25-hydroxycholesterol 7-alpha-hydroxylase activity
Catalysis of the reactions: 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts (25R)-cholest-5-ene-3beta,26-diol to (25R)-cholest-5-en-3beta,7alpha,26-triol.
GO:0008387
steroid 7-alpha-hydroxylase activity
is_a
GO:0016712
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
is_a
25-hydroxycholesterol 7alpha-monooxygenase activity
related
CYP7B1
related
CYP7B1 oxysterol 7alpha-hydroxylase activity
related
cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity
related