ubiquitin activating enzyme activity
Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
GO:0008641
ubiquitin-like modifier activating enzyme activity
is_a
E1 ubiquitin-activating enzyme
related
SPBC1604.21c