glioblastoma
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
MONDO:0016680
high grade astrocytic tumor
is_a
GBM
exact
GBM (glioblastoma)
exact
WHO grade IV glioma
exact
giant cell glioblastoma (histologic variant)
related
glioblastoma
exact
glioblastoma (disease)
exact
glioblastoma multiforme
exact
glioblastoma multiforme (disease)
exact
gliosarcoma (histologic variant)
related
grade IV adult astrocytic tumor
narrow
grade IV adult astrocytic tumour
narrow
grade IV astrocytic neoplasm
exact
grade IV astrocytic tumor
exact
grade IV astrocytic tumour
exact
grade IV astrocytoma
exact
spongioblastoma multiforme
exact