nuclear exosome (RNase complex)
eukaryotic exosome multienzyme ribonuclease complex
exact
nuclear exosome (ribonuclease complex)
exact
nuclear exosome multienzyme ribonuclease complex
exact
A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
GO:0000178
exosome (RNase complex)
is_a
GO:0140513
nuclear protein-containing complex
is_a
GO:0031981
nuclear lumen
part_of
SPAC1F3.01 SPBC16G5.10 SPBC211.08c SPCC1739.07 SPACUNK4.11c SPBC17D1.03c SPBC115.01c SPBC26H8.10 SPAC3G9.10c SPCC757.08 SPAC2F7.14c SPAC22A12.12c SPCC1840.11