Ire1 complex
A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
GO:0098796
membrane protein complex
is_a
GO:0140534
endoplasmic reticulum protein-containing complex
is_a
GO:1902554
serine/threonine protein kinase complex
is_a
GO:1902555
endoribonuclease complex
is_a
GO:0005789
endoplasmic reticulum membrane
part_of
ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1
exact
ERN1 complex
related
IRE1 dimer
exact
Ire1 complex dimer
exact
Ire1 complex homodimer
exact
Ire1 complex homooligomer
exact