T/G mismatch-specific endonuclease activity
Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine.
GO:0004520
DNA endonuclease activity
is_a
DNA mismatch endonuclease
broad
V.EcoKDcm
related
Vsr mismatch endonuclease
related
very short patch repair protein
related