complement component 5 deficiency
A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the fifth complement component, C5. C5 deficiency may also be acquired acutely post-infection. If C5 is adequately synthesized, its rapid depletion may result in a functional deficiency. Clinical signs of the inherited deficiency present within the second decade of life and are consistent with the signs of recurrent systemic infection. Deficiency of serum C5 and its major cleavage product, C5b, a component of the membrane attack complex, increases susceptibility to Neisserial infections.
MONDO:0000015
classic complement early component deficiency
is_a
MONDO:0015700
immunodeficiency due to a late component of complement deficiency
is_a
C5 complement deficiency
exact
C5 deficiency
exact
C5D
related
complement component 5 deficiency
exact
complement deficiency caused by mutation in C5
exact
dysfunction of the fifth component of complement (C5)
related