Prp19 complex
A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
GO:0032991
protein-containing complex
is_a
MOS4-Associated Complex
narrow
NTC
related
Prp19/CDC5 complex
narrow
nineteen complex
narrow
SPBC146.05c SPCC188.11 SPAC2C4.03c SPAC57A10.03 SPCC550.02c SPBC3E7.13c SPAC3A12.11c SPBC32F12.05c SPBP22H7.07 SPBC13E7.01 SPCC1620.10 SPBC24C6.11 SPBC646.02 SPAC30D11.09 SPBC6B1.10 SPBC28F2.04c SPAC4F8.12c SPCP1E11.07c SPAC1F3.09 SPAC29A4.08c SPBC211.02c SPBC215.12 SPAC9.13c SPAC644.12 SPAC4A8.09c SPBC31F10.11c SPBC337.06c