id: gomodel:5fadbcf000000632
title: " \np38MAPK cascade (GO:0038066)"
taxon: NCBITaxon:4896
status: production
date_modified: '2026-04-24'
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    term: GO:0038066
- id: gomodel:5fadbcf000000632/682fbcd000006850
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:8649397
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:7657164
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-11'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC19D5.01
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0033550
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:10233152
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-01-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:10233152
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-01-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005737
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:8649397
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:7657164
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:7657164
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-11'
      provided_by:
      - http://www.pombase.org
    term: GO:1903753
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:8649397
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:7657164
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-11'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002630
    downstream_activity: gomodel:5fadbcf000000632/5fadbcf000000819
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:8649397
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:7657164
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-11'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002630
    downstream_activity: gomodel:5fadbcf000000632/5fadbcf000000819
- id: gomodel:5fadbcf000000632/5fadbcf000000819
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:9251044
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2020-11-17'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:12080074
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2020-11-17'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:18272791
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2020-11-17'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC24B11.06c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004707
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:10398679
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-03-26'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-26'
      provided_by:
      - http://www.pombase.org
    term: GO:0038066
molecules:
- id: gomodel:5fadbcf000000632/69729a3800002390
  term: PomBase:SPAC24B11.06c
- id: gomodel:5fadbcf000000632/69729a3800002248
  term: PomBase:SPAC24H6.05
objects:
- id: GO:0004707
  label: MAP kinase activity
  type: gocam:Object
- id: PomBase:SPAC24B11.06c
  label: sty1 Spom
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0033549
  label: MAP kinase phosphatase activity
  type: gocam:Object
- id: PomBase:SPAC4A8.03c
  label: ptc4 Spom
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0033550
  label: MAP kinase tyrosine phosphatase activity
  type: gocam:Object
- id: PomBase:SPAC26F1.10c
  label: pyp1 Spom
  type: gocam:Object
- id: GO:1903753
  label: negative regulation of p38MAPK cascade
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC19D5.01
  label: pyp2 Spom
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0006611
  label: protein export from nucleus
  type: gocam:Object
- id: GO:0005634
  label: nucleus
  type: gocam:Object
- id: GO:0010971
  label: positive regulation of G2/M transition of mitotic cell cycle
  type: gocam:Object
- id: GO:0038066
  label: p38MAPK cascade
  type: gocam:Object
- id: GO:0010972
  label: negative regulation of G2/M transition of mitotic cell cycle
  type: gocam:Object
- id: ECO:0000353
  label: physical interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0005737
  label: cytoplasm
  type: gocam:Object
- id: GO:0034599
  label: cellular response to oxidative stress
  type: gocam:Object
- id: GO:0004709
  label: MAP kinase kinase kinase activity
  type: gocam:Object
- id: PomBase:SPAC9G1.02
  label: wis4 Spom
  type: gocam:Object
- id: GO:0000155
  label: phosphorelay sensor kinase activity
  type: gocam:Object
- id: PomBase:SPCC74.06
  label: mak3 Spom
  type: gocam:Object
- id: GO:1900745
  label: positive regulation of p38MAPK cascade
  type: gocam:Object
- id: GO:1990439
  label: MAP kinase serine/threonine phosphatase activity
  type: gocam:Object
- id: PomBase:SPCC4F11.02
  label: ptc1 Spom
  type: gocam:Object
- id: PomBase:SPAC2G11.07c
  label: ptc3 Spom
  type: gocam:Object
- id: GO:0004674
  label: protein serine/threonine kinase activity
  type: gocam:Object
- id: PomBase:SPCC1322.08
  label: srk1 Spom
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: GO:0004725
  label: protein tyrosine phosphatase activity
  type: gocam:Object
- id: PomBase:SPAC24H6.05
  label: cdc25 Spom
  type: gocam:Object
- id: PomBase:SPAC27E2.09
  label: mak2 Spom
  type: gocam:Object
- id: GO:0009927
  label: histidine phosphotransfer kinase activity
  type: gocam:Object
- id: PomBase:SPBC725.02
  label: mpr1 Spom
  type: gocam:Object
- id: GO:0000156
  label: phosphorelay response regulator activity
  type: gocam:Object
- id: PomBase:SPBC887.10
  label: mcs4 Spom
  type: gocam:Object
- id: PomBase:SPAC1006.09
  label: win1 Spom
  type: gocam:Object
- id: GO:0004708
  label: MAP kinase kinase activity
  type: gocam:Object
- id: PomBase:SPBC409.07c
  label: wis1 Spom
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0004693
  label: cyclin-dependent protein serine/threonine kinase activity
  type: gocam:Object
- id: GO:0000308
  label: cytoplasmic cyclin-dependent protein kinase holoenzyme complex
  type: gocam:Object
- id: GO:0000086
  label: G2/M transition of mitotic cell cycle
  type: gocam:Object
- id: PomBase:SPBC11B10.09
  label: cdc2 Spom
  type: gocam:Object
- id: PomBase:SPBC582.03
  label: cdc13 Spom
  type: gocam:Object
- id: GO:0140311
  label: protein sequestering activity
  type: gocam:Object
- id: PomBase:SPAC8E11.02c
  label: rad24 Spom
  type: gocam:Object
- id: GO:0005049
  label: nuclear export signal receptor activity
  type: gocam:Object
- id: PomBase:SPAC1805.17
  label: crm1 Spom
  type: gocam:Object
- id: GO:0061608
  label: nuclear import signal receptor activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0006607
  label: NLS-bearing protein import into nucleus
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2026-04-24'
  provided_by:
  - http://www.pombase.org
