srp7 (SPNCRNA.98)

Gene Standard Namesrp7 Characterisation Status
Systematic IDSPNCRNA.98 Feature TypencRNA
Synonymssrp Name Description
Product7SL signal recognition particle component Product Size255nt
Genomic Location Chromosome I, 4268662-4268916, 255nt

Ensembl Gene Location
GO Biological Process
Term NameCount
SRP-dependent cotranslational protein targeting to membrane15
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
signal recognition particle, endoplasmic reticulum targeting7
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at high temperaturesrp7-TS-point (G107A, G112A)142
decreased cell population growth at low temperatureG159A/C164U (G159A, C164U)68
inviable vegetative cell population (G155A, G156A, G160A)1443
(U88G, nt84 deletion, 8 nucleotides inserted after nt83)
srp7::ura4+ (disruption)
G159U/A162C (G159U, A162C)
srp7-T-160 (G160T)
D4E-2 (G160C, GC inserted after nt 158, GC inserted after nt 164)
D4E-1 (GC inserted after nt 158, GC inserted after nt 164)
srp7-C-160 (G160C)
G159U/A162U (G159U, A162U)
(U88G, nt84-88 deletion, 131 nucleotides inserted after nt83)
(G153A, G155A)
A154C,G155A (A154C, G155A)
(A146U, G159U, nt148-150 deletion)
A154G,G155A (A154G, G155A)
(G160A, C164A)
srp7Δ-domIII (70-87, 137-204)
(G72A, G78A, G100A, G107A, Gl12A, G141A)
srp7-TS-point (G107A, G112A)
U158C/A166C (U158C, A166C)
srp7-A-159,A-160 (G159A, G160A)
srp7-C-159 (G159C)
G159C/C164A (G159C, C164A)
sensitive to high osmolaritysrp7-C-163 (A163C)11
srp7-C-162,C-163 (A162C, A163C)
U157G/A165G (U157G, A165G)
srp7-A154U (A154U)
A166C (A166C)
G159U (G159U)
srp7-G-163 (A163G)
A154U (A154U)
srp7-A-159,C-161 (G159A, A161C)
srp7-C-163,A-164 (A163C, G164A)
G159U/C164A (G159U, C164A)
srp7-T-164 (C164T)
srp7-T-159,T-164 (G159T, C164T)
G159A (G159A)
C164A (C164A)
(C180U, U inserted after nt 176)
A162 (A162)
G159C/C164G (G159C, C164G)
G155A (G155A)
srp7-T-163 (A163T)
srp7-A-160 (G160A)
A162C/C164G (A162C, C164G)
srp7-G4C (G4C)
srp7-G-164 (C164G)
slow vegetative cell population growthsrp7-A-159,C-161 (G159A, A161C)329
viable vegetative cell populationsrp7-A-160 (G160A)3815
(G139C, G144C, A162C)
srp7-T-163 (A163T)
(G144C, G149C)
A166C (A166C)
C164A (C164A)
srp7-A154U (A154U)
(G139A, G141A)
G159A (G159A)
BP-Comp (U157G, U158C, A165G, A166C)
(C69A, G127A)
srp7-G-161 (A161G)
srp7-TS-point (G107A, G112A)
A162C/C164G (A162C, C164G)
(U88G, UCGA inserted after nt84)
srp7-C-161 (A161C)
(T(-61)C, G(-75)C, U62C, U101C)
U158C (U158C)
(C180A, G181A)
(C69A, U70C)
(G141A, C148A)
G159U/C164A (G159U, C164A)
G159U (G159U)
(G60A, G61A)
D4E-3 (GC inserted after nt 164)
srp7-G-164 (C164G)
(U88G, nt84-88 deletion, 131 nucleotides inserted after nt83)
(C180U, U inserted after nt 176)
(C69U, U70C)
U157G (U157G)
(A192C, G193C)
(G4A, G9A)
srp7-T-159,T-164 (G159T, C164T)
U157G/U158C (U157G, U158C)
(U133C, A135C)
(U12A, U13A, U47A)
(T(-5)C, T(-3)C, U88C)
A165G (A165G)
U157G/A165G (U157G, A165G)
A162C (A162C)
(G72A, G78A, G100A, G107A, Gl12A, G141A)
G159A/C164U (G159A, C164U)
(U57C, U62C, U90C)
srp7-C-163 (A163C)
(U24C, U45C, U62C, U119C, G144C)
(U119C, U126C)
(U101C, U140C)
(G100A, C103A, G112A)
(U88G, U133C, A135C)
(G156A, G159A)
(C138G, A150G)
srp7-G-163 (A163G)
(G149A, G152A)
srp7-C-162,C-163 (A162C, A163C)
srp7-G4C (G4C)
srp7-C-163,A-164 (A163C, G164A)
(C179U, C180U)
srp7-T-164 (C164T)
(A163U, C169U6)
(U101C, A136C, G149C)

