The Wellcome Lecture, 1992. Cell cycle control.
Genetic analysis using the fission yeast has provided a powerful methodology to investigate the eukaryotic cell cycle and its control. The onset of M-phase in fission yeast is controlled by a regulatory gene network which activates the p34cdc2 protein kinase encoded by the cdc2+ gene. The coupling of M-phase to the completion of S-phase also works through p34cdc2. A similar network is operative in vertebrate cells. Future work will focus on the controls regulating onset of S-phase and on the mechanisms by which a cell duplicates itself in space during division.
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