Cortical ER lipid binding protein and scramblase; one of six proteins that tether the ER and plasma membrane (PM), regulating access of Sac1p to PI4P on the PM; N-terminal membrane-inserted domain functions as a lipid scramblase; localizes lipid transfer proteins Osh6p/7p to ER/PM contact sites, facilitating rapid, directed and sustained ER to PM phosphatidylserine transport; mRNA transported to the bud tip in an actomyosin-driven process, creating asymmetry in Ist2p levels; TMEM16 family member