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protein coding gene - bqt2 (SPAC1002.06c) - bouquet formation protein Bqt2

Gene summary

Standard name
bqt2
Systematic ID
SPAC1002.06c
Product
bouquet formation protein Bqt2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug18, rec23
UniProt ID
Q9US52
ORFeome ID
05/05A07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1807270..1807781 reverse strand

Annotation

Comment

PBO:0001192 - promoter contains MCB

References:

GO biological process

GO:0032121 - meiotic attachment of telomeric heterochromatin to spindle pole body

References:

GO:0045141 - meiotic telomere clustering

References:

GO cellular component

GO:0140445 - chromosome, telomeric repeat region

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GO:0035974 - meiotic spindle pole body

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GO:0044732 - mitotic spindle pole body

References:

GO:0110092 - nucleus leading edge

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0030674 - protein-macromolecule adaptor activity

References:

Multi-locus phenotype

FYPO:0004159 - abnormal homologous chromosome segregation

References:

Genotypes:

FYPO:0005652 - abnormal spindle morphology during meiosis I

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Genotypes:

FYPO:0006366 - abolished meiotic telomere clustering

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Genotypes:

FYPO:0004605 - decreased distance travelled by the spindle pole body during horsetail movement

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Genotypes:

FYPO:0004656 - increased protein localization to telomere during vegetative growth

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Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002890 - abnormal horsetail nucleus morphology

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Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000172 - abnormal meiotic telomere clustering

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Genotypes:

FYPO:0003567 - abnormal mitotic spindle pole body insertion into nuclear envelope

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0001894 - abnormal sporulation resulting in formation of ascus with more or fewer than four spores

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Genotypes:

FYPO:0006366 - abolished meiotic telomere clustering

References:

Genotypes:

FYPO:0004605 - decreased distance travelled by the spindle pole body during horsetail movement

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

FYPO:0002772 - decreased protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0006363 - monopolar spindle during meiosis I

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Genotypes:

FYPO:0003541 - normal protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0004569 - normal spindle during meiosis I

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Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

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Genotypes:

FYPO:0002905 - normal telomere maintenance

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0006930 - sensitive to butylated hydroxyanisole

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0006364 - spindle microtubules detached from spindle pole body during meiosis I

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23133674 - Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.
Fujita I et al. PLoS One 2012;7(11):e49151
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:22959349 - Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation.
Fujita I et al. Curr Biol 2012 Oct 23;22(20):1932-7
PMID:19948484 - Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation.
Chikashige Y et al. J Cell Biol 2009 Nov 02;187(3):413-27
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
PMID:20364342 - Functional interactions among members of the meiotic initiation complex in fission yeast.
Steiner S et al. Curr Genet 2010 Jun;56(3):237-49
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:26058898 - Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation.
Amelina H et al. BMC Biol 2015 Jun 10;13:37
PMID:23337086 - Purification and characterization of the fission yeast telomere clustering factors, Bqt1 and Bqt2.
Ichikawa Y et al. Protein Expr Purif 2013 Apr;88(2):207-13
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24954111 - Chromosomes rein back the spindle pole body during horsetail movement in fission yeast meiosis.
Chikashige Y et al. Cell Struct Funct 2014;39(2):93-100
PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:31131414 - Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.
Inoue H et al. Nucleic Acids Res 2019 Jul 26;47(13):6871-6884
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.
Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837