I-kappaB phosphorylation
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
GO:0006468
protein phosphorylation
is_a
GO:0007249
canonical NF-kappaB signal transduction
part_of
IKB phosphorylation
exact
IkappaB phosphorylation
exact
inhibitor of NF-kappaB phosphorylation
exact
inhibitor of kappaB phosphorylation
exact