ERAD pathway
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
GO:0010498
proteasomal protein catabolic process
is_a
GO:0034976
response to endoplasmic reticulum stress
is_a
GO:0042221
response to chemical
is_a
ER-associated degradation pathway
related
endoplasmic reticulum-associated degradation
exact
endoplasmic reticulum-associated protein degradation pathway
related
protein degradation by ERAD
exact
SPAC1565.08 SPAC4G9.19 SPBC17D11.02c SPAC1952.03 SPAC1B3.10c SPAC23A1.04c SPBC1711.10c SPCC1682.16 SPAC10F6.05c SPAC3C7.11c SPAC167.07c SPBC2D10.20 SPBP4H10.19c SPAC20H4.10 SPAC4D7.14 SPCC1827.04 SPAC959.05c SPAC1687.17c SPBC1709.14 SPBP16F5.04 SPBC16A3.09c SPAC227.11c SPCC285.11 SPAC22A12.15c SPAC2E1P5.01c SPBC2D10.12 SPAC1782.01 SPAC24C9.14 SPAC25B8.17 SPAC328.06 SPAC6G9.08 SPBC1347.05c SPCC1840.08c SPCC4G3.13c SPBC28F2.08c SPBC14F5.07 SPAC23A1.07 SPAC26A3.16 SPBC365.08c