aromatase excess syndrome
Aromatase excess syndrome is a rare, genetic endocrine disease characterized by increased levels of estrogen due to elevated extraglandular aromatase activity. Males present with heterosexual precocious puberty which manifests with pre- or peripubertal onset of gynecomastia, premature growth spurt, accelerated bone maturation resulting in decreased adult stature, and may present mild hypogonadotropic hypogonadism. Female patients may have isosexual precocious puberty or not have any manifestations at all.
MONDO:0016072
obsolete anomaly of puberty or/and menstrual cycle of genetic origin (obsolete MONDO:0016072)
excluded_subClassOf
MONDO:0018561
precocious puberty in female
excluded_subClassOf
MONDO:0005039
reproductive system disorder
is_a
MONDO:0019052
inborn errors of metabolism
is_a
AEXS
exact
aromatase excess syndrome
exact
familial hyperestrogenism
exact
gynecomastia, familial, due to increased aromatase activity
exact
gynecomastia, hereditary
exact
hereditary prepubertal gynecomastia
exact