heparan sulfate proteoglycan biosynthetic process
The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
GO:0030166
proteoglycan biosynthetic process
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GO:0030201
heparan sulfate proteoglycan metabolic process
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GO:0180064
protein O-linked glycosylation via xylose
is_a
heparan sulfate proteoglycan anabolism
exact
heparan sulfate proteoglycan biosynthesis
exact
heparan sulfate proteoglycan formation
exact
heparan sulfate proteoglycan synthesis
exact
heparan sulphate proteoglycan biosynthesis
exact
heparan sulphate proteoglycan biosynthetic process
exact
heparin proteoglycan biosynthetic process
related