id: gomodel:67086be200000251
title: 'pyruvate decarboxylation to acetyl-CoA (GO:0006086) '
taxon: NCBITaxon:4896
status: production
date_modified: '2026-04-27'
comments:
- 'Automated change 2026-03-26: GO:0019427 replaced by GO:0006085'
- Is this DEFINITELY ACETYL TRANSFERING?
- 'REGULATION https://pubmed.ncbi.nlm.nih.gov/37754565/#&gid=article-figures&pid=fig-9-uid-8 '
- Should all be mitochondrial matrix?
- 'file:///Users/vw253/Downloads/micropub-biology-001209.pdf '
- 'need https://github.com/geneontology/go-ontology/issues/17825

  DONE'
- 'need https://github.com/geneontology/go-ontology/issues/24350

  DONE'
- 'vw: added pyruvate reansporter and connection to upstream pathway (glycolysis)'
- 'yeast pyruvate dehydrogenase bypass https://www.jbc.org/article/S0021-9258%2

  819%2972544-7/fulltext'
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    term: GO:0005759
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    term: GO:0006086
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    term: GO:0005759
objects:
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  label: coenzyme A(4-)
  type: gocam:Object
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  label: mitochondrial matrix
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- id: GO:0003852
  label: 2-isopropylmalate synthase activity
  type: gocam:Object
- id: PomBase:SPBC3E7.16c
  label: leu3 Spom
  type: gocam:Object
- id: GO:0009098
  label: L-leucine biosynthetic process
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0004739
  label: pyruvate dehydrogenase (acetyl-transferring) activity
  type: gocam:Object
- id: PomBase:SPAC26F1.03
  label: pda1 Spom
  type: gocam:Object
- id: GO:0006086
  label: pyruvate decarboxylation to acetyl-CoA
  type: gocam:Object
- id: PomBase:SPBC30D10.13c
  label: pdb1 Spom
  type: gocam:Object
- id: GO:0005198
  label: structural molecule activity
  type: gocam:Object
- id: PomBase:SPCC1259.09c
  label: pdx1 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0004742
  label: dihydrolipoyllysine-residue acetyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC794.07
  label: lat1 Spom
  type: gocam:Object
- id: CHEBI:15361
  label: pyruvate
  type: gocam:Object
- id: GO:0004148
  label: dihydrolipoyl dehydrogenase (NADH) activity
  type: gocam:Object
- id: PomBase:SPAC1002.09c
  label: dld1 Spom
  type: gocam:Object
- id: GO:0004740
  label: pyruvate dehydrogenase (acetyl-transferring) kinase activity
  type: gocam:Object
- id: PomBase:SPAC644.11c
  label: pkp1 Spom
  type: gocam:Object
- id: GO:0004741
  label: '[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity'
  type: gocam:Object
- id: PomBase:SPAC10F6.17c
  label: ptc5 Spom
  type: gocam:Object
- id: CHEBI:57288
  label: acetyl-CoA(4-)
  type: gocam:Object
- id: GO:0015228
  label: coenzyme A transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC17H9.08
  label: leu5 Spom
  type: gocam:Object
- id: GO:1990559
  label: mitochondrial coenzyme A transmembrane transport
  type: gocam:Object
- id: GO:0006085
  label: acetyl-CoA biosynthetic process
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: GO:0036440
  label: citrate synthase activity
  type: gocam:Object
- id: PomBase:SPAC6C3.04
  label: cit1 Spom
  type: gocam:Object
- id: GO:0006099
  label: tricarboxylic acid cycle
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:16947
  label: citrate(3-)
  type: gocam:Object
- id: GO:0016979
  label: lipoate-protein ligase activity
  type: gocam:Object
- id: PomBase:SPBC17A3.09c
  label: aim22 Spom
  type: gocam:Object
- id: GO:0009249
  label: protein lipoylation
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: GO:0004021
  label: L-alanine:2-oxoglutarate transaminase activity
  type: gocam:Object
- id: PomBase:SPBC582.08
  label: alt1 Spom
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:29985
  label: L-glutamate(1-)
  type: gocam:Object
- id: GO:0090422
  label: thiamine pyrophosphate transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPBC1604.04
  label: SPBC1604.04 Spom
  type: gocam:Object
- id: GO:1990545
  label: mitochondrial thiamine pyrophosphate transmembrane transport
  type: gocam:Object
- id: CHEBI:58937
  label: thiamine(1+) diphosphate(3-)
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: CHEBI:11851
  label: 3-methyl-2-oxobutanoate
  type: gocam:Object
- id: CHEBI:1178
  label: (2S)-2-isopropylmalate(2-)
  type: gocam:Object
- id: CHEBI:83088
  label: (R)-lipoate
  type: gocam:Object
- id: CHEBI:29969
  label: L-lysinium residue
  type: gocam:Object
- id: CHEBI:83099
  label: N(6)-[(R)-lipoyl]-L-lysine residue
  type: gocam:Object
- id: GO:0045254
  label: pyruvate dehydrogenase complex
  type: gocam:Object
- id: CHEBI:83111
  label: N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysine residue
  type: gocam:Object
- id: CHEBI:83100
  label: N(6)-[(R)-dihydrolipoyl]-L-lysine residue
  type: gocam:Object
- id: CHEBI:16452
  label: oxaloacetate(2-)
  type: gocam:Object
- id: GO:0050833
  label: pyruvate transmembrane transporter activity
  type: gocam:Object
- id: GO:7770001
  label: mitochondrial pyruvate carrier complex
  type: gocam:Object
- id: PomBase:SPCC1235.11
  label: mpc1 Spom
  type: gocam:Object
- id: PomBase:SPAC24B11.09
  label: mpc2 Spom
  type: gocam:Object
- id: GO:0006850
  label: pyruvate import into mitochondria
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0042853
  label: L-alanine catabolic process
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2026-04-27'
  provided_by:
  - http://www.pombase.org
