negative regulation of pyruvate decarboxylation to acetyl-CoA
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions.
GO:0010510
regulation of pyruvate decarboxylation to acetyl-CoA
is_a
GO:0140391
negative regulation of acetyl-CoA biosynthesis
is_a
GO:0006086
pyruvate decarboxylation to acetyl-CoA
negatively_regulates
negative regulation of acetyl-CoA biosynthetic process from pyruvate
exact