error-prone translesion synthesis
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.
GO:0019985
translesion synthesis
is_a
error-prone postreplication DNA repair
related
mutagenic PRR
exact
mutagenic postreplication DNA repair
related
SPBC713.02c SPBC16D10.09 SPBP8B7.14c SPCC553.07c SPBC12D12.09 SPBC1347.01c SPBC16A3.11 SPAC688.10 SPAC2F7.06c