obsolete positive regulation of molecular function, epigenetic (obsolete GO:0045858)
OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
activation of protein activity, epigenetic
narrow
positive regulation of protein activity, epigenetic
exact
stimulation of protein activity, epigenetic
narrow
up regulation of protein activity, epigenetic
exact
up-regulation of protein activity, epigenetic
exact
upregulation of protein activity, epigenetic
exact