hippo signaling
An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
GO:0035556
intracellular signal transduction
is_a
SWH pathway
narrow
Salvador-Warts-Hippo signaling pathway
narrow
hippo signal transduction
exact
hippo signaling cascade
related
hippo signaling pathway
exact
hippo signalling cascade
related
SPBC27B12.04c