ISG15 conjugating enzyme activity
Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue.
GO:0042296
ISG15 transferase activity
is_a
GO:0061650
ubiquitin-like protein conjugating enzyme activity
is_a
E2
broad