nut midline carcinoma
A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene.
MONDO:0005617
undifferentiated carcinoma
is_a
Midline carcinoma of children and Young adults with NUT rearrangement
exact
NMC
exact
NUT Midline carcinoma
exact
NUT carcinoma
exact
NUT midline carcinoma of the head and neck
related
carcinoma with t(15;19)(q13;p13.1) translocation
exact
nuclear protein in testis midline carcinoma
exact