srp7 (SPNCRNA.98)

Gene Standard Namesrp7 Characterisation Status
Systematic IDSPNCRNA.98 Feature TypencRNA
Synonymssrp Name Description
Product7SL signal recognition particle component Product Size255nt
Genomic Location Chromosome I, 4268662-4268916, 255nt

Ensembl Gene Location
GO Biological Process
Term NameCount
SRP-dependent cotranslational protein targeting to membrane15
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
signal recognition particle, endoplasmic reticulum targeting7
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at high temperaturesrp7-TS-point (G107A, G112A)178
decreased cell population growth at low temperatureG159A,C164U (G159A, C164U)95
inviable vegetative cell populationG159U,A162C (G159U, A162C)1455
srp7-C-160 (G160C)
D4E-1 (GC inserted after nt 158, GC inserted after nt 164)
srp7-A-159,A-160 (G159A, G160A)
G159C,C164A (G159C, C164A)
(U88G, nt84 deletion, 8 nucleotides inserted after nt83)
(A146U, G159U, nt148-150 deletion)
srp7-C-159 (G159C)
srp7Δ-domIII (70-87, 137-204)
G159U,A162U (G159U, A162U)
srp7-T-160 (G160T)
D4E-2 (G160C, GC inserted after nt 158, GC inserted after nt 164)
(G72A, G78A, G100A, G107A, Gl12A, G141A)
srp7-TS-point (G107A, G112A)
(G153A, G155A)
A154G,G155A (A154G, G155A)
(U88G, nt84-88 deletion, 131 nucleotides inserted after nt83)
A154C,G155A (A154C, G155A)
(G155A, G156A, G160A)
U158C,A166C (U158C, A166C)
(G160A, C164A)
sensitive to high osmolaritysrp7-C-163 (A163C)17
G159U (G159U)
srp7-G-164 (C164G)
srp7-A-159,C-161 (G159A, A161C)
G159U,C164A (G159U, C164A)
srp7-C-163,A-164 (A163C, G164A)
srp7-G-163 (A163G)
A162C,C164G (A162C, C164G)
U157G,A165G (U157G, A165G)
G155A (G155A)
G159C,C164G (G159C, C164G)
A162 (A162)
srp7-C-162,C-163 (A162C, A163C)
srp7-T-159,T-164 (G159T, C164T)
srp7-G4C (G4C)
C164A (C164A)
(C180U, U inserted after nt 176)
srp7-T-163 (A163T)
A166C (A166C)
srp7-T-164 (C164T)
srp7-A154U (A154U)
srp7-A-160 (G160A)
A154U (A154U)
G159A (G159A)
slow vegetative cell population growthsrp7-A-159,C-161 (G159A, A161C)367
viable vegetative cell population (U101C, U140C)3850
srp7-A154U (A154U)
srp7-C-161 (A161C)
(G144C, G149C)
U158C (U158C)
(G100A, C103A, G112A)
G159A,C164U (G159A, C164U)
U157G (U157G)
(C69A, G127A)
srp7-T-163 (A163T)
(U24C, U45C, U62C, U119C, G144C)
G159U (G159U)
srp7-T-159,T-164 (G159T, C164T)
A166C (A166C)
(U88G, nt84-88 deletion, 131 nucleotides inserted after nt83)
(C69U, U70C)
BP-Comp (U157G, U158C, A165G, A166C)
(T(-61)C, G(-75)C, U62C, U101C)
(U88G, UCGA inserted after nt84)
srp7-G-161 (A161G)
(G72A, G78A, G100A, G107A, Gl12A, G141A)
srp7-TS-point (G107A, G112A)
G159U,C164A (G159U, C164A)
D4E-3 (GC inserted after nt 164)
(U119C, U126C)
(G139A, G141A)
srp7-G-163 (A163G)
(U12A, U13A, U47A)
(C180A, G181A)
A162C,C164G (A162C, C164G)
U157G,U158C (U157G, U158C)
srp7-A-160 (G160A)
(U57C, U62C, U90C)
(C179U, C180U)
srp7-C-162,C-163 (A162C, A163C)
srp7-C-163 (A163C)
U157G,A165G (U157G, A165G)
srp7-G-164 (C164G)
(A163U, C169U6)
srp7-C-163,A-164 (A163C, G164A)
(C69A, U70C)
(G156A, G159A)
(A192C, G193C)
(U133C, A135C)
(G4A, G9A)
(G141A, C148A)
(C138G, A150G)
(U88G, U133C, A135C)
srp7-T-164 (C164T)
srp7-G4C (G4C)
A162C (A162C)
(T(-5)C, T(-3)C, U88C)
(U101C, A136C, G149C)
G159A (G159A)
(G149A, G152A)
C164A (C164A)
(C180U, U inserted after nt 176)
(G139C, G144C, A162C)
A165G (A165G)
(G60A, G61A)

