srp7 (SPNCRNA.98)


Gene Standard Namesrp7 Characterisation Status
Systematic IDSPNCRNA.98 Feature TypencRNA
Synonymssrp Name Description
Product7SL signal recognition particle component Product Size499nt
Genomic Location Chromosome I, 4268566-4269064, 499nt

Ensembl Gene Location
GO Biological Process

GO Slim Terms

protein targeting


Term NameCount
SRP-dependent cotranslational protein targeting to membrane15
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
signal recognition particle, endoplasmic reticulum targeting7
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth at high temperaturesrp7-TS-point (G107A, G112A)Not specified152
inviable vegetative cell populationA154C,G155A (A154C, G155A)1428
A154G,G155A (A154G, G155A)
D4E-1 (GC inserted after nt 158, GC inserted after nt 164)
D4E-2 (G160C, GC inserted after nt 158, GC inserted after nt 164)
G159C/C164A (G159C, C164A)
G159U/A162C (G159U, A162C)
G159U/A162U (G159U, A162U)
PTL1-2 (GAAA160CUUC)
PTL2C (GAAAC160CUUCA)
PTL2U (GAAAC160UUUCA)
srp7-A-159,A-160 (G159A, G160A)
srp7-C-159 (G159C)
srp7-C-160 (G160C)
srp7-T-160 (G160T)
srp7-TS-point (G107A, G112A)Not specified
srp7::ura4+ (disruption)Null
srp7Δ-domIII (70-87, 137-204)Not specified
STL1-1 (GAAAC160UUCGG)
STL1-2 (GGAAA159CUUCG)
U158C/A166C (U158C, A166C)
unnamed (118-120)
unnamed (139-144)
unnamed (159-161)
unnamed (A146U, G159U, nt148-150 deletion)
unnamed (G153A, G155A)
unnamed (G155A, G156A, G160A)
unnamed (G160A, C164A)
unnamed (G72A, G78A, G100A, G107A, Gl12A, G141A)
unnamed (U88G, nt84 deletion, 8 nucleotides inserted after nt83)
unnamed (U88G, nt84-88 deletion, 131 nucleotides inserted after nt83)
sensitive to coldG159A/C164U (G159A, C164U)45
sensitive to high osmolarityA154U (A154U)11
A162 (A162)
A162C/C164G (A162C, C164G)
A166C (A166C)
C164A (C164A)
G155A (G155A)
G159A (G159A)
G159C/C164G (G159C, C164G)
G159U (G159U)
G159U/C164A (G159U, C164A)
PTL1-1 (GAAA160UUUC)
srp7-A-159,C-161 (G159A, A161C)
srp7-A-160 (G160A)
srp7-A154U (A154U)Not specified
srp7-C-162,C-163 (A162C, A163C)
srp7-C-163 (A163C)
srp7-C-163,A-164 (A163C, G164A)
srp7-G-163 (A163G)
srp7-G-164 (C164G)
srp7-G4C (G4C)Not specified
srp7-T-159,T-164 (G159T, C164T)
srp7-T-163 (A163T)
srp7-T-164 (C164T)
STL1-3 (GAAA160UUCG)
STL2-1 (GGAAAC159CUUCGG)
U157G/A165G (U157G, A165G)
unnamed (C180U, U inserted after nt 176)
slow vegetative cell population growthsrp7-A-159,C-161 (G159A, A161C)318
viable vegetative cell populationA162C (A162C)3783
A162C/C164G (A162C, C164G)
A165G (A165G)
A166C (A166C)
BP-Comp (U157G, U158C, A165G, A166C)
C164A (C164A)
D4E-3 (GC inserted after nt 164)
G159A (G159A)
G159A/C164U (G159A, C164U)
G159U (G159U)
G159U/C164A (G159U, C164A)
PTL1-1 (GAAA160UUUC)
srp7-A-160 (G160A)
srp7-A154U (A154U)Not specified
srp7-C-161 (A161C)
srp7-C-162,C-163 (A162C, A163C)
srp7-C-163 (A163C)
srp7-C-163,A-164 (A163C, G164A)
srp7-G-161 (A161G)
srp7-G-163 (A163G)
srp7-G-164 (C164G)
srp7-G4C (G4C)Not specified
srp7-T-159,T-164 (G159T, C164T)
srp7-T-163 (A163T)
srp7-T-164 (C164T)
srp7-TS-point (G107A, G112A)Not specified
STL2-1 (GGAAAC159CUUCGG)
U157G (U157G)
U157G/A165G (U157G, A165G)
U157G/U158C (U157G, U158C)
U158C (U158C)
unnamed (A149)
unnamed (A163U, C169U6)
unnamed (A163U, C169U6)
unnamed (A170C)
unnamed (A172U)
unnamed (A175G)
unnamed (A192C, G193C)
unnamed (C138G, A150G)
unnamed (C174G)
unnamed (C179U, C180U)
unnamed (C180A)
unnamed (C180A, G181A)
unnamed (C180G)
unnamed (C180U)
unnamed (C180U, U inserted after nt 176)
unnamed (C69A, G127A)
unnamed (C69A, U70C)
unnamed (C69U)
unnamed (C69U, U70C)
unnamed (C77A)
unnamed (G100A, C103A, G112A)
unnamed (G104A)
unnamed (G118A)
unnamed (G121C)
unnamed (G139A, G141A)
unnamed (G139C, G144C, A162C)
unnamed (G139C, G144C, A162C)
unnamed (G141A, C148A)
unnamed (G144C)
unnamed (G144C, G149C)
unnamed (G149A)
unnamed (G149A, G152A)
unnamed (G149A, G152A)
unnamed (G156A, G159A)
unnamed (G156A, G159A)
unnamed (G15A)
unnamed (G15A)
unnamed (G181C)
unnamed (G182A)
unnamed (G226C)
unnamed (G4A)
unnamed (G4A)
unnamed (G4A, G9A)
unnamed (G4A, G9A)
unnamed (G4C)
unnamed (G60A, G61A)
unnamed (G72A, G78A, G100A, G107A, Gl12A, G141A)
unnamed (G78A)
unnamed (G9A)
unnamed (G9A)
unnamed (T(-5)C, T(-3)C, U88C)
unnamed (T(-61)C, G(-75)C, U62C, U101C)
unnamed (U101C)
unnamed (U101C, A136C, G149C)
unnamed (U101C, U140C)
unnamed (U119C, U126C)
unnamed (U12A, U13A, U47A)
unnamed (U133C, A135C)
unnamed (U142C)
unnamed (U167G)
unnamed (U167G)
unnamed (U173C)
unnamed (U24C, U45C, U62C, U119C, G144C)
unnamed (U24C, U45C, U62C, U119C, G144C)
unnamed (U57C, U62C, U90C)
unnamed (U70C)
unnamed (U88G)
unnamed (U88G, nt84-88 deletion, 131 nucleotides inserted after nt83)
unnamed (U88G, U133C, A135C)
unnamed (U88G, UCGA inserted after nt84)

