IgE responsiveness, atopic
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.
MONDO:0004980
atopic eczema
excluded_subClassOf
MONDO:0000605
hypersensitivity reaction disease
is_a
MONDO:0003847
hereditary disease
is_a
IGER
related
IgE responsiveness, atopic
exact
IgE, elevated level of
exact
immediate hypersensitivity
exact
type 1 hypersensitivity
exact
type 1 hypersensitivity reaction
exact
type I hypersensitivity
exact
type I hypersensitivity reaction
exact
type I immediate hypersensitivity reaction
exact