heparin proteoglycan biosynthetic process
heparan sulfate biosynthetic process
related
heparin anabolism
exact
heparin biosynthesis
exact
heparin formation
exact
heparin synthesis
exact
The chemical reactions and pathways resulting in the formation of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
GO:0030202
heparin proteoglycan metabolic process
is_a
GO:0180064
protein O-linked glycosylation via xylose
is_a