Phosphoinositide binding protein; binds PI3P, PI4P and PI(3,5)P2; activates the lipid transfer activity of Atg2p; required for the CVT pathway, and both autophagic vesicle and autophagosome formation; PROPPIN family member that contains WD-40 repeats and an AIM motif; forms higher order helical assemblies; relocalizes from the vacuole to cytoplasm upon replication stress; human WDR45, one of many mammalian homologs, causes static encephalopathy of childhood with neurodegeneration in adulthood