diphthine methyl ester synthase activity
Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine.
GO:0008276
protein methyltransferase activity
is_a
GO:0008757
S-adenosylmethionine-dependent methyltransferase activity
is_a
SPCC576.14