PERK-mediated unfolded protein response
The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
GO:0006984
ER-nucleus signaling pathway
is_a
GO:0030968
endoplasmic reticulum unfolded protein response
is_a
GO:0140467
integrated stress response signaling
is_a
EIF2AK3-mediated unfolded protein response
related
PERK branch of UPR
exact
PERK signal transduction pathway
broad
PERK signaling in response to endoplasmic reticulum stress
related
PKR-like ER kinase signal transduction
exact
UPR signaling by PERK stress sensor
exact
endoplasmic reticulum unfolded protein response; PERK signaling
exact
eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response
related