ichthyosis
Disorders of cornification that are characterized by visible scaling and/or hyperkeratosis of most or all of the skin. Inherited ichthyoses, defined as the generalized form of Mendelian disorders of cornification, affect most or all of the skin. This etiologically and phenotypically heterogenous group of conditions is caused by mutations in various different genes important for keratinocyte differentiation and epidermal barrier function. Acquired forms of ichthyosis can be observed with certain autoimmune, inflammatory, metabolic, endocrine, or infectious diseases or with malignancies.
MONDO:0019268
epidermal disease
is_a
DOC
exact
disorder of cornification
exact
fish scale disease
exact
fish skin disease
exact
ichthyosis
exact
ichthyosis (disease)
exact
SPBC3E7.15c SPBC19C2.09 SPAC1A6.09c SPBC354.05c