Cytosolic protein involved in the regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to PM substrate PI4P; VAMP-associated protein (VAP) homolog; role in NVJ integrity and micronucleophagy; SCS22 has a paralog, SCS2, that arose from the whole genome duplication