leukodystrophy
Leukodystrophies are a group of rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. Each type of leukodystrophy is caused by a specific gene abnormality that leads to abnormal development or destruction of the white matter (myelin sheath) of the brain. The myelin sheath is the protective covering of the nerve and nerves can't function normally without it. Each type of leukodystrophy affects a different part of the myelin sheath, leading to a range of neurological problems.
MONDO:0024237
inherited neurodegenerative disorder
is_a
hypomyelinating leukodystrophy
exact
hypomyelinating leukoencephalopathy
related
SPAC30C2.04 SPAC4G9.02 SPBC21H7.06c SPAC17A5.01 SPBC17A3.10 SPAC823.12 SPAPB1A10.11c SPAC12B10.15c SPBC4C3.05c SPBC3B9.17 SPBC1703.08c SPAC343.14c SPBC1289.07c SPAC8C9.15c SPAC24H6.13 SPBC725.07 SPAC16A10.03c SPAC2G11.09 SPCC736.06 SPAC4D7.09 SPAC21E11.06 SPBC1347.08c SPAC17A5.15c SPAC3C7.10 SPAPB17E12.03 SPBC646.15c SPAC22A12.05 SPAC144.12 SPAPYUG7.05 SPBP8B7.13 SPAC17D4.01 SPBPB10D8.02c SPAC23C11.09 SPCC11E10.07c SPBC651.08c SPCC1223.07c SPBC1198.14c SPAC29A4.14c SPAC17C9.14 SPCC16C4.04 SPBC582.09 SPBC13G1.03c SPBC16A3.06 SPBC26H8.07c SPAC1F12.04c SPAC12G12.04 SPBC354.08c SPAC24B11.13 SPBC19C7.06 SPCC553.03 SPBC3B8.07c SPAC4G9.08c