Delta4-3-oxosteroid 5beta-reductase activity
Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.
GO:0035671
enone reductase activity
is_a
3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity
exact
3-oxo-Delta(4)-steroid 5-beta-reductase activity
exact
3-oxo-Delta4-steroid 5beta-reductase activity
exact
4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity
narrow
5-beta-reductase activity
broad
5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity
narrow
5beta-reductase activity
related
Delta(4)-3-ketosteroid 5-beta-reductase activity
related
Delta(4)-5-beta-reductase activity
related
Delta(4)-hydrogenase activity
related
Delta4-3-ketosteroid 5beta-reductase activity
related
Delta4-3-oxosteroid 5-beta-reductase activity
exact
Delta4-5beta-reductase activity
related
Delta4-hydrogenase activity
related
androstenedione 5-beta-reductase activity
narrow
androstenedione 5beta-reductase activity
narrow
cholestenone 5-beta-reductase activity
narrow
cholestenone 5b-reductase activity
narrow
cholestenone 5beta-reductase activity
narrow
cortisone 5-beta-reductase activity
narrow
cortisone 5beta-reductase activity
narrow
cortisone b-reductase activity
narrow
cortisone beta-reductase activity
narrow
cortisone delta(4)-5-beta-reductase activity
narrow
cortisone delta4-5beta-reductase activity
related
steroid 5-beta-reductase activity
related
steroid 5beta-reductase activity
related
testosterone 5-beta-reductase activity
narrow
testosterone 5beta-reductase activity
narrow