ATF6-mediated unfolded protein response
The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
GO:0006984
ER-nucleus signaling pathway
is_a
GO:0030968
endoplasmic reticulum unfolded protein response
is_a
ATF6 branch of UPR
exact
ATF6 signal transduction pathway
broad
ATF6 signaling in response to endoplasmic reticulum stress
related
ATF6-alpha UPR branch
narrow
ATF6-beta UPR branch
narrow
UPR signaling by ATF6 stress sensor
exact
activating transcription factor 6 signaling in unfolded protein response
exact
endoplasmic reticulum unfolded protein response; ATF6 signaling
exact