Priority Unstudied Genes

Fission yeast genes are classed as "unknown" if there is no information about the broad cellular role (biological process) in which it participates (corresponding to any of the high level GO Slim classes). For these, we have been unable to identify a broad biological role based on experimental data in fission yeast or any other organism. Note that, as all genes in fission yeast have been curated, these genes are documented as "unknown" (they are not "unannotated").

In fission yeast the "unknown" inventory is around 830 entries, many of which are apparently species-specific. However, a large number (503) are conserved, and a significant number of these (181) have orthologs in vertebrates. These genes are listed below.

You can retrieve a current list of conserved unknown genes using the Advanced Search, with or without specifying whether the genes are conserved. See the relevant FAQ and the Advanced Search documentation for details.

IDNameDescriptionsort iconFeature_TypeChromosomestrandstartend
SPBC30B4.03cadn1adhesion defective protein protein_codingII-113042741306121
SPBC115.02cafg1AFG1 family mitochondrial ATPase Afg1 (predicted) protein_codingII1637370639291
SPAC26F1.14caif1apoptosis-inducing factor homolog Aif1 (predicted) protein_codingI151461235148353
SPCC962.05ast1asteroid homolog, XP-G family protein protein_codingIII1553995556291
SPBC32H8.03bem46esterase/lipase (predicted) protein_codingII114575571458849
SPBC1289.16ccao2copper amine oxidase-like protein Cao2 protein_codingII-144261574428785
SPCC970.03cbr1cytochrome b5 reductase Cbr1 (predicted) protein_codingIII-1509925511627
SPAC23H4.09cdb4curved DNA-binding protein Cdb4, peptidase family protein_codingI-115918731593194
SPAC4F10.22cmc4mitochondrial intermembrane space protein involved in respiratory growth Cmc4 protein_codingI148782414878453
SPCC1235.03cue2SMR domain protein, possibly involved in DNA repair and neddylation protein_codingIII1178975180813
SPCC1906.02ccue3CUE domain protein Cue3, human ASCC2 ortholog (predicted) protein_codingIII-120145842016628
SPCC553.01cdbl2meiotic chromosome segregation protein Dbl2 protein_codingIII1310158312895
SPAC3A11.10cdpe1dipeptidyl peptidase (predicted) protein_codingI134481253449855
SPCC965.12dpe2dipeptidyl peptidase (predicted) protein_codingIII123059022307857
SPAC19G12.17erh1enhancer of rudimentary homolog Erh1 protein_codingI-140662584066971
SPCC1259.02cerm1Endoplasmic Reticulum metallopeptidase Erm1 (predicted) protein_codingIII-110340651037848
SPAC22A12.06cfsh2serine hydrolase-like protein_codingI-111637451165581
SPCC4G3.17hdd1HD domain protein (predicted) protein_codingIII-1438715439928
SPAC26F1.12chgh1conserved eukaryotic protein Hgh1 protein_codingI151538235155228
SPAC23G3.12chtr12serine protease (predicted) protein_codingI-1889058892211
SPAC23C11.05ipp1inorganic pyrophosphatase Ipp1 (predicted) protein_codingI121403792141698
SPBC2A9.11ciss9conserved eukaryotic protein protein_codingII-129651052966645
SPBC16G5.09kex1serine carboxypeptidase (predicted) protein_codingII142287414230768
SPBC28E12.06clvs1beige protein homolog Lvs1 (predicted) protein_codingII-118463871854534
SPAC15A10.10mde6Muskelin homolog (predicted) protein_codingI136965493700027
SPBC530.09cmrl1cation dependent mannose-6-phosphate cargo receptor Mrl1 (predicted) protein_codingII-1809383810978
SPAC25H1.04mug105ubiquitin-fold modifier-specific protease (predicted) protein_codingI125290852529901
SPBC359.06mug14adducin protein_codingII1128660129742
