Factor XII activation
Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
GO:0002673
regulation of acute inflammatory response
is_a
GO:0010954
positive regulation of protein processing
is_a
GO:0002353
plasma kallikrein-kinin cascade
part_of
GO:0002541
activation of plasma proteins involved in acute inflammatory response
positively_regulates
Hageman factor activation
exact