MCM complex loading
MCM complex loading at replication origin
exact
MCM double hexamer formation at replication origin
exact
The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.
GO:0022402
cell cycle process
is_a
GO:0065004
protein-DNA complex assembly
is_a
GO:1902315
nuclear cell cycle DNA replication initiation
part_of
SPBC14C8.07c