Phosphoinositide binding protein; binds PI(3,5)P2 with high affinity; required for vacuolar membrane scission; activates Atg2p lipid transfer activity; required for the CVT pathway, autophagic vesicle and autophagosome formation; PROPPIN family member with WD-40 repeats and an AIM motif; PI(3,5)P2 induces higher order helical assemblies; relocalizes from the vacuole to cytoplasm upon replication stress; WIPI gene family member, mutations of which are associated with neurodegenerative diseases