id: gomodel:6994852c00000143
title: TOM-TIM22-mediated mitochondrial inner membrane protein insertion (GO:7770061)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-05-20'
activities:
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      - RGD:708467
      - SGD:S000003314
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      term: GO:0140596
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      date: '2026-04-15'
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- id: gomodel:6994852c00000143/6994852c00000612
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    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000003413
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-20'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-20'
      provided_by:
      - http://www.pombase.org
    term: GO:0042719
    has_part:
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000266
        reference: GO_REF:0000024
        with_objects:
        - SGD:S000003413
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2026-04-15'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPAC17C9.09c
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000266
        reference: GO_REF:0000024
        with_objects:
        - SGD:S000007348
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2026-04-15'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPAC13G6.04
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0140309
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0042719
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-20'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-20'
      provided_by:
      - http://www.pombase.org
    term: GO:0005758
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0042719
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-15'
      provided_by:
      - http://www.pombase.org
    term: GO:7770061
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-25'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:6994852c00000143/69b3372b00003694
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:6994852c00000143/6994852c00000621
- id: gomodel:6994852c00000143/6994852c00000631
  enabled_by:
    type: EnabledByProteinComplexAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000007256
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-20'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-20'
      provided_by:
      - http://www.pombase.org
    term: GO:0042719
    has_part:
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000266
        reference: GO_REF:0000024
        with_objects:
        - SGD:S000007256
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2026-04-15'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPCC24B10.05
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000266
        reference: GO_REF:0000024
        with_objects:
        - SGD:S000003530
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2026-04-15'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPAC222.03c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0140309
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0042719
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-20'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-20'
      provided_by:
      - http://www.pombase.org
    term: GO:0005758
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0042719
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-15'
      provided_by:
      - http://www.pombase.org
    term: GO:7770061
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:6994852c00000143/6994852c00001393
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:6994852c00000143/6994852c00001394
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:6994852c00000143/6994852c00000621
- id: gomodel:6994852c00000143/6994852c00000179
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC823.17
    part_of:
    - type: PartOfProteinComplexAssociation
      evidence:
      - term: ECO:0000266
        reference: GO_REF:0000024
        with_objects:
        - SGD:S000003314
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2026-02-18'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
      term: GO:0140596
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003674
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0140596
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0005741
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0140596
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-15'
      provided_by:
      - http://www.pombase.org
    term: GO:7770061
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-05-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:6994852c00000143/6994852c00000144
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-05-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-05-11'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-05-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:6994852c00000143/6994852c00000167
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-05-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:6994852c00000143/6994852c00000167
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:6994852c00000143/6994852c00000144
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:6994852c00000143/6994852c00000167
- id: gomodel:6994852c00000143/6994852c00000196
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC27B12.10c
    part_of:
    - type: PartOfProteinComplexAssociation
      evidence:
      - term: ECO:0000266
        reference: GO_REF:0000024
        with_objects:
        - SGD:S000005014
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2026-02-18'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
      term: GO:0140596
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003674
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN002439577
      - SGD:S000005014
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-02-18'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    term: GO:0005741
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0140596
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-04-15'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-04-15'
      provided_by:
      - http://www.pombase.org
    term: GO:7770061
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-02-18'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:6994852c00000143/6994852c00000144
molecules:
- id: gomodel:6994852c00000143/6994852c00001031
  term: PomBase:SPAC12B10.09
- id: gomodel:6994852c00000143/6994852c00001021
  term: PomBase:SPAC8C9.12c
- id: gomodel:6994852c00000143/6994852c00001035
  term: PomBase:SPBC1604.04
- id: gomodel:6994852c00000143/6994852c00001025
  term: PomBase:SPAC227.03c
- id: gomodel:6994852c00000143/6994852c00001024
  term: PomBase:SPCC1442.03
- id: gomodel:6994852c00000143/6994852c00001039
  term: PomBase:SPAC3A12.16c
- id: gomodel:6994852c00000143/6994852c00001013
  term: PomBase:SPAC19G12.05
- id: gomodel:6994852c00000143/6994852c00001012
  term: PomBase:SPBC530.10c
- id: gomodel:6994852c00000143/6994852c00001009
  term: PomBase:SPAC328.09
- id: gomodel:6994852c00000143/6994852c00001014
  term: PomBase:SPAC17H9.08
- id: gomodel:6994852c00000143/6994852c00001028
  term: PomBase:SPAC688.09
- id: gomodel:6994852c00000143/6994852c00001058
  term: PomBase:SPBC1347.04
- id: gomodel:6994852c00000143/6994852c00001034
  term: PomBase:SPAC17G6.15c
- id: gomodel:6994852c00000143/6994852c00001029
  term: PomBase:SPCC1235.11
- id: gomodel:6994852c00000143/6994852c00002737
  term: PomBase:SPBC83.13
- id: gomodel:6994852c00000143/6994852c00001011
  term: PomBase:SPBC12D12.05c
- id: gomodel:6994852c00000143/6994852c00001030
  term: PomBase:SPAC24B11.09
- id: gomodel:6994852c00000143/6994852c00001057
  term: PomBase:SPBP23A10.16
- id: gomodel:6994852c00000143/6994852c00001033
  term: PomBase:SPBC1271.11
- id: gomodel:6994852c00000143/6994852c00001010
  term: PomBase:SPAPB17E12.12c
- id: gomodel:6994852c00000143/6994852c00001017
  term: PomBase:SPAC4G9.20c
- id: gomodel:6994852c00000143/6994852c00001018
  term: PomBase:SPAC823.10c
- id: gomodel:6994852c00000143/6994852c00001027
  term: PomBase:SPAC139.02c
- id: gomodel:6994852c00000143/69b3372b00003694
  term: PomBase:SPCC16A11.09c
- id: gomodel:6994852c00000143/6994852c00001056
  term: PomBase:SPCC330.12c
- id: gomodel:6994852c00000143/6994852c00001015
  term: PomBase:SPBC27B12.09c
- id: gomodel:6994852c00000143/6994852c00001393
  term: PomBase:SPCC1235.11
- id: gomodel:6994852c00000143/6994852c00001026
  term: PomBase:SPBC29A3.11c
- id: gomodel:6994852c00000143/6994852c00001037
  term: PomBase:SPBC25H2.04c
- id: gomodel:6994852c00000143/6994852c00001016
  term: PomBase:SPBP23A10.06
- id: gomodel:6994852c00000143/6994852c00001394
  term: PomBase:SPAC24B11.09
- id: gomodel:6994852c00000143/6994852c00001022
  term: PomBase:SPAC4G8.08
- id: gomodel:6994852c00000143/6994852c00001019
  term: PomBase:SPCC1682.09c
- id: gomodel:6994852c00000143/6994852c00001020
  term: PomBase:SPBC1703.13c
objects:
- id: GO:0043495
  label: protein-membrane adaptor activity
  type: gocam:Object
- id: PomBase:SPCC330.12c
  label: sdh3 Spom
  type: gocam:Object
- id: GO:0042721
  label: TIM22 mitochondrial import inner membrane insertion complex
  type: gocam:Object
- id: GO:7770061
  label: TOM-TIM22-mediated mitochondrial inner membrane protein insertion
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPCC16A11.09c
  label: tim23 Spom
  type: gocam:Object
- id: GO:0008320
  label: transmembrane protein transporter activity
  type: gocam:Object
- id: PomBase:SPBC27B12.13
  label: tom40 Spom
  type: gocam:Object
- id: GO:0005741
  label: mitochondrial outer membrane
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0030943
  label: mitochondrion targeting sequence binding
  type: gocam:Object
- id: PomBase:SPAC6B12.12
  label: tom70 Spom
  type: gocam:Object
- id: GO:0140596
  label: TOM complex
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPBC19G7.19
  label: tom5 Spom
  type: gocam:Object
- id: PomBase:SPAC17H9.16
  label: tom22 Spom
  type: gocam:Object
- id: PomBase:SPAC823.17
  label: tom6 Spom
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: PomBase:SPBC27B12.10c
  label: tom7 Spom
  type: gocam:Object
- id: GO:0032977
  label: membrane insertase activity
  type: gocam:Object
- id: PomBase:SPBC25H2.04c
  label: tim22 Spom
  type: gocam:Object
- id: PomBase:SPBC1347.04
  label: tim54 Spom
  type: gocam:Object
- id: GO:0140309
  label: unfolded protein holdase activity
  type: gocam:Object
- id: GO:0042719
  label: mitochondrial intermembrane space chaperone complex
  type: gocam:Object
- id: PomBase:SPCC24B10.05
  label: tim9 Spom
  type: gocam:Object
- id: PomBase:SPAC222.03c
  label: tim10 Spom
  type: gocam:Object
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- id: GO:0005758
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provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2026-05-20'
  provided_by:
  - http://www.pombase.org
