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protein coding gene - mtf1 (SPAC1002.08c) - mitochondrial RNA polymerase specificity factor, predicted rRNA methyltransferase Mtf1

Gene summary

Standard name
mtf1
Systematic ID
SPAC1002.08c
Product
mitochondrial RNA polymerase specificity factor, predicted rRNA methyltransferase Mtf1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9US51
ORFeome ID
17/17C03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1809480..1811330 reverse strand

Annotation

GO biological process

GO:0006390 - mitochondrial transcription

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0006391 - transcription initiation at mitochondrial promoter

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0034245 - mitochondrial DNA-directed RNA polymerase complex

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0034246 - mitochondrial transcription factor activity

References:

GO:0016433 - rRNA (adenine) methyltransferase activity

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000809 - abnormal mitochondrion organization

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0003423 - decreased mitochondrial RNA level

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0000849 - increased cytoplasmic protein level during vegetative growth

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0003422 - inviable after spore germination, multiple cell divisions, elongated multiseptate tapered cell

References:

Genotypes:

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00398RrnaADKsgA/ErmPFAM
PS51689SAM_RNA_A_N6_MTKsgA/ErmPROSITE_PROFILES
SSF53335S-adenosyl-L-methionine-dependent methyltransferasesSAM-dependent_MTases_sfSUPERFAMILY
G3DSA:3.40.50.150Vaccinia Virus protein VP39SAM-dependent_MTases_sfGENE3D
G3DSA:1.10.8.100rRNA_Ade_diMease-like_CGENE3D
PTHR11727DIMETHYLADENOSINE TRANSFERASEKsgA/ErmPANTHER

Orthologs

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21357609 - Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe.
Jiang H et al. Nucleic Acids Res 2011 Jul;39(12):5119-30
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:21138961 - A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1.
Sun W et al. Nucleic Acids Res 2011 Apr;39(7):2690-700
PMID:23035257 - Targeting mitochondrial transcription in fission yeast with ETB, an inhibitor of HSP60, the chaperone that binds to the mitochondrial transcription factor Mtf1.
Sun W et al. Genes Cells 2012 Feb;17(2):122-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6