prion disease
A transmissible disease that is caused by a protein that is able to induce abnormal folding of normal cellular proteins, leading to characteristic spongiform brain changes, which are associated with neuronal loss without an inflammatory response. Such disorders have typically long incubation periods, but are then generally rapidly progressive and are uniformly fatal.
MONDO:0005560
brain disorder
is_a
MONDO:0024619
central nervous system infectious disorder
is_a
spongiform encephalopathy
exact