Zeocin-specific modulator of the double-strand damage response; interacts with Ptc2p to promote Rad53p dephosphorylation, acting through the mitotic DNA damage checkpoint to assist in recovery from DNA damage and ensure genomic stability; integral membrane protein that localizes to eisosomes and to mitochondria; slight defects in sporulation and altered plasma membrane sphingolipid composition; SUR7 family member; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication