general transcription initiation factor activity
GTF activity
exact
basal transcription factor activity
exact
general transcription factor activity
exact
A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
GO:0003674
molecular_function
is_a
SPBC336.09c SPAC17G8.03c SPBC21H7.02 SPBC30B4.07c SPBC336.07 SPAC1D4.12 SPCC1919.14c SPAC823.06 SPBC32F12.15 SPCC1259.06 SPAC3A12.05c SPCC1672.08c SPAC23G3.09 SPAC16E8.11c SPAC15A10.02 SPBC13G1.13 SPCC5E4.03c SPCC553.11c SPBC3B8.11 SPBP16F5.02 SPBC28F2.09 SPBC15D4.14 SPAC29A4.10 SPAC2G11.14 SPCC1494.02c SPCC16C4.14c SPCC16C4.18c SPBC1198.13c SPAC18G6.11c SPAC12G12.05c SPAC22E12.08 SPBC17D1.04 SPBC8D2.07c SPAC1250.07 SPAC17A5.06 SPAC13A11.04c SPCC285.17 SPBC776.18c SPAC13F5.02c SPCC1620.09c SPBC1826.01c SPAC16E8.16 SPAC22H12.02 SPBC30D10.02 SPAC144.09c SPBC21H7.05 SPAC1002.04c SPCC1682.07 SPAC6F12.11c SPBC13E7.10c SPAC458.07 SPBC725.17c SPBC28F2.11 SPBC19F8.07 SPAC29E6.08