broad specificity oxidative DNA demethylase activity
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
GO:0016706
2-oxoglutarate-dependent dioxygenase activity
is_a
GO:0035514
DNA demethylase activity
is_a
1-ethyladenine demethylase activity
narrow
2-oxoglutarate-dependent DNA demethylase
exact
5-formylcytosine dioxygenase activity
narrow
5-hydroxymethylcytosine dioxygenase activity
narrow
5fC dioxygenase
narrow
5hmC dioxygenase
narrow
N1-methyladenine demethylase activity
narrow
N3-methylcytosine demethylase activity
narrow
oxidative DNA demethylase activity
broad