Rhino-Deadlock-Cutoff Complex
Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation.
GO:0140513
nuclear protein-containing complex
is_a
GO:1990923
PET complex
is_a
GO:0043073
germ cell nucleus
part_of
RDC complex
exact
rhi-del-cuff complex
exact