double-strand break repair via synthesis-dependent strand annealing
SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
GO:0000724
double-strand break repair via homologous recombination
is_a
SDSA
broad
mitotic gene conversion
related
SPAC8E11.03c SPAC144.05 SPAC9.05 SPAC15A10.03c SPAC20H4.07 SPAC644.14c SPAC3C7.03c SPBC119.14 SPBC28F2.07 SPBC409.03 SPBC2D10.16 SPAC30D11.10 SPCC576.12c SPAC20H4.04