nuclear exosome (RNase complex)
A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
GO:0000178
exosome (RNase complex)
is_a
GO:0140513
nuclear protein-containing complex
is_a
GO:0031981
nuclear lumen
part_of
eukaryotic exosome multienzyme ribonuclease complex
exact
nuclear exosome (ribonuclease complex)
exact
nuclear exosome multienzyme ribonuclease complex
exact
SPBC26H8.10 SPBC16G5.10 SPAC3G9.10c SPCC757.08 SPBC17D1.03c SPBC115.01c SPAC22A12.12c SPAC2F7.14c SPBC211.08c SPACUNK4.11c SPCC1739.07 SPCC1840.11 SPAC1F3.01