cholate-CoA ligase activity
Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates.
GO:0016405
CoA-ligase activity
is_a
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity
related
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity
exact
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity
related
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity
related
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity
related
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity
related
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity
related
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
related
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity
related
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity
related
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity
related
BAL activity
related
THCA-CoA ligase activity
related
bile acid CoA ligase activity
related
bile acid coenzyme A ligase activity
related
cholate thiokinase activity
related
cholate:CoA ligase (AMP-forming)
related
cholic acid:CoA ligase activity
related
cholic thiokinase activity
related
choloyl coenzyme A synthetase activity
related
choloyl-CoA synthetase activity
related
cholyl-CoA synthetase activity
related
trihydroxycoprostanoyl-CoA synthetase activity
related