SIN/MEN two-component GAP complex
A protein complex that acts as a two-component GTPase-activating protein for the Tem1/Spg1 GTPase, thus regulating a signal transduction cascade (the mitotic exit network, MEN, in budding yeast; the septation initiation network, SIN, in fission yeast), which is required for mitotic exit and cytokinesis. The complex keeps the GTPase inactive until the spindle is properly oriented, thus inhibiting MEN/SIN activation.
GO:1902773
GTPase activator complex
is_a
GO:0005816
spindle pole body
part_of
Bfa1-Bub2 complex
narrow
Byr4-Cdc16 GAP complex
narrow
SPAC6F6.08c SPAC222.10c