SPAC3H1.03mug151mouse transcriptional regulator, HCNGP-like (predicted) protein_codingI119350151935958
SPBC25H2.14mug16UNC-50 family Golgi membrane protein protein_codingII-132501993251263
SPCC584.14mug160human ATXN10 ortholog protein_codingIII115184481520391
SPCC1620.03mug163conserved eukaryotic protein, mitochondrial protein_codingIII121485882151955
SPAC1834.09mug51variant protein kinase 19 family protein protein_codingI147165494717760
SPAC22F3.04mug62AMP binding enzyme (predicted) protein_codingI-1697960702755
SPAC8C9.16cmug63TLDc domain protein 1 protein_codingI-136719263673470
SPAC56E4.05mug69ENV10 family protein (predicted) protein_codingI112553241256414
SPBC13G1.10cmug81ATP-dependent helicase Slh1, human ASCC3 ortholog (predicted) protein_codingII-137439733749997
SPBC839.19new20conserved eukaryotic protein protein_codingII-1604418604920
SPAC3H5.13new4conserved eukaryotic protein protein_codingI134125273413053
SPAC869.08pcm2protein-L-isoaspartate O-methyltransferase Pcm2 (predicted) protein_codingI-154979185499280
SPBC15D4.15pho24-nitrophenylphosphatase protein_codingII130361043037146
SPAC4H3.07crdl2mitochondrial thiosulfate sulfurtransferase Rdl2 (predicted) protein_codingI-138386603839443
SPAC688.13scn3TatD DNase family Scn1 protein_codingI131393953141117
SPAPYUG7.06sdu1PPPDE peptidase family (predicted) protein_codingI147541304754926
SPCC16C4.01sif2mitochondrial conserved protein (predicted) protein_codingIII1658752660714
SPAC12G12.15sif3mitochondrial conserved protein (predicted) protein_codingI-1316996319185
SPAC4G9.14sym1mitochondrial Mpv17/PMP22 family protein 2 (predicted) protein_codingI122802032281847
SPBC14C8.19tam10small acidic protein (SMAP) domain containing protein protein_codingII-122185402219196
SPCC330.20tam14stress associated Endoplasmic Reticulum protein Tam14 protein_codingIII1114921115256
SPCC736.09ctfx1TRAX protein_codingIII-1329570330657
SPAC30.03ctsn1translin protein_codingI-143943764395639
SPCC895.09cucp12ATP-dependent RNA helicase Ucp12 (predicted) protein_codingIII-110166961022436
SPBC18A7.01xpa1X-Pro dipeptidase (predicted) protein_codingII127291952730774
SPAC105.02cSPAC105.02cankyrin repeat protein, human PPP1R16A ortholog protein_codingI-117440191745658
SPAC10F6.14cSPAC10F6.14cABC1 kinase family protein (predicted) protein_codingI-112322621234076
SPAC11E3.12SPAC11E3.12conserved eukaryotic protein, thioredoxin family protein_codingI153056965308686
SPAC11E3.14SPAC11E3.14conserved eukaryotic protein protein_codingI153113445314362
SPAC12G12.11cSPAC12G12.11cDUF544 family protein protein_codingI1326440328122
SPAC15F9.01cSPAC15F9.01ccentral kinetochore associated family protein protein_codingI-123972482398350
SPAC1687.21SPAC1687.21phosphoglycerate mutase family (predicted) protein_codingI1941942943335
SPAC1705.02SPAC1705.02human 4F5S homolog protein_codingI115688381569449
SPAC1782.12cSPAC1782.12cDUF423 protein protein_codingI-147734594775369
SPAC17A2.02cSPAC17A2.02cDUF887 family protein protein_codingI-135522903554138
SPAC17G8.08cSPAC17G8.08chuman TMEM165 homolog, implicated in calcium tranport protein_codingI-123552782356601
SPAC17H9.06cSPAC17H9.06cconserved eukaryotic protein protein_codingI-120140632016932
SPAC186.05cSPAC186.05chuman TMEM165 homolog, implicated in calcium transport protein_codingI-155400325541502
SPAC19B12.01SPAC19B12.01TPR repeat protein, TTC27 family protein_codingI148754184878120
SPAC19B12.07cSPAC19B12.07chuman ZNF277 ortholog protein_codingI-148954584897099
