ERAD pathway
ER-associated degradation pathway
related
endoplasmic reticulum-associated degradation
exact
endoplasmic reticulum-associated protein degradation pathway
related
protein degradation by ERAD
exact
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
GO:0010498
proteasomal protein catabolic process
is_a
GO:0034976
response to endoplasmic reticulum stress
is_a
GO:0042221
response to chemical
is_a
SPBC2D10.20 SPAC20H4.10 SPCC1827.04 SPBP4H10.19c SPAC1565.08 SPBC365.08c SPAC1782.01 SPBC1709.14 SPCC1840.08c SPAC959.05c SPAC4D7.14 SPBC14F5.07 SPBC16A3.09c SPAC6G9.08 SPBC28F2.08c SPCC4G3.13c SPBC2D10.12 SPAC22A12.15c SPAC23A1.07 SPAC1B3.10c SPAC23A1.04c SPAC2E1P5.01c SPAC1952.03 SPAC1687.17c SPAC3C7.11c SPAC25B8.17 SPBC1347.05c SPBP16F5.04 SPAC227.11c SPBC1711.10c SPBC17D11.02c SPAC328.06 SPAC24C9.14 SPAC167.07c SPCC285.11 SPAC4G9.19 SPCC1682.16 SPAC10F6.05c SPAC26A3.16