Lynch syndrome 2
An autosomal dominant hereditary neoplastic syndrome caused by pathogenic variants in the MLH1 mismatch repair gene. It is characterized by an increased risk of colorectal cancer in the absence of extensive polyposis, endometrial, ovarian, gastric, small intestinal, and urinary tract cancers, often occurring at younger ages.
MONDO:0005835
Lynch syndrome
is_a
COCA2
related
HNPCC2
related
Hereditary non-polyposis colon cancer type 2
exact
Hereditary nonpolyposis colorectal cancer type 2
exact
Lynch 2 syndrome
exact
MLH1-related Lynch syndrome
exact
colorectal cancer, hereditary nonpolyposis, type 2
exact
familial non-polyposis colon cancer type 2
exact
SPBC1703.04