mediator complex
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
GO:0140513
nuclear protein-containing complex
is_a
CDK8-containing TRAP/mediator complex
related
L mediator complex
exact
Srb-mediator complex
exact
TRAP complex
narrow
SPAC29A4.07 SPAC24C9.04 SPAC688.08 SPBC1A4.10c SPBC1604.10 SPBC31F10.04c SPAC589.02c SPAC5D6.05 SPCP31B10.03c SPBC31F10.09c SPCC1450.05c SPAC17C9.05c SPAC2F7.04 SPBC1105.06 SPAC644.10 SPAC23H4.17c SPBC14F5.08 SPBC12D12.06 SPBC146.01 SPBC21.04 SPAC1002.15c SPAC17G8.05