mitotic spindle assembly checkpoint override
A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to mitotic cell cycle spindle assembly checkpoint signaling does not occur. As a result, the septation initiation network (SIN) signaling pathway is activated despite activation of the mitotic spindle assembly checkpoint (SAC). Normally, under conditions that activate the SAC, SIN activation is inhibited and the cell cycle arrests in anaphase. In this phenotype, premature SIN activation leads to premature cytokinesis and the formation of cut cells.
FYPO:0000229
cut
has_output
FYPO:0004536
abnormal response to mitotic cell cycle spindle assembly checkpoint signaling
is_a
SIN activation in presence of active mitotic SAC
exact
abolished response to mitotic cell cycle spindle assembly checkpoint signaling
exact
mitotic SAC override
exact
mitotic cell cycle spindle assembly checkpoint override
exact
septation initiation signaling activation in presence of active mitotic spindle assembly checkpoint
exact