eukaryotic translation initiation factor 3 complex
A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
GO:0032991
protein-containing complex
is_a
GO:0005737
cytoplasm
part_of
eIF-3
exact
eIF3
exact
SPBC4C3.07 SPAC637.07 SPBC18H10.03 SPAC4A8.16c SPBC17D11.05 SPAC3A12.13c SPAC821.05 SPAC25G10.08 SPAC4D7.05 SPBC646.09c SPAC1751.03