non-ribosomal peptide synthetase activity
Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.
GO:0003824
catalytic activity
is_a
PCP
related
peptidyl carrier protein
related
peptidyl carrier protein activity
related
peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis
exact
peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process
exact
SPAC3F10.04 SPAC23G3.02c