heteromeric SMAD protein complex
A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
GO:0071141
SMAD protein complex
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GO:0090575
RNA polymerase II transcription regulator complex
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SMAD1-SMAD4 protein complex
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SMAD2-SMAD3-SMAD4 protein complex
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SMAD2-SMAD4 protein complex
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SMAD3-SMAD4 protein complex
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