celiac disease
An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
MONDO:0000588
autoimmune disorder of gastrointestinal tract
is_a
MONDO:0003847
hereditary disease
is_a
MONDO:0020598
malabsorption syndrome
is_a
MONDO:0024635
small intestine disorder
is_a
celiac disease
exact
celiac sprue
exact
coeliac sprue
exact
gluten intolerance
exact
gluten-induced enteropathy
exact
non tropical sprue
exact