CAAX-protein geranylgeranyltransferase activity
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
GO:0004661
protein geranylgeranyltransferase activity
is_a
GGTase-I activity
exact
GGTaseI activity
exact
geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
exact
geranylgeranyltransferase type I activity
exact
protein geranylgeranyltransferase type I
related
type I protein geranyl-geranyltransferase activity
related
SPAC2E1P5.04c SPAPB1A10.04c