hypoxia-inducible factor-proline dioxygenase activity
Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit].
GO:0031545
peptidyl-proline 4-dioxygenase activity
is_a
HIF hydroxylase
broad
HIF prolyl hydroxylase
exact