collagenous sprue
A rare disorder affecting the digestive tract. Its cause is unclear but may be attributed, in part, to increased collagen synthesis without adequate fibrolysis. It is characterized histologically by atrophy of mucosal villi and crypts with extensive subepithelial collagen deposition. Clinical signs include nausea, vomiting, diarrhea and weight loss. Unlike celiac sprue (celiac disease), a gluten-free diet does not predict a certain regression of the disease. The clinical course follows a progression of malabsorption leading to nutritional deficiencies, small bowel ulceration/perforation, lymphoma and infection. Prognosis is usually dismal.
MONDO:0005130
celiac disease
excluded_subClassOf
MONDO:0005020
intestinal disorder
is_a
MONDO:0005066
metabolic disease
is_a
Sprues, collagenous
related
collagenous Sprues
related
collagenous sprue
exact
non-gluten sensitive enteropathy syndrome
exact
sprue, collagenous
related