Clathrin-coated vesicle component, regulator of endocytosis; subunit of the DSC ubiquitin ligase complex; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; required for efficient clathrin-mediated endocytosis; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; ortholog of fission yeast dsc5