diethylstilbestrol syndrome
Diethylstilbestrol (DES) syndrome is a malformation syndrome reported in offspring (children and grandchildren) of women exposed to DES during pregnancy and is characterized by reproductive tract malformations, decreased fertility and increased risk of developing clear cell carcinoma of the vagina and cervix in young women. Reproductive malformations reported in DES syndrome include small, T-shaped uteri and other uterotubal anomalies that increase the risk of miscarriages in women and epididymal cysts, microphallus, cryptorchidism, or testicular hypoplasia in men. DES, a synthetic nonsteroidal estrogen was widely prescribed from 1940-1970 to prevent miscarriage.
MONDO:0005039
reproductive system disorder
is_a
MONDO:0016677
toxic or drug-related embryofetopathy
is_a
DES embryofetopathy
exact
DES syndrome
exact
Distilbene embryofetopathy
exact
antenatal diethylstilbestrol exposure
related
diethylstilbestrol embryofetopathy
exact
fetal diethylstilbestrol syndrome
related
foetal diethylstilbestrol syndrome
related