AP-2 adaptor complex
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
GO:0030131
clathrin adaptor complex
is_a
GO:0098797
plasma membrane protein complex
is_a
GO:0030128
clathrin coat of endocytic vesicle
part_of
GO:0030132
clathrin coat of coated pit
part_of
HA2
exact
HA2 clathrin adaptor
exact
SPAC31A2.09c SPBC685.04c SPBC691.03c SPBC2G2.06c