shelterin complex
A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.
GO:0000783
nuclear telomere cap complex
is_a
Pot1 complex
exact
Pot1-Tpz1 complex
exact
telosome
exact
SPCC188.07 SPBC1778.02 SPAC6F6.16c SPAC16A10.07c SPAC26H5.06 SPAC19G12.13c