p38MAPK cascade
MAPK14 cascade
related
osmosensory signaling MAPK cascade
narrow
p38 MAPK cascade
exact
p38 cascade
exact
A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
GO:0000165
MAPK cascade
is_a
SPBC409.07c SPCC4F11.02 SPAC24B11.06c SPBC32F12.11 SPAC19D5.01 SPCC757.09c SPAC26F1.10c SPAC4A8.03c SPAC27E2.09 SPCC576.03c SPAC2G11.07c SPCC74.06 SPAC9G1.02 SPAPYUG7.02c SPBC887.10 SPAC6B12.15 SPAC1006.09 SPBC725.02