MHC class I peptide loading complex
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
GO:0098796
membrane protein complex
is_a
GO:0140534
endoplasmic reticulum protein-containing complex
is_a
GO:0005789
endoplasmic reticulum membrane
part_of
PLC
related
peptide-loading complex
exact