Mis6-Sim4 complex
A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
GO:0032991
protein-containing complex
is_a
GO:0000939
inner kinetochore
part_of
Mcm21
related
Mis6 centromere subcomplex
narrow
Mis6-Mal2-Sim4 centromere complex
exact
Sim4 complex
exact
SPCC1393.04 SPAC25B8.14 SPBC21.01 SPBP8B7.12c SPCC1235.07 SPAC11H11.05c SPAC4F10.12 SPAC1783.03 SPBP22H7.09c SPBC18E5.03c SPAC23H4.11c SPAC1687.20c