Notch receptor processing, ligand-dependent
The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
GO:0031293
membrane protein intracellular domain proteolysis
is_a
GO:0007219
Notch signaling pathway
part_of
GO:0007220
Notch receptor processing
part_of
Notch S2 cleavage
narrow
Notch S3 cleavage
narrow