Cell Phenotype

Term NameAlleleExpressionCount
abolished RNA binding10
affecting srp7srp7-A154U (A154U)Not specified
affecting srp7srp7-G4C (G4C)Not specified
affecting srp7srp7-TS-point (G107A, G112A)Not specified
decreased protein binding52
affecting srp54 and srp7A154U (A154U)
affecting srp54 and srp7A166C (A166C)
affecting srp54 and srp7G155A (G155A)
affecting srp54 and srp7G156A (G156A)
affecting srp54 and srp7G159A (G159A)
affecting srp54 and srp7srp7-A-159,A-160 (G159A, G160A)
affecting srp54 and srp7STL1-3 (GAAA160UUCG)
affecting srp54 and srp7unnamed (U158C, A166C)
increased RNA level during vegetative growth173
affecting srp7srp7-A-159,A-160 (G159A, G160A)
affecting srp7srp7-C-159 (G159C)
affecting srp7srp7-C-160 (G160C)
affecting srp7srp7-T-160 (G160T)
inviable after spore germination, single or double cell divisionsrp7::ura4+ (disruption)Null101
inviable sporesrp7.1 (disruption (srp7::m-Tn3(Leu2)))Null468
normal protein binding52
affecting srp54 and srp7A161C (A161C)
affecting srp54 and srp7G159C,C164G (G159C, C164G)
affecting srp54 and srp7G160A (G160A)
affecting srp54 and srp7STL2-1 (GGAAAC159CUUCGG)
affecting srp54 and srp7U157G,A165G (U157G, A165G)
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in smn1 SMN family protein Smn1 PMID:23221635
FYPO affected by mutation in srp7 7SL signal recognition particle component PMID:2657742
FYPO affected by mutation in srp7 7SL signal recognition particle component PMID:8041618
FYPO affected by mutation in srp7 7SL signal recognition particle component PMID:8382769
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
142685664269064

UTRs

Region Coordinates Reference
exon4268662..4268916PMID:2837764
ncRNA4268662..4268916PMID:2837764
exon4268662..4268916PMID:16453822
ncRNA4268662..4268916PMID:16453822
exon4268662..4268916X15220
ncRNA4268662..4268916X15220
Sequence
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1300during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
280during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
population wideexperimental evidencePMID:23101633
Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bysmn1SMN family protein Smn1 Affinity Capture-RNAPMID:23221635
co-purifies withsrp54signal recognition particle subunit Srp54 Co-purificationPMID:8041618
External References
Database Identifier Description
NBRP SPNCRNA.98 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPNCRNA.98 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPNCRNA.98 BioGRID Interaction Datasets
Expression Viewer SPNCRNA.98 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPNCRNA.98 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPNCRNA.98 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPNCRNA.98 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPNCRNA.98 Polyadenylation Viewer (Gullerova lab)
pombeTV SPNCRNA.98 Transcriptome Viewer (Bähler Lab)
Cyclebase SPNCRNA.98 Cell Cycle Data
GEO SPNCRNA.98 GEO profiles
PInt SPNCRNA.98 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPNCRNA.98 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPNCRNA.98 Fission yeast phenotypic data & analysis
RfamRF00017Rfam hosted at the Wellcome Trust Sanger Institute

Literature for srp7

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015