diffuse nonepidermolytic palmoplantar keratoderma
A rare, genetic, isolated diffuse palmoplantar keratoderma characterized by diffuse, mild to thick, finely demarcated hyperkeratosis of palms and soles. Additional clinical findings include knuckle pad-like keratoses on fingers, hyperkeratosis of umbilicus and areolae, diffuse dry skin, hyperhidrosis, hangnails and frequent fungal infections. Histological examination of lesions reveals orthokeratotic hyperkeratosis, acanthosis, hypergranulosis, and mild lymphocyte infiltrations in the upper dermis with no evidence of epidermolysis.
MONDO:0000426
autosomal dominant disease
is_a
MONDO:0017666
diffuse palmoplantar keratoderma
is_a
KRT1-related diffuse nonepidermolytic keratoderma
exact
NEPPK
exact
PPK diffusa circumscripta
related
PPKNE
related
Thost-Unna disease
related
Thost-Unna palmoplantar keratoderma
related
Thost-Unna syndrome
related
Unna-Thost palmoplantar keratoderma
related
Unna-Thost syndrome
related
autosomal dominant diffuse palmoplantar keratoderma, Norrbotten type
narrow
diffuse NEPPK
related
diffuse nonepidermolytic palmoplantar keratoderma
exact
diffuse palmoplantar keratoderma, Bothnian type
exact
non-epidermolytic palmoplantar keratoderma
exact
nonepidermolytic palmoplantar keratoderma
exact
palmoplantar keratoderma, nonepidermolytic
exact