NAD+ nucleosidase activity, cyclic ADP-ribose generating
Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+, in a two step reaction: first an ADP-ribosyl cyclase reaction to synthesise cyclic ADP-ribose, followed by a cyclic ADP-ribose hydrolase reaction to generate (linear) ADP-ribose.
GO:0016799
hydrolase activity, hydrolyzing N-glycosyl compounds
is_a
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
exact
NAD hydrolase
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NAD(+) nucleosidase
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NADase
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nicotinamide adenine dinucleotide nucleosidase
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