serine palmitoyltransferase complex
A protein complex that catalyses the condensation of L-serine with palmitoyl-CoA to form 3-ketosphinganine, the sphingoid base which is the starting point for all sphingolipids. In bacteria the enzyme is a cytoplasmic homodimer, whereas in eukaryotes the enzyme is a multiprotein complex localised to the endoplasmic reticulum. The eukaryotic complex consists of catalytic components (SPTLC1, SPTLC2 and SPTLC3 in humans; LCB1 and LCB2 in S. cerevisiae) and regulatory components, which include activators (SPTSSA/SPTSSB in humans, TSC3 in S. cerevisiae) and negative regulators (ORMDL1/ORMDL2/ORMDL3 in humans, ORM1/2 in S. cerevisiae ).
GO:0002178
palmitoyltransferase complex
is_a
SPOTS complex
related
SPT
related
serine C-palmitoyltransferase complex
related
serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex
related
SPAC23A1.05 SPBC18E5.02c SPBC19F5.03 SPBC119.09c SPAC3C7.01c SPAC21E11.08