pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma
A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years.
MONDO:0003864
chronic lymphocytic leukemia/small lymphocytic lymphoma
is_a
CLL/SLL with unmutated IGVH
exact
chronic lymphocytic leukemia/small lymphocytic lymphoma with unmutated Immunoglobulin heavy chain variable-region Gene
exact
pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma
exact