2-oxoglutarate decarboxylation to succinyl-CoA
The chemical reactions and pathways resulting in the formation of succinyl-CoA from 2-oxoglutarate.  In most organisms, this pathway is part of the TCA cycle and comprises a series of three reactions carried out by a multisubunit complex called the '2-oxoglutarate dehydrogenase complex', even though 2-oxoglutarate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: 2-oxoglutarate + coenzyme A + NAD+ -> succinyl-CoA + CO2 + NADH.
GO:0006103
2-oxoglutarate metabolic process
is_a
GO:1901290
succinyl-CoA biosynthetic process
is_a
GO:0006099
tricarboxylic acid cycle
part_of
2-ketoglutarate dehydrogenase system
exact
2-oxoglutarate dehydrogenase system
exact
2alpha-ketoglutarate dehydrogenase system
exact