intrinsic apoptotic signaling pathway in response to hypoxia
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered.
GO:0097193
intrinsic apoptotic signaling pathway
is_a
GO:0071456
cellular response to hypoxia
part_of