Cell Phenotype

Term NameGenotypesCount
abolished RNA binding10
affecting srp7srp7-G4C (G4C)
affecting srp7srp7-A154U (A154U)
affecting srp7srp7-TS-point (G107A, G112A)
decreased protein binding71
affecting srp54 and srp7G159A (G159A)
affecting srp54 and srp7G155A (G155A)
affecting srp54 and srp7A166C (A166C)
affecting srp54 and srp7G156A (G156A)
affecting srp54 and srp7STL1-3 (GAAA160UUCG)
affecting srp54 and srp7 (U158C, A166C)
affecting srp54 and srp7srp7-A-159,A-160 (G159A, G160A)
affecting srp54 and srp7A154U (A154U)
increased RNA level during vegetative growth210
affecting srp7srp7-C-159 (G159C)
affecting srp7srp7-T-160 (G160T)
affecting srp7srp7-A-159,A-160 (G159A, G160A)
affecting srp7srp7-C-160 (G160C)
inviable after spore germination, single or double cell divisionsrp7::ura4+ (disruption)105
inviable sporesrp7.1 (disruption (srp7::m-Tn3(Leu2)))474
normal protein binding57
affecting srp54 and srp7G160A (G160A)
affecting srp54 and srp7G159C,C164G (G159C, C164G)
affecting srp54 and srp7U157G,A165G (U157G, A165G)
affecting srp54 and srp7A161C (A161C)
affecting srp54 and srp7STL2-1 (GGAAAC159CUUCGG)

Multi-allele phenotypes

Population Phenotype

Term NameGenotypes
sensitive to high osmolaritysrp7-G4C (G4C), srp54+
viable vegetative cell populationsrp7-A154U (A154U), srp54+
srp54+, srp7-TS-point (G107A, G112A)

Cell Phenotype

Term NameGenotypes
Target Of
FYPO affected by mutation in smn1 SMN family protein Smn1
FYPO affected by mutation in srp7 7SL signal recognition particle component
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1300during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
280during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
population wideexperimental evidencePMID:23101633
Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bysmn1SMN family protein Smn1 Affinity Capture-RNAPMID:23221635
co-purifies withsrp54signal recognition particle subunit Srp54 Co-purificationPMID:8041618
External References
Database Identifier Description
NBRP SPNCRNA.98 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPNCRNA.98 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPNCRNA.98 BioGRID Interaction Datasets
Expression Viewer SPNCRNA.98 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPNCRNA.98 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPNCRNA.98 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPNCRNA.98 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPNCRNA.98 Polyadenylation Viewer (Gullerova lab)
pombeTV SPNCRNA.98 Transcriptome Viewer (Bähler Lab)
GEO SPNCRNA.98 GEO profiles
PInt SPNCRNA.98 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPNCRNA.98 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPNCRNA.98 Fission yeast phenotypic data & analysis
Cyclebase SPNCRNA.98.1 Cell Cycle Data
RfamRF00017Rfam hosted at the Wellcome Trust Sanger Institute

Literature for srp7

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015