eukaryotic 48S preinitiation complex
The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.
GO:0070993
cytosolic translation preinitiation complex
is_a
eukaryotic 48S initiation complex
related
eukaryotic 48S pre-initiation complex
exact
SPBC4C3.07 SPBC646.09c SPAC3A12.13c SPAC56F8.03 SPBC18H10.03 SPAC2F7.05c SPAC821.05 SPAC4A8.16c SPAC25G10.08 SPBC17D11.05 SPAC3G9.09c SPAC1751.03 SPAC4D7.05