Phosphoinositide binding protein; binds PI(3,5)P2, PI3P and PI4P; required for autophagic vesicle formation, autophagosome formation and the CVT pathway; PROPPIN family member that contains multiple WD-40 repeats and an AIM motif; forms higher order helical assemblies; relocalizes from the vacuole to cytoplasm upon replication stress; human WDR45, one of many mammalian homologs (WIPI1, WIPI2, WIPI3 and WDR45), causes static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)