necroptotic process
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
GO:0097300
programmed necrotic cell death
is_a
PARP-dependent cell death
related
RIPK1-mediated regulated necrosis
exact
TNF-induced necroptosis
narrow
activation of necroptosis
related
activation of necroptosis by extracellular signals
related
activation of necroptosis in response to extracellular signals
related
activation of necroptosis of activated-T cells
related
establishment of necroptosis
related
establishment of necroptosis of activated-T cells
related
extracellular signal-induced necroptosis
related
induction of necroptosis
broad
induction of necroptosis by extracellular signals
broad
induction of necroptosis of activated-T cells
broad
necroptosis
narrow
parthanatos
related
programmed necrosis
broad
programmed necrotic cell death
broad