RNA polymerase II, core complex
DNA-directed RNA polymerase II, core complex
exact
RNA polymerase II complex
broad
RNAP II complex
broad
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
GO:0055029
nuclear DNA-directed RNA polymerase complex
is_a
GO:0016591
RNA polymerase II, holoenzyme
part_of
SPCC1442.10c SPAC23C4.15 SPAPYUG7.04c SPCC1020.04c SPBC337.14 SPBC28F2.12 SPBC19C2.03 SPBC14C8.12 SPBC947.13 SPACUNK4.06c SPAC1B3.12c SPAC3A12.07 SPAC23G3.01