protein-glutamine gamma-glutamyltransferase activity
Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
GO:0016755
aminoacyltransferase activity
is_a
GO:0140096
catalytic activity, acting on a protein
is_a
R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
related
TGase activity
exact
factor XIIIa
related
fibrin stabilizing factor
related
fibrinoligase activity
exact
glutaminylpeptide gamma-glutamyltransferase activity
related
polyamine transglutaminase activity
related
protein-glutamine:amine gamma-glutamyltransferase
related
tissue transglutaminase
narrow
transglutaminase activity
exact