Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes.
The histone code, comprised of diverse histone post-translational modifications, intricately regulates nucleosome organization and gene expression. Histone marks also serve as binding sites for a diverse array of protein complexes and enzymes, orchestrating downstream cellular functions. Some modifications are crucial for enabling the complete activation of alternative gene expression programs in response to environmental changes.
This study provides insights into the complex histone crosstalk regulating gene expression and underscores the pivotal role of histone ubiquitination in promoting efficient nucleosome dynamics during Pol II transcription.
The online version contains supplementary material available at 10.1186/s13059-025-03891-1.
Barrios R, Vega M, Gracia-Domingo R, Boronat S, García-Santamarina S, Tanny JC, Ayté J, Hidalgo E