1071AAAA)
circularized chromosometer1::his38
decreased protein localization to telomere11
affects localization of taz1ter1-STEloop (UUUU1071AAAA)
affects localization of pot1ter1-STEloop (UUUU1071AAAA)
decreased protein-protein interaction109
affecting est1 and trt1ter1Δ
decreased telomerase RNA reverse transcriptase activity1
affecting activity of trt1ter1-STEloop (UUUU1071AAAA)
normal DNA recombination frequency at subtelomereter1-STEloop (UUUU1071AAAA)1
normal protein level during vegetative growth103
affecting pot1ter1-STEloop (UUUU1071AAAA)
normal protein localization to telomere during vegetative growth14
affecting taz1ter1Δ-415-507 (415-507)
normal RNA localization to nucleus1
affecting ter1ter1-STEloop (UUUU1071AAAA)
normal telomerase holoenzyme complex assemblyter1-STEloop (UUUU1071AAAA)1
normal telomere lengthter1+35
ter1Δ-415-507 (415-507)
normal telomere-telomerase complex assemblyter1-STEloop (UUUU1071AAAA)1
normal telomeric repeat sequenceter1-3 (C226A)2
ter1-6 (A237U)
progressively shortening telomerester1::his37
shortened telomerester1-6 (A237U)44
ter1-5 (U236C)
Mutant B (U225A, C226G, G227C, U228A)
ΔSm (1200-1208)
ter1-1 (T228G)
ter1-7 (G235C)
ter1-4 (G235U)
ter1-8 (C226A, G227C, U228C, G229C, G235C)
stable shortened telomerester1-STEloop (UUUU1071AAAA)5
telomeric regions absent from linear chromosomester1Δ-1036-1095 (1036-1095)2
ter1Δ-1055-1064 (1055-1064)
ter1Δ-1066-1080 (1066-1080)

FYPO Multi-allele Phenotypes

Cell Phenotype

Term NameGenotypes
normal telomere lengthter1-CATG/(A)4 (CAUG1058AAAA), ter1+
ter1Δ-415-507 (415-507), ter1+
shortened telomeresC7U (C7U), ter1+
ter1Δ-1066-1080 (1066-1080), ter1+
U3G,A5U (U3G, A5U), ter1+
ter1Δ-1055-1064 (1055-1064), ter1+
ter1-STEloop (UUUU1071AAAA), ter1+
stable shortened telomerester1-STEloop (UUUU1071AAAA), rad51Δ
telomeric regions absent from linear chromosomesest1Δ, ter1-STEloop (UUUU1071AAAA)
Target Of
FYPO affected by mutation in ctr1 conserved eukaryotic protein, human CCDC174 ortholog
FYPO affected by mutation in mpn1 RNA processing protein (predicted)
FYPO affected by mutation in mtl1 TRAMP/MTREC complex subunit, ATP-dependent RNA helicase (predicted)
FYPO affected by mutation in rad3 ATR checkpoint kinase Rad3
GO binds ssb1 DNA replication factor A subunit Ssb1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference

Protein Modifications

Term NameResidueCount
methylated residue 18
Annotation ExtensionEvidenceResidueReference
IDA PMID:18157149
IDA PMID:18157152
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for ter1 (SPNCRNA.214)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
RNA trimethylguanosine cappedInferred from Direct Assay PMID:181571521
Physical Interactions

Source: BioGRID

Load genes that interact physically with SPNCRNA.214 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byccq1telomere maintenance protein Ccq1 Affinity Capture-RNAPMID:22101932
affinity captured bylsm5U6 snRNP-associated protein Lsm5 (predicted) Affinity Capture-WesternPMID:22446625
affinity captured bysmd2Sm snRNP core protein Smd2 Affinity Capture-WesternPMID:22446625
affinity captured byest1telomerase regulator Est1 Affinity Capture-RNAPMID:22354040
affinity captured bylsm4U6 snRNP-associated protein Lsm4 (predicted) Affinity Capture-WesternPMID:22446625
affinity captured bylsm2U6 snRNP-associated protein core protein (predicted) Affinity Capture-WesternPMID:22446625
affinity captured bysme1Sm snRNP core protein Sme1 Affinity Capture-WesternPMID:22446625
affinity captured bysmb1Sm snRNP core protein Smb1 Affinity Capture-WesternPMID:22446625
affinity captured bylsm3U6 snRNP-associated protein Lsm3 (predicted) Affinity Capture-WesternPMID:22446625
affinity captured byplp1thioredoxin fold protein Plp1 (predicted) Affinity Capture-WesternPMID:22446625
affinity captured bytrt1telomerase reverse transcriptase 1 protein Trt1 Affinity Capture-WesternPMID:22446625
affinity captured byssb1DNA replication factor A subunit Ssb1 Affinity Capture-RNAPMID:22354040
affinity captured bysmf1Sm snRNP core protein Smf1 Affinity Capture-WesternPMID:22446625
affinity captured bylsm7U6 snRNP-associated protein Lsm7 (predicted) Affinity Capture-WesternPMID:22446625
binds to proteintrt1telomerase reverse transcriptase 1 protein Trt1 Protein-RNAPMID:22302936
binds to proteinccq1telomere maintenance protein Ccq1 Protein-RNAPMID:22302936
binds to proteinest1telomerase regulator Est1 Protein-RNAPMID:22215813
forms complex withsme1Sm snRNP core protein Sme1 Reconstituted ComplexPMID:22446625
forms complex withlsm4U6 snRNP-associated protein Lsm4 (predicted) Reconstituted ComplexPMID:22446625
forms complex withsmd2Sm snRNP core protein Smd2 Reconstituted ComplexPMID:22446625
forms complex withsmb1Sm snRNP core protein Smb1 Reconstituted ComplexPMID:22446625
forms complex withlsm3U6 snRNP-associated protein Lsm3 (predicted) Reconstituted ComplexPMID:22446625
forms complex withlsm8U6 snRNP-associated protein Lsm8 (predicted) Reconstituted ComplexPMID:22446625
affinity capturesccq1telomere maintenance protein Ccq1 Affinity Capture-RNAPMID:22215813
co-purifies withtrt1telomerase reverse transcriptase 1 protein Trt1 Co-purificationPMID:18157149
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPNCRNA.214 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withSPAC227.17cconserved eukaryotic protein, human c22orf39 ortholog Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPNCRNA.214 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPNCRNA.214 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPNCRNA.214 BioGRID Interaction Datasets
Expression Viewer SPNCRNA.214 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPNCRNA.214 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPNCRNA.214 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPNCRNA.214 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPNCRNA.214 Polyadenylation Viewer (Gullerova lab)
pombeTV SPNCRNA.214 Transcriptome Viewer (Bähler Lab)
GEO SPNCRNA.214 GEO profiles
PInt SPNCRNA.214 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPNCRNA.214 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPNCRNA.214 Fission yeast phenotypic data & analysis
Cyclebase SPNCRNA.214.1 Cell Cycle Data

Literature for ter1

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017