histone deacetylase activity, NAD-dependent
Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide.
GO:0004407
histone deacetylase activity
is_a
GO:0034979
NAD-dependent protein lysine deacetylase activity
is_a
NAD-dependent histone deacetylase activity
exact
NAD-dependent histone lysine deacetylase activity
exact
SIR2
related
histone deacetylase activity
broad
sirtuin
narrow
SPCC132.02 SPAC1783.04c SPBC16D10.07c