N-terminal protein N-methyltransferase activity
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
GO:0008276
protein methyltransferase activity
is_a
GO:0008757
S-adenosylmethionine-dependent methyltransferase activity
is_a
X-Pro-Lys N-terminal methyltransferase
narrow
SPAC8F11.09c SPAC16E8.14c