IgG4-related dacryoadenitis and sialadenitis
IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis.
MONDO:0000587
autoimmune disease of ear, nose and throat
is_a
MONDO:0001854
lacrimal apparatus disorder
is_a
MONDO:0018675
IgG4-related ophthalmic disorder
is_a
Mikulicz disease
exact
Mikulicz disease (former)
related
Mikulicz syndrome (former)
related
Mikulicz's disease (former)
related
chronic dacryoadenitis and sialadenitis
exact