Recent Insights on Alzheimer's Disease Originating from Yeast Models.
In this review article, yeast model-based research advances regarding the role of Amyloid-&beta; (A&beta;), Tau and frameshift Ubiquitin UBB +1  in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown their added value as complementary models for the study of the molecular aspects of these proteins, including their interplay with AD-related cellular processes such as mitochondrial dysfunction and altered proteostasis. Moreover, these yeast models have also shown their importance in translational research, e.g., in compound screenings and for AD diagnostics development. In addition to well-established  Saccharomyces cerevisiae  models, new upcoming  Schizosaccharomyces pombe ,  Candida glabrata  and  Kluyveromyces lactis  yeast models for Aβ and Tau are briefly described. Finally, traditional and more innovative research methodologies, e.g., for studying protein oligomerization/aggregation, are highlighted.
Seynnaeve D, Vecchio MD, Fruhmann G, Verelst J, Cools M, Beckers J, Mulvihill DP, Winderickx J, Franssens V