oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
GO:0000702
oxidized base lesion DNA N-glycosylase activity
is_a
DNA glycosylase/AP-lyase
broad
DNA glycosylase/beta-lyase
broad
bifunctional DNA glycosylase
broad
endodeoxyribonuclease III
related
endonuclease III
related
endonuclease VIII activity
related
oxidized pyrimidine base lesion DNA N-glycosylase activity
exact
pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
related
SPAC30D11.07