LMNA-related cardiocutaneous progeria syndrome
A rare, genetic, premature aging syndrome characterized by adulthood-onset cutaneous manifestations that result in a prematurely aged appearance (i.e. premature thinning and graying of scalp hair, loss of subcutaneous fat, tightening of skin) associated with prominent cardiovascular manifestations, such as accelerated atherosclerosis, calcific valve disease, and cardiomyopathy. Patients present loss of eyebrows and eyelashes in childhood and have a predisposition to develop malignancies.
MONDO:0019303
premature aging syndrome
is_a
MONDO:0100547
cardiogenetic disease
is_a
LCPS
exact