Oxidative stress induction as a cause of Ba2+-dependent fungicidal action of UMP-derivative on the yeast Shizosaccharomyces pombe.
A UMP-derivative, uridine 5'-hexadecylphosphate (UMPC16), exhibited a fungicidal action against various yeast strains including the fission yeast Schizosaccharomyces pombe in combination with Ba2+ ion. UMPC16 accelerated reactive oxygen species (ROS) generation in medium with Ba2+ ion in a dose- and time-dependent manner. Additional supplementation of Ca2+ ion into medium could suppress such a combined fungicidal action due to oxidative stress induction.
Tanaka T, Usuki Y