STING complex
A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.
GO:0098796
membrane protein complex
is_a
GO:0030659
cytoplasmic vesicle membrane
part_of
stimulator of interferon genes complex
exact