hippo signaling
SWH pathway
narrow
Salvador-Warts-Hippo signaling pathway
narrow
hippo signal transduction
exact
hippo signaling cascade
related
hippo signaling pathway
exact
hippo signalling cascade
related
An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
GO:0035556
intracellular signal transduction
is_a
SPBC27B12.04c