Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
In this issue of Molecular Cell, Day et al. (2012) reveal a surprising benefit of peroxiredoxin inactivation at high H(2)O(2), showing that in Schizosaccharomyces pombe turning off peroxide defenses preserves the pool of reduced thioredoxin for repairing proteins vital to survival.
Karplus PA, Poole LB