intrinsic apoptotic signaling pathway
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
GO:0035556
intracellular signal transduction
is_a
GO:0097190
apoptotic signaling pathway
is_a
induction of apoptosis by intracellular signals
related
intrinsic apoptosis
narrow
intrinsic apoptotic pathway
exact
intrinsic apoptotic signalling pathway
exact
mitochondrial-mediated apoptotic pathway
exact