IRE1-mediated unfolded protein response
The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
GO:0030968
endoplasmic reticulum unfolded protein response
is_a
ERN1-mediated unfolded protein response
related
IRE1 branch of UPR
exact
IRE1 signal transduction pathway
broad
IRE1 signaling in response to endoplasmic reticulum stress
related
IRE1alpha unfolded protein response
narrow
IRE1p unfolded protein response
narrow
UPR signaling by IRE1 stress sensor
exact
endoplasmic reticulum unfolded protein response; IRE1 signaling
exact
inositol-requiring enzyme 1-mediated unfolded protein response
related
inositol-requiring transmembrane kinase/endonuclease signal transduction
related
SPAC167.01 SPAC22A12.15c