P-type transmembrane transporter activity
Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
GO:0042626
ATPase-coupled transmembrane transporter activity
is_a
E1-E2 ATPase
exact
P-type ATPase
exact
SPCC1020.01c SPAC1071.10c SPAPB2B4.04c SPBC29A3.01 SPBC839.06 SPACUNK4.07c SPCC1672.11c SPAC29A4.19c SPBC31E1.02c