spastic paraplegia-Paget disease of bone syndrome
Spastic paraplegia-Paget disease of bone syndrome is an extremely rare, complex form of hereditary spastic paraplegia characterized by a slowly progressive spastic paraplegia (with increased muscle tone, decreased strength in the anterior tibial muscles and hyperreflexia in the lower extremities with Babinski sign) presenting in adulthood, associated with Paget disease of the bone. Cognitive decline, dementia and myopathic changes at muscle biopsy have not been reported.
MONDO:0019708
obsolete primary bone dysplasia with disorganized development of skeletal components (obsolete MONDO:0019708)
excluded_subClassOf
MONDO:0015087
autosomal dominant complex spastic paraplegia
is_a