hepatocellular carcinoma
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.
MONDO:0004970
adenocarcinoma
is_a
MONDO:0018531
carcinoma of liver and intrahepatic biliary tract
is_a
HCC
exact
adult hepatoma
narrow
adult primary hepatocellular carcinoma
narrow
cancer, hepatocellular
exact
carcinoma of liver
exact
carcinoma of liver cells
exact
carcinoma of the liver cells
exact
carcinoma, hepatocellular, malignant
exact
hepatoblastoma, somatic
exact
hepatocellular adenocarcinoma
exact
hepatocellular cancer
exact
hepatocellular cancer, somatic
exact
hepatocellular carcinoma
exact
hepatocellular carcinoma, childhood type, somatic
exact
hepatocellular carcinoma, somatic
exact
hepatoma
exact
liver carcinoma
exact
liver cell cancer (hepatocellular carcinoma)
exact
liver cell carcinoma
exact
primary carcinoma of liver cells
exact
primary carcinoma of the liver cells
exact
SPBC530.09c SPAC6C3.08