branched-chain 2-oxo acid dehydrogenase activity
Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H+ = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2. Also acts on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.
GO:0016624
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
is_a
2-oxoisocaproate dehydrogenase activity
related
2-oxoisovalerate (lipoate) dehydrogenase activity
related
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
narrow
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
related
3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
related
3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
related
BCKDH activity
related
BCOAD activity
related
alpha-keto-alpha-methylvalerate dehydrogenase activity
related
alpha-ketoacid dehydrogenase activity
narrow
alpha-ketoisocaproate dehydrogenase activity
related
alpha-ketoisocaproic dehydrogenase activity
related
alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
related
alpha-ketoisovalerate dehydrogenase activity
related
alpha-oxoisocaproate dehydrogenase activity
related
branched chain keto acid dehydrogenase activity
related
branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
related
branched-chain 2-keto acid dehydrogenase activity
related
branched-chain alpha-keto acid dehydrogenase activity
related
branched-chain alpha-oxo acid dehydrogenase activity
related
branched-chain keto acid dehydrogenase activity
related
branched-chain ketoacid dehydrogenase activity
related
dehydrogenase, 2-oxoisovalerate (lipoate) activity
related
dehydrogenase, branched chain alpha-keto acid activity
related