id: gomodel:67086be200000363
title: cardiolipin metabolic process (GO:0032048) (Spom)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-04-03'
comments:
- https://www.pombase.org/results/from/id/3cf1abdc-1a95-4603-a17d-26f84425bfb8
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      - PomBase:SPAC22A12.08c
      - UniProtKB:A0A2K3D1C8
      provenances:
      - contributor:
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        date: '2026-01-03'
        provided_by:
        - http://www.pombase.org
    provenances:
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      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67086be200000363/693b3c0900005022
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000370438
      - FB:FBgn0039360
      - TAIR:locus:2138962
      - SGD:S000002301
      - WB:WBGene00017763
      - RGD:1311037
      - UniProtKB:Q9UJA2
      - PomBase:SPAC22A12.08c
      - UniProtKB:A0A2K3D1C8
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
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        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67086be200000363/693b3c0900005028
- id: gomodel:67086be200000363/693b3c0900005046
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-03-01'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-01'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC4D7.02c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0034479
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0034479
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0032473
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000597716
      - MGI:MGI:1915866
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
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        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0046475
  molecular_associations:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-01-03'
        provided_by:
        - http://www.pombase.org
    provenances:
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      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/693b3c0900005062
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/69c59f8a00001916
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/69c59f8a00001916
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-01-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/693b3c0900005062
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-01-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/693b3c0900005062
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001155729
      - SGD:S000006127
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
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      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67086be200000363/69c59f8a00001921
- id: gomodel:67086be200000363/69c59f8a00001925
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0120013
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
  molecular_associations:
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    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000370438
      - FB:FBgn0039360
      - TAIR:locus:2138962
      - SGD:S000002301
      - WB:WBGene00017763
      - RGD:1311037
      - UniProtKB:Q9UJA2
      - PomBase:SPAC22A12.08c
      - UniProtKB:A0A2K3D1C8
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
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      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67086be200000363/693b3c0900005022
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67086be200000363/69c59f8a00001932
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67086be200000363/69c59f8a00001932
- id: gomodel:67086be200000363/69c59f8a00001932
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0140303
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005758
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0034204
  molecular_associations:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/69c59f8a00001921
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/69c59f8a00001921
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67086be200000363/69c59f8a00001921
molecules:
- id: gomodel:67086be200000363/69c59f8a00001921
  term: CHEBI:64716
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005741
- id: gomodel:67086be200000363/693b3c0900005035
  term: CHEBI:58332
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:67086be200000363/693b3c0900005062
  term: CHEBI:17815
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:67086be200000363/69c59f8a00001916
  term: CHEBI:57597
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:67086be200000363/67086be200000462
  term: CHEBI:62237
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-01'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:67086be200000363/693b3c0900005016
  term: CHEBI:60110
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:67086be200000363/693b3c0900005041
  term: CHEBI:57597
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:67086be200000363/69a0c46f00000462
  term: CHEBI:58608
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-01'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:67086be200000363/693b3c0900005022
  term: CHEBI:64716
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:67086be200000363/693b3c0900005028
  term: CHEBI:58332
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-01-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:67086be200000363/69a0c46f00000458
  term: CHEBI:37563
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-01'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
objects:
- id: GO:0043337
  label: cardiolipin synthase (CMP-forming) activity
  type: gocam:Object
- id: PomBase:SPAC22A12.08c
  label: crd1 Spom
  type: gocam:Object
- id: GO:0032049
  label: cardiolipin biosynthetic process
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0008962
  label: phosphatidylglycerophosphatase activity
  type: gocam:Object
- id: PomBase:SPCC645.02
  label: gep4 Spom
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0008444
  label: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
  type: gocam:Object
- id: PomBase:SPBP18G5.02
  label: pgs1 Spom
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004605
  label: phosphatidate cytidylyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC1A4.06c
  label: tam41 Spom
  type: gocam:Object
- id: GO:0016024
  label: CDP-diacylglycerol biosynthetic process
  type: gocam:Object
- id: CHEBI:62237
  label: cardiolipin(2-)
  type: gocam:Object
- id: CHEBI:37563
  label: CTP(4-)
  type: gocam:Object
- id: CHEBI:58608
  label: 1,2-diacyl-sn-glycerol 3-phosphate(2-)
  type: gocam:Object
- id: GO:0032473
  label: cytoplasmic side of mitochondrial outer membrane
  type: gocam:Object
- id: CHEBI:57597
  label: sn-glycerol 3-phosphate(2-)
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: CHEBI:64716
  label: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
  type: gocam:Object
- id: GO:0005741
  label: mitochondrial outer membrane
  type: gocam:Object
- id: GO:0120013
  label: lipid transfer activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: GO:0140303
  label: intramembrane lipid carrier activity
  type: gocam:Object
- id: GO:0034204
  label: lipid translocation
  type: gocam:Object
- id: GO:0005758
  label: mitochondrial intermembrane space
  type: gocam:Object
- id: CHEBI:60110
  label: 1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate(3-)
  type: gocam:Object
- id: CHEBI:58332
  label: CDP-diacylglycerol(2-)
  type: gocam:Object
- id: GO:0034479
  label: phosphatidylglycerol phospholipase C activity
  type: gocam:Object
- id: PomBase:SPAC4D7.02c
  label: pgc1 Spom
  type: gocam:Object
- id: GO:0046475
  label: glycerophospholipid catabolic process
  type: gocam:Object
- id: CHEBI:17815
  label: 1,2-diacyl-sn-glycerol
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0000-0003-1179-5999
  date: '2026-04-03'
  provided_by:
  - http://www.pombase.org