SPAC19B12.11cSPAC19B12.11czinc finger protein, human ZNF593 ortholog protein_codingI-149034184904283
SPAC1B3.10cSPAC1B3.10cSEL1 repeat protein, unknown biological role protein_codingI-149460904948084
SPAC20G4.05cSPAC20G4.05cUPF0061 family mitochondrial protein (predicted) protein_codingI-148228694824867
SPAC227.17cSPAC227.17cconserved eukaryotic protein, DUF3128, human c22orf39 ortholog protein_codingI-1529167530275
SPAC22A12.14cSPAC22A12.14cBSD domain protein, unknown biological role protein_codingI-111809991182528
SPAC23C4.06cSPAC23C4.06cmethyltransferase, human Fam119 ortholog (predicted) protein_codingI-110385151042027
SPAC23C4.09cSPAC23C4.09cDNA-binding TFAR19-related protein (predicted) protein_codingI-110419801044240
SPAC25A8.03cSPAC25A8.03cDUF185 protein, mitochondrial protein_codingI-120961622098083
SPAC26A3.11SPAC26A3.11omega-amidase (predicted) protein_codingI133563753357902
SPAC27D7.08cSPAC27D7.08cDUF890 family protein, predicted methyltransferase protein_codingI-145213754523223
SPAC27E2.03cSPAC27E2.03cObg-Like ATPase (predicted) protein_codingI-140057174007722
SPAC29B12.11cSPAC29B12.11chuman WW domain binding protein-2 ortholog protein_codingI-154358725437295
SPAC2C4.04cSPAC2C4.04cconserved eukaryotic protein protein_codingI-142655054266618
SPAC2F3.18cSPAC2F3.18cribonuclease kappa ortholog (predicted) protein_codingI-139420403942965
SPAC30D11.11SPAC30D11.11Haemolysin-III family protein (predicted) protein_codingI-110974491099554
SPAC31G5.21SPAC31G5.21human FAM32A homolog, implicated in splicing protein_codingI130099883010684
SPAC328.04SPAC328.04AAA family ATPase, unknown biological role protein_codingI134815053484605
SPAC3A11.11cSPAC3A11.11coxidoreductase (predicted) protein_codingI134462623448081
SPAC3G6.03cSPAC3G6.03cMaf-like protein protein_codingI-153837055385561
SPAC3G6.05SPAC3G6.05mitochondrial Mpv17/PMP22 family protein 1 (predicted) protein_codingI153878845389677
SPAC3H5.08cSPAC3H5.08cWD repeat protein, human WDR44 family protein_codingI134258733429364
SPAC3H5.09cSPAC3H5.09cconserved mitochondrial protein (predicted) protein_codingI134165443425062
SPAC3H8.04SPAC3H8.04possible chromosome segregation protein (predicted) protein_codingI1592226593906
SPAC4H3.04cSPAC4H3.04cUPF0103 family protein_codingI-138308053832278
SPAC4H3.06SPAC4H3.06human C19orf60 homolog protein_codingI138373063839626
SPAC521.03SPAC521.03short chain dehydrogenase (predicted) protein_codingI1844948846142
SPAC56F8.02SPAC56F8.02AMP binding enzyme (predicted) protein_codingI111240581129104
SPAC5H10.01SPAC5H10.01DUF1445 family mitochondrial protein (predicted) protein_codingI1146974148055
SPAC607.08cSPAC607.08cDUF726 family protein protein_codingI-120484212050160
SPAC652.01SPAC652.01BC10 family protein protein_codingI132814083283071
SPAC683.02cSPAC683.02czf-CCHC type zinc finger protein (predicted) protein_codingI-141974664198686
SPAC688.03cSPAC688.03chuman AMMECR1 homolog protein_codingI-131145083115380
SPAC688.16SPAC688.16human TMEM254 ortholog protein_codingI131438643144530
SPAC694.02SPAC694.02DEAD/DEAH box helicase protein_codingI142001484205612
SPAC694.04cSPAC694.04cconserved eukaryotic protein protein_codingI-142066934208253
SPAC6B12.04cSPAC6B12.04c2-aminoadipate transaminase (predicted) protein_codingI-124159522418241
SPAC6C3.02cSPAC6C3.02cmitochondrial CHCH domain protein (predicted) protein_codingI-123244812325288
SPAC6F6.13cSPAC6F6.13cDUF726 family protein protein_codingI-127563182758924
