marginal zone B cell differentiation
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
GO:0002313
mature B cell differentiation involved in immune response
is_a
marginal zone B cell development
related
marginal zone B lymphocyte differentiation
exact
marginal zone B-cell differentiation
exact
marginal zone B-lymphocyte differentiation
exact