activity_directly_negatively_regulates_activity_of
Holds between molecular entities A and B where A can physically interact with B and in doing so negatively regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
RO:0002448
activity_directly_regulates_activity_of
is_a
molecularly decreases activity of
exact