myeloid neoplasm associated with PDGFRB rearrangement
A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRB gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic myelomonocytic leukemia with eosinophilia, chronic eosinophilic leukemia, atypical chronic myelogenous leukemia, juvenile myelomonocytic leukemia, myelodysplastic syndrome, acute myeloid leukemia or acute lymphoblastic leukemia. Patients usually present with anemia, leukocytosis, monocytosis, eosinophilia and/or splenomegaly, or systemic symptoms, such as fever, sweating and/or weight loss.
MONDO:0015688
myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2
is_a
myeloid and lymphoid neoplasms with PDGFRB rearrangement
exact
myeloid neoplasms associated with PDGFRB rearrangement
exact
myeloid neoplasms with PDGFRB rearrangement
exact
myeloid/lymphoid neoplasms with PDGFRB rearrangement
exact