selective IgA deficiency disease
A dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class A (IgA). It is the most common primary antibody deficiency. It may be inherited or the reversible sequela of infection or certain drugs. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Though affected persons may be asymptomatic, low levels of IgA will reduce the immune system's ability to combat infection where IgA is normally secreted, at mucosal surfaces. Selective IgA deficiency is seen in greater proportion among patients with autoimmune disorders.
MONDO:0001342
dysgammaglobulinemia
is_a
IgA deficiencies
related
SIgAD
exact
deficiencies, IgA
related
deficiency, IgA
related
immunoglobulin A deficiency
exact
selective IgA immunodeficiency
exact