8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
GO:0047429
nucleoside triphosphate diphosphatase activity
is_a
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity
exact
8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity
exact
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity
exact
8-oxo-dGTP pyrophosphohydrolase activity
exact
8-oxo-dGTPase activity
exact