Malpighian tubule principal cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule.
GO:0030855
epithelial cell differentiation
is_a
GO:0072002
Malpighian tubule development
part_of