chronic myeloid leukemia
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.
MONDO:0004643
myeloid leukemia
is_a
MONDO:0023603
hereditary disorder of connective tissue
is_a
BCR-ABL Positive chronic myelogenous leukaemia
exact
BCR-ABL Positive chronic myelogenous leukemia
exact
CML
exact
CML - chronic myelogenous leukaemia
exact
CML - chronic myelogenous leukemia
exact
chronic granulocytic leukemia
exact
chronic myelocytic leukaemia
exact
chronic myelocytic leukemia
exact
chronic myelogenous leukaemia (CML)
exact
chronic myelogenous leukemia
exact
chronic myelogenous leukemia (CML)
exact
chronic myelogenous leukemia, BCR-ABL1 Positive
exact
chronic myelogenous leukemias
exact
chronic myeloid leukemia
exact
hematopoeitic - chronic myelocytic leukaemia (CML)
exact
hematopoeitic - chronic myelocytic leukemia (CML)
exact
leukimia, chronic myeloid
exact
myeloid leukemia, chronic
exact