Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination.
In a recent issue of Molecular Cell, Limbo et al. (2007) identify a new homologous recombination factor, Ctp1 in S. pombe, a homolog of Sae2/Com1 in S. cerevisiae and CtIP in mammals, that operates cooperatively with the MRN complex.
Takeda S, Nakamura K, Taniguchi Y, Paull TT