ER protein involved in zinc ion homeostasis; interacts genetically with SCS3, impacting the ER stress response, aiding lipid and protein homeostasis; transcription directly regulated by Zap1p with expression induced by zinc deficiency and fatty acids; putative membrane protein; member of the four-protein IZH family and the PQRA clade of the PAQR (Progestin and AdipoQ Receptor) superfamily; IZH1 has a paralog, IZH4, that arose from the whole genome duplication