NAD-dependent protein de-2-hydroxyisobutyrylase activity
Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
GO:0016747
acyltransferase activity, transferring groups other than amino-acyl groups
is_a