pyruvate decarboxylation to acetyl-CoA
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.  In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH.
GO:0006085
acetyl-CoA biosynthetic process
is_a
GO:0006090
pyruvate metabolic process
is_a
GO:0009060
aerobic respiration
part_of
acetyl-CoA anabolism from pyruvate
exact
acetyl-CoA biosynthetic process from pyruvate
exact
acetyl-CoA formation from pyruvate
exact
acetyl-CoA synthesis from pyruvate
exact
oxidative decarboxylation of pyruvate
exact
pyruvate decarboxylation
narrow
pyruvate dehydrogenase pathway
exact
SPCC794.07 SPAC1002.09c SPAC644.11c SPAC26F1.03 SPAC10F6.17c SPCC1259.09c SPBC30D10.13c