Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates protein sorting and deubiquitination in the multivesicular body pathway, recruiting Doa4p to endosomes; required for ESCRT-dependent transport of ubiquitinated cargo to the vacuole; localizes to extracellular vesicles during heat stress with proposed role in thermotolerance; ortholog of mammalian ESCRT-associated protein ALIX (PDCD6IP); N-terminal banana-shaped Bro1 domain involved in endosomal targeting is shared with Rim20p