Cell Phenotype

Term NameGenotypesCount
abolished RNA binding10
affecting srp7srp7-A154U (A154U)
affecting srp7srp7-TS-point (G107A, G112A)
affecting srp7srp7-G4C (G4C)
decreased protein binding99
affecting srp54 and srp7G159A (G159A)
affecting srp54 and srp7A166C (A166C)
affecting srp54 and srp7G155A (G155A)
affecting srp54 and srp7G156A (G156A)
affecting srp54 and srp7U158C,A166C (U158C, A166C)
affecting srp54 and srp7STL1-3 (GAAA160UUCG)
affecting srp54 and srp7A154U (A154U)
affecting srp54 and srp7srp7-A-159,A-160 (G159A, G160A)
increased RNA level during vegetative growth342
affecting srp7srp7-C-159 (G159C)
affecting srp7srp7-T-160 (G160T)
affecting srp7srp7-A-159,A-160 (G159A, G160A)
affecting srp7srp7-C-160 (G160C)
inviable after spore germination, single or double cell divisionsrp7::ura4+107
inviable sporesrp7.1 (disruption (srp7::m-Tn3(Leu2)))476
normal protein binding91
affecting srp54 and srp7U157G,A165G (U157G, A165G)
affecting srp54 and srp7A161C (A161C)
affecting srp54 and srp7G159C,C164G (G159C, C164G)
affecting srp54 and srp7STL2-1 (GGAAAC159CUUCGG)
affecting srp54 and srp7G160A (G160A)

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
sensitive to high osmolaritysrp7-G4C (G4C), srp54+
viable vegetative cell populationsrp7-A154U (A154U), srp54+
srp54+, srp7-TS-point (G107A, G112A)
Target Of
FYPO affected by mutation in smn1 SMN family protein Smn1
FYPO affected by mutation in srp7 7SL signal recognition particle component
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for srp7 (SPNCRNA.98)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1300during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
280during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Physical Interactions

Source: BioGRID

Load genes that interact physically with SPNCRNA.98 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bysmn1SMN family protein Smn1 Affinity Capture-RNAPMID:23221635
co-purifies withsrp54signal recognition particle subunit Srp54 Co-purificationPMID:8041618
External References
Database Identifier Description
NBRP SPNCRNA.98 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPNCRNA.98 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPNCRNA.98 BioGRID Interaction Datasets
Expression Viewer SPNCRNA.98 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPNCRNA.98 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPNCRNA.98 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPNCRNA.98 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPNCRNA.98 Polyadenylation Viewer (Gullerova lab)
pombeTV SPNCRNA.98 Transcriptome Viewer (Bähler Lab)
GEO SPNCRNA.98 GEO profiles
PInt SPNCRNA.98 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPNCRNA.98 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPNCRNA.98 Fission yeast phenotypic data & analysis
Cyclebase SPNCRNA.98.1 Cell Cycle Data
RfamRF00017Rfam hosted at the Wellcome Trust Sanger Institute

Literature for srp7

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016