integrated stress response signaling
The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
GO:0033554
cellular response to stress
is_a
GO:0141124
intracellular signaling cassette
is_a
ISR
related
SPBC14C8.09c SPAC27E2.02 SPAC6B12.15 SPBC36B7.09