id: gomodel:662af8fa00000408
title: 'ubiquinone metabolic process (GO:0006743)

  '
taxon: NCBITaxon:4896
status: production
comments:
- 'PMID: 38425362  COQ9 has been shown to facilitate COQ7 activity in vivo38,39. Consistently,
  addition of COQ9 increased catalytic efficiency by 1.5-fold, substantiating its
  role for COQ7 function (Fig. 5b and Extended Data Fig. 2).

  '
- 'PMID: 38425362 . We therefore hypothesized that COQ8B could act as a COQ3 kinase.
  Intact protein MS validated this idea: COQ3, but not COQ6, is phosphorylated by
  COQ8B at multiple sites (Supplementary Fig. 13). This finding resonates with the
  work by Clarke and co-workers demonstrating that yeast mitochondrial Coq3 is phosphorylated48.
  Consistent with the increased activities for COQ6:COQ3, we noticed that this pair
  stimulates ATPase activity of COQ8B by ten-fold '
- https://www.frontiersin.org/files/Articles/626971/fonc-11-626971-HTML/image_m/fonc-11-626971-g001.jpg
- https://www.mdpi.com/2072-6643/11/9/2221
- https://www.pombase.org/reference/PMID:37156397
activities:
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    type: EnabledByGeneProductAssociation
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      reference: 'PMID:38425362 '
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    term: PomBase:SPBC2D10.18
  molecular_function:
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      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000132977
      - PomBase:SPBC337.15c
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-16'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-16'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:231829
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:18808426
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000132977
      - PomBase:SPBC337.15c
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
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      - https://orcid.org/0000-0001-6330-7526
      date: '2024-04-28'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:662af8fa00000408/662af8fa00000474
- id: gomodel:662af8fa00000408/680ad14200001314
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0022857
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: GO:0006744
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:175763
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:175763
objects:
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: GO:0008412
  label: 4-hydroxybenzoate polyprenyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC56F8.04c
  label: ppt1 Spom
  type: gocam:Object
- id: GO:0006744
  label: ubiquinone biosynthetic process
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0010420
  label: polyprenyldihydroxybenzoate methyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC162.05
  label: coq3 Spom
  type: gocam:Object
- id: GO:0031314
  label: extrinsic component of mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: GO:0008425
  label: 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC4G3.04c
  label: coq5 Spom
  type: gocam:Object
- id: GO:0160224
  label: 3-demethoxyubiquinone 3-hydroxylase (NADH) activity
  type: gocam:Object
- id: PomBase:SPBC337.15c
  label: coq7 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0061542
  label: 3-demethylubiquinol 3-O-methyltransferase activity
  type: gocam:Object
- id: GO:0097269
  label: all-trans-decaprenyl-diphosphate synthase activity
  type: gocam:Object
- id: PomBase:SPBPJ4664.01
  label: dps1 Spom
  type: gocam:Object
- id: PomBase:SPAC19G12.12
  label: dlp1 Spom
  type: gocam:Object
- id: GO:0140104
  label: molecular carrier activity
  type: gocam:Object
- id: PomBase:SPCC16A11.07
  label: coq10 Spom
  type: gocam:Object
- id: CHEBI:46245
  label: coenzyme Q10
  type: gocam:Object
- id: GO:0106364
  label: 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity
  type: gocam:Object
- id: PomBase:SPBC146.12
  label: coq6 Spom
  type: gocam:Object
- id: GO:0004722
  label: protein serine/threonine phosphatase activity
  type: gocam:Object
- id: PomBase:SPAC1556.03
  label: azr1 Spom
  type: gocam:Object
- id: GO:1904775
  label: positive regulation of ubiquinone biosynthetic process
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: GO:0004324
  label: ferredoxin-NADP+ reductase activity
  type: gocam:Object
- id: PomBase:SPBC3B8.01c
  label: arh1 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0009055
  label: electron transfer activity
  type: gocam:Object
- id: PomBase:SPAC22E12.10c
  label: etp1 Spom
  type: gocam:Object
- id: GO:0099617
  label: matrix side of mitochondrial inner membrane
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPCC1840.09
  label: coq11 Spom
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: CHEBI:128769
  label: isopentenyl diphosphate(3-)
  type: gocam:Object
- id: GO:0006743
  label: ubiquinone metabolic process
  type: gocam:Object
- id: GO:0120539
  label: 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity
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- id: PomBase:SPAC1687.12c
  label: coq4 Spom
  type: gocam:Object
- id: GO:0098772
  label: molecular function regulator activity
  type: gocam:Object
- id: PomBase:SPAC19G12.11
  label: coq9 Spom
  type: gocam:Object
- id: GO:0004672
  label: protein kinase activity
  type: gocam:Object
- id: PomBase:SPBC2D10.18
  label: coq8 Spom
  type: gocam:Object
- id: GO:0016301
  label: kinase activity
  type: gocam:Object
- id: CHEBI:17879
  label: 4-hydroxybenzoate
  type: gocam:Object
- id: CHEBI:55337
  label: all-trans-polyprenyl diphosphate
  type: gocam:Object
- id: GO:0036382
  label: flavin reductase (NADH) activity
  type: gocam:Object
- id: PomBase:SPAC1071.11
  label: coq12 Spom
  type: gocam:Object
- id: GO:0120538
  label: 2-methoxy-6-polyprenolphenol 4-hydroxylase activity
  type: gocam:Object
- id: GO:0004497
  label: monooxygenase activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: CHEBI:64181
  label: 2-decaprenyl-6-methoxy-3-methylhydroquinone
  type: gocam:Object
- id: CHEBI:231829
  label: 2-methoxy-5-methyl-6-all-trans-polyprenylbenzoquinone
  type: gocam:Object
- id: CHEBI:175763
  label: 2-trans,6-trans-farnesyl diphosphate(3-)
  type: gocam:Object
- id: GO:0022857
  label: transmembrane transporter activity
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-04-28'
  provided_by:
  - http://www.pombase.org