DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GO:0004857
enzyme inhibitor activity
is_a
GO:0042030
ATPase inhibitor activity
is_a
GO:0072586
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity
is_a
DNA gyrase inhibitor activity
exact