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protein coding gene - dld1 (SPAC1002.09c) - mitochondrial dihydrolipoamide dehydrogenase (e3 component of oxoglutarate dehydrogenase complex) Dld1

Gene summary

Standard name
dld1
Systematic ID
SPAC1002.09c
Product
mitochondrial dihydrolipoamide dehydrogenase (e3 component of oxoglutarate dehydrogenase complex) Dld1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
dldh
UniProt ID
O00087
ORFeome ID
24/24H06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1811408..1813740 reverse strand

Annotation

Disease association

MONDO:0004736 - inborn disorder of amino acid metabolism

References:

MONDO:0000688 - inborn organic aciduria

References:

MONDO:0009563 - maple syrup urine disease

References:

MONDO:0000440 - metabolic acidosis

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0009529 - pyruvate dehydrogenase E3 deficiency

References:

GO biological process

GO:0019464 - glycine decarboxylation via glycine cleavage system

References:

GO:0006086 - pyruvate decarboxylation to acetyl-CoA

References:

GO cellular component

GO:0005960 - glycine cleavage complex

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO:0045252 - oxoglutarate dehydrogenase complex

References:

GO:0045254 - pyruvate dehydrogenase complex

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GO molecular function

GO:0004148 - dihydrolipoyl dehydrogenase (NADH) activity

References:

GO:0050660 - flavin adenine dinucleotide binding

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000394 - abnormal mitotic G1/S phase transition

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002251 - inviable swollen elongated vegetative cell

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02852Pyr_redox_dimPyr_nucl-diS_OxRdtase_dimerPfam
PF07992Pyr_redox_2FAD/NAD-binding_domPfam
PS00076PYRIDINE_REDOX_1Pyr_OxRdtase_I_ASPROSITE patterns
PR00368FADPNRPRINTS
PR00411PNDRDTASEIPRINTS
G3DSA:3.30.390.30:FF:000001CATH-FunFam
G3DSA:3.50.50.60:FF:000001CATH-FunFam
G3DSA:3.30.390.30FAD/NAD-linked_Rdtase_dimer_sfCATH-Gene3D
G3DSA:3.50.50.60FAD/NAD-bd_sfCATH-Gene3D
SSF51905FAD/NAD-bd_sfSUPERFAMILY
SSF55424FAD/NAD-linked_Rdtase_dimer_sfSUPERFAMILY
PTHR22912Class-I_Pyr_Nuc-Dis_OxidoredPANTHER
PIRSF000350Mercury_reductase_MerAPyr_nuc-diS_OxRdtasePIRSF
TIGR01350lipoamide_DHLipoamide_DHNCBIFAM

Orthologs

References / Literature

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000036 - Manual annotations that require more than one source of functional data to support the assignment of the associated GO term
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000003 - Disease Association Curation
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:9366254 - Fission yeast dihydrolipoamide dehydrogenase gene is involved in G1/S cell cycle progression.
Jang YJ et al. Biochim Biophys Acta 1997 Oct 11;1358(3):229-39
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025