17-hydroxyprogesterone 21-hydroxylase activity
Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
GO:0004509
steroid 21-monooxygenase activity
is_a