obsolete adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (obsolete GO:0086102)
OBSOLETE. An adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate.
AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate
related
G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity
exact
Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
broad
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
exact
muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel
exact
muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current
exact