hypoxia-inducible factor-1alpha signaling pathway
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
GO:0035556
intracellular signal transduction
is_a
GO:0071456
cellular response to hypoxia
part_of
HIF1alpha pathway
exact
hypoxia-inducible factor signaling
exact
hypoxia-inducible factor-1alpha signalling pathway
exact