VCP-NPL4-UFD1 AAA ATPase complex
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
GO:0098796
membrane protein complex
is_a
GO:0140534
endoplasmic reticulum protein-containing complex
is_a
GO:0005789
endoplasmic reticulum membrane
part_of
Cdc48p-Npl4p-Ufd1p AAA ATPase complex
narrow
p97-Ufd1-Npl4 complex
exact
SPAC1565.08 SPBC16A3.09c