tyrosyl-RNA phosphodiesterase activity
Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.
GO:0008081
phosphoric diester hydrolase activity
is_a
GO:0140098
catalytic activity, acting on RNA
is_a
VPg unlinkase activity
exact
Y-pUpN PDE activity
exact
unlinkase activity
exact
uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity
exact