Microbial reduction of 1,3-dioxo-2-methyl-2-(3'0oxo-6'-carbomethoxyhexyl)-cyclopentane to form 1 beta-hydroxy-3-oxo-2beta-methyl-2alpha-(3'-oxo-6'-carbomethoxyhexyl)-cyclopentane, an intermediate for steroid total syntheses.
The rate and extent of stereoselective reduction of 1,3-dioxo-2-methyl-2-(3'-oxo-6'-carbomethoxyhexyl)-cyclopentane to form the 1beta-hydroxy-2beta-methyl isomer by cultures of Schizosaccharomyces pombe ATCC 2476 was dramatically increased by addition to the fermentation of certain alpha,beta-unsaturated ketones and allyl alcohol.
Lanzilotta RP, Bradley DG, Beard CC