isotretinoin syndrome
Isotretinoin embryopathy is an association of malformations caused by the teratogenic effect of isotretinoin, an oral synthetic vitamin A derivative, which is used to treat severe recalcitrant cystic acne. Exposure to isotretinoin during the first trimester of pregnancy has been associated with an increased risk of spontaneous abortions and severe birth defects including serious craniofacial (microcephaly, asymmetric crying facies, microphthalmia, developmental abnormalities of the external ear, ocular hypertelorism), cardio vascular (conotruncal heart defects, aortic arch abnormalities), and central nervous system (hydrocephalus, microcephaly, lissencephaly, Dandy-Walker malformation, cognitive deficit) anomalies and thymic aplasia. Isoretinoin is contraindicated during pregnancy.
MONDO:0002254
syndromic disease
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MONDO:0009473
isotretinoin-like syndrome
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MONDO:0016677
toxic or drug-related embryofetopathy
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Accutane fetal effects of
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Accutane foetal effects of
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Accutane-exposed pregnancies
related
Acutane embryopathy
related
Fetal Retinoid Syndrome
exact
Isotretinoin (RoAccutane) embryopathy
related
Isotretinoin embryopathy
exact
Isotretinoin fetal effects of
related
Isotretinoin foetal effects of
related
Isotretinoin teratogen syndrome
related
Retinoids embryopathy
exact
fetal isotretinoin syndrome
exact
fetal retinoid syndrome
exact
foetal isotretinoin syndrome
exact
foetal retinoid syndrome
exact
retinoic acid embryopathy
exact