Loss of  epe1  +   extends chronological lifespan in  Schizosaccharomyces pombe .
Aging is a complex phenomenon that is characterized by the altered regulation of various biological processes over time. One of these, epigenetics, play a crucial role throughout the different stages of eukaryotic life and its alteration is considered a key molecular hallmark of aging. However, the epigenetic factors which are important for lifespan control remain elusive. Here, we used  S. pombe  as a model organism to study the epigenetic basis of aging. Our study reveals that loss of the  epe1  + gene, encoding for the JmjC domain protein Epe1 , extends chronological lifespan and increases H3K9me3 in aged  S. pombe  cells  . 
Basu S, Xu Y, Vo T