insulin-like growth factor binding receptor complex
A plasma membrane-localized protein complex that binds insulin-like growth factors (IGF1 or IGF2). This class includes both signaling receptor complexes, such as the insulin-like growth factor 1 receptor (IGF1R) complex, which possesses intrinsic tyrosine kinase activity and initiates intracellular signaling cascades upon ligand binding, and non-signaling receptor complexes such as the insulin-like growth factor 2 receptor (IGF2R), which functions to sequester IGF2 and regulate its bioavailability by directing it to lysosomal degradation. These complexes regulate cell growth, proliferation, survival, and development by modulating IGF signaling.
GO:0098802
plasma membrane signaling receptor complex
is_a
IGF-binding receptor complex
exact