SPAC6F6.19SPAC6F6.19RNA-binding protein, G-patch type protein_codingI-127591552759709
SPAC6G10.10cSPAC6G10.10chuman hmmtag2 homolog protein_codingI-132361793237503
SPAC7D4.05SPAC7D4.05hydrolase (predicted) protein_codingI-126286352630262
SPAC806.04cSPAC806.04cprotein-glutamate O-methyltransferase (predicted) protein_codingI-1241008243122
SPAC977.15SPAC977.15dienelactone hydrolase family protein_codingI16296163862
SPAC9E9.15SPAC9E9.15CIA30 protein (predicted) protein_codingI144705614471415
SPACUNK4.13cSPACUNK4.13cmitochondrial NTPase Ylf2 (predicted) protein_codingI128852222886782
SPAP11E10.01SPAP11E10.01ornithine cyclodeaminase family (predicted) protein_codingI118553181856904
SPAP14E8.05cSPAP14E8.05cUPF0136 family mitochondrial protein, implicated in heme biosynthesis protein_codingI-119278031928465
SPAP27G11.12SPAP27G11.12human HID1 ortholog 1 protein_codingI116320681634832
SPAPB1A11.02SPAPB1A11.02esterase/lipase (predicted) protein_codingI129804282981839
SPAPB24D3.08cSPAPB24D3.08cNADP-dependent oxidoreductase (predicted) protein_codingI-129610732962670
SPAPB2B4.07SPAPB2B4.07ubiquitin family protein, human UBTD1 homolog protein_codingI127243382725954
SPAPJ691.02SPAPJ691.02yippee-like protein protein_codingI151876475189187
SPBC119.03SPBC119.03human COMT catechol O-methyltransferase homolog 1 protein_codingII1717888718991
SPBC119.16cSPBC119.16cconserved eukaryotic protein, implicated in vesicle-mediated transport protein_codingII-1745971750738
SPBC1539.02SPBC1539.02conserved eukaryotic nuclear protein implicated in meiotic chromosome segregation protein_codingII143638634367876
SPBC15D4.05SPBC15D4.05conserved CobW/HypB/UreG nucleotide binding domain protein (predicted) protein_codingII130206813022237
SPBC15D4.13cSPBC15D4.13chuman ASCC1 ortholog protein_codingII-130324923033222
SPBC1604.16cSPBC1604.16cRNA-binding protein, G-patch type (predicted) protein_codingII139016323902410
SPBC16A3.02cSPBC16A3.02cmitochondrial conserved protein (predicted) protein_codingII142969794298874
SPBC16C6.01cSPBC16C6.01clysine methyltransferase (predicted) protein_codingII-143198374321858
SPBC16H5.13SPBC16H5.13WD repeat protein, human WDR7 ortholog protein_codingII-122693972273358
SPBC16H5.14cSPBC16H5.14cshort chain dehydrogenase DHRS family (predicted) protein_codingII122680732270305
SPBC1703.11SPBC1703.11optic atrophy 3 family protein protein_codingII129345962936122
SPBC1778.07SPBC1778.07methyltransferase N2227 family protein_codingII131098923111270
SPBC18E5.10SPBC18E5.10iron-sulfur cluster protein (predicted) protein_codingII120927132095872
SPBC18H10.05SPBC18H10.05WD repeat protein, human WDR44 family protein_codingII117792591781985
SPBC20F10.02cSPBC20F10.02cDUF1741 family protein protein_codingII-132844363286488
SPBC20F10.03SPBC20F10.03conserved eukaryotic protein protein_codingII132876753289422
SPBC20F10.07SPBC20F10.07GRAM domain protein protein_codingII132954123298548
SPBC21.03cSPBC21.03cEVE domain (PUA-related) protein protein_codingII-132158723219354
SPBC215.06cSPBC215.06chuman LYAR homolog protein_codingII-140379894038940
SPBC21C3.03SPBC21C3.03ABC1 kinase family protein protein_codingII138019003804469
SPBC21C3.12cSPBC21C3.12cDUF953 thioredoxin family protein protein_codingII-138168903817780
SPBC21H7.03cSPBC21H7.03cacid phosphatase (predicted) protein_codingII-122565572258458
SPBC23G7.06cSPBC23G7.06cconserved eukaryotic protein protein_codingII-121063312108971
SPBC26H8.13cSPBC26H8.13cSiva family protein, human apoptosis-inducing factor ortholog (predicted) protein_codingII-139599393961152
SPBC29A10.12SPBC29A10.12DUF1014 family protein, HMG-box clan member protein_codingII125662132567353
SPBC2D10.03cSPBC2D10.03cDUF866 domain protein protein_codingII-129682632968967
SPBC30D10.09cSPBC30D10.09cHVA22/TB2/DP1 family protein protein_codingII130833173084348
SPBC32F12.07cSPBC32F12.07cubiquitin-protein ligase E3, MARCH family (predicted) protein_codingII-127952402797769
SPBC36B7.05cSPBC36B7.05cubiquitin-protein ligase E3/phosphatidylinositol(3)-phosphate binding protein (predicted) protein_codingII-123909372392223
SPBC3B8.08SPBC3B8.08Sjogren's syndrome/scleroderma autoantigen 1 family (predicted) protein_codingII-133777093378587
SPBC3E7.04cSPBC3E7.04cRic8 family guanine nucleotide exchange factor synembryn family protein_codingII-126624882664652
SPBC3E7.07cSPBC3E7.07cDUF757 family protein protein_codingII-126718772672919
SPBC3F6.01cSPBC3F6.01cserine/threonine protein phosphatase (predicted) protein_codingII-141845994187022
SPBC4.06SPBC4.06acid phosphatase (predicted) protein_codingII111959871197756
SPBC428.15SPBC428.15Obg-like ATPase (predicted) protein_codingII1472084473687
SPBC543.02cSPBC543.02cDNAJ/TPR domain protein DNAJC7 family protein_codingII-143007464302738
SPBC577.03cSPBC577.03cGCN5-related N-acetyltransferase (predicted) protein_codingII-1754411756616
SPBC83.10SPBC83.10transthyretin superfamily member, human ER membrane protein complex subunit 7 ortholog protein_codingII115276161528831
SPBC83.16cSPBC83.16cconserved eukaryotic protein protein_codingII-115386361541448
SPBC8D2.16cSPBC8D2.16cDUF171 family protein protein_codingII-113863121389186
SPBC9B6.03SPBC9B6.03zf-FYVE type zinc finger protein protein_codingII118174541819848
SPBP19A11.07cSPBP19A11.07chuman HID1 ortholog 2 protein_codingII-128684132871156
SPBP22H7.04SPBP22H7.04human TMEM186 ortholog protein_codingII114379671440557
SPBP4H10.17cSPBP4H10.17ccarboxyl methyl esterase (predicted) protein_codingII-129071782908713
SPBP8B7.31SPBP8B7.31acid phosphatase (predicted) protein_codingII136980723699346
SPBPB21E7.04cSPBPB21E7.04chuman COMT ortholog 2 protein_codingII-16448765620
SPCC126.12SPCC126.12GTP cyclohydrolase (predicted) protein_codingIII121375952139203
SPCC1393.13SPCC1393.13protein carboxyl methyltransferase, implicated in DNA damage response protein_codingIII1824949827652
SPCC1442.02SPCC1442.02central kinetochore associated family protein (predicted) protein_codingIII117689601771181
SPCC16C4.02cSPCC16C4.02cDUF1941 family protein, human neurochondrin ortholog protein_codingIII-1661446664355
SPCC16C4.16cSPCC16C4.16cconserved eukaryotic protein protein_codingIII-1697422698599
SPCC24B10.18SPCC24B10.18human Leydig cell tumor 10 kDa protein homolog protein_codingIII1931924932847
SPCC550.07SPCC550.07acetamidase (predicted) protein_codingIII111967291199999
SPCC5E4.10cSPCC5E4.10chuman leukocyte receptor 1 ortholog protein_codingIII-1650897652710
SPCC622.11SPCC622.11LMBR1-like membrane protein protein_codingIII114171001419224
SPCC63.03SPCC63.03DNAJ domain protein, DNAJC11 family protein_codingIII1837458840012
SPCC63.06SPCC63.06human WDR89 family WD repeat protein protein_codingIII1845924847352
SPCC736.13SPCC736.13short chain dehydrogenase (predicted) protein_codingIII-1340648342096
SPCC777.12cSPCC777.12cthioredoxin family protein protein_codingIII-116165921618210
SPCC965.09SPCC965.09omega-amidase (predicted) protein_codingIII123005432302268
SPCP31B10.02SPCP31B10.02mitochondrial conserved eukaryotic protein (predicted) protein_codingIII1525361525831