sphingolipid 8-(E/Z)-desaturase activity
Catalysis of the reaction: an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O or an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O. This results in the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid.
GO:0016717
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a
8 fatty acid desaturase
exact
8-sphingolipid desaturase
exact
sphingolipid delta-8 desaturase activity
exact