negative regulation of insulin receptor signaling pathway by insulin receptor internalization
Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.
GO:0038011
negative regulation of signal transduction by receptor internalization
is_a
GO:0038016
insulin receptor internalization
is_a
GO:0046627
negative regulation of insulin receptor signaling pathway
is_a
agonist-stimulated insulin receptor internalization
broad
negative regulation of insulin receptor signalling pathway by insulin receptor internalization
exact