JNK cascade
A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
GO:0000165
MAPK cascade
is_a
JNK1 cascade
narrow
JNK2 cascade
narrow
JNK3 cascade
narrow
MAPK10 cascade
narrow
MAPK8 cascade
exact
MAPK9 cascade
narrow
SAPK cascade
broad
c-Jun N-terminal kinase cascade
exact
stress-activated protein kinase cascade
broad