Long RNA-Mediated Chromatin Regulation in Fission Yeast and Mammals.
As part of a complex network of genome control, long regulatory RNAs exert significant influences on chromatin dynamics. Understanding how this occurs could illuminate new avenues for disease treatment and lead to new hypotheses that would advance gene regulatory research. Recent studies using the model fission yeast  Schizosaccharomyces pombe  ( S. pombe ) and powerful parallel sequencing technologies have provided many insights in this area. This review will give an overview of key findings in  S. pombe  that relate long RNAs to multiple levels of chromatin regulation: histone modifications, gene neighborhood regulation in  cis  and higher-order chromosomal ordering. Moreover, we discuss parallels recently found in mammals to help bridge the knowledge gap between the study systems.
Faber MW, Vo TV