cell surface receptor signaling pathway via JAK-STAT
A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
GO:0097696
cell surface receptor signaling pathway via STAT
is_a
JAK-STAT cascade
narrow
JAK-STAT signal transduction
exact
receptor signaling pathway via JAK-STAT
exact