RNA polymerase II, core complex
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
GO:0055029
nuclear DNA-directed RNA polymerase complex
is_a
GO:0016591
RNA polymerase II, holoenzyme
part_of
DNA-directed RNA polymerase II, core complex
exact
RNA polymerase II complex
broad
RNAP II complex
broad
SPACUNK4.06c SPAPYUG7.04c SPAC1B3.12c SPCC1020.04c SPAC23C4.15 SPBC337.14 SPBC19C2.03 SPCC1442.10c SPBC14C8.12 SPBC28F2.12 SPAC3A12.07 SPAC23G3.01 SPBC947.13