SRP-dependent cotranslational protein targeting to membrane, translocation
The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
GO:0065002
intracellular protein transmembrane transport
is_a
GO:0006614
SRP-dependent cotranslational protein targeting to membrane
part_of
ER translocation
broad
SRP-dependent cotranslational membrane targeting, translocation
exact
SRP-dependent cotranslational protein-membrane targeting, translocation
exact
translocation during SRP-dependent cotranslational protein targeting to membrane
exact
SPBC19G7.17 SPBC2G2.03c SPCC188.06c SPBC354.02c SPAC4G8.02c SPBC1271.05c SPAC1071.03c SPAC19B12.09