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protein coding gene - jmj2 (SPAC1002.05c) - histone demethylase Jmj2

Gene summary

Standard name
jmj2
Systematic ID
SPAC1002.05c
Product
histone demethylase Jmj2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
kdm5
UniProt ID
Q9US53
ORFeome ID
37/37E11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1804548..1806797 reverse strand

Annotation

Disease association

MONDO:0970951 - El Hayek-Chahrour neurodevelopmental disorder

References:

MONDO:0020850 - intellectual disability, autosomal recessive 65

References:

MONDO:0010355 - syndromic X-linked intellectual disability Claes-Jensen type

References:

GO biological process

GO:0006338 - chromatin remodeling

References:

GO:0006355 - regulation of DNA-templated transcription

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0051864 - histone H3K36 demethylase activity

References:

GO:0032453 - histone H3K4 demethylase activity

References:

GO:0034647 - histone H3K4me/H3K4me2/H3K4me3 demethylase activity

References:

Protein features

PBO:0111840 - ARID domain

PBO:0111833 - jmjC domain

PBO:0111834 - jmjN domain

PBO:0111832 - zf-C5HC2 type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0004765 - normal cell population growth during glucose starvation

References:

Genotypes:

FYPO:0002335 - normal chromatin silencing

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF02373JmjCJmjC_domPfam
PF02375JmjNJmjNPfam
PF02928zf-C5HC2Znf_C5HC2Pfam
cd16100ARIDCDD
PS51011ARIDARID_domPROSITE profiles
PS51183JMJNJmjNPROSITE profiles
PS51184JMJCJmjC_domPROSITE profiles
SM00501BRIGHTARID_domSMART
SM00545JmjNJmjNSMART
SM00558JmjCJmjC_domSMART
SM01014ARIDSMART
G3DSA:1.10.150.60ARID_dom_sfCATH-Gene3D
G3DSA:2.60.120.650CATH-Gene3D
SSF46774ARID_dom_sfSUPERFAMILY
SSF51197SUPERFAMILY
PTHR10694PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
PMID:17550896 - The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation.
Huarte M et al. J Biol Chem 2007 Jul 27;282(30):21662-70
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:28600551 - Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2.
Chen Y et al. Sci Rep 2017 Jun 09;7(1):3208
GO_REF:0000002 - Comments
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25838386 - Epigenetics. Restricted epigenetic inheritance of H3K9 methylation.
Audergon PN et al. Science 2015 Apr 03;348(6230):132-5