ER lipid binding protein and scramblase; one of six proteins that tether the ER and plasma membrane, regulating access of Sac1p to PI4P on the PM; N-terminal membrane-inserted domain acts as a phospholipid scramblase; localizes Osh6p/7p to ER/PM contact sites, facilitating rapid, directed and sustained ER to PM phosphatidylserine transport; links ER lipid transport and homeostasis; mRNA transported to the bud tip in an actomyosin-driven process, creating Ist2p asymmetry; TMEM16 family member