p38MAPK cascade
A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
GO:0000165
MAPK cascade
is_a
MAPK14 cascade
related
osmosensory signaling MAPK cascade
narrow
p38 MAPK cascade
exact
p38 cascade
exact
SPAC4A8.03c SPCC757.09c SPBC32F12.11 SPBC725.02 SPBC409.07c SPAC19D5.01 SPAC2G11.07c SPAPYUG7.02c SPCC4F11.02 SPAC27E2.09 SPAC9G1.02 SPAC26F1.10c SPCC74.06 SPAC1006.09 SPBC887.10 SPCC576.03c SPAC24B11.06c SPAC6B12.15