methylmalonate-semialdehyde dehydrogenase (acylating, NAD+) activity
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
GO:0016620
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
is_a
MMSA dehydrogenase activity
related
MSDH activity
related
methylmalonate-semialdehyde dehydrogenase (acylating) activity
related