Ragulator complex
A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).
GO:0032045
guanyl-nucleotide exchange factor complex
is_a
GO:0098796
membrane protein complex
is_a
GO:0005774
vacuolar membrane
part_of
EGO complex
related
EGO-GSE complex
related
GSE complex
related
GTPase-containing complex for Gap1p sorting in the endosome
related
MAPKSP1/ROBLD3/C11orf59 complex
exact
Rag GEF
exact
SPAC222.19 SPBC29A10.17 SPAC23D3.16 SPBC1778.05c