Bre1-Rad6 ubiquitin ligase complex
A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis.
GO:1990234
transferase complex
is_a
GO:0005622
intracellular anatomical structure
part_of
Bre1-Rad6 